수종 악성종양 환자 및 정상인 혈청내의 표피세포질 항체에 관한 연구

정상립(Sang Lip Chung),서무규(Moo Gyu Suh) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.6

For the purpose of studying the compiarson of normal persons with patients with malignant tumors, the author investigated the incidence of epidermal cytoplasmic antibodies (EC-Ab) with sera taken from 15 normal persons, 38 patients with malignant tumors, and 2 patients with miscellaneous disorders by method of indirect immunofluorescence. The results were as follow: 1) .Positive reactions of EC-Ab were found in 2(13%) of 15 normal persons and 9 (24%) of 38 patients with malignant tumors. 2)Incidence of positive reactions of EC-Ab in various types of malignant turnors were found in 3(75%) of 4 patients with lung cancer, 2(40%) of 5 patients with rectal cancer, 3(13%) of 24 patients with stomach cancer, and 1(100%) patient with Hodgkins lymphoma. 3) Among 9 patients with malignant tumors of positive EC-Ab, 5 patients yielded the upper epiderrnaI cytoplasrnic (UEC) antibodies, 3 patients the general epidermal cytoplasmic (GEC) antibodies, and 1 patient basal cell layer (BCL) antibody. 4) A.mong 9 patients with malignant tumors of positive, the deposition of IgG was discovered in 7 patients, IgA in 1 patient and C, in 1 patient.

건선 병변에 대한 직접 면역형광 검사의 관찰

정상립(Sang Lip Chung),강수찬(Soo Chan Kang) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.5

In order to study immunological responses in psoriatic lesions, direct immunofluorescence(DIF) findings in stratum corneum of psoriatic lesions are compared with histopathological changes. The results are summerized as follows: 1) Deposition of Igs or C 3 in stratum corneum of psoriatic lesions was demonstrated in 14(56%) of 25 psoriasis patients. IgG was present in 40% IgA in 48%, IgM in 24%, and C 3 in 32%. However, DIF findings are negative in the str,atum corneum in the uninvolved skin of psoriasiis. In control groups of 12 cases of various skin diseases, DIF findings were negative in the stratum corneum except 1 case of a patient with acne rosacea. 2)DIF findings in 22 cases of histopathologic changes of psoriatic lesions were found in 50% of hyperkeratosis in 48% of parakeratosis in 50% of Munro microabscess, in 50%, of spongiform pustule, and in 57% of the absence of stratum granulosum: ie, about only 50% were positive in DIF results. Histopathologic changes in 11 cases of positive DIF finding in psoriatic lesions were hyperkeratosis in 100%, parakeratosis in 91%, Munro microabscess in 64%, spongiform pustule in 55%, and the absence of stratum granulosum in 73%.

청년기 지루피부염 환자의 아토피 증상 조직 조사 및 혈중 IgE치와 호산구수 측정

정상립(Sang Lip Chung),김도원(Do Won Kim),이석종(Seok Jong Lee),권순백(Soon Baek Kwon),장재원(Jae Won Chang) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.9

N/A Background : Seborrheic dermatits and atopic dermatitis are clinically different diseases, but symptoms and signs of atopic dermatitis often can be found simultaneously in patients with seborrheic dermatitis. Objective : The aim of this study was to investigate if patients with seborrheic dermatitis have the symptoms and sign of atopic dermatitis at the same time, and to measure the levels of serum IgE and eosinophil counts. Methods : Sevently eight patients with seborrheic dermatitis on the scalp and face, 64 patients with atopic dermatitis and 88 normal subjects were observed clinically by the dermatologist and studide statistically using questionnaires. Levels of total IgE and eosinophil counts were measured by blood sampling in the total number of subjects. Results : Among 20 items of the questionnaire regarding the symptoms and signs of atopic dermatitis, 6 items were more frequent in only the atopic patients than in the normal control, 2 items were more frequent in only the seborrheic dermatitis patients and 8 in both diseases. The mean levels of serum IgE in seborrheic dermatitis patients were lower than in atopic patients, but significantly higher than that of the normal control and 21.3% of those had IgE levels above the normal range. When we classified the seborrheic dermatitis patients according to the combined skin diseases, the mean levels of IgE were highest in the patients with dermatitis and male pattern bladness, but the value was not significant compared to that of the normal control. The mean levels of eosinophil counts in seborrheic dermatitis patients were higher than in the normal control, but it was not significant statistically. Conclusion : According to the results of the study, the patients with seborrheic dermatitis showed a higher incidence of symptoms and signs of atopic dermatitis and higher levels of serum IgE than the normal subjects. Further studies will be needed to elucidate the relationship between seborrheic dermatitis and atopic dermatitis. (Korea J Dermatol 1999;37(9) : 1269∼1275)

