유파골세포형 다핵거대세포를 동반한 침윤성 유방관암종의 세침흡인세포학적 소견 - 1예 보고 -

정은하,박혜림,손진희,Jung, Eun-Ha,Park, Hye-Rim,Sohn, Jin-Hee 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.2

Malignant tumors of the breast with stromal multinucleated giant cells are rare entity of uncertain clinical significance. There have been few reports on the fine needle aspiration cytologic(FNAC) findings about these rare tumors. We report a FNAC case of invasive mammary carcinoma with osteoclast-like giant cells not only for its rare occurrence but in particular for its distinctive cytologic picture on aspirated material. The patient was a 40-year-old woman who presented with a right breast mass for one month. Mammography showed a well-demarcated rounded mass density without calcification. The aspirates of FNAC were highly cellular and two main cell types were seen; malignant epithelial cells and osteoclast-like multinucleated giant cells. The carcinoma cells occurred singly or arranged in loose clusters with ill-defined cytoplasm, oval nuclei, coarse chromatin and small but distinct nucleoli. The multinucleated giant cells showed variable number of nuclei with prominent nucleoli and abundant dense oxyphilic cytoplasm. The immunocytochemical studies suggested that osteoclast-like giant cells were not of epithelial origin, but rather of histlocytic origin.

액상형 고령친화식품의 치아부식능 평가

정은하 ( Eun-ha Jung ),강정윤 ( Jung-yun Kang ),한선영 ( Sun-young Han ) 한국치위생학회 2022 한국치위생학회지 Vol.22 No.5

Objectives: To investigate the effect of several elder-friendly foods on oral health and suggest guidelines for proper food intake. Methods: Six elderly-friendly foods (liquid type) and two control groups (mineral water and mixed coffee) were selected for this study. The pH of the food was measured using a calibrated pH meter, and the titratable acidity was determined using 1 M NaOH until 7.0 (TA 7.0). The screening method suggested by the International Organization for Standards was performed using an undersaturated hydroxyapatite solution to determine the difference between the initial and final pH of the screening solution (△pH). In addition, the sugar content was measured and expressed as Brix (%). Results: All the elder-friendly foods tested in this study showed a neutral pH (6.68-7.35), similar to mineral water (pH 7.84). The range of TA 7.0 values was 0.00-0.54 ㎖. The changes in pH determined using the screening solution confirmed that the largest change in pH was found in Careon (△pH 1.14±0.02), which has no erosive potential. Nevertheless, all elder-friendly foods had higher sugar content than the negative control group. Conclusions: Low tooth erosive potential was found in elder-friendly foods, but these foods showed high sugar content.

만삭 전 조기양막파수 임신부에서 양수 내 백혈구 수와 태반 염증성 병변의 관련성에 관한 연구

정은하 ( Eun Ha Jeong ),박교훈 ( Kyo Hoon Park ),오경준 ( Kyung Joon Oh ),이성윤 ( Sung Youn Lee ),김시내 ( Shi Nae Kim ),정희정 ( Hee Jung Jung ),이정연 ( Jeong Yeun Lee ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.2

