증례 : 혈액종양 ; 원발성 미만성 B세포 위림프종과 간세포암이 병발된 1예

정민욱 ( Min Wook Jung ),이홍섭 ( Hong Sub Lee ),송준하 ( Jun Ha Song ),김선미 ( Sun Mi Kim ),김현경 ( Hyun Kyung Kim ),이효정 ( Hyo Jung Lee ),정성현 ( Seong Hyun Jung ) 대한내과학회 2011 대한내과학회지 Vol.81 No.3

위에 발생하는 악성종양 중 원발성 위림프종은 상당히 드문편으로 동시에 간세포암이 병발한 경우는 매우 드물다. 본 증례는 원발성 위림프종과 간세포암의 병발로 진단된 46세 남자에 대한 보고로서 각각의 종양에 대하여 조직검사 및 면역조직화학 검사를 시행하여 진단하였다. 림프종에 대하여는 R-CHOP 항암화학요법(rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone)을 시행하여 완전관해를 하였고, 항암화학요법 중간에 간동맥 화학 색전술 및 간좌엽 절제술을 시행하여 간세포암에 대한 근치적 치료를 시행하였고, 현재 추적관찰 중이다. Primary gastric lymphoma is relatively rare in the context of gastric malignancies. Synchronous primary gastric lymphoma and hepatocellular carcinoma (HCC) are even rarer. We report a case of synchronous primary gastric lymphoma and HCC in a 46-year-old man that appeared to be associated with hepatitis B virus infection. Pathologic examination and immunohistochemical analysis of gastric and liver specimens showed diffuse large B-cell lymphoma and HCC, respectively. The patient was initially treated for primary gastric lymphoma with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone) chemotherapy. During the chemotherapy interval, he was treated for HCC by transarterial chemoembolization (TACE) and laparoscopy-assisted left hemihepatectomy. (Korean J Med 2011;81:403-407)

주관절의 외상과 관련된 척골 신경병증

박민종(Min Jong Park),정민욱(Min Wook Jung) 대한정형외과학회 2002 대한정형외과학회지 Vol.37 No.3

관절경적 Bankart 봉합술후 적극적 재활치료 - 전향적 임상연구 -

김승호,하권익,정민욱,임문섭,김영민,박종혁,조양범,Kim Seung-Ho,Ha Kwon-Ick,Jung Min-Wook,Lim Moon-Sup,Kim Young-Min,Park Jong-Hyuk,Cho Yang-Bum 대한정형외과스포츠의학회 2002 대한정형외과스포츠의학회지 Vol.1 No.1

목적 : 관절경적Bankart 봉합술후조기운동과일반적인고정법의임상결과를전향적방법으로비교하고자하였다. 대상및방법 : 외상성재발성전방불안정성이있는62명의환자를대상으로봉합나사를이용하여관절경적 Bankart 봉합술을시행후, 2개의무작위그룹으로분류하였다. 그룹1(28명, 평균나이28세)은3주동안고정한뒤고식적인재활운동을시작하였고그룹2(34명, 평균나이29세)는단계적인관절운동및근력강화운동으로구성된적극적재활운동을수술다음날부터시작하였다. 환자선택의기준은재발성불안정성이있으며전형적인Bankart 병변을가진비운동선수를대상으로하였으며평균31개월동안추시관찰하였다. 결과는통증점수, 관절운동범위, 일상생활로의회복, 재발율, 각재활프로그램에대한환자의만족도그리고shoulder score (ASES, UCLA and Rowe)를분석하였다. 결과 : 두그룹간재발율의차이는없었으며, 어느그룹에서도재발성탈구는나타나지않았다. 각각의그룹에서2명의환자에서전방불안유발검사에서양성소견을나타냈다. 적극적재활치료를한환자는기능적관절운동이더빨랐으며활동의기능적인면에서도더빨리회복되었다. 적극적재활치료를한경우에는술후통증은감소하였고, 재활프로그램에만족하고있으나shoulder scores, 일상생활로의복귀, 통증점수그리고관절운동범위는최종추시시, 두그룹간차이는없었다.결론 : 조기재활은관절경적Bankart 봉합술후선택적환자군에서재발율은증가하지않았다. 두그룹간최종결과는동일하였지만적극적재활운동은기능적회복을촉진하고술후통증을감소시켜일상생활로의빠른복귀가가능하였다. Purpose: In this prospective, randomized study, we compared the results of early motion versus conventional immobilization after the arthroscopic Bankart repair. Materilal and Methods : We performed an arthroscopic Bankart repair using suture anchors in 62 patients with traumatic anterior shoulder instability and randomized them into two groups; Group 1 (n=28; mean age, 28 years) underwent three-week of immobilization and conventional rehabilitation program, while Group 2 (n=34; mean age, 29 years) underwent an accelerated rehabilitation program with staged range of motion and strengthening exercises starting from the immediate postoperative day. Selected patients were non-athletes with a classic Bankart lesion and a robust labrum. Analysis of outcome included pain scores (6-week and follow-up: 31(9 months), range of motion, return to activity, recurrence, patients’ satisfaction with each program, and shoulder scores (ASES, UCLA, and Rowe). Results : The recurrent rate was not different between the two groups (2 anterior apprehension from each group) (p=0.842). Patients with accelerated rehabilitation resumed functional range-of-motion faster and returned earlier to the functional level of activity (p<0.05). Accelerated rehabilitation decreased postoperative pain and more patients were satisfied with this program (p<0.05). No differences were found between the two groups at the follow-up with regards to the shoulder scores, return to activity, pain score, and the range-of-motion. Conclusions : Early mobilization after arthroscopic Bankart repair does not increase the recurrence rate in selected patients. Although the final outcomes are similar in both groups, the accelerated rehabilitation program promotes functional recovery and reduces postoperative pain, which enables patients an early institution of desired activities.