개선 (疥癬) 에 있어서 직접면역형광법 (直接免疫螢光法) 의 관찰

정상립(Sang Lip Chung),오수희(Su Hee Oh) 대한피부과학회 1984 大韓皮膚科學會誌 Vol.22 No.4

There are many reports about the deposition of immunoglobulins and complement by direct immunofluorescence(DIF) in the lesion of scabies. The authors investigated the immunoglobulins and C, for the purpose of studying the immunologic reactivity of the host to scabies mites by DIF. The results are summerized as follows: Total number of the cases investigated were 20 (18 males, 2 females), of whom 11 were in their third decade of age. The clinical forms of the tested lesions were papular type (7 cases), nodular type (12 cases), and Norwegian type (1 case). The durations of the patients were mostly within 2 months, but was 9 months in 1 case of nodular type, Deposition of immunoglobulin and C, was demonstrated by DIF in 10 of 12 cases (83. 3%) of nodular type, and 1 of 7 cases (14. 3%) of papular type. The Norwegian type showed negative results. There seemed to be no relation between the duration of scabies and positive rates. Of 20 cases tested, immunoglobulin and C, were deposited in the vascular wall in 11 lesions (55%), and at the dermoepidermal junction in 3 lesions (15%). While in 1 of 7 cases of papular type both IgM and C, were observed, IgM and C, were noted in 7 and 9, respectively, in 12 cases of nodular type.

건선환자와 정상인 혈청에서 각질층 항체 및 상부표피세포질 항체의 출현빈도에 관한 연구

정상립(Sang Lip Chung),서기석(Kee Suck Suh) 대한피부과학회 1988 大韓皮膚科學會誌 Vol.26 No.5

The authors investigated the incidence of stratum corneum and upper epidermal cytoplasmic antibodies with 30 untreated and 20 treated psoriasis sera, and normal human sera using normal human skins of 5 different sites and psoriatic lesion by the method of indirect immunofluorescence in order to evaluate immunologic responses i n psoreasis. The results are summarized as follows . I) The positivity of stratum corneum antibodies in untreated psoriasis sera(78.7%) was si, nificantly higher than that in normal sera(64.0%). The incidence of stratum corneum antibodies in untreated psoriasis sera was found to be the highest in the arm, followed by the scalp, leg, abdomen, and face as substrate. 2) The positivity of stratum corneum antibodies in psoriasis and normal human sera was significantly higher when tested with the psoriatic lesion as substrate than norma! skin as substrate, 3) The titer of stratum corneum antibodies in 5 sera using human skin obtained from 5 different sites on the body as substrate are the highest in the arm, and leg, and(in decreasing order of frequency) the scalp, abdomen, and face. 4) The positivity of upper epidermal cytoplhsmic antibodies in normal human sera (40.7%) was significa.ntly higher than that in untreated psoriasis sera(21.3%). 5) Ir.. the majority of cases, upper epidermal cytoplasmic antibodies coexisted with straturn corneum antibodies in the sera of patients with psoriasis and in the sera of normal humans.

홍반성(紅斑性)루푸스에서의 Lupus Band Test 관(關)한 연구(硏究)

정상립 ( Sang Lip Chung ),김성화 ( Sung Hwa Kim ) 대한피부과학회 1983 大韓皮膚科學會誌 Vol.21 No.6

만성 신부전증 환자에서 발생한 수포성 유천포창

상영호,이국형,정상립,김도원 ( Young Ho Sang,Kuk Hyeong Lee,Sang Lip Chung,Do Won Kim ) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.5

A Case of Bullous Pemphigoid in a Patient with Chronic Renal Faiure Young Ho Sang, M.D., Kuk Hyeong Lee, M.D., Sang Lip Chung, M.D., Do Won Kim, M.D. Department of Dermatology, Kyungpook National University, School of Medicine, Toegu, Korea We report a case of bullous pemphigoid in patient with chronic renal failure. The patient was a 17 years-old female who had noted Henoch Schoenlein purpura with nephrotic syndrom(HSPN) 8 years ago. Three years prior to visit, HSPN had progressed to renal failure. Therefore she discontinued furosemide therapy for hypertension and has been treated with maintenance hemodialysis. She revealed multiple tense bullae on the face, neck, abdomen and axilla for 10 days. Histologic findings of early bullous lesion showed subepidermal bullae and direct immunofluorescent study of perilesional skin revealed linear lgG deposition at the dermoepidermal junction. We suggest that there is close relationship between bullous pemphigoid and chronic renal failure, especially uremia. (Kor J Dermatol 28(5) : 615-619, 1990)

