수술로 절제한 위장관기질종양에서 Ki-67 발현의 예후적 중요성

정성연 ( Seong Yeon Jeong ),박원우 ( Won Wo Park ),김유선 ( You Sun Kim ),박영일 ( Young Il Park ),김승협 ( Seung Hyup Kim ),윤원재 ( Won Jae Yoon ),문정섭 ( Jeong Seop Moon ),이병모 ( Byung Mo Lee ),홍성우 ( Seong Woo Hong ),강 대한소화기학회 2014 대한소화기학회지 Vol.64 No.2

목적: 현재까지 위장관기질종양(GIST)을 양성과 악성으로 분류할 수 있는 명확한 조직학적 기준은 없지만, 전이나 재발을 일으킬 수 있는 위험도를 종양세포의 유사분열 수와 종양의 크기를 기준으로 나누고 있다. Ki-67은 세포 증식의 표지자로 사용되는 단백질로, GIST의 예후 인자로의 가능성이 주목되고 있다. 이에 저자들은 수술 치료를 시행한 GIST 환자 중 Ki-67 면역조직화학염색을 시행한 32예의 Ki-67 지수와 유사 분열 지수와의 관련성, GIST의 재발률 및 무병 생존율에 대하여 분석 검토하여 보았다. 대상 및 방법: 인제대학교 서울백병원에서 수술 치료를 통하여 GIST를 제거한 32명의 환자를 대상으로 연구를 시행하였고 환자들의 의무기록을 통하여 성별, 연령, 증상 등의 임상적 특징과, 종양의 크기, 위치 등의 조직학적 특징 및 재발률에 대하여 조사하였다. 결과: NIH 진단기준으로 very low risk는 4예, low risk는 9예, intermediate risk는 14예, high risk는 5예였다. Ki-67 지수는 1-18%의 범위 내에 있었고, 평균은 5.56±4.48%였다. 평균 추적관찰 기간은 35.72±29.04개월이었고 관찰 도중 6 예(18.7%)에서 재발 혹은 전이가 발견되었다. Ki-67 지수가 5% 이하인 군의 누적 무병 생존율은 12개월, 24개월, 60개월에 각각 100%, 100%, 86%였다. 반면 Ki-67 지수가 5% 초과인 군의 누적 무병 생존율은 12개월, 24개월, 60개월에 각각 82.1%, 70.3%, 46.9%로 Ki-67 지수가 5% 이하인 환자에 비하여 무병 생존율에 유의한 차이를 보였다(p=0.007) 결론: Ki-67 지수가 5% 초과할 경우 GIST 재발의 고위험성을 시사한다. 향후 Ki-67 지수의 표준화와 치료 방향의 결정에 미치는 Ki-67 지수의 역할에 대한 연구가 필요하다. Background/Aims: Assessment of malignant potential in gastrointestinal stromal tumor (GIST) is still problematic. The maximum tumor diameter and the mitotic index are generally used as an index of malignancy of GISTs. The Ki-67 labeling index has recently been used as an index of cell growth. The aim of this study was to investigate the prognostic value of K -67 in GIST. Methods: We retrospectively reviewed the medical records of 32 patients with GIST who underwent surgical resection at Inje University Seoul Paik Hospital. We analyzed their Ki-67 expression, histologic finding, and prognosis. Results: According to the tumor size and mitotic count, 4 patients were classified as very low risk, 9 patients as low risk, 14 patients as intermediate risk and 5 patients as high risk. The average Ki-67 index was 5.56±4.48%. The median follow-up duration was 35.72±29.04 months, and local/distant recurrences were observed in 6 (18.7%) patients. The overall cumulative disease free survival rates in patients with Ki-67 index ≤5% at 1 year, 2 years, and 5 years were 100%, 100%, and 86%, respectively. The overall cumulative disease free survival rates in patients with Ki-67 index >5% were at 1 year, 2 years, and 5 years were 82.1%, 70.3%, and 46.9%, respectively. There was significant relationship between elevated Ki-67 and disease free survival rate (p=0.007). Conclusions: Our study suggests that Ki-67 index >5% confers a higher risk of relapse in patients with GIST. Future work should focus on standardization of Ki-67 assessment and specification of its role in making treatment decisions.(Korean J Gastroenterol 2014,64:87-92)