일정한 신전 간격 절제를 위한 대퇴 경골 연계식 슬관절 절골술

서재곤(Jai Gon Seo),정민욱(Min Wook Jung) 대한정형외과학회 2001 대한정형외과학회지 Vol.36 No.3

고지방사료를 섭취한 C57BL/6N 마우스에서 한천식이섬유의 혈청 지질과 인슐린 농도 저해효과

박진주(Jin Ju Park),김지은(Ji Eun Kim),윤우빈(Woo Bin Yun),이미림(Mi Lim Lee),최준영(Jun Young Choi),송보람(Bo Ram Song),김동섭(Dong Seob Kim),이충열(Chung Yeoul Lee),이희섭(Hee Seob Lee),임용(Yong Lim),정민욱(Min Wook Jung),황대연(Dae 한국생명과학회 2017 생명과학회지 Vol.27 No.8

본 연구에서는 한천식이섬유(Diet fiber of agar)가 지방과 포도당대사에 미치는 효과를 연구하고자, 고지방사료(High fat diet, HFD)를 급여한 C57BL/6 마우스에 한천함유음료(beverage contained agar, BCA)를 9주 동안 투여하고 지방축적, 지질농도, 인슐린농도 등의 변화를 분석하였다. 식이섭취효율은 HFD+BCA 처리그룹에서 유의적으로 감소하였지만, 체중과 식이섭취량은 HFD+BCA 처리그룹에서 일정하게 유지되었다. 또한, 지방조직과 간조직에서 지방의 축적은 HFD+Vehicle처리그룹에 비하여 HFD+BCA 처리그룹에서 낮게 관찰되었다. 더불어, BCA처리후에 유의적인 변화는 total cholesterol (TC)과 LDL에서 관찰되었지만, HDL의 농도는 BCA처리에 의해 변화가 없었다. 인슐린의 농도는 HFD+BCAMi 처리그룹과 비교하여 HFD+BCALo과 HFD+BCAMi 처리그룹에서 유의적으로 감소하였다. 따라서 이러한 결과는 한천식이섬유의 장기간 투여는 고지방사료를 급여한 동물에서 지방축적, 혈청내 지방프로파일, 인슐린농도의 개선을 유도할 수 있음을 제시하고 있다. 또한, 이러한 결과는 한천식이섬유를 함유하는 음료는 혈청내 지질과 인슐린 작용을 유도할 수 있음을 제시하고 있다. To investigate the beneficial effects of fiber derived from agar on the lipid and glucose metabolism of obese model mice, changes in the fat accumulation, lipid content, and insulin concentration were measured in C57BL/6N mice fed a high-fat diet (HFD) and treated with a beverage containing agar (BCA) for 9 weeks. The feed efficiency ratio was significantly decreased in the HFD+BCA treatment group, although the body weight and food intake were maintained a constant level. Also, the fat accumulation in the fatty tissue and liver were lower in the HFD+BCA treatment group than in the HFD+Vehicle treatment group. Furthermore, a significant decrease was detected in the levels of total cholesterol (TC) and LDL after the BCA treatment, while a constant HDL level was maintained in the same group. Moreover, the serum insulin concentration was significantly decreased in the HFD+ BCALo (Low concentration) and HFD+BCAMi (Middle concentration) groups compared to the HFD+ Vehicle group. Therefore, the results suggest that the long-term administration of dietary fiber from agar can improve fat accumulation in the fatty tissue and liver, the serum lipid profile, and the insulin concentration in the blood. Also, the results provide evidence that the inclusion of agar fiber in beverages results in significant hypolipidemic and hypoinsulinemic effects.

