위눈꺼풀수술 후 0.15% 히알루론산 나트륨 점안액이 안구 표면에 미치는 임상적 효과

남정우(Jeoung Woo Nam),박도희(Do Hee Park),윤현정(Hyeon Jeong Yoon),윤경철(Kyung Chul Yoon) 대한안과학회 2021 대한안과학회지 Vol.62 No.5

목적: 무방부제성 0.15% 히알루론산 나트륨 점안액이 위눈꺼풀수술 후 안구 표면에 미치는 임상적 효과를 알아보고자 하였다. 대상과 방법: 2018년 12월부터 2019년 5월까지 위눈꺼풀수술을 시행 받은 43명의 환자를 수술 후 무방부제성 0.15% 히알루론산 나트륨 점안액을 사용한 A군(23명 23안), 사용하지 않은 B군(20명 20안)으로 분류하였다. 안구 표면질환지수, 눈물막파괴시간, 쉬르머검사, 플루레신을 이용한 각막염색점수, 마이봄샘 질 및 배출 점수, 마이봄점수를 수술 전과 수술 후 1주째, 1개월째 및 2개월째 각각 시행하여 비교 분석하였다. 결과: 안구 표면질환지수, 눈물막파괴시간, 각막염색점수는 A군에서 수술 전과 비교하였을 때, 수술 후 1주일째 증가(p<0.05)하였다가 수술 후 1개월째 및 2개월째는 유의한 차이를 보이지 않았다. B군에서 안구 표면질환지수, 눈물막파괴시간, 각막염색점수는 수술전과 비교하였을 때, 수술 후 1주일째 및 1개월째 증가(p<0.05)하였다가 수술 후 2개월째는 유의한 차이를 보이지 않았다. 수술 후 1개월째 안구 표면질환지수(p=0.03)와 각막염색점수(p<0.01)는 두 군 간에 차이를 보였으나, 눈물막파괴시간은 두 군 간의 유의한 차이가 없었다. 쉬르머검사 수치, 마이봄샘 질 및 마이봄샘 배출 점수, 마이봄점수는 각 군 내에서 수술 전후 차이를 보이지 않았으며, 모든 기간 동안 두 군 간에 유의한 차이를 보이지 않았다. 결론: 위눈꺼풀수술 후 무방부제성 0.15% 히알루론산 나트륨 점안액은 초기 안구건조증 증상과 안구 표면 손상의 빠른 완화에 도움이 됨을 알 수 있었다. Purpose: To evaluate the clinical efficacy of preservative-free 0.15% sodium hyaluronate eye drops on the ocular surface after upper eyelid surgery. Methods: This study included 43 patients who underwent upper eyelid surgery between December 2018 and May 2019. Patients were randomly assigned to group A (those treated with preservative-free 0.15% sodium hyaluronate eye drops) and group B (the control group). Ocular surface disease index score (OSDI), tear break up time (TBUT), Schirmer’s test, corneal staining score (CSS), meibomian gland (MG) quality, MG expressibility, and meiboscore were evaluated before surgery and at 1 week, 1 month, and 2 months after surgery. Results: In group A, OSDI and TBUT showed a significant increase at 1 week after surgery compared with baseline values (all p < 0.05). In group B, OSDI, TBUT, and CSS were significantly higher at 1 week and 1 month after surgery (all p < 0.05), whereas there were no significant changes at 2 months after surgery compared with baseline values. At 1 month after surgery, OSDI (p = 0.03) and CSS (p < 0.01) showed significant changes between group A and group B; however, there was no significant change in the TBUT. There were no significant within-group differences in Schirmer’s test values, MG quality, MG expressibility, or meiboscore, and there were no significant between-group differences over time. Conclusions: Preservative-free 0.15% sodium hyaluronate eye drops were shown to be an effective treatment for early dry-eye symptoms and ocular surface damage after upper eyelid surgery.

