http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 정신영 ( Sin-yeong Jeong ) (검색결과 5 건)
- 무료
- 기관 내 무료
- 유료
-
이차성 레이노 현상 의심소견에 대한 당귀사역탕 투여 경과 : 증례보고
정신영,강수우,조희근,Jeong, Sin-yeong,Kang, Su-woo,Jo, Hee-geun 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.4
Objective: The aim of this report is to report the effects of Danggwisaeyeok-tang (當歸四逆湯) on Raynaud phenomenon in a patient. Methods: A 57-year-old male diagnosed in 2016 with Raynaud's phenomenon complained of pain, digital ulceration, and discoloration of his fingers. He underwent acupuncture and electroacupuncture treatment, but the symptoms gradually worsened, so we administered herbal medicine, Danggwisaeyeok-tang (當歸四逆湯). Visual observation of the affected part, changes in subjective symptoms, and a verbal numerical rating scale (VNAS) were used to assess the clinical response. Results: After treatment with Danggwisaeyeok-tang, the patient reported improvement in his symptoms of cold sensation, ulceration, and sclerosis of his digits. Furthermore, the patient exhibited no general adverse effects. Conclusions: Danggwisaeyeok-tang (當歸四逆湯) significantly improved the patient's clinical symptoms. This case suggests that Danggwisaeyeok-tang (當歸四逆湯) may represent a good option for the treatment of Raynaud's phenomenon.
-
대사증후군과 자가 면역성 갑상선염을 동반한 Turner 증후군
최정욱 ( Choe Jeong Ug ),변종원 ( Byeon Jong Won ),이연 ( Lee Yeon ),심명숙 ( Sim Myeong Sug ),신영구 ( Sin Yeong Gu ),정춘희 ( Jeong Chun Hui ) 대한내과학회 2003 대한내과학회지 증례 특집호 65-5 부록3 Vol.0 No.-
Autoimmune thyroiditis in Turner syndrome is more prevalent in women with the X isochromosome karyotype, compared with other karyotypes. The cause of obesity in Turner syndrome is not to be sure, it may be related to metabolic syndrome inducing insulin re
-
외상 후 슬관절 강직에 대한 복합 한의치료의 경과: 증례보고
이건영 ( Geon-yeong Lee ),설재욱 ( Jae-uk Seol ),조희근 ( Hee-geun Jo ),권민구 ( Min-gu Kwon ),정신영 ( Sin-yeong Jeong ),김종환 ( Jong-hwan Kim ),박어진 ( Eo-jin Park ) 대한한의학회 한방재활의학과학회 2017 한방재활의학과학회지 Vol.27 No.2
The purpose of this study is to illustrate the potential for clinical improvement in treating a patient with a case of Posttraumatic Knee Stiffness with a combination of Korean medicine therapy. We treated the patient with acupuncture, electroacupuncture, CHUNA manual therapy and Interferential Current Therapy from 5<sup>th</sup> December 2016 to 13<sup>th</sup> January 2017 (total 29 times) by evaluating knee function with VAS score. After six weeks of treatment, this patient achieved effective outcome following the technique, showing that clinical symptom as able to walked and pain was relieved, VAS changed from 10 to 2 and the knee flexion ROM (active/passive) changed from 30/60 degrees to 120/140 degrees. This result shows that Korean Medicine therapy may be an effective option for Posttraumatic Knee Stiffness. Further clinical studies are needed to clarify the effect of Korean Medicine therapy on Posttraumatic Knee Stiffness. (J Korean Med Rehabil 2017;27(2):109-115)
-
수종의 암세포에서 Verapamil이 Tc-99m MIBI와 Tetrofosmin의 섭취에 미치는 영향
김대현 ( Kim Dae Hyeon ),유정아 ( Yu Jeong A ),서명랑 ( Seo Myeong Lang ),배진호 ( Bae Jin Ho ),정신영 ( Jeong Sin Yeong ),안병철 ( An Byeong Cheol ),이규보 ( Lee Gyu Bo ),이재태 ( Lee Jae Tae ) 대한핵의학회 2004 핵의학 분자영상 Vol.38 No.1
목적: 다약제내성(MDR) 극복제 verapamil은 MDR이 발현된 암세포에서 Tc-99m MIBI(MIBI)와 tetrofosmin(TF)의 섭취를 증가시키는 것으로 알려져 있으나, 세포의 종류에 따라서는 MIBI와 TF의 섭취를 감소시킬 수 있다는 보고가 있다. 본 연구는 암세포의 종류에 따라 verpamile이 MIBI와 TF의 섭취에 미치는 영향이 세포에 따른 차이가 있는지를 알아보고, 이러한 차이가 세포독성이나 PKC효소의 발현에 따른 차이인가를 알아보았다. 방법: 백혈병세포 K562세포와 유방암세포 MCF7, 난소암세포 SK-OV-3은 세포 및 MDR이 유발된 K562(Adr)세포를 배양하였다. 시험관에서 1×10^(6) cells/㎖ 농도의 single-cell suspension 상태로 분주하고 verapamil을 1, 10, 50, 100, 200 μM의 농도로 처리한 후 MIBI와 TF를 배양한 후, 37℃에서 1, 15, 30, 45, 60분 동안 반응시킨 후 pellet과 supernatant의 방사능 치를 감마계수기로 측정하여 투여한 방사능 치에 대한 세포내 섭취백분율로 표시하였다. Verapamil의 세포독성은 MTT assay로 측정하였고, 세포내의 PKC isotypes의 변화는 western blotting analysis로 평가하였다. 