목적: 만삭 전 조기양막파수 임신부에서 양수 내 백혈구 수와 태반 염증성 병변의 존재 및 정도와의 관련성을 확인하고자 한다. 연구방법: 만삭 전 조기양막파수로 입원한 단태임신 임신부 중 양수 내 백혈구 수 측정 및 양수 배양검사를 위해 경복부 양수천자가 시행되고, 양수 천자 후 72시간 내에 조기분만(임신 24.0-35.6주 사이)되었으며, 태반의 조직학적 검사가 시행된 90명의 임신부를 대상으로 하였다. 결과: 조직학적 융모양막염의 빈도는 32%였으며 양성 양수 배양인 경우는 21%였다. 태반 염증성 병변이 존재하는 경우는 존재하지 않는 경우에 비하여 양수 내 백혈구 수가 유의하게 많았다. 양수 내 백혈구 수는 교란변수의 영향을 보정한 후에도 태반 염증성 병변의 존재와 유의한 관련성을 나타내었다. 또한 양수 내 백혈구 수는 각각의 태반 부위별 염증 정도가 심할수록 유의하게 증가하였다. 태반 염증성 병변 존재를 가장 잘 예측할 수 있는 양수 백혈구 수의 절단치는 25개/mm3였고 이때 민감도 62%, 특이도 77%를 나타내었다. 결론: 만삭 전 조기양막파수 임신부에서 양수 내 백혈구 수는 태반의 염증성 병변의 존재 및 정도와 유의한 관련성을 가지고 있으며 산전에 이의 존재 유무를 예측할 수 있는 독립적 인자이다. Objective: To examine the relationship between amniotic fluid (AF) white blood cell (WBC) count and the presence and severity of inflammatory lesions of the placenta in women with preterm premature rupture of membranes (PPROM). Methods: This retrospective cohort study included 90 consecutive women with PPROM (24.0-35.6 weeks) who met the following criteria: singleton gestation; transabdominal amniocentesis performed to obtain AF for culture and WBC count; delivery within 72 hours of amniocentesis; placental histologic examination after preterm delivery. Results: The prevalence of histologic chorioamnionitis was 32% (29/90) and that of positive amniotic fluid culture was 21% (19/90). Patients with histologic chorioamnionitis had a significantly higher AF WBC count than those without this lesion. Logistic regression analysis demonstrated that AF WBC count had a significant relationship with histologic chorioamnionitis after controlling for gestational age and AF culture. The median AF WBC count increased significantly according to the higher severity of inflammation in each type of placental histologic section. According to receiver operating characteristic curve analysis, the best cut-off value of AF WBC count for predicting histological chorioamnionitis was 25 cells/mm3, with a sensitivity of 62% and a specificity of 77%. Conclusion: Both the presence and greater severity of inflammatory lesions of the placenta are associated with an elevated AF WBC count. AF WBC count is an important and independent predictor for inflammatory lesions of the placenta in women with PPROM.

치태의 산생성 능력을 이용한 새로운 우식활성검사법의 임상적 활용 가능성 평가

정은하 ( Eun Ha Jung ),이은송 ( Eun Song Lee ),강시묵 ( Si Mook Kang ),권호근 ( Ho Keun Kwon ),김백일 ( Baek Il Kim ) 대한예방치과·구강보건학회 2014 大韓口腔保健學會誌 Vol.38 No.2

Objectives: This study was aimed at evaluating the clinical usability of a new caries activity test (Cariview®), which was based on the acidogenic potential of plaque by evaluating it`s correlation with the DMFT index and comparing the results of Cariview® with those of previous caries activity tests in an adult group. Methods: Teeth of 74 subjects were examined, and the DMFT index was calculated according to World Health Organization (WHO) criteria to determine the past caries experience. Caries activity tests were performed according to manufacturer`s instructions. For Cariview® test, plaque samples were collected from the tooth surface by using a sterile cotton swab and incubated at 37oC for 48 h; an indicator was added to observe the color changes according to the plaque acidogenicity. The subjects were classified into three groups (Low, Moderate, High) according to the level of caries risk. The data were assessed using one-way ANOVA to compare the caries experiences of risk groups according to the caries activity test results, and the relationships between the caries activity tests and the DMFT index were evaluated. Results: The overall mean DMFT index was 5.70±4.42. There was a significant difference in the DMFT index among the caries risk groups (Low, Moderate, High) according to the Cariview® test result (P=0.036). Further, there was a positive correlation between the Cariview® score and the DMFT index (r=0.23, P=0.047) and between the Cariview® score and the previous caries activity tests score (P<0.01). Conclusions: The new caries activity test (Cariview®) can be easily used at dental clinics and enables precise caries risk assessment.

