부분 조절 내사시의 근거리각 기준 수술 후 장기간의 경과 관찰

정인영,박영걸,박상우,In Young Jeong,Yeoung Geol Park,Sang Woo Park 대한안과학회 2008 대한안과학회지 Vol.49 No.4

Purpose: To analyze the long-term outcome of near geared standard surgery with full hyperopic correction for partially accommodative esotropia. Methods: The medical records of a total of 24 patients with partially accommodative esotorpia, who had undergone bilateral or unilateral medial rectus recession were retrospectively reviewed. The amount of medial rectus recession was measured based on the near deviation after full hyperopic correction. During the follow-up period the changes of refractive error and angle of deviation were evaluated, and the titmus test and Worth 4-Dot test were performed. Results: The mean ages were 36.63±13.38 months (14~59 months) at the time of wearing glasses and 61.25±25.55 months (25~132 months) at the time of operation. The average follow-up period was 59.67±32.12 months (18~120 months) and preoperative refractive errors were +3.93±1.73 D sph and refractive errors at final visit were +3.64±2.07 D sph (p=0.53). The mean amount of esodeviation were 26.08±8.13PD and 4.25±6.63PD for pre- and post-operatively respectively. Nineteen patients showed postoperative deviation of 10PD or less, one patient was overcorrected, and four patients were undercorrected. Worth 4-Dot test resulted in a fusion response at near and far in one patient preoperatively and in 17 patients postoperatively (p=0.30). A titmus stereotest of less than 100 seconds of arc resulted in 1 of 7 patients and 6 of 14 patients at the time of preoperation and postoperation each (p=0.34). The results were not statistically significant. Four of ten high hyperopic patients (≥ +4.00 diopter) had under- or over-correction (p=0.12), though it was not statistically significant. There were no significant differences in combined conditions. Conclusions: Near geared standard surgery with full hyperopic correction in partially accommodative esotropia patients gave a good surgical result for patients in the mean follow-up duration of 59.67 months.

투과체에 적용된 채광방식이 사무소공간의 색도 및 색온도분포에 미치는 영향 분석

정인영,김정태,Jeong, In-Young,Kim, Jeong-Tai 한국조명전기설비학회 2007 조명·전기설비학회논문지 Vol.21 No.3

투과체는 기본적으로 외부환경과 접촉할 수 있는 친화적이고 생태학적인 기능을 가지고 있으며, 이를 통해 유입되는 빛은 실내공간에 다양한 분위기를 연출할 수 있도록 해준다. 이에 본 연구는 투과체가 적용된 사무소건물을 대상으로 채광유입을 증대시킬 수 있는 채광방식을 설계하여 적용 시 실내의 색도와 색온도에 미치는 영향을 분석하였다. 이를 위하여 1/10축소모형을 제작하였으며, Prometric 1421이라는 측정기기를 이용하여 실험을 수행하였다. 측정결과 투과체가 갖는 파장대별 투과특성이 실내의 색도에 영향을 미치는 것으로 나타났으며, 빛의 유입을 증대시키는 채광방식을 설치할 경우 천정면의 색온도에 많은 영향을 주었으며, $5{\sim}20[%]$정도의 색온도를 증가시키는 것으로 나타났다. 따라서 채광시스템을 설치할 경우 활동적인 분의기의 공간이 연출될 수 있을 것으로 기대된다. One basic function of glazing system has always been the maintenance of visual contact with the natural environment-a fundamentally ecological function. In addition, penetration light through glazing system have an effect on variable atmosphere of interior. In this study, a typical office space was selected as a evaluation model and a 1/10 scale model was made. The conventional window, differentiated window and interior lightshelf were designed to enhance daylighting performance. The chromaticity and color temperature of interior space was measured using Prometric 1421. The result showed that transmittance by wavelength range of the glazing had an effect on chromaticity and color temperature. Also, color temperature of indoor environment were increased by $5{\sim}20[%]$ using differentiated window and interior lightshelf. Accordingly, it is thought that the use of a daylighting system will create activate indoor atmosphere.

