백서두개골 결손부에서 BMP전달체의 골재생효과분석

정성원,정지희,채경준,정의원,김창성,조규성,채중규,김종관,최성호,Jung, Sung-Won,Jung, Jee-Hee,Chae, Gyung-Joon,Jung, Ui-Won,Kim, Chang-Sung,Cho, Kyoo-Sung,Chai, Jung-Kiu,Kim, Chong-Kwan,Choi, Seong-Ho 대한치주과학회 2007 Journal of Periodontal & Implant Science Vol.37 No.4

Bone morphogenetic proteins have been shown to possess significant osteoinSductive potential, but in order to take advantage of this effect for tissue engineering, carrier systems are essential. Successful carrier systems must enable vascular and cellular invasion, allowing BMP to act as a differentiation factor. The carrier should be reproducible, non-immunogenic, moldable, and space-providing, to define the contours of the resulting bone. The purpose of this study was to review available literature, in comparing various carriers of BMP on rat calvarial defect model. The following conclusions were deduced. 1. Bone regeneration of ACS/BMP, ${\beta}-TCP/BMP$, FFSS/BMP, $FFSS/{\beta}-TCP/BMP$, MBCP/BMP group were significantly greater than the control groups. 2. Bone density in the ACS/BMP group was greater than that in ${\beta}-TCP$, FFSS, $FFSS/{\beta}-TCP$ carrier group. 3. Bone regeneration in FFSS/BMP group was less than in ACS/BMP, ${\beta}-TCP/BMP$, MBCP/BMP group. However, New bone area of $FFSS/{\beta}-TCP/BMP$ carrier group were more greater than that of FFSS/BMP group. ACS, ${\beta}-TCP$, FFSS, $FFSS/{\beta}-TCP$, MBCP were used for carrier of BMP. However, an ideal carrier which was reproducible, non-immunogenic, moldable, and space-providing did not exist. Therefore, further investigation are required in developing a new carrier system.

한국적 특수성을 고려한 지역특성과 개인의 건강

정성원,조영태,Jung, Sung-Won,Cho, Young-Tae 대한예방의학회 2005 예방의학회지 Vol.38 No.3

Recently much attention has been paid to the effect of neighborhood characteristics on the health of individuals, independent of individual demographic and/or socioeconomic characteristics. Although many empirical studies of a kind, mostly based on Western society, have appeared on various international journals, few studies have shown empirical evidence of neighborhood characteristics as an independent and significant risk factor of ill health in Korea. This paper discusses possible reasons that neighborhood seems to be neither significant nor substantial regarding its impact on the health of Koreans. Addressing the uniqueness of Korean society regarding the concept of neighborhood, attributes of neighborhoods, and methodological challenges, authors suggest that more sophisticated conceptual and methodological approach, specific to Korean society, should enable to reveal the effect of neighborhood characteristics on individual health in Korea.

Protein transduction domain을 이용한 recombinant human bone morphogenetic protein-2의 골재생효과

정성원,김남희,육종인,김창성,김형준,조규성,Jung, Sung-Won,Kim, Nam-Hee,Yook, Jong-In,Kim, Chang-Sung,Kim, Hyung-Jun,Cho, Kyoo-Sung 대한치주과학회 2007 Journal of Periodontal & Implant Science Vol.37 No.3

