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장인순,Jang, In-Sun 한국가정간호학회 1995 가정간호학회지 Vol.2 No.-
The purpose of this study was to analysis level on family caregiver's burden for the elderly with senile dementia in a rural area and to choose priority care group, thereby facilitating the development of interventions to reduce the caregiver's burden. For this purpose, data were collected by questionaire from June 10 to October 8, 1994. The instruments for data collection were Caregiver Burden Inventory by Novak(1989) and Zarit et al(1982), severity of dementia by Hughes Scales (1982), ADL by Lawton (1971), patients' family caregiving activity by pre-survey and reference review(Lee, 1993 ; Jang, 1990 ; Yoo, 1982). The subjects were 60 family caregiver of senile dementia in a rural area. The data was analysed by the use of t-test, ANOVA, correlation and multiple regression. The results were as follows : 1. Total burden was evaluated over average, the mean of family burden was 61.24. 2. Significant variables which were correlated to the family caregiver's burden were the severity of dementia(F=30.52, p<0.001), ADL(F=5.43, p<0.01), PADL(F=6.14, p<0.01), caregiver's health status(F=6.05, p<0.01), a view of patient's prognosis(F=4.08, p<0.05), the number of hours per day spent on caregiving(F=19.64, p<0.001), level of intimacy of caregiver and patients(F=7.16, p<0.001), the frequency of caregiving activity(F=5.31, p<0.01). 3. ADL was the most important predictor to family caregiver burden(R2=0.6611). In addition to this, the severity of dementia, level of intimacy of caregiver and patient, relationship with the patient accounted for 79% of family caregiver burden. 4. The criteria of priority care group were as follows ; the mean of family caregiver burden was above 58, above of moderate ADL, the number of hours per day spent on caregiving above of 8 hours, above of moderate dementia. By the the severity of dementia, number of priority care group, mild dementia was 10(43.4%), moderate dementia 23 (92.0%), sever dementia 12(100.0%).
간호대학생의 임상실습 스트레스와 간호전문직관과의 관계에서 정서조절력의 효과
장인순,Jang, Insun 한국데이터정보과학회 2016 한국데이터정보과학회지 Vol.27 No.3
The purpose of this study was to investigate the effects of emotional regulation between clinical practice stress and nursing professionalism in nursing students. Participants were 192 nursing students and data were collected from September to November, 2015. This study has shown that nursing professionalism is negatively associated with clinical practice stress (r=-.40, p<.001) and positively associated with emotional regulation (r=.55, p<.001). In addition, a negative correlation has been found significant between emotional regulation and clinical practice stress (r=-.20, p<.001). In a final model of hierarchial multiple regression, professor support (${\beta}=.19$, p<.01), satisfaction with nursing as a major (${\beta}=.14$, p<.05), clinical practice stress (${\beta}=-.19$, p<.01) and emotional regulation (${\beta}=.32$, p <.001) were associated with nursing professionalism. In this study, we also have shown that emotional regulation does not play a moderating role on the relationship between clinical practice stress and nursing professionalism. The results of this study suggests that, in order to improve nursing professionalism, it is important to promote support system, develop clinical-practice-stress-relief programs, and enhance emotional regulation training for nursing students. 본 연구는 간호대학생의 간호전문직관에 영향을 미치는 요인과 임상실습 스트레스가 간호전문직관에 영향을 미치는데 정서조절력이 조절변수로서 효과를 가지는지 규명하고자 실시하였다. 간호대학생 192명의 자료를 사용하였고, 2015년 9월부터 11월까지 자료를 수집하였다. SPSS 21.0 프로그램을 활용하여 기술통계분석, t-test, ANOVA, 상관분석, 위계적 회귀분석을 하였다. 간호전문직관은 임상실습 스트레스와 음의 상관관계를 (r=-.40, p<.001), 정서조절력과는 양의 상관관계 (r=.55, p <.001)가 있었다. 그리고 정서조절력은 임상실습 스트레스 (r=-.20, p <.001)와 음의 상관관계가 있었다. 간호전문직관에 교수지지, 전공만족도, 임상실습 스트레스, 정서조절력이 유의한 영향을 미치는 요인으로 나타났고, 정서조절력은 임상실습 스트레스와 간호전문직관의 관계에서 조절효과는 없는 것으로 나타났다. 본 연구 결과는 간호대학생의 간호전문직관을 높이기 위해 지지체계 구축과 임상실습 스트레스 관리와 정서조절력 훈련 개발의 중요함을 보여준다.
장인순,김수진,Ra-Young Song,Kwangsoo Kim,Seongmin Choi,Jang-Seok Lee,Min-Kyeong Gwon,Moon-Woo Seong,이규은,김정희 대한내분비학회 2021 Endocrinology and metabolism Vol.36 No.6
Background: An activating mutation (c.617A>C/p.Lys206Arg, L206R) in protein kinase cAMP-activated catalytic subunit alpha(PRKACA) has been reported in 35% to 65% of cases of cortisol-producing adenomas (CPAs). We aimed to compare the clinical characteristics and transcriptome analysis between PRKACA L206R mutants and wild-type CPAs in Korea. Methods: We included 57 subjects with CPAs who underwent adrenalectomy at Seoul National University Hospital. Sanger sequencing for PRKACA was conducted in 57 CPA tumor tissues. RNA sequencing was performed in 13 fresh-frozen tumor tissues. Results: The prevalence of the PRKACA L206R mutation was 51% (29/57). The mean age of the study subjects was 42±12 years, and 87.7% (50/57) of the patients were female. Subjects with PRKACA L206R mutant CPAs showed smaller adenoma size (3.3±0.7 cm vs. 3.8±1.2 cm, P=0.059) and lower dehydroepiandrosterone sulfate levels (218±180 ng/mL vs. 1,511±3,307 ng/mL, P=0.001) than those with PRKACA wild-type CPAs. Transcriptome profiling identified 244 differentially expressed genes (DEGs) between PRKACA L206R mutant (n=8) and wild-type CPAs (n=5), including five upregulated and 239 downregulated genes in PRKACA L206R mutant CPAs (|fold change| ≥2, P<0.05). Among the upstream regulators of DEGs, CTNNB1 was the most significant transcription regulator. In several pathway analyses, the Wnt signaling pathway was downregulated and the steroid biosynthesis pathway was upregulated in PRKACA mutants. Protein-protein interaction analysis also showed that PRKACA downregulates Wnt signaling and upregulates steroid biosynthesis. Conclusion: The PRKACA L206R mutation in CPAs causes high hormonal activity with a limited proliferative capacity, as supported by transcriptome profiling.