감염성 각막궤양에 의한 절박천공에서 구조 전층각막이식술의 효과

정인영,유인천,박영걸,윤경철,In-Young Jeong,In-Cheon You,Yeoung-Geol Park,PhD,Kyung Chul Yoon 대한안과학회 2007 대한안과학회지 Vol.48 No.7

Purpose: To investigate the effect of tectonic penetrating keratoplasty for the treatment of impending perforations caused by infectious corneal ulcers. Methods: We analyzed preoperative and postoperative visual acuity, lesion location and size, graft size, postoperative outcome, and complications in 19 patients (19 eyes) with impending perforations due to infectious corneal ulcers. All patients underwent tectonic penetrating keratoplasty and had a minimum follow-up period of 6 months. Results: In our study, eight eyes (42.1%) had herpes simplex keratitis, 6 eyes (31.6%) had bacterial keratitis, and 5 eyes (26.3%) had fungal keratitis. Twelve eyes had a lesion located in the central cornea, while 7 eyes had a lesion located in the paracentral cornea. Visual acuity improved in 13 eyes (68.4%) and anatomical success was achieved in 16 eyes (84.2%). Three eyes (15.8%) developed a graft melting secondary to rejection. Complications included bullous keratopathy (3 eyes, 15.8%), graft infection (3 eyes, 15.8%), neovascularization (2 eyes, 10.5%), and secondary glaucoma (1 eye, 5.3%). Conclusions: Tectonic penetrating keratoplasty maintains ocular integrity and effectively treats impending perforations caused by infectious corneal ulcers.

각막이식술 후 재발한 단순포진바이러스 각막염에 대한 분석

정인영,이광훈,유인천,윤경철,In Young Jeong,MD,Kwang Hoon Lee,MD,In Cheon You,MD,PhD,Kyung Chul Yoon,MD,PhD 대한안과학회 2009 대한안과학회지 Vol.50 No.5

Purpose: To analyze the clinical aspects and risk factors for recurrent herpes simplex keratitis (HSK) after penetrating keratoplasty (PKP). Methods: Records from 78 eyes of 41 patients who underwent PKP for HSV keratitis with a mean follow-up duration of 31.83±21.35 months (24~97 months) were reviewed. The clinical aspects of recurrent keratitis, rejection, and survival rate were evaluated. Previous operation history, preoperative inflammation and neovascularization, graft size, suture methods, and antiviral use were analyzed to elucidate the risk factor for recurrent HSK after PKP. Results: HSK recurred in 47.4% of the patients at a mean time of 18.36±21.02 months after PKP. The mean duration of keratitis was 2.16±1.71 months and the mean frequency of recurrence was 1.41±0.69 times. Epithelial keratitis developed in 46.2% of the patients, and epithelial keratitis combined with stromal inflammation developed in 36.5%. Previous graft failure due to recurrent HSK and preoperative inflammation were significant risk factors for recurrent HSK after PKP (p=0.019, p=0.006). There were no statistically significant differences in graft rejection and survival rate between the two groups with and without recurrent HSK. Conclusions: The majority of cases of recurrent HSK after PKP were epithelial keratitis or epithelial keratitis combined with stromal inflammation, and risk factors for the recurrence of HSK were previous graft failure due to recurrent HSK and preoperative inflammation.

치료레이저각막절제술과 양막이식술의 동시 시행에 의한 잘쯔만결절변성의 치료효과

정인영,윤경철,In Young Jeong,Kyung Chul Yoon 대한안과학회 2006 대한안과학회지 Vol.47 No.6

Characterization of Melanin-concentrating Hormone from Olive Flounder (Paralichthys olivaceus)

In Young Chung(정인영),Jeong Min Jeon(전정민),Young Hwan Song(송영환) 한국생명과학회 2018 생명과학회지 Vol.28 No.3