결과: 4종류의 세포 모두에서 MIBI와 TF의 섭취는 1, 15, 30, 45, 60분 배양 시간에 따라 증가하였다. verapamil을 처리시 다약제 내성이 유발된 K562(Adr)세포에서 100 μM의 농도까지는 MIBI와 TF 섭취가 증가하였고, 최대 50 μM에서 10배 증가하였다. 그러나 K562세포를 verapamil 1 μM로 처리하였을 때는 기저치와 유사하였으나, verapamil의 농도가 증가함에 따라 MIBI와 TF의 세포섭취는 모두 감소하였다. K562세포의 60분 MIBI 섭취율은 79%(10 μM), 47%(50 μM), 29%(100 μM), 60%(50μM), 42%(100 μM), 2.7%(200 μM)로 감소하였다. MCF7, SK-OV-3세포에서는 verapamil 10 μM까지는 MIBI와 TF의 섭취가 기저치와 유사하거나 소량 증가하였으나 50 μM이상의 용량에서는 감소하여 100 μM에서는 각각 40%와 5%만 섭취되었다. MTT assay상 K562(Adr)세포에서는 verapamil 100 μM 이상에서는 유의하게 낮았으나 다른 세포는 200 μM까지에도 차이가 없었다. PKC 아형의 분석상 PKC ε이 K562(Adr)세포에서 많이 발현되었으나, K562와 K562(Adr)세포에서는 verapamil처리에 따른 PKC 아형의 변화는 없었다. 결론: Verapamil은 암세포의 종류에 따라 MIBI와 TF의 섭취를 감소시켰고, 고용량에는 MDR 세포의 섭취도 감소시켰으며 이러한 현상은 세포독성이나 PKC효소 아형과는 관련이 없었다. 그러므로 MDR의 진단시 verapamil을 처치에 따른 MIBI와 TF의 섭취 정도를 기준으로 하는 경우에는, verapamil의 농도와 세포의 종류에 따라 현저한 차이가 있을 수 있다는 점을 생각하여야 한다. Purpose: Cellular uptake of ^(99)mTc-sestamibi (MIBI) and ^(99)mTc-tetrofosmin (TF) is low in cancer cells expressing multidrug resistance(MDR) by p-glycoprotein(Pgp) or multidrug related protein(MRP). Verapamil is known to increase cellular uptake of MlBl in MDR cancer cells, but is recently reported to have different effects on tracer uptake in certain cancer cells. This study was prepared to evaluate effects of verapamil on cellular uptake of MlBl and TF in several cancer cells. Materials and Methods: Cellular uptakes of Tc-99m MlBl and TF were measured in erythroleukemia K562 cell, breast cancer MCF7 cell, and human ovarian cancer SK-OV-3 cells, and data were compared with those of doxorubicin-resistant K(562(Ad) cells. RT-PCR and Western blot analysis were used for the detection of mdrl mRNA and Pgp expression, and to observe changes in isotypes of PKC enzyme. Effects of verapamil on MlBl and TF uptake were evaluated at different concentrations upto 200 μM at 1×10^(6) cells/^(㎖) at 37℃. Radioactivity in supernatant and pellet was measured with gamma counter to calculate cellular uptake ratio. Toxicity of verapamil was measured with MTT assay. Results: Cellular uptakes of MlBl and TF were increased by time in four cancer cells studied. Co-incubation with verapamil resulted in an increase in uptake of MlBl and TF in K562(Adr) cell at a concentration of 100 μM and the maximal increase at 50μM was 10-times to baseline. In contrast, uptakes of MlBl and TF in K562, MCF7, SK-OV3 cells were decreased with verapamil treatment at a concentration over 1μM. With a concentration of 200μM verapamil, MlBl and TF uptakes in K562 cells were decreased to 1.5% and 2.7% of those without verapamil, respectively. Cellular uptakes of MlBl and TF in MCF7 and SK-OV-3 cells were not changed with 10μM, but were also decreased with verapamil higher than 10μM, resulting 40% and 5% of baseline at 50μM. MTT assay of four cells revealed that K562, MCF7, SK-OV3 were not damaged with verapamil at 200μM. Conclusion: Although verapamil increases uptake of MlBl and TF in MDR cancer cells, cellular uptakes were further decreased with verapamil in certain cancer cells, which is not related to cytotoxicity of drug. These results suggest that cellular uptakes of both tracers might differ among different cells, and interpretation of changes in tracer uptake with verapamil in vitro should be different when different cell lines are used.
-
김미진 ( Kim Mi Jin ),유광하 ( Yu Gwang Ha ),강동구 ( Kang Dong Gu ),이준상 ( Lee Jun Sang ),조승제 ( Jo Seung Je ),신영구 ( Sin Yeong Gu ),정춘희 ( Jeong Chun Hui ) 대한내과학회 2003 대한내과학회지 증례 특집호 65-5 부록3 Vol.0 No.-
Thyroid tuberculosis is rare. We experienced case of a 50-year-old woman with tuberculosis of the thyroid associated with miliary tuberculosis. She complained of chronic cough and weight loss. She was clinically and biochemically euthyroid. Thyroid sonogr
ScienceON
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
