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아드리아마이신의 유사제제 합성 (1) -안트라싸이클리논의 Isostere로서 Tetrahydrobenzo(b)phenazine 유도체의 합성-
장영동(Yurng Dong Jahng),장선영(Sun Young Chang) 대한약학회 1990 약학회지 Vol.34 No.4
7,8-Dihydro-6,11-dihydroxy-9(1OH)benzo(b)phenazinone was prepared from 1,2,3,4-tetra-hydrophenazine as a potential isostere of anthracyclinone. The attempts to functionalize at C9 were not successful due to the unstability of the above ketone.
연구논문 : 의약화학 ; COX 및 5-LOX에 대한 이중 억제 활성을 갖는 프로페논 모핵의 간단한 방향족 화합물의 합성
장영동 ( Yurng Dong Jahng ),조룡현 ( Long Xuan Zhao ),문윤수 ( Yoon Soo Moon ),알준바스넷 ( Arjun Basnet ),김은경 ( Eun Kyung Kim ),장현욱 ( Hyeun Wook Chang ),주혜경 ( Hye Kyung Ju ),정태천 ( Tae Cheon Jeong ),이응석 ( Eung Seok 영남대학교 약품개발연구소 2004 영남대학교 약품개발연구소 연구업적집 Vol.14 No.-
고콜레스테롤혈증 치료제로서 3-치환 4,5-헥사메틸렌피라졸 유도체의 합성
최영희,김진일,장영동,Choe, Young-Hee,Kim, Jin-Il,Jahng, Yurng-Dong 대한약학회 1994 약학회지 Vol.38 No.4
A series of 6-[2-(3-substituted 4,5-hexamethylenepyrazo-1-yl)ethyl]tetrahydro-4-hydroxy-2H-pyran-2-ones were synthesized from 3-substituted 4,5-hexamethylenepyrazole in 7 steps as potential antihypercholesterolemic agents.
p-Xylene의 디니트로화와 2,3-, 2,5- 및 2,6-dinitro-p-xylene의 효율적 분리
로 양(Yang Lu),장영동(Yurng dong Jahng) 대한약학회 2018 약학회지 Vol.62 No.5
A practical method for the preparation and separation of 2,3-, 2,5- and 2,6-dinitro-p-xylenes is described herein. The direct nitration of p-xylene with nitric acid (d 1.42) in the presence of sulfuric acid at 80oC afforded 2,3-, 2,5-, and 2,6- dinitro-p-xylenes in a ratio of 6.86:1:3.41, and the isomeric mixture could be readily separated by column chromatography on silica gel eluting with hexanes:EtOAc (19:1) as an eluent.
문승욱(Seung Wook Moon),장영동(Yurng Dong Jahng),서병천(Byeong Chon Seoh) 대한약학회 1992 약학회지 Vol.36 No.1
2-Substituted benzimdazoles were prepared by reaction o-phenylenediamine with acid chlorides, which has advantages over the known synthetic procedures. The compounds prepared Showed no significant antiinflammatory activity, thus are of no interest as antiinflammatory agents.
6-(티에닐메칠렌)페남 설폰의 합성과 ${\beta}$-Lactamase 저해활성
김동현,프리텀다빠,라다깔끼,장영동,이응석,Kim, Dong-Hyeon,Thapa, Pritam,Karki, Radha,Jahng, Yurng-Dong,Lee, Eung-Seok 대한약학회 2007 약학회지 Vol.51 No.6
The resistance of bacteria against ${\beta}$-lactam antibiotics is mainly caused by the production of ${\beta}$-lactamase enzymes. ${\beta}$-Lactamase inhibitors are used in combination with known antibiotics to overcome the growing problem of bacterial resistance. We prepared 6-(thienylmethylene)penam sulfones for the development of potent ${\beta}$-lactamase inhibitors and evaluated their ${\beta}$-lactamase inhibitory activities.
김동현,프리텀다빠,라다깔끼,장영동,이응석,Kim, Dong-Hyeon,Thapa, Pritam,Karki, Radha,Jahng, Yurng-Dong,Lee, Eung-Seok 대한약학회 2007 약학회지 Vol.51 No.6
TRH (thyrotropin-releasing hormone) was chemically synthesized utilizing solution phase peptide chemistry for the process development of large scaled synthesis. All the synthetic steps performed in relatively mild conditions, higher yields, easier preparations, minimum racemizations, and separation and purification by recrystallizations.