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- 저자 : 장판섭(Pan Sup Chang) (검색결과 4 건)
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정상인뇨의 가수분해에 의한 의약품결합 저해유도인자의 추출
장판섭(Pan Sup Chang) 대한약학회 1982 약학회지 Vol.26 No.4
Uremia is associated with defective protein binding of weakly acidic drugs, whereas the protein binding of basic drugs tends to be normal. The exact chemical nature of compound(s) and mechanism for these changes as yet is unknown, and has not been defined. Organic solvent extraction of pooled normal human urine following hydrolysis by hydrochloric acid produced an extract, which when added to normal human serum, was capable of inducing binding defects similar to those in uremia. Binding defects were observed with the weakly acidic drugs such as nafcillin, salicylate, sulfamethoxazole and phenytoin while the binding of the basic drugs such as trimethoprim and quinidine were unaffected. The binding defects induced by the hydrolyzed urine extract could readily be corrected by same organic solvent extraction of acidified serum and the defects could be transfered to the normal human serum using the organic solvent layer at the physiologic pH (7.4). Followed by reacidification and extraction of the binding defects induced serum with the same solvent, separated several fractions were obtained on thin-layer chromatography. One of these fractions could reinduce the binding effects and this factor(s) is apparently weakly acidic compound(s) and tightly bound to serum at physiologic pH, but extractable at acidic pH, and its molecular weight range is approximately 500 or less similar to those seen in uremia. These findings strongly support the hypothesis that the drug binding defect in uremia is due to the accumulation of endogenous metabolic products which are normally excreted by the kidneys but accumulate in renal failure.
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5-Fluorouracil-지질 결합체 합성 및 in vitro 항암효과 평가
이희주(Hee Joo Lee),장판섭(Pan Sup Chang),김재완(Jae Wan Kim),정기화(Ki Hwa Jung),신순희(Soon Hee Shin),신혜순(Hae Soon Shin),정순복(Soon Bog Jung) 대한약학회 1990 약학회지 Vol.34 No.6
The FU-fat conjugates(4a-e) as a prodrug have been synthesized by condensing various fatty acids(1a-e) via isocyanates(2a-e) as carbamoyl group at N1-position of 5-fluorouracil and their structures characterized. Preliminary testing for their antitumor effect was carried out on leukemia L1210 cells in culture. Most of them(4a-d) like the parent FU exhibited less than 50% inhibition on grouth of the cultrued cells at the concentration of 1X10-7M. Only a dicarboxylic acid derivative, 4e, showed over 50% inhibition at the same level.
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Polychlorinated Biophenyl類의 毒性에 대한 數種 抽出液의 解毒效果에 關한 硏究
오호정,장판섭 德成女子大學校 藥學硏究所 1990 藥學論文誌 Vol.1 No.1
The effect of the water extracts and ethanol extracts from picrorrhiza kurroa, Gentiana scabra and Lycium chinense on the toxicity of polychlorinated biphenyls (PCBs) were examined and following results were obtained. 1. In the PCBs control group, the body weights were decreased while the weight of liver was increased in comparison with that of normal control group. However, by the administration of these extracts, PCBs intoxicated rats showed the increase in body weight but did not show marked recovery of liver weight. 2. By the administration of these extracts, the hematological parameters of red blood cell and white blood cell, hemoglobin content and hematocrit value which were decreased by the administration of PCBs were shown to be increased. Among these extracts, the extracts of Lycium chinense were especially effective. 3. Cholesterol and total lipids levels in serum were significantly increased in the group fed PCBs. These extracts ameliorated the elevated levels but the recovery was not completed. 4. The activities of s-GOT, s-GPT and alkaline phosphatase were significantly stimulated by PCBs and their stimulation was inhibited by the adminstration of these extracts. Furthermore, the extracts of Picrorrhiza kurroa showed the normalizing tendency in s-GOT, s-GPT and alkaline phosphatase.
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5-Fluorouracil-지질 결합체 및 in vitro 항암효과 평가
이희주,장판섭,김재완,정기화,신순희,신혜순,정순복 德成女子大學校 藥學硏究所 1991 藥學論文誌 Vol.2 No.1
The FU-fat conjugates(4a-e) as a prodrug have been synthesized by condensing various fatty acids(1a-e) via isocyanates(2a-e) as carbamoyl group at N^1-position of 5-fluorouracil and their structures characterized. Preliminary testing for their antitumor effect was carried out on leukemia L 1210 cells in culture. Most of them(4a-d) like the parent FU exhibited less than 50% inhibition on grouth of the cultrued cells at the concentration of 1×10^-7 M. Only a dicarboxylic acid derivative, 4e, showed over 50% inhibition at the same level.
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