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RISS 인기검색어
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- 저자 : 전아림(Ah-Lim Jeon) (검색결과 2 건)
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전아림 ( Ah Lim Jeon ),김정은 ( Jung Eun Kim ),이남호 ( Nam Ho Lee ) 대한화장품학회 2017 대한화장품학회지 Vol.43 No.1
본 연구에서는 수박 덩굴(잎 및 줄기) 추출물 및 용매 분획물의 미백 및 항염 활성을 검색하고 유효성분을 분리하여 화학구조를 규명하였다. 수박 덩굴 에탄올 추출물 및 용매 분획물의 멜라닌 생성 억제활성을 측정한 결과, 헥산 및 에틸아세테이트 분획물에서 우수한 멜라닌 생성 억제 효과가 있음을 확인하였다. 또한 항염 활성 측정 결과, 헥산 및 에틸아세테이트 분획물에서 활성이 나타남을 확인하였다. 헥산 및 에틸아세테이트 분획물에서 유효성분을 찾고자 칼럼 크로마토그라피를 실시하여 3개의 화합물을 분리하였으며 <sup>1</sup>H 및 <sup>13</sup>C NMR 데이터 분석 및 문헌치 비교를 통하여 화학구조를 동정하였다; α-linolenic acid (1), sigmast-7-en-O-β-D-glucopyranoside (2), 1-feruloyl-β-D-glucopyranoside (3). 분리된 화합물에 대한 미백 활성 실험 결과, 화합물 1과 3에서 멜라닌 생성 및 세포 내 티로시나제 효소의 활성을 감소시키고 있음을 확인하였다. 또한 항염 활성 실험 결과 화합물 1과 3이 nitric oxide (NO) 및 전염증성 사이토카인(TNF-α, IL-6)의 생성을 억제시킴을 확인하였다. 이상의 연구 결과를 바탕으로 수박 덩굴 추출물을 이용한 천연 미백 및 항염 소재로의 개발이 가능할 것이라 사료된다. In this study, we investigated whitening and anti-inflammatory constituents from a watermelon (Citrullus lanatus, C. lanatus) vines (leaves and stems). As anti-melanogenesis and anti-inflammatory activities were screened for the ethanol extract and solvent fractions, n-hexane (n-Hex) and ethyl acetate (EtOAc) fractions showed the most potent activities. Three constituents were isolated from the n-Hex and EtOAc fractions of C. lanatus; α-linolenic acid (1), sigmast-7-en-O-β-D-glucopyranoside (2), 1-feruloyl-β-D-glucopyrinoside (3). The chemical structures of the isolated compounds were elucidated based on the spectroscopic data including <sup>1</sup>H and <sup>13</sup>C NMR spectra, as well as comparison of the data to the literature values. Whitening and anti-inflammatory effects were studied for the isolated compounds. Upon the anti-melanogenesis tests using α-MSH stimulated B16F10 melanoma cells, the compounds 1 and 3 inhibited the cellular melanogenesis and intracellular tyrosinase activities effectively. For the anti-inflammation tests using lipopolysaccharide (LPS)-induced RAW 264.7 cells, the isolates 1 and 3 were determined to decrease the production of nitric oxide (NO) and pro-inflammatory cytokines (TNF-α, IL-6). Based on these results, C. lanatus vines extract could be potentially applicable as whitening and anti-inflammatory ingredients in cosmetic formulations.
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전아림 ( Ah-lim Jeon ),이미란 ( Mi-ran Yi ),강창희 ( Chang-hee Kang ),부희정 ( Hee-jung Bu ) 대한미용학회(구 대한미용과학회) 2016 대한미용학회지 Vol.12 No.4
This study examined the antioxidant and anti-inflammatory effects of essential oil from the flowers of Lanicera japonica in order to verify whether the oil can be used as a cosmetic ingredient. Antioxidative capacity was evaluated by bioassay using total polyphenol and flavonoid contents as well as 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity. Total polyphenol and flavonoid contents were 31.8±1.1 mg GAE/g and 42.0±0.6 mg QE/g, respectively. ABTS radical scavenging activity was 84.6±0.3% and DPPH free radical scavenging activity was 42.2±1.3% (at a concentration of 500 μg/mL). The antimicrobial activity of essential oil from the flowers of L. japonica against skin pathogens was determined using the paper disc diffusion method, the minimum inhibitory concentration, and the minimum bactericidal concentration values. Essential oil from L. japonica flowers showed antimicrobial activities against Staphylococcus aureus and Propionibacterium acnes. For the study of anti-inflammatory activity in RAW 264.7 cell, essential oil from L. japonica flowers inhibited not only nitrogen oxide production but also the expression of pre-inflammatory cytokines such as, tumor necrosis factor-α, interleukin (IL)-6 and IL-1β in a dose-dependent manner. Especially, at a concentration of 400 μg/mL, essential oil from L. japonica flowers strongly inhibited the cytokines production by 96.4±0.2, 72.6±4.5, 99.1±5.7, 97.6±2.6%, respectively. These results suggests that essential oil from L. japonica flowers has considerable potential as a cosmetic ingredient with antioxidative and anti-inflammation effects.
ScienceON
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