‘가명정보에 관한 재산상 권리’ 인정에 대한 고찰

정성연(Jeong, Seong-Yeon) 한국정보법학회 2021 정보법학 Vol.25 No.1

개인정보 보호법이 2020. 2. 4. 개정됨에 따라 가명정보 활용에 관한 법적근거가 마련되었고, 이로써 가명정보가 시장에서 자유롭게 이용될 가능성이 높아졌다. 그러나 가명정보에 관한 권리는 어떻게 취급해야 하는지에 대한 논의는 아직 부족한 상황이다. 가명정보의 처리에 관한 특례 조항이 신설된 현재, 개인정보에 관한 권리에 대한 지금까지의 논의가 여전히 유효한 것인지, 가명정보에 관한 권리를 개인정보에 관한 권리와 구별하여 독자적으로 취급할 수 있는지 문제된다. 특히 가명정보의 재산성 인정 여부 및 가명정보에 관한 권리를 재산권으로 인정해야 할지 여부는 아직 정리되지 않은 과제이다. 나아가 가명정보에 관한 권리가 인정된다면, 그 권리를 정보주체 혹은 개인정보처리자 중 누구에게 귀속시킬지도 문제 된다. 한편, 지식재산권(저작권)의 법리는 가명정보에 관한 권리를 다루기 위한 법리와 유사하므로, 입법론 측면에서 유용한 도구가 될 수 있다. 특히, 저작권법상 편집저작물 및 데이터베이스 제작자의 권리, 저작물의 공정한 이용 등의 법리는 가명정보 활용을 통한 개인정보 이용과 보호의 균형점을 찾는데 참고가 될 것으로 기대한다. 또한 데이터세 부과에 대한 논의 역시 가명정보 이용과 관련하여 고민해 볼 주제이다. 이 글에서는 이상 언급한 가명정보의 재산성과 관련된 여러 특성을 살펴보고, 가명정보에 대한 재산상 권리의 인정 여부 및 권리의 보호 방안, 그 권리의 귀속을 중심으로 검토해 보고자 한다. As the Personal Information Protection Act was amended on February 4, 2020, the legal basis for the use of pseudonymous data has been established, which increases the possibility that pseudonymous data will be freely utilized in diverse industries and markets. However, there are still insufficient discussions on how to deal with the right to ‘pseudonymous data’. Now that the special cases concerning pseudonymous data are newly established, it is a question whether the discussions on ‘the rights regarding personal information’ as of today could still have valid meaning, and whether ‘the rights to the pseudonymous data’ can be separately considered with ‘the rights regarding personal information’. In particular, whether ‘pseudonymous data’ is recognized as property or whether ‘rights related to pseudonymous data’ are recognized as property rights is not yet cleared up. Furthermore, if ‘the right on pseudonymous data’ is recognized, it can also be an issue whether the right will belong to the data subject or the personal information controller. On the other hand, the legal principle of intellectual property rights (copyright law) is similar to that of dealing with the right to pseudonymous data, so it is necessary to refer to the legal principle of intellectual property rights from a legislative theory perspective. Specifically, it is expected that compilation works and the rights of producer of database under the current Copyright Act and the fair use of works can be useful examples when we seek a balance point between use and protection of personal information. Also, the method of imposing data tax is a subject that should be considered in relation to the use of pseudonymous data. Accordingly, this paper reviewed various issues related to the nature of ‘pseudonymous data’ as property, and the requirement for recognition of ‘pseudonymous data’ as a property right, measures to protect the right thereof properly, and the attribution of the right.

Boost DC/DC 컨버터에서 Error amplifier의 Autozero 기법을 이용한 Offset 보상에 관한 연구

정성연(Jeong Seong Yon),김진규(Kim Jin Kyu),두수연(Du Sue Yeon),곽계달(Kwack Kae Dal) 대한전자공학회 2006 대한전자공학회 학술대회 Vol.2006 No.11

CO₂ 레이저와 scalpel을 이용한 위 절개 시 개에서의 창상 치유 평가

이재연,황유선,김한결,최현석,정성목,조성환,박창식,김명철,Lee, Jae-Yeon,Hwang, You-Sun,Kim, Han-Kyul,Choi, Hyun-Suk,Jeong, Seong-Mok,Cho, Sung-Whan,Park, Chang-Sik,Kim, Myung-Cheol 대한수의학회 2010 大韓獸醫學會誌 Vol.50 No.2

