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클로스트리디움 보툴리눔 독소 A형은 미페프리스톤으로 유발된 조기진통 쥐 모델에서 자궁수축을 현저하게 감소시킨다
장항용 ( Hang Yong Jang ),이경미 ( Kyung Mi Lee ),박영신 ( Young Sin Park ),문명진 ( Myung Jin Moon ),한원보 ( Won Bo Hahn ),안은희 ( Eun Hee Ahn ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.9
목적: 우리는 클로스트리디움 보툴리눔 독소 A형(BoNT/A)이 미페프리스톤으로 유발된 조기진통 쥐 모델에 대해 자궁수축억제 효과가 있는지 in vivo 연구를 실시하였다. 연구방법: 임신 17일, 개복 후 자궁 양측 뿔에 식염수 또는 20 유니트의 BoNT/A를 투여하였다. 임신 18일, 미페프리스톤을 근주하여 자궁의 조기진통을 유발시켰다. 임신 19일, 근전도검사기를 통하여 자궁수축 활동을 측정하였다. 결과: BoNT/A 20 유니트를 투여한 군은 자궁수축 강도가 BoNT/A를 투여하지 않은 군에 비해 45.2% (P<0.05)로 유의하게 감소하였으며, 자궁수축 기간은 51.6% (P<0.01)로 유의하게 감소하였다. 하지만 자궁수축 빈도에 대한 감소는 5.6% ( P = 0.4)로 유의하게 감소는 없었다. 결론: 미페프리스톤으로 유발된 조기진통 쥐 모델에서 BoNT/A는 자궁의 수축력을 유의하게 감소시켰다. 자궁수축의 감소는 자궁수축 빈도에 대한 억제효과보다는 자궁수축의 기간 및 강도의 억제효과가 유의했다. Objective: We investigated the in vivo tocolytic effect of Clostridium botulinum toxin A (BoNT/A) on mifepristone-induced preterm labor in rats. Methods: On day 17 of gestation, an incision was made to expose the uterus, and BoNT/A (normal saline or 20 units) was injected into the uterine horns, On day 18, mifepristone was used to induce uterine contractions, Electrical activity of uterine contractions was measured via electromyography on day 19, Results: In rats treated with 20 units of BoNT/A, the amplitude of uterine contractions was significantly decreased by 45.2 ± 18.4 (P<0.05) from baseline, respectively. The total duration of uterine contractions was significantly decreased by 51.7 ± 7.9 (P<0.01), respectively. The frequency of contraction bursts after treatment with 20 units of BoNT/A was decreased by 5.6 ± 16.3 from the baseline (P=0.4). Conclusion: In rats undergoing mifepristone-induced preterm labor, BoNT/A significantly inhibited uterine contractility. The decrease in uterine activity was mainly caused by a decline in the duration and intensity rather than frequency of uterine contractions.
박영신 ( Young Sin Park ),이미화 ( Mee Hwa Lee ),김태헌 ( Tae Heon Kim ),장항용 ( Hang Yong Jang ),이경미 ( Gyong Mi Lee ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.1
A 28-year-old female presented with Rathke`s cleft cysts (RCC) manifesting as primary amenorrhea and no development of secondary sexual characteristics. She had no symptoms of headache, visual disturbance, anosmia or galactorrhea.. The endocrinologic study demonstrated partial hypopituitarism. Magnetic resonance imaging revealed about 1.5 cm sized sellar and suprasellar cystic tumor, extending into the pituitary stalk. Its tentative diagnosis was benign pituitary cystic tumor, such as RCC. She underwent surgery by a transsphenoidal approach. Histological examination revealed a ciliated columnar epithelium those consistent with RCC. RCC is rarely symptomatic, but mechanical compression by the cyst or infl ammation itself causes headache, visual fi eld defects, or symptoms of pituitary dysfunction. The present case shows that RCC may manifest as hypogonadotropic hypogonadism.
복강경하 자궁각절제술과 자궁경부이형성증 병력있는 환자에서 임신 제3분기에 일어난 연속적인 자궁파열사례
김영란 ( Young Ran Kim ),문명진 ( Myung Jin Moon ),장성운 ( Sung Woon Chang ),안은희 ( Eun Hee Ahn ),장항용 ( Hang Yong Jang ),이경미 ( Gyong Mi Lee ),정상희 ( Sang Hee Jong ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.12
Uterine rupture during the course of pregnancy is an uncommon obstetric event. Rupture of an unscarred uterus is rare, whereas rupture of a scarred uterus is more common and is usually the result of a Cesarean section. Uterine rupture during pregnancy usually occurs in patient with a scarred uterus, and recurrent uterine rupture usually occurs at a prior ruptured site. However, recurrent uterine rupture that occurs at a different site, regardless of prior rupture site, has yet to be reported. The patient described in this case report had cervical dysplasia with positive for human papilloma virus (HPV) type 16. As the presence of a precancerous lesion in the cervix is reported to increase the risk of preterm birth and spontaneous uterine rupture, a possible correlation between recurrent uterine rupture and cervical dysplasia was considered for this patient.