폐경 여성에서 3년 동안 호르몬 요법, Raloxifene, Alendronate 치료 후 골밀도의 변화

정은하 ( Eun Ha Jeong ),최훈 ( Hoon Choi ),정희정 ( Hee Jung Jung ),이경 ( Kyung Lee ),정희라 ( Hee Ra Jung ),김명환 ( Myoung Hwan Kim ),고지경 ( Ji Kyung Ko ),이철민 ( Chul Min Lee ),조용균 ( Yong Kyoon Cho ),김복린 ( Bok Rin K 대한폐경학회 2009 대한폐경학회지 Vol.15 No.1

Objectives: To evaluate the effects of three-year hormone therapy with raloxifene and alendronate treatment on bone mineral density (BMD) and vertebral fractures in postmenopausal Korean women. Methods: We studied 127 postmenopausal women who had visited the Department of Obstetrics and Gynecology of Inje University Sanggye Paik Hospital between January 2000 and June 2008. These patients were divided into alendronate (n=26), raloxifene (n=18), estrogen therapy (ET) (n=43), and estrogen-progesterone therapy (EPT) (n=40) groups. We measured BMD in the lumbar spine (L1-L4) and femoral neck at baseline at one, two, and three-years after treatment. Vertebral fractures were also assessed at baseline and at three years after treatment initiation. Results: The BMD of the lumber spine increased significantly in the alendronate group by 7.2, 8.8%, and 9.5% at 1, 2, and 3 years after treatment initiation, respectively. It increased by 0.8% in the EPT group at 1 year. The BMD of the femoral neck increased significantly in the alendronate group by 3.4, 5.3%, and 5.8% at 1, 2, and 3 years, respectively. It increased in the raloxifene group by 3.5% at 2 years. It increased in the EPT group by 3.6, 2.6%, and 2.4% at 1, 2, and 3 years, respectively. After 3 years of hormone therapy, women with osteopenia or osteoporosis showed a greater increase in BMD than did women with normal BMD, but not to a statistically significant degree. There were no new vertebral fractures in any of the four groups three years after treatment initiation. Conclusion: In postmenopausal women, treatment with alendronate, raloxifene, or hormone therapy increases bone mineral density in the spine and femoral neck and is helpful in preventing new vertebral fractures. 연구목적: 폐경 여성에서 3년간 호르몬 요법, raloxifene, alendronate 치료 후 골밀도와 척추 골절 발생에 미치는 영향을 평가하고자 하였다. 연구재료 및 방법: 상계백병원 산부인과에서 3년간 호르몬 요법, raloxifene, alendronate 치료 중 한가지 치료를 받은 폐경 여성 중 선별된 127명을 대상으로 의무기록을 통해 후향적으로 연구하였다. 이들을 alendronate군 (n=26), raloxifene군 (n=18), ET군 (n=43), EPT군 (n=40)으로 나누어 기저치와 치료 1, 2, 3년 후 골밀도를 측정하고 3년간 척추 골절의 발생 유무를 평가하였다. 결과: 요추 골밀도는 alendronate군, EPT 군에서 유의하게 증가하였다. Alendronate 군에서는 1, 2, 3년 후 모두 유의하게 증가하였다 (각각 7.2, 8.8, 9.5%). EPT군에서는 1년 후 0.8% 유의하게 증가하였다. Raloxifene군에서는 1, 2년 후 각각 1.4%와 0.4% 증가하고 3년 후 0.1%감소하였으나 통계적 유의성은 없었다. ET군에서는 3년 후 0.1% 증가하였으나 통계적으로 유의한 차이는 없었다. 대퇴골 경부 골밀도는 alendronate군, raloxifene군, EPT군에서 유의하게 증가하였다. Alendronate군에서는 1, 2, 3년 후 모두 유의하게 증가하였으며 (각각 3.4, 5.3, 5.8%), raloxifene군에서는 2년 후 3.5% 유의하게 증가하였으며, 1, 3년 후에는 증가하였으나 통계적 유의성은 없었다. EPT군에서는 1, 2, 3년 후 모두 유의하게 증가하였다 (각각 3.6, 2.6, 2.4%). ET군에서는 증가하였으나 통계적으로 유의한 차이는 없었다. 호르몬 요법군에서 요추 및 대퇴골 경부 골밀도가 정상인 여성보다 저골량인 여성에서 골밀도가 증가 하였으나 유의한 차이는 없었다. 3년 후 새로운 척추 골절의 발생은 네 군 모두에서 나타나지 않았다. 결론: 폐경 여성에서 3년간의 호르몬 요법, raloxifene, alendronate 치료는 골밀도를 증가시키며 골절 예방에도 도움이 될 것으로 생각된다.