The objective of this study was to compare wound healing in stomach with $CO_{2}$ laser and scalpel incision by measuring the extent of bleeding, the ease of gastric incision, incision time, degree of adhesion and wound healing degree in dogs. Sixteen healthy dogs were used. Two symmetrical incisions were made in ventral aspect of the stomach between the greater and lesser curvatures were made with scalpel and 0.2 mm spot diameter $CO_{2}$ laser (8W, continuous wave) in sixteen dogs. And then each wound was closed with absorbable suture in a two-layer inverting seromuscular pattern. At 3, 7, 14 and 21 days after initial wounding, each wound was taken for histological observation. On surgery, the extent of bleeding, the ease of incision and incision time showed significant differences between the groups. The $CO_{2}$ laser provided better hemostasis (p < 0.05) and smaller postoperative adhesion compared with the scalpel. However, the scalpel produced faster speed of incision and was easier to handle than the $CO_{2}$ laser (p < 0.05). Although there was no considerable difference between the two groups in histological observation, necrosis and calcium deposit tended to be larger in the $CO_{2}$ laser than in the scalpel.

Indomethacin으로 유발된 생쥐의 위점막 손상에 대한 쑥을 함유한 천연물 복합제의 효과

정성연 ( Seong-yeon ),주인환 ( Jeong In-hwan Joo ),박종민 ( Jong-min Park ) 대전대학교 한의학연구소 2022 혜화의학회지 Vol.32 No.1

Objectives : This study was aimed to investigate whether gastritis care mixture (GCM) with artemisi a can prevent indomethacin-induced gastric damages. GCM consisted of artemisiae argyi folium, diosc oreae rhizoma, crataegi fructus, zizyphi fructus, and glycyrrhizae radix. Methods : Antioxidant activities were evaluated using 2,2-dipheny-1-picrylhydrazyl (DPPH), 2,2'-a zinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), and ferric reducing antioxidant power (FRA P) method. GCM were pretreated 6 h before indomethacin treatment on rat gastricmucosal epithelial BGM1 cells. Cytoprotection effects eavluated by MTT. [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide]. Reverse-transcription PCR (RT-PCR) and Western blot was performed to check anti-inflammatory actions. Different doses of GCM were administrated intragastrically before the indomethacin administration in mouse models. After killing, addition to gross and pathological evaluation of ulcer, the expressions of inflammatory mediators were analyzed by enzyme-linked immunosorbent assay (ELISA). Results : GCM was very effective in preventing indomethacin-induced gastric damages in a low dose. indomethacin increased the expression of cyclooxygenase-2 (COX-2) and decreased the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and Heme oxygenase-1 (HO-1), but GCM significantly attenuated indomethacin-induced COX-2 expression. Interestingly, GCM induced expression of 15-PGDH and HO-1. These in vitro findings were exactly validated in indomethacin-induced gastritis mouse models. GCM groups showed significantly ameliorated patheologic lesion compared to the control group. The serum levels of proinflammatory cytokines including interleukin-6 and tumor necrosis factor were significantly attenuated in the GCM group. However, these preventive effects of G CM were dependent on dosage of GCM; higher dose above 200mg/kg paradoxically aggravated indomethacin-induced inflammation. Conclusions : GCM is a candidate substance which can attenuate NSAIDs-induced gastritis on potent anti-inflammatory action.

CO₂ Laser와 Scalpel을 이용한 절개 시 돼지 방광에서의 창상치유 평가

이재연,정성목,조성환,박창식,김명철,Lee, Jae-Yeon,Jeong, Seong-Mok,Cho, Sung-Whan,Park, Chang-Sik,Kim, Myung-Cheol 대한수의학회 2010 大韓獸醫學會誌 Vol.50 No.3

This study compared the instrument performance and tissue healing of a steel scalpel with a $CO_2$ laser in an animal urinary bladder surgery model. Landrace and Yorkshire mixed breed pigs were used. Two symmetrical incisions were made in urinary bladder of each pig. One incision was made on the left side of ventral aspect on urinary bladder using a steel scalpel, while the other incision was performed on the right side using a $CO_2$ laser with an 8W output power. Each instrument was evaluated clinically for speed, ease of incision, and extent of bleeding. At 7 and 21 days after initial wounding, each wound was taken for histological observations. The scalpel was an easier instrument to use in the confines of the urinary bladder tissue, compared with the laser. However, there was no significant difference between the two groups. The amount of bleeding was less in the laser group but the time of the incisions was shorter with the scalpel. Scalpel incisions showed complete restoration of the epithelium and muscularis. On the other hand, the laser incisions showed incomplete restoration of the epithelium and muscularis. However, most of wound healing in the laser incisions was accomplished according to the time lapse. Although the scalpel produced less damage to the urinary bladder tissue and was easier to handle than the $CO_2$ laser, it did not provide hemostasis that was helpful for use on highly vascular tissue. The $CO_2$ laser provided good hemostasis, but delayed wound healing. In conclusion, the $CO_2$ laser provided better hemostasis and better surgical field than the scalpel. The $CO_2$ laser was used effectively in urinary bladder incision.