파랑 중 오일붐 성능 예측을 위한 2차원 입자법 시뮬레이션

남정우(Jung-Woo Nam),박지인(Ji-In Park),황성철(Sung-Chul Hwang),박종천(Jong-Chun Park),정세민(Se-Min Jeong) 한국해양공학회 2013 韓國海洋工學會誌 Vol.27 No.4

Oil booms are one of the most widely used types of equipment for the protection of coastal areas against oil spills. In some situations, however, there are several types of oil leaks from the oil boom. Important factors regarding these phenomena include the surrounding ocean environment, such as waves, the density and viscosity of oil, the length of the oil boom skirt, etc. To estimate the performance of the oil boom, it is necessary to predict the behavior of the spilled oil and oil boom. In the present study, the prediction of oil boom performance in waves was carried out using the Pusan?National?University?modified Moving Particle Semi?implicit (PNU?MPS) method, which is an improved version of the original MPS proposed by Koshizuka and Oka (1996). The governing equations, which consist of continuity and Navier?Stokes equations, are solved by Lagrangian moving particles, and all terms expressed by differential operators in the governing equations are replaced by the particle interaction models based on a kernel function. The simulation results were validated through a comparison with the results of Violeau et al. (2007).

난치성 지속각막상피결손에서 양막추출물 점안액의 임상효과

남정우(Jeoung Woo Nam),김종화(Jonghwa Kim),윤현정(Hyeon Jeong Yoon),윤경철(Kyung Chul Yoon) 대한안과학회 2021 대한안과학회지 Vol.62 No.10

목적: 난치성 지속각막상피결손 환자에서 양막추출물 점안액의 임상적 효과를 알아보고자 하였다. 대상과 방법: 지속적인 치료에도 불구하고 지속각막상피결손이 적어도 4주 이상 지속된 환자 16명, 16안을 대상으로 추가적으로 양막추출물 점안액을 하루 6회 점안하여 치료를 시작하였다. 양막추출물 점안액 치료 전, 치료 1개월째 그리고 치료 2개월째 최대교정시력, 안구통증점수, 각막지각점수, 각막상피결손 면적을 측정하였다. 치료 2개월 후 각막상피결손 면적이 모두 호전된 경우 효과적, 각막상피결손 면적이 감소하였으나, 남아있는 경우 부분 효과적, 각막상피결손 면적이 증가하여 추가적인 치료가 시행된 경우 효과 없음으로 판정하였다. 결과: 양막추출물 점안액 치료 전과 비교하여 치료 2개월째 최대교정시력(0.8 ± 0.5 vs. 0.6 ± 0.3 LogMAR, p=0.03)의 증가, 안구통증점수(4.3 ± 1.0 vs. 2.8 ± 0.7, p=0.04)의 감소, 각막상피결손 면적(5.2 ± 3.1 vs. 0.1 ± 0.1 mm2, p=0.01)의 감소를 보였다. 양막추출물 점안액 치료는 13안(81.3%)에서 효과적이었으며, 3안(18.8%)에서 일부 효과적이었다. 결론: 양막추출물 점안은 난치성 지속각막상피결손 환자에서 안구 증상을 완화시키고 각막상피회복을 촉진하는 효과적인 치료 방법으로 사용될 수 있다. Purpose: To evaluate the clinical efficacy of amniotic membrane extract eye drops (AMEEDs) in patients with persistent epithelial defects (PEDs) of the cornea. Methods: Sixteen patients with PEDs refractory to the conventional treatment were further treated with AMEEDs six times a day. Visual acuity, visual analog scale (VAS), esthesiometer score, and areas of the epithelial defects before and after 1 and 2 months of treatment were evaluated. After 2 months, AMEEDs were considered effective if all epithelial defects were healed, partially effective if the epithelial defects decreased in size compared with the baseline, and ineffective if the epithelial defects increased in size and required additional treatment. Results: After 2 months of treatment with AMEEDs, there was a reduction in the area of epithelial defects (5.2 ± 3.1 mm2 vs. 0.1 ± 0.1 mm2, respectively, p = 0.01), as well as a significant improvement in best-corrected visual acuity (0.8 ± 0.5 logarithm of minimal angle of resolution [LogMAR] vs. 0.6 ± 0.3 LogMAR, respectively, p = 0.03), and VAS scores (4.3 ± 1.0 vs. 2.8 ± 0.7, respectively, p = 0.04) compared with the baseline values. Treatment with AMEEDs was effective in 13 (81.3%) patients and partially effective in three (18.8%) patients. Conclusions: AMEEDs could stimulate epithelial wound healing and improve ocular symptoms in patients with refractory PED. Therefore, AMEEDs could be considered an effective treatment option for refractory PEDs. J Korean Ophthalmol Soc 2021;62(10):1340-1347