Bone morphogenetic proteins(BMPs) are regarded as members of the transforming growth $factor-{\beta}$ superfamily with characteristic features in their amino acid sequences. A number of studies have demonstrated the biologic activities of BMPs, which include the induction of cartilage and bone formation. Recently there was a attempt to overcome a limitation of mass production, and economical efficieny of rh-BMPs. The method producing PTD by using bacteria have advantages of acquiry a mass of proteins. Hences, a new treatment which deliver protein employed by protein transduction domain(PTD) has been tried. The purpose of this study was to evaluate the bone regenerative effect of TATBMP-2 and TAT-HA2-BMP-2 employed by PTD from HlV-1 TAT protein for protein translocation in the rat calvarial model. An 8mm calvarial, critical size osteotomy defect was created in each of 32 male Spraque-Dawley rats(weight $250{\sim}300g$). The animals were divided into 4 groups of 32 animals each (4 animals/group/healing interval). The defect was treated with TATBMP-2/ACS(Absorbable collagen sponge) (TATBMP-2 0.1mg/ml), TAT-HA2-BMP-2/ACS(TAT-HA2-BMP-2 0.1mg/ml), ACS alone or left untreated for surgical control(negative control). The rats were sacrificed at 2 or 8 weeks postsurgery, and the results were evaluated histologically. The results were as follows: New bone formation were not significantly greater in the TATBMP-2/ACS group relative to negative, and positive control groups. New bone was evident at the defect sites in TAT-HA2-BMP-2/ACS group relative to negative, positive control and TATBMP-2 groups. There were a little bone regeneration in TATBMP-2 groups. While, enhanced local bone formation were observed in TAT-HA2-BMP-2 group. But, The results was not the same in all rat defects. Therefore, further investigations are required to develop a method. which disperse homogenously, and adhere to target cells.

전기응석 부상분리에 의한 바이오매스의 처리에 관한 연구

정성원(Sung-Won Chung),정용택(Yong-Teak Jung) 한국산업융합학회 2005 한국산업응용학회 학술대회 논문집 Vol.- No.-

본 연구에서는 전기응석 분리법을 이용하여 호수에서 녹조현상으로 인해 오염된 물의 정화를 위한 실험결과,통전에 의해 조류는 현저히 응석 부상분리되고, 그 결과 회수수의 정수효과가 확실히 나타났다. 이것은 조류의 농도가 높을수록 상승하였다.<br/> 전기응석법에 의해 부상분리되어 얻어진 회수수의 SS, Chl-a, Org-N은 감소하고, DO, pH는 저하 하였다.<br/> 통전에 의해 회수수의 투과율이 증대하는 하편, 임의 한도를 넘으면 SS가 증대하는 현상이 관찰 되었다. 때로는 투명하게된 회수수의 SS가 원수의 SS보다 높은 경우도 있었다. 이것을 조류 농도가 낮고, 장시간 통전 했을때에 현저 하였다. 이들은 통전에 따른 Al(OH)₃의 생성에 기인하는 것이다.<br/> 통전에 의한 조류의 응석부상분리의 효과와 청정효과, 회수수의 Al(OH)₃의 용출에 관한 실용적인 조작조건을 정하는 것이 절실히 요망된다.<br/> 특히 본 실험은 조류의 농도가 클때 유효한 방법이므로 일사량이 많은 하기에 태양전지를 전원으로 이용한 제작에 의해 실용화 시기 할 수 있을 것으로 사료 된다.

우울증의 진단평가 지침 -우울증 평가도구를 중심으로-

정성원 ( Sung Won Jung ),이은정 ( Eun Jung Lee ),최윤경 ( Yun Kyeung Choi ),성형모 ( Hyung Mo Sung ),김대현 ( Dae Hyeon Kim ),최정식 ( Jeong Shik Choi ),김정범 ( Jung Bum Kim ) 한국정신병리진단분류학회 2009 精神病理學 Vol.18 No.1

Depression is the second most common chronic disease in primary care. However, depression is commonly misdiagnosed, or though diagnosed properly, it is easy to treat inadequate doses or duration of antidepressants. It is of importance to diagnose and treat properly. Because of a wide range of symptoms and comorbidities, it is difficult to make a diagnosis of depression. Rating scales can be useful for the diagnosis of depression. It is feasible that the clinicians assess the patients with depression appropriately and determine therapeutic strategies by rating scales for depression. We have reviewed the purpose of rating scales for depression, including screening, ratings of symptoms, diagnosis, the progress, and the results of treatment. We also have described the actual condition of rating scales in Korea, which were performed by clinical research center for depression. It is restricted within marrow limits to select certain rating scale for depression and poorly known that some scales have been developed. Therefore, it is important task to announce the rating scales for depression so that the clinicians and researchers can be familiar with these scales. It is also important to develop a diversity of scales so that the clinicians can select appropriate scales.