태반 조기박리에서 주산기 예후와 관련된 산과적 요인에 대한 연구

정희정 ( Hee Jung Jung ),정은하 ( Eun Ha Jeong ),이경 ( Kyung Lee ),정희라 ( Hee Ra Jung ),김명환 ( Myoung Hwan Kim ),고지경 ( Ji Kyung Ko ),조용균 ( Yong Kyoon Cho ),최훈 ( Hoon Choi ),김복린 ( Bok Rin Kim ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.10

목적: 태반 조기박리에서 주산기 예후에 영향을 미치는 산과적 요인을 분석하고자 하였다. 방법: 2000년 1월부터 2007년 12월까지 인제대학교 상계 백병원에 입원하여 태반 조기박리를 진단받고 분만한 54예의 임상 기록지를 관찰, 분석하였다. 결과: 태반 조기박리의 빈도는 0.55%였고, 연령별 분포에서 26세에서 30세의 산모가 가장 높은 빈도 (42.1%)를 나타냈다. 임상 증상으로는 질출혈이 57.4%로 가장 많았고 자궁내 태아사망이 9.3%를 차지하였다. 주산기사망률은 13.0%였으며 모성 사망률은 없었다. 태반 조기박리의 38.9%는 임신주수 33주에서 36주 사이에 진단되었다. 태반 조기박리의 38.9%는 분만 전에 초음파로 진단되었고 9.3%는 만성 태반 조기박리였다. 태반 조기박리의 원인으로는 원인을 알 수 없는 경우를 제외하고 임신성 고혈압 (33.3%)이 가장 많았고 그 밖에 조기양막파수 (24.1%), 자궁근종 (3.7%), 만성 고혈압 (1.9%), 흡연력 (1.9%) 등이 있었다. 특히 임신 중 고혈압이 동반된 경우는 태아곤란증이 정상 혈압 임신부에 비해 의미 있게 높은 빈도를 보였다 (63.2% vs 20.0%, P-value: 0.005). 태반 조기박리에서 주산기사망에 통계학적으로 의미 있는 영향을 미치는 산과적 요인은 임신주수와 태반 조기박리의 중증도였으며 임신주수가 빠르면 빠를수록 (mean G.A (days): 194±32.8 vs 248.12±28.0, P-value<0.001), 태반 조기박리의 정도가 심하면 심할수록 (P-value: 0.005) 주산기 예후는 좋지 않았다. 태반 조기박리의 가장 흔한 합병증은 DIC (16예, 29.6%)였고 Couvelaire uterus (4예, 7.4%), 자궁파열 (1예, 1.9%)순이었다. 결론: 태반 조기박리에서 주산기 예후와 관련이 있는 산과적 요인은 진단 당시 임신주수와 태반 조기박리의 중증도임을 알 수 있었다. Objective: To evaluate obstetric variables in the placental abruption that affect on perinatal mortality. Methods: We reviewed clinical data of all singleton deliveries complicated with placental abruption between January 2000 and December 2007, in Department of Ob. & Gyn., Sanggye Paik Hospital. Results: Placental abruption complicated 54 cases (0.55%) of all deliveries (n=9,903) from January 2000 to December 2007. The peak age was 26-30 years (42.1%). The most common symptom was vaginal bleeding (57.4%) and intrauterine fetal death had already occurred in 9.3%. Perinatal mortality rate was 13.0% and there was no maternal death. 38.9% of placental abruption occurred between 33 to 36weeks of gestational age. 38.9% of placental abruption was diagnosed before delivery with ultrasonography and 9.3% was chronic placental abruption. 33.3% of placental abruption was associated with preeclampsia, and then associated with PPROM (24.1%), uterine myoma (3.7%), chronic hypertension (1.9%) and smoking (1.9%). When the hypertensive disorders were associated, fetal distress rate was higher than normotensive pregnancy (63.2% vs 20.0%, P-value: 0.005). Mean gestational age (days) (194±32.8 vs 248.12±28.0, P-value<0.001) and the severity of placental abruption (P-value: 0.005) affect perinatal mortality in placental abruption. The most common complication of placental abruption was DIC (16 cases, 29.6%), followed by Couvelaire uterus (4 cases, 7.4%) and uterine rupture (1 case, 1.9%). Conclusion: Obstetric variables that affect perinatal mortality were gestational age at the diagnosis and the severity of placental abruption.

