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이영주 ( Young Joo Lee ),최상태 ( Sang Tae Choi ),김세현 ( Se Hyun Kim ),정경수 ( Kyung Soo Jung ),윤설희 ( Sul Hee Yoon ),정수진 ( Soo Jin Jeung ),이승우 ( Seung Woo Yi ),김주항 ( Joo Hang Kim ) 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.62 No.1
A thymic carcinoma is a rare malignant neoplasm of the thymus epithelium, which can be distinguished from a benign or invasive thymoma. Contrary to a thymoma, the association of a thymic carcinoma and autoimmune disease is rare, with only a few cases having been reported. Herein, a case of thymic carcinoma diagnosed concurrently with systemic lupus erythematosus (SLE) is reported. A 49 year-old man presented at our clinic with myalgia. He was diagnosed with SLE, based on an oral ulcer, lymphopenia, and positive ANA and anti-Sm antibodies. Incidentally, a routine chest X-ray showed a large mediastinal mass. Pathological examination of the mediastinal mass revealed an undifferentiated thymic carcinoma, of WHO classification type C. Further work-up for staging showed multiple bone and lung metastases. With a palliative aim, he received systemic chemotherapy, but refused further chemotherapy after the 2(nd) course. Currently, the patient has not been followed up since the chemotherapy. (Tuberc Respir Dis 2007; 62: 67-70)