택사(澤瀉) 시간별 투여(投與)가 Streptozotocin으로 유발된 고혈당 백서(白鼠)의 실험적(實驗的) 당뇨(糖尿)에 미치는 영향(影響)

남정우,이시형,강미숙,최유경,전찬용,박종형,김동우,Nam, Jeong-Woo,Rhee, See-Hyung,Kang, Mi-Suk,Choi, You-Kyung,Jun, Chan-Yong,Park, Chong-Hyeong,Kim, Dong-Woo 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.4

Objectives : The objective of the study was to observe the effects of different treatment lengths of Rhizoma Alismatis on diabetes mellitus. Methods : Rats were divided into three groups: normal(non-treated group), control (group administered saline for 4, 11, and 18 days), and RA (group administered 2.45mg/200g Rhizoma Alismatis for 4, 11, and 18 days). The experimental results were derived from the measurement of the levels of glucose, ALP, AST, ALT, creatinine and BUN in the serum from the rats on days 4, 11, and 18. Results : The glucose level in the serum significantly decreased on the 18th day. The ALP level in the serum did not show statistical significance. The GOT and GPT levels in the serum slightly decreased on the 4th, 11th, and 18th days, but did not show statistical significance. The creatinine level in the serum was unchanged for all of them. The BUN level in the serum did not show statistical significance. Conclusions : According to the above results, it is concluded that Rhizoma Alismatis has a therapeutic effect on diabetes mellitus with a longer period ofintake. As to influence upon the liver and kidney, there was no damage orside effects.

자유표면 유동해석을 위한 WMLS 기반 입자법 기술 개발

남정우(Jung-Woo Nam),박종천(Jong-Chun Park),박지인(Ji-In Park),황성철(Sung-Chul Hwang),허재경(Jae-Kyung Heo),정세민(Se-Min Jeong) 한국해양공학회 2014 韓國海洋工學會誌 Vol.28 No.2

In general, particle simulation methods such as the MPS(Moving Particle Simulation) or SPH(Smoothed Particle Hydrodynamics) methods have some serious drawbacks for pressure solution. The pressure field shows spurious high fluctuations both temporally and spatially. It is well known that pressure fluctuation primarily occurs because of the numerical approximation of the partial differential operators. The MPS and SPH methods employ a pre-defined kernel function in the approximation of the gradient and Laplacian operators. Because this kernel function is constructed artificially, an accurate solution cannot be guaranteed, especially when the distribution of particles is irregular. In this paper, we propose a particle simulation method based on the moving least-square technique for solving the partial differential operators using a Taylor-series expansion. The developed method was applied to the hydro-static pressure and dam-broken problems to validate it

자율운항선박에 대비한 선박관리감독(SI) 역량 분석에 관한 연구

정진옥(Jin-Ok Jung),남정우(Jung-Woo Nam),이정민(Jeong-Min Lee),한대송(Dae-song Han),나인권(In-Gwon Na),김율성(Yul-Seong Kim) 한국항해항만학회 2021 한국항해항만학회 학술대회논문집 Vol.2021 No.11

전층각막이식술 후 발생한 진균각막염의 임상양상

박도희(Do Hee Park),남정우(Jeoung Woo Nam),윤현정(Hyeon Jeong Yoon),윤경철(Kyung-Chul Yoon) 대한안과학회 2021 대한안과학회지 Vol.62 No.4