전염성 단핵구중 림프절염의 세침흡인 세포학적 소견 - 4예 보고 -

손진희,정은하,박혜림,Sohn, Jin-Hee,Jung, Eun-Ha,Park, Hye-Rim 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.2

Infectious mononucleosis(IM) Is an acute self-limiting lymphoproliferative disorder associated with infection by the Epstein-Barr Virus(EBV), with the characteristic triad of fever, sore throat, and cervical or generalized lymphadenopathy. And also there are atypical lymphocytes in the peripheral blood. Cytological findings of IM lymphadenitis are characterized by a florid immunoblastic and atypical lymphoid cell proliferation. However, the small number of cases were studied by fineneedle aspiration cytology(FNAC) even though there was a complexity of lymph node pathology. It is important to recognize the reactive pattern of IM that would initiate EBV study and to avoid unnecessary biopsy We studied findings of lymph node FNAC from 4 patients with EBV infection confirmed by EBV-specific serologic studios. All of the cases were positive for viral capsid antigen(VCA) and one case was positive for anti-EBV nuclear antigen(EBNA). Cytologically, all of the cases exhibited high cellularity and atypia with great numbers of large immunoblastic lymphocytes.

고분자연료전지의 전해질-전극 접합체의 열화 가속시험

이정훈(Lee, Jung-Hun),윤영기(Yoon, Young-Gi),정은하(Jung, Eun-Ha),이원용(Lee, Won-Yong),김창수(Kim, Chang-Soo) 한국신재생에너지학회 2007 한국신재생에너지학회 학술대회논문집 Vol.2007 No.06

Recently, much attentions have been paid on the commercialization of PEMFC, especially for the applications of residential and portable. In order to achieve the early commercialization of PEMFC, thee are two hurdles to overcome. One is cost down and the other is improvement of durability of the system components. Numerous companies have tried to reduce the production cost and the main research topics have been changed from performance to durability improvement. In this work, acceleration test were performed to find and evaluate the main reason of degradation of the MEA(membrane-electrode assembly) which is one of the core component of the PEMFC system. Based upon the test results, a way to make durable MEA was suggested. Acceleration tests were made by applying high voltage of 1.2V to the several kinds of single cells to increase the growth of catalyst particles. Cell performance, ac-impedance and electrochemically active area measurements were made atfter every 8 hours of acceleration test. Degradations of catalyst and membrane were examined by SEM, TEM and XRD. Obtained results were discussed in terms of structural stability and loss of catalyt and ionomers in the electrode layer. In addition, the way to make highly durable MEA was suggested.