국내 유우 (Holstein)의 단태 또는 쌍태분만 후 태반정체와 제4위전위증 발생우의 수태 관련성에 대한 조사

조진행,김명철,정성목,이재연,신범준,Cho, Jin-Haeng,Kim, Myung-Cheol,Jeong, Seong-Mok,Lee, Jae-Yeon,Shin, Beom-Jun 대한수의학회 2012 大韓獸醫學會誌 Vol.52 No.2

Calving records of Holstein dairy cows from 2005 to 2010 comprising Goyang and Paju cities herd with 2,362 calving events representing 240 twin births were used to evaluate the effect of abomasal displacement and retained placenta after single or twin births on fertility. In retained placenta cows, the period of twin pregnancy (mean 270.5 days) was shorter than that of single pregnancy (mean 274.8 days), however first artificial insemination period (twin: mean 107.4 days, single: mean 92.0 days), non-pregnant period (twin: 154.8 days, single: 132.2 days), and number of insemination (twin: mean 2.00 times, single: mean 1.87 times) of twin pregnancy were increased as compared with single pregnancy. In abomasal displacement cows, first artificial insemination period (twin: mean 122.9 days, single: mean 106.0 days), non-pregnant period (twin: 172.4 days, single: 152.0 days), and number of insemination (twin: mean 2.16 times, single: mean 1.89 times) of twin pregnancy were increased as compared with single pregnancy. The prevalence of complication such as retained placenta, abomasal displacement with single or twin births increased first artificial insemination period, non-pregnant period, and number of insemination period.

위장관 ; 장내시경 장정결제로서 Sodium Phosphate 정제와 2 L Polyethylene Glycol with Ascorbic Acid의 무작위 대조군 연구

이연호 ( Yun Ho Lee ),정성연 ( Seong Yeon Jeong ),김유선 ( You Sun Kim ),정혜진 ( Hye Jin Jung ),권민정 ( Min Jung Kwon ),곽철훈 ( Cheol Hun Kwak ),배송이 ( Song I Bae ),문정섭 ( Jeong Seop Moon ),김지원 ( Ji Won Kim ),김수환 ( Su 대한소화기학회 2015 대한소화기학회지 Vol.65 No.1