도심지 보행네트워크 분석

정성원(Jung Sung-Won),이승욱(Lee Seung-Wook) 대한건축학회 2008 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.28 No.1(계획계)

The purpose of this study was to analyze the urban pedestrian behavior according to the walk purpose and to moving distance from the viewpoint of user. A methodology of this study was used with the data which were obtained by walking volume survey and questionnaire survey. The sample distance was 2.32㎞ from Gwang-hwa gate to Seoul station. As a result of having analyzed a walk movement route, it was hello to derive the fact that physics street of an object magazine spend a human scale, and was devised excessively. It was wached high numerical value partly additionally on the mail side and back road with an axis in an area.

2002년 8월 낙동강 홍수 호우특성 분석

정성원(Jung Sung Won),문장원(Moon Jang Won),한명선(Han Myoung Sun),김동희(Kim Dong Hee) 대한토목학회 2002 대한토목학회 학술대회 Vol.2002 No.11

신기능 저하 환자에서 위막성 대장염 발생의 임상적 특징

정성원 ( Sung Won Jung ),이유민 ( Yu Min Lee ),정덕은 ( Duk Eun Jung ),이재훈 ( Jae Hoon Lee ),김현정 ( Hyun Jung Kim ),이지은 ( Ji Eun Lee ),송주흥 ( Ju Hung Song ),박도심 ( Do Sim Park ),안선호 ( Seon Ho Ahn ) 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.2

목적: Clostridium difficile-associated diarrhea (CDAD)는 항생제 사용 후 장내세균 변화로 인해 C. difficile 독소 A에 의해 발생되는 위막성 대장염에 의한 것으로 알려져 있다. 본 연구는 대장내시경 후 조직검사를 통해 위막성 대장염으로 확진된 CDAD 환자에서 임상적 및 검사실적 소견의 분석을 통해 신기능의 저하가 CDAD 발생에 어떤 영향을 미치는지 알아보고자 하였다. 방법: 1998년 1월부터 2006년 12월까지 원광대학교 의과대학 병원에서 2일 이상 묽은 변과 고열이 발생한 환자에서 CDAD가 의심되어 C. difficile 독소 A를 시행하고 대장내시경을 통해 조직학적으로 CDCA로 확진된 환자 56명을 대상으로 신기능 저하, 당뇨 및 악성종양의 유무를 조사하여 항생제 투여 기간에 따른 CDAD 발생 빈도를 비교하였다. 결과: 연구 기간 동안 CDAD가 의심되어 C. difficile 독소 A를 검사한 환자는 452명이었으며, 이중 양성 환자 416명 (92.03%), 음성 환자 36명 (7.96%)이었다. 452명 중 대장내시경을 시행한 환자는 92명 (20.7%)이었고, 이중 조직검사에서 위막성 대장염으로 진단된 환자는 56명 (60.8%)이었다. 조직 검사로 진단된 위막성 대장염 환자 56명 (남자 26명; 여자 30명)이었고, 이중 신기능 저하 환자 8명 (14.2%), 당뇨환자 10명 (17.8%), 악성종양 환자 13명 (23.2%)이었다. 또한 독소 A가 음성인 환자는 36명 (64.3%)었다. 조직검사로 확진된 신기능 저하 환자 8명 중 5명 (62.5%)은 C. difficile 독소 A 검사에서 음성으로 신기능 저하 유무에 따른 독소 반응의 차이는 없었다 (62.5% vs. 64.6%). 신기능이 저하된 환자에서 당뇨 2명 (25%), 악성종양 환자 1명 (12.5%)이었다. CDAD 발생까지의 항생제 투여 기간은 신기능이 정상인 환자 보다 신기능이 저하된 환자에서 짧았고 (23.44±3.28일 vs. 11.13±2.386일, p=0.034), 당뇨 및 악성 종양 유무에 따른 비교에서 (20.85±2.221일 vs. 25.50±13.07일; 23.30±3.67일 vs. 16.31±2.31일) 차이가 없었다. 결론: 면역력이 저하된 당뇨 및 악성종양 환자에 비해 신기능이 저하된 환자에서 CDAD 발생까지의 항생제 투여 일수가 적어 신기능 저하 상태에서 특히 항생제 투여에 주의가 필요하다. 또한 항생제 투여 후 발생된 설사 환자에서 C. difficile 독소 A가 음성이라 할지라도 환자가 대장내시경을 시행할 수 있는 상태인 경우 반드시 대장내시경과 조직검사를 시행하여 CDAD를 감별해야 할 것으로 생각한다. Purpose: Clostridium difficile-associated diarrhea (CDAD) is a potentially life-threatening illness which has been shown to be more common and more severe in patient with chronic renal failure. The aim of this study was to investigate clinical characteristics of renal insufficiency patients with clostridium difficile-associated pseudomembranous colitis. Methods: We reviewed charts of fifty-six patients with clostridium difficile-associated pseudomembranous colitis, who have clostridial toxin A assay in stool and a diagnosis made on histology of colonic biopsies. Results: There was no difference in age, serum albumin, C-reactive protein (CRP) and negative incidence of clostridial toxin A between patients who had renal insufficiency with serum creatinine more than 1.5 mg/dL and those who did not. But duration of antibiotic use administered prior to development of the clostridium difficile infection was more shorter in patients with impaired renal function than in patients with normal renal function. Conclusion: These data suggest that it may take a short period to development of the clostridium difficile infection in patients with impaired renal function, and histologic evaluation by sigmoidoscopy should be performed to make a diagnosis in CDAD-suggested patients, who have impaired renal function and even negative clostridial toxin A.