노인의 구강건강상태에 따른 고령친화식품 섭취 차이

전지은(Ji-Eun Jeon),정은하(Eun-Ha Jung),김수민(Soo-Min Kim),한선영(Sun-Young Han) 한국콘텐츠학회 2021 한국콘텐츠학회논문지 Vol.21 No.12

인구 고령화에 따라 고령친화식품에 대한 수요가 커지고 있다. 이 연구는 노인의 구강건강상태에 따른 고령친화식품 섭취 실태를 분석하여 구강건강수준에 맞는 식품 개발에 기초자료를 제공하고자 수행하였다. 제7기 국민건강영양조사의 건강설문, 구강검진, 영양조사 자료를 이용하여 노인의 고령친화식품 단계별 구강건강상태와 영양 섭취 실태를 복합표본분석방법으로 분석하였다. 그 결과, 75세 이상의 고령자일수록(p=0.013), 저소득과 고소득 양극단에서(p=0.008) 고령친화식품의 3단계 섭취자가 유의하게 많아 상대적으로 혀로 섭취할 수준의 무른 음식을 주로 먹는 것으로 나타났고, 의치를 보유하거나(p=0.024, 0.008) 임플란트를 보유하지 않은 경우(p=0.003)에서 고령친화식품의 3단계 섭취자가 유의하게 많았으며, 저작불편 등 주관적 지표보다 보철물 보유 등과 같은 객관적 지표에서 유의한 차이가 나타났다. 또한 영양소에 따라 고령친화식품 3단계 섭취자가 전반적으로 영양소 기준보다 적게 섭취하고 있었다. 고령친화식품의 3단계를 주로 섭취하는 노인은 구강건강수준과 영양상태가 매우 취약한 것으로 보인다. 따라서 고령친화식품 개발 시 노인의 구강건강상태 및 적절한 영양소를 고려한 다양한 식품 개발과 체계적인 교육이 필요하다. This study was conducted to provide data for the development of foods suitable for the level of oral health by analyzing the consumption of elderly-friendly foods according to the oral health status of the elderly. Using data from the health questionnaire, oral examination, and nutrition survey of the 7th National Health and Nutrition Examination Survey, the oral health status and nutritional intake status of the elderly by each stage of elderly-friendly foods were analyzed, and a complex sample analysis method was applied. The elderly who mainly consume stage 3 elderly-friendly foods appear to have very poor oral health and nutritional status. Therefore, when developing elderly-friendly foods, it is necessary to develop various foods and provide systematic education considering the oral health status of the elderly and appropriate nutrients.

인천지역 유기동물 현황 및 개 질병 조사

윤가리 ( Ga Ri Yun ),정은하 ( Eun Ha Jung ),라도경 ( Do Kyung Ra ),정철 ( Cheol Jeong ),이경민 ( Kyung Min Lee ),채현우 ( Hyun Woo Chae ),이정구 ( Jung Goo Lee ),이성모 ( Sung Mo Lee ) 한국동물위생학회 2014 韓國家畜衛生學會誌 Vol.37 No.4

Animals and disease frequency of the rescued dogs were investigated in Incheon Veterinary Medical Association Animal Shelter from January in 2012 to December in 2013. Three zoonoses (rabies, brucellosis, and dirofilariosis) and three infectious diseases (canine distemper, canine parvoviral enteritis, and canine influenza) were examined for stray dogs. Among 5,603 heads, 647 (11.5%) went back to their owner and 969 (17.3%) were adopted to new families. Prevalence of dirofilariosis, canine distemper and canine parvoviral enteritis were 2.2% (16/718), 6.0% (24/399) and 6.1% (24/396), respectively. Positive antibody rates against rabies, B. canis and canine influenza virus were 20.5% (41/200), 0.1% (1/718) and 2.0% (4/200), respectively. Protective antibody for canine distemper virus and canine parvovirus were shown in 47.0% (94/200). The data indicate that control measures including facility standards and disease control program are one of the important aspects of the shelter management because stray dogs are exposed to various infectious agents.