UV조사에 의해 유발된 SKH-1 hairless 마우스의 피부노화에 미치는 한천마스크의 개선효과

송보람(Bo Ram Song),김지은(Ji Eun Kim),윤우빈(Woo Bin Yun),이미림(Mi Rim Lee),최준영(Jun Young Choi),박진주(Jin Ju Park),김동섭(Dong Seob Kim),이충열(Chung Yeoul Lee),이희섭(Hee Seob Lee),임용(Yong Lim),정민욱(Min Wook Jung),김배환(Bae 한국생명과학회 2017 생명과학회지 Vol.27 No.9

UV 조사에 의해 유도된 광노화(photoaging)에 대한 한천젤마스크(agar gel mask, AGM)의 효과를 평가하기 위해, SKH-1 hairless 마우스의 피부에 4주간의 UV조사와 AGM 및 에센스처리 한천젤마스크(agar gel mask dipped in essence, AGMdE)를 동시에 처리한 후 피부주름, 피부표현형, 피부조직구조, 항산화조건 및 독성 등을 분석하였다. AGM과 AGMdE의 부착은 주름형성의 억제, 홍반지수의 감소, 피부수분의 증진뿐만 아니라 경피 수분 손실(TEWL)을 방지하였다. 또한, 표피두께는 UV+Vehicle 처리군과 비교했을 때, UV+AGM 및 UV+AGMdE 처리군에서 UV를 조사하지 않은 그룹과 유사한 수준으로 회복되었다. MMP-1과 tyrosinase의 발현수준은 UV+Vehicle 처리군에서 가장 높게 증가하였으나 UV+AGM 및 UV+AGMdE 처리군에서 유의적으로 감소하였다. 더불어, SOD 활성은 UV+Vehicle 처리군에 비하여 UV+AGM 및 UV+AGMdE 처리군에서 유의적으로 감소되었지만, 대부분의 독성화합물 처리에 의해 유도되는 혈청생화학적 지표와 조직학적 특성의 변화는 UV+AGM 및 UV+AGMdE 처리군에서 관찰되지 않았다. 따라서, 이러한 결과들은 AGM이 피부형태, 조직학적 구조, 산화적 상태를 조절함으로써 피부노화를 예방하는 마스크팩으로 활용될 수 있는 가능성을 있음을 제시한다. To investigate the beneficial effects of an agar gel mask (AGM) on UV-induced photoaging, SKH-1 hairless mice were treated with a topical application of AGM and an AGM dipped in essence (AGMdE). The mice were divided into an no radiation group, UV + AGM, UV + AGMdE, and UV + vehicle (PBS) treatment groups. Alterations in skin wrinkles, skin phenotype, histological structures, oxidative status, and toxicity were then evaluated during 4 weeks of exposure. The topical application of AGM and AGMdE inhibited wrinkle formation, suppressed the erythema index, prevented transepidermal water loss, and enhanced skin hydration. In addition, epidermal thickness recovered to a similar level as that in the no irradiation group in the UV + AGM and UV + AGMdE treatment groups compared with the UV + vehicle (distilled water) group. Furthermore, the expression levels of matrix metalloproteinase-1 (MMP-1) and tyrosinase were reduced in the UV + AGM and UV + AGMdE treatment groups, although the highest level varied. Moreover, superoxide dismutase (SOD) activity was significantly lower in the UV + AGM and UV + AGMdE treatment groups as compared with the UV + vehicle group. No significant alterations induced by most toxic compounds were measured in serum biochemical markers and liver and kidney histological features of the UV + AGM and UV + AGMdE treatment groups. These results suggest that AGM may protect against skin aging by regulating skin morphology, histopathological structures, and oxidative conditions.

관절경적 전방 십자 인대 재 재건술

안진환,윤상학,하권익,정민욱 대한슬관절학회 2000 대한슬관절학회지 Vol.12 No.1

Purpose : We analyzed the 11 knees in 11 patients who had arthroscopic revision anterior cruciate ligament(ACL) reconstruction and demonstrate the causes of failure of ACL reconstruction and report the clinical result of arthroscopic revision ACL reconstruction. Methods and Materials: From March 1997 to April 1999, l l patients who underwent ACL reconstruction at other hospital had been treated by revision ACL reconstruction. Their mean age at revision was 26.4 years, average time from primary to revision surgery was 26.8 months and average length of follow up was 22 months. We evaluated the results of revision surgery by symptom, Lysholm knee score, physical examination and KT-1000 arthrometer. Results: The causes of failure of ACL reconstruction were 8 improper tunnel placements(6 femoral tunnels, 2 tibial tunnels), 2 graft incorporation failure and 1 multiple ligament injury(N=l1). After revision all patients had improved symptom. There was improvement of average Lysholm knee score from 70 to 87( 2 excellents, 7 goods, 1 fair, 1 poor) with success rate of 82%( 9/11). The data showed decrease of the mean side to side difference from 10.9 mm to 1.7 mm by KT-1000 arthrometer. Conclusion : The most common causes of failure of ACL reconstruction were surgical techniques and anatomical tunnel placement was the most important among them.