진단 및 치료 대장 내시경의 합병증으로 발생한 대장 천공의 치료에 대한 임상적 고찰순천향대학교 의과대학 내과학교실 소화기 연구소, 대전 속편한 내과

정성원 ( Song Won Jung ),유창범 ( Chang Beom Ryu ),송민수 ( Yon Soo Kim ),김연수 ( Min Soo Song ),고봉민 ( Bong Min Ko ),차상우 ( Sang Woo Cha ),류권호 ( Kwon Ho You ),홍수진 ( Soo Jin Hong ),김영석 ( Young Seok Kim ),문종호 ( Jon 대한장연구학회 2004 Intestinal Research Vol.2 No.1

Colonoscopy is used increasingly because the indication for therapeutic colonoscopy has been increased and the technique has been developed continuously as well as colonosopy is useful for diagnosis of colonic disease. Therefore, It is important understanding precisely about the complication of colonoscopy and managing the complication immediately and properly. In particular, colon perforation is the most fatal, emergency case and have needed surgical treatment, generally. Recently, the case treated with endoscopic clipping and conservative management has been reported. but until now, when perforated, wheather the endoscopic clipping or the surgical management at each other case is beneficial is not confirmed.

퍼지 집합의 소속함수에 대한 가중치 함수와 비퍼지화에서의 적용

정성원(Sung-Won Jung),이광형(Hyung Lee-Kwang) 한국정보과학회 2001 한국정보과학회 학술발표논문집 Vol.28 No.1B

본 논문에서는 퍼지집합의 소속함수에 대한 가중치 함수를 제안한다. 제안하는 가중치 함수는 퍼지집합의 소속함수에 곱해지는 형태로서 적용되어지며, 이것은 소속함수에 대한 사용자의 선호도를 의미한다. 제안하는 가중치 함수의 개념은 기본적으로 소속함수를 사용하는 어떤 퍼지 집합의 응용에서도 적용될 수 있을 것으로 보이나, 본 논문에서는 그 중 한가지 경우로 비퍼지화 방법을 적용 대상으로 선택하였다. 제안하는 가중치 함수가 비퍼지화 방법에 있어서 가지는 의미를 보이며, 기존의 비퍼지화 방법들에서 이러한 가중치 함수의 개념이 어떻게 적용되어 왔는지를 보인다. 또한 기존의 비퍼지화 방법들의 개념에 적용되지 않은 형태의 가중치 함수를 선택하여, 비퍼지화 방법에 특정 가중치 함수를 적용하였을 때의 특성 변화를 보인다. 이러한 일반적인 형태의 가중치 함수를 퍼지집합의 소속함수에 적용함으로서, 다양한 형태의 선호도를 퍼지집합의 형태에 반영할 수 있을 것으로 보인다.