멜라닌 농축 호르몬(melanin-concentrating hormone, MCH)은 17개의 아미노산으로 구성된 환형의 시상하부 펩티드로 색소 침착의 조절인자로서 연어에서 처음 분리되었다. 포유동물의 MCH는 19개의 아미노산으로 구성되어 있으며 섭식 및 에너지 항상성을 조절하는데 관여한다. 본 연구에서는 양식넙치의 다양한 조직에서 MCH 유전자의 발현 분포, 멜라닌 함유 세포의 집적, 포유동물 MCH 수용체와 양식넙치 MCH의 상호작용을 조사하였다. Real-time qPCR을 이용하여 뇌, 정소, 난소에서 MCH 유전자의 발현이 나타나는 것을 확인하였고, 수정 후 발달단계에서도 MCH 유전자의 발현을 확인할 수 있었다. 합성된 연어 sMCH, 포유류 hMCH, 양식넙치 fMCH, dN-fMCH, dC-fMCH를 양식 넙치의 표피에 처리했을 때 다양한 농도에 따라 멜라닌 함유 세포의 집적이 다양하게 나타났다. 연어 sMCH, 포유류 hMCH에 비해 양식넙치 fMCH의 멜라닌 함유세포의 집적도가 36~99.85%로 비역가를 나타났으나 양식넙치 dN-fMCH, dC-fMCH를 처리한 경우 양식넙치 fMCH에 비해 높은 농도에서 집적이 나타나고 짧은 시간에 분산되었다. 또한, 인간 MCH 수용체와 쥐 MCH 수용체가 발현된 포유동물의 세포주에 양식넙치 fMCH를 처리하여 각 수용체와 결합하는 것을 확인하였다. 이러한 결과는 어류에서 발현되는 MCH가 포유동물의 MCH와 유사한 구조를 가지고 있어 MCH 수용체에 대한 새로운 리간드로서 제공될 수 있으며, 향후 어류의 MCH 수용체에 확대 적용할 수 있을 것이다. The melanin-concentrating hormone (MCH), a cyclic hypothalamic peptide composed of 17 amino acids, was initially identified in chum salmon (Oncorhynchus keta) as a regulator of pigmentation. Mammalian MCHs are cyclic hypothalamic peptides composed of 19 amino acids that regulate food intake and energy homeostasis. The present study examined not only MCH expression of different tissues but also the melanohore aggregation and intracellular Ca<SUP>2+</SUP> influx of fMCH and the other MCH. Real-time qPCR showed that MCH expressed specially in the brain, gonad, and ovary, and expression of MCH was observed during the developmental stages. In the application of synthetic fMCH and both types of synthetic fMCH, dN-fMCH and dC-fMCH, scale melanophore induced significant changes in aggregation activity with various concentrations of MCH. Also, compared to hMCH and sMCH, fMCH exhibited a 36~99.85% increase in relative potency (%), whereas aggregation of dN-fMCH and dC-fMCH remained in a high concentration. However, dispersion was induced rapidly according to be low concentration of dN-fMCH and dC-fMCH. We show that fMCH and its derivates were bound human MCHR1 and rat MCHR expressed in HEK293T cells with nano-molar affinity and are likely to be ligand-induced to mobilize intracellular Ca<SUP>2+</SUP>. These results may provide new ligands for binding assay with MCHew ligands, as a structure similar to the mammalian MCH structure was discovered in fish. Once the fMCH receptor system is in place, it can be compared to the MCH system of mammals in terms of MCH function.

Cloning and Characterization of BTG-1 Gene from Pacific Oyster (Crassostrea gigas)

In Young Chung(정인영),Jeong Hwan Oh(오정환),Young Hwan Song(송영환) 한국생명과학회 2017 생명과학회지 Vol.27 No.4