목적: 전층각막이식술 후 발생한 진균각막염의 임상양상과 위험인자, 치료 경과 및 예후를 알아보고자 한다. 대상과 방법: 2005년 1월부터 2020년 1월까지 전층각막이식술 후 진균각막염이 발생한 환자 18명의 의무기록을 후향적으로 조사하였다. 성별, 연령, 기저질환, 각막이식의 적응증, 증상 발생으로부터 치료 시작까지의 기간, 감염시 및 치료 후 시력, 감염 전 이식 각막의 상태, 봉합사 관련 여부, 각막상피결손의 크기 및 각막침윤 깊이, 전방축농 여부, 감염 전 사용 안약, 미생물배양검사 결과 등의 임상지표를 조사하였다. 또한 진균각막염 치료 결과에 따라 치료 성공군 및 실패군으로 나누어 이에 대한 위험인자를 비교 분석하였다. 결과: 전층각막이식술을 받은 후 평균 55.31 ± 44.72개월 후에 진균각막염이 발생하였다. 증상 발생으로부터 치료 시작까지의 기간은 평균 10.33 ± 7.36일이었다. 전체 18명의 환자 중 5명(27.8%)이 치료 성공이군, 13명(72.2%)이 치료 실패군으로 분류되었으며, 치료실패군 중 7명(38.9%)이 수술적 치료를 시행 받았다. 감염 전 발생한 이식 실패 상태, 증상 발생 후 내원까지의 소요 시간, 각막상피결손의 크기가 치료 실패와 유의한 상관관계가 있었다(모두 p<0.05). 다변량 회귀분석에서 치료 실패의 위험인자는 이식 실패 상태(p=0.046)였다. 결론: 감염 발생 전 각막 상태, 증상 발생 후 내원까지의 기간, 각막상피결손의 크기가 전층각막이식 후 발생한 진균 감염의 예후와 관련이 있으며, 치료 실패와 연관된 위험인자는 감염 전 이식 실패 상태이다. Purpose: We evaluated the clinical manifestations and risk factors of fungal keratitis after penetrating keratoplasty (PKP). Methods: Eighteen patients who experienced fungal keratitis after PKP between January 2005 and January 2020 were included in this retrospective study. Clinical characteristics including sex, age, underlying disease, indication for PKP, symptom duration, visual acuity, graft state before infection, suture-related problems, size of epithelial defect, depth of infiltration, presence of hypopyon, use of eyedrops before infection, and the results of microbiological tests were analyzed. Patients were classified into the treatment success or failure group, and the risk factors were evaluated accordingly. Results: The mean age at diagnosis was 63.94 ± 15.53 years. Fungal infection occurred a mean of 55.31 ± 44.72 months after PKP. The mean symptom duration was 10.33 ± 7.36 days. Of the 18 patients, 5 (27.8%) and 13 (72.2%) were in the treatment success and failure groups, respectively. Of the treatment failure group, seven patients (38.9%) underwent surgical management. The graft state before infection, symptom duration, and size of epithelial defects had significant correlations with treatment failure (all p < 0.05). Multivariate analysis identified graft state (p = 0.046) as a significant risk factor for treatment failure. Conclusions: Graft state before infection, symptom duration, and size of epithelial defects were associated with the prognosis of fungal keratitis after PKP. Graft state before infection was a significant risk factor for treatment failure.

내안각 췌피의 Rovda operation 에 대한 임상적 고찰

홍기룡(Ki Ryong Hong),남정우(Jeong Woo Nam),이문기(Moon Gi Lee) 대한안과학회 1982 대한안과학회지 Vol.23 No.1

[학생기자단 기사] 포스트 코로나 시대, 소규모 공연시설을 묻다

김하은(Kim, Ha-Eun),남정우(Nam, Jung-Woo),도현진(Do, Hyun-Jin),용승현(Yong, Seung-Hyeon),유지원(Yu, Ji-Won),윤정민(Yoon, Jeong-Min) 대한건축학회 2021 建築 Vol.65 No.7

중풍 후 운동 장애에 대한 『의부집성(醫部集成)』의 침구치료 고찰

정동원,민인규,문상관,박성욱,정우상,박정미,고창남,조기호,배형섭,김영석,Jeong, Dong-won,Min, In-kyu,Moon, Sang-kwan,Park, Seong-uk,Jung, Woo-sang,Park, Jung-mee,Ko, Chang-nam,Cho, Ki-ho,Bae, Hyung-sup,Kim, Young-suk 대한중풍순환신경학회 2006 대한중풍.순환신경학회지 Vol.7 No.1

Objectives and methods : The Euibujipsung is the one of the huge-scale encyclopedias about Oriental Medicine. To investigate the most frequently used acupoints for hemiparesis after stroke, we used Euibujipsung CR-ROM database with several key words concerned with motor weakness (半身不遂 不遂不隨 癱瘓 中臟 中腑 風痱, etc.). Results : In the result, we found five popular acupoints (GV20, LI11, LI15, ST36 and GB39), and four meridians (Stomach, Gall bladder, Large intestine and Small intestine). We also found that the Yang meridians were cited more frequently than the Yin. Conclusion : Therefore we think that these findings can give further ideas to clinical practice and research fields for stroke rehabilitation in Oriental medicine.