목적: PEG (polyethylene glycol)는 안정적인 장정결제로 인정받아 왔지만, 환자의 순응도가 좋지 않아 장 정결이 제대로 되지 않을 수 있다는 단점이 있다. 이 연구에서는 sodium phosphate (NaP) 정제와 PEGA (PEG with ascorbic acid)를 사용하는 대장 정결법의 효용성과 순응도를 알아보고자 하였다. 대상 및 방법: 다기관, 전향적 무작위 대조 연구이며, 1차 연구 목적은 대장내시경 전처치에서 NaP 정제와 PEGA 방법의 대장 정결도를 비교하는 것이고, 2차 목적은 대장 내시경 시행 직전 조사한 설문을 이용하여 양 군 간의 환자의 순응도와 만족도를 비교하는 것이다. 결과: 총 189명 중 사전 무작위 배정을 통해서 NaP 정제(n=96) 또는 PEGA (n=93) 방법을 통해 장정결한 뒤 대장내시경을 시행하였다. 양 군 간에 BBPS는 NaP 정제군에서 평균 8.3 (SD, ±1.12)이었고, PEGA군에서는 평균 8.4 (SD, ±0.96)로 나타나 통계적으로 유의한 차이는 없었다(p=0.441). 양 군 간의 폴립 및 선종의 발견율 또한 유의한 차이가 나지 않았다(p=0.079, 0.790, respectively). 반면 NaP 정제를 복용한 환자의 2.0%가 복용해야 할 분량을 다복용하지 못하였고, PEGA군에서는 8.6%가 복용하지 못하였다(p=0.045). 또한 만족도는 NaP 정제군에서 평균 7.9 (SD, ±1.63)였고, PEGA군에서는 평균 7.4 (SD ±1.53)로 나타나 유의한 차이를 보였다(p=0.022). 결론: NaP 정제를 이용해 대장 정결을 하는 것은 PEGA 방법과 비교하여 정결도, 폴립(선종)의 발견율, 부작용 발생에 큰 차이가 없으면서 순응도 및 만족도가 더 높은 방법이다. Background/Aims: Performance of polyethylene glycol solution (PEG) is often unsatisfactory as bowel preparation agent for colonoscopy. In order to provide equivalent efficacy with better patient tolerance, sodium phosphate tablet (SPT) has been developed. This study was carried out to compare the efficacy and compliance of two bowel preparation methods: PEG with ascorbic acid (PEGA) vs. SPT preparation. Methods: A multicenter, randomized controlled trial was performed. Primary efficacy variable was overall quality of colon cleansing assessed by Boston bowel preparation scale (BBPS) during colonoscopy. Patient`s satisfaction and adverse events were evaluated by means of symptom questionnaire completed by each patient immediately before colonoscopy. Results: A total of 189 patients were randomly assigned to undergo pre-colonoscopic bowel preparation with either SPT (n=96) or PEGA (n=93). Overall BBPS score was 8.3±1.12 in the SPT group and 8.4±0.96 in the PEGA group (p=0.441). Among the 189 patients, 90 had polyps (47.6%) and 50 had adenomas (26.5%). The polyp/adenoma detection rate was 54.2% (n=52)/27.1% (n=26) for SPT group and 40.9% (n=38)/25.8% (n=24) for PEGA group (p=0.079 and 0.790, respectively). More number of patients were unable to take the prescribed dose of PEGA compared with the SPT regimen (8.6% vs. 2.0%, p=0.045). Overall satisfaction score was 7.9±1.63 in the SPT group and 7.4±1.53 in the PEGA group (p=0.022). Conclusions: Degree of colon preparation, polyp/adenoma detection rate and adverse effect were similar between SPT group and PEGA group. Patient compliance and satisfaction were greater in the SPT group.

전신마취하에 제왕절개술을 받는 전자간증 환자에서 마취유도 시 사용되는 Remifentanil이 산모와 신생아에 미치는 영향

박병윤 ( Byoung Yun Park ),유경연 ( Kyung Yeon Yoo ),이미경 ( Mi Kyoung Lee ),정철원 ( Cheol Won Jeong ),정성욱 ( Seong Wook Jeong ),정성수 ( Sung Su Chung ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.1

Background: Endotracheal intubation elicits cardiovascular and arousal responses. The present study was aimed to determine whether remifentanil affects these responses in patients with preeclampsia. Methods: Thirty preeclamptic women who were scheduled to undergo cesarean delivery under general anesthesia were randomly assigned to receive either remifentanil 1 μg/kg (n=15) or saline (n=15) before induction of anesthesia. Systolic arterial pressure (SBP), heart rate (HR) and bispectral index (BIS) value as well as plasma catecholamine concentrations were measured. Neonatal effects were assessed using Apgar score and umbilical cord blood gas analysis. Results: Induction with thiopental caused a reduction in SBP and BIS (P<0.01) in both groups. Following the tracheal intubation SBP and HR increased in both groups, the magnitude of which was lower in the remifentanil group. BIS values also increased, of which magnitude did not differ between the groups. Norepinephrine concentrations increased significantly following the intubation in the control, while remained unaltered in the remifentanil group. The neonatal Apgar scores (5 min), and umbilical gas values were similar in the two groups except for higher incidence of Apgar score <7 at 1 min in the remifentanil group. Conclusions: Remifentanil 1 μg/kg effectively attenuates hemodynamic and catecholamine but not BIS responses to tracheal intubation in preeclamptic patients undergoing cesarean delivery. However, remifentanil may cause mild neonatal depression and thus should be used when adequate facilities for neonatal resuscitation are available. (Korean J Anesthesiol 2009; 57: 62~8)

Current Limit을 이용한 Current Mode Boost DC/DC 컨버터의 효율 향상에 관한 연구

김진규(Kim Jin Kyu),정성연(Jeong Seong Yon),두수연(Doo Sue Yeon),박용식(Park Young Sik),곽계달(Kwack Kae Dal) 대한전자공학회 2006 대한전자공학회 학술대회 Vol.2006 No.11