BTG1 (B-cell translocation gene 1)은 APRO family (anti-proliferative protein family)에 속하며, 이들은 공통의 생물학적 기능은 세포증식을 억제하는 것으로 알려져 있다. 본 연구에서, 굴의 gill cDNA library를 random sequencing을 통한 EST 분석과정에서 BTG1 clone을 확보하였으며, 분자생물학적 특성을 조사하였다. 굴의 BTG1은 182 개의 아미노산으로 구성되며, zebrafish와 57%, human과 56%의 상동성을 나타냈으며, 사람이나 설치류와 달리 ORF (open reading frame) 내에 intron이 존재하지 않았다. Genomic DNA walking을 통해 굴의 BTG1의 predicted promoter를 확인하였으며, 분석결과 AP-1 element와 SRE (serum response element) 부위가 존재하였으며, 5’flanking region에 cAMP response element (CRE) 부위가 확인되었다. 굴의 BTG1의 조직별 유전자발현 수준을 확인하기 위해 real-time PCR을 수행하였으며, 6 개 조직 모두에서 BTG1의 유전자발현이 나타났으며, 그 중에서 heart와 mantle에서 높은 수준의 mRNA 발현을 확인할 수 있었다. BTG 1 (B-cell translocation gene 1) gene was first identified as a translocation gene in a case of B-cell chronic lympocytic leukemia. BTG1 is a member of the BTG/TOB family with sharing a conserved N-terminal region, which shows anti-proliferation properties and is able to stimulate cell differentiation. In this study, we identified and characterized the pacific oyster Crassostrea gigas BTG1 (cg-BTG1) gene from the gill cDNA library by an Expressed Sequence Tag (EST) analysis and its nucleotide sequence was determined. The cg-BTG1 gene encodes a predicted protein of 182 amino acids with 57% 56% identities to its zebrafish and human counterparts, and is an intron-less gene, which was confirmed by PCR analysis of genomic DNA. Maximal homologies were shown in conserved Box A and B. The deduced amino acid sequence shares high identity with other BTG1 genes of human, rat, mouse and zebrafish. The phylogenic analysis and sequence comparison of cg-BTG1 with other BTG1 were found to be closely related to the BTG1 gene structure. In addition, the predicted promoter region and the different transcription-factor binding site like an activator protein-1 (AP-1) response element involved in negative regulation and serum response element (SRE) were able to be identified by the genomic DNA walking experiment. The quantitative real-time PCR analysis showed that the mRNA of cg-BTG1 gene was expressed in gill, heart, digestive gland, intestine, stomach and mantle. The cg-BTG1 gene was expressed mainly in heart and mantle.

익상편에서 파이브린 글루를 이용한 자가결막이식술

윤경철,허환,정인영,박영걸,Kyung Chul Yoon,Hwan Heo,In Young Jeong Yeoung Geol Park 대한안과학회 2006 대한안과학회지 Vol.47 No.2

Purpose: To investigate the efficacy of fibrin glue for conjunctival autotransplantation in pterygium. Methods: Forty eyes of 32 patients who underwent conjunctival autotransplantation for primary pterygium with a minimum follow-up period of 6 months were included. Postopertive pain, foreign body sensation, tearing, subconjunctival hemorrhage, surgery time, complication, and recurrence were evaluated prospectively in 20 eyes of 15 patients undergoing surgery with fibrin glue, and in 20 eyes of 17 patients undergoing surgery with sutures. Results: One day postoperative, the scores of pain (P<0.01), foreign body sensation (P<0.01), tearing (P<0.01), and subconjunctival hemorrhage (P=0.01) were significantly lower in the fibrin glue group than in the suture group. One week postoperative, the scores of foreign body sensation (P=0.01) and tearing (P=0.01) were significantly lower in the fibrin glue group than in the suture group. Mean surgery time in the fibrin glue group (18±8 minutes) was significantly shorter than in the sutures group (32±11 minutes) (P<0.01). There was no significant difference in the recurrence rates of the two groups. Conclusions: Use of fibrin glue for conjunctival autotransplantation in pterygium can reduce postoperative discomfort and required surgical time.

P-138 : 진위천 및 유입지류의 수질특성과 유달부하량 및 유달부하밀도 산정

정인영 ( In Young Chung ),방규철 ( Kyu Chul Bang ),김진혁 ( Jin Hyuk Kim ),곽승민 ( Seung Min Kwak ),이동준 ( Dong Jun Lee ),박선영 ( Sun Young Park ),양희정 ( Hee Jeong Yang ),이형진 ( Hyung Jin Lee ) 한국물환경학회(구 한국수질보전학회) 2013 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2013 No.-

축소모형을 이용한 가변 유리투과체의 채광유형별 성능평가 비교

정인영(Jeong, In Young),김정태(Kim, Jeong Tai) 한국생태환경건축학회 2004 한국생태환경건축학회 논문집 Vol.4 No.3