정상인에서 두피 모발의 군집 양상과 복합모에 대한 관찰

이석종(Seok Jong Lee),김도원(Do Won Kim),전재복(Jae Bok Jun),정상립(Sang Lip Chung),이국형(Kuk Hyeong Lee) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.6

Beckground : Although one hair usually arises from a single follicular opening in normal healthy subjects, we can see two or more hairs emerging frogin he single opening through close inspection. The latter is called compound hair, describefly Lowenthal in 1946, however, few reports on this have been made since. Histopathologially two or more hairs which have an independaat external root sheath arise from one follicul arl opening like its clinical appearance. We examined the distribution and density of compot no hair in order to define its difference according to anatomical site and aging process. Objectlvs end Method : We counted the number of hairs in the circle(2 cm in diameter) at the frontal, temporal and occipital scalp of 48 healthy adult nae persons composed of 24 young men(22.5+2.0 years old) and 24 old men(64.4+ 12.9 years old), respectively. Results : The summated nurnber of grouped hair, which was mostly regarded at compound hair, was greater in the young group than in old group in the for oreal area, but was smaller in young group than in old group in from the temporal and occnt 1 areas. The proportion of grouped hair to total hair in the older group was lower in the reital area, but higher in the temporal and occipital areas than that of the younger men. The atio of single hair to compound hair was significantly decreased in the temporal and occupral areas(p<0.05, p<0.01) according to aging process, however, no significant change was seen between the frontal area and the sum of the three tested areas. Conclusion : Compound hairs are observed frequently on the occipitalp of normal healthy subjects and are most frequently seen on the occipital scalp in both of the young and old. (Kor J Deimatol 1994; 32(6): 998-1004)

모발을 동반한 미만형 신경섬유종

김성애 ( Sung Ae Kim ),강민철 ( Min Chul Kang ),정상립 ( Sang Lip Chung ),이규석 ( Kyu Suk Lee ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.6

Diffuse neurofibroma is an uncommon subtype of neurofibroma that occurs principally in children and young adults. It is most common in the head and neck region and appears clinically as a plaque-like elevation of the skin. A 3-year-old girl presented to our hospital with a complaint of skin-colored elevated plaques with hair on her lower back since birth. An ultrasonogram showed several 5∼10 mm sized subcutaneous hypoechoic nodules with increased vascularity. The histopathologic examination revealed ill-defined, uncapsulated infiltrative, spindle shaped cells within the dermis and subcutaneous tissue. Immunohistochemical examination with antibodies to S-100 protein showed positive. We report a rare case of diffuse neurofibroma with hair. (Korean J Dermatol 2009;47(6):696∼698)

초음파가 Methyl nicotinate 경피흡수에 미치는 영향

황성주,정상립,김도원,전재복 ( Sung Joo Hwang,Sang Lip Chung,Do Won Kim,Jae Bok Jun ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.5

Background: The mechanism of enhancing effect of ultrasound on the percutaneous absorption of a drug is unclear. But thermal, chemical and mechanical effects are assumed to play a role in enhancing transdermal drug delivery. Objective : The aim of this study was to determine if ultrasound enhances percutaneous absorption of methyl nicotinate(MN) without raising the skins surface temperature. Methods . Treatment consisted of the application of ultrasound massage(1.0 MHz, 1.0 watt/cm, continuous output) or placebo massage(0 MHz) for 3 min to the forearms of the volunteers, followed by a standardized application of MN at intervals of 15 sec and 10 min postmassage. Percutaneous absorption of MN was monitored using laser doppler flowmetry. Results : 1. Data from the ultrasound treated sites after 15 sec showed significant decrease(p < 0.05, paired t-test) in the T(time between MN application and its initial response), T(time between MN application and maximuvi response) and increase in the LDF .(maximum cutaneous blood flow) compared to those of the control sites. 2. Data from the ultrasound treated sites after 10 min showed no difference in the T0 and T but significant increase in the LDF compared to those of the control sites. 3. Data from ultrasound trvated sites both after 15 sec and 10 min showed significant increase in basal cutaneous blood flow(LDF) compared to those of the control sites. 4. There was no difference between the ultrasound treated sites and the control sites in the skins surface temper ature. Conclusion : The results of this study suggest that ultrasound may affect the skin structure to provide skin penetration enharcement even without raising the skins surface temperature. (Korean J Dermatol 1997;35(5): 947 955)