궤양성 대장염에서 점소유전자 MUC2 , MUC3 , mRNA 발현

장세경(Sae Kyung Chang) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.1

N/A N/A

의료관광 전략 수립 및 비즈니스 서비스 모델 설계에 관한 연구

장세경(Sae Kyung Chang),백종선(Jong Sun Baek) 한국전자거래학회 2017 한국전자거래학회지 Vol.22 No.3

세계의료관광 서비스의 시장 규모는 날로 커지고 있으며, 국내 의료관광 시장 또한 높은 성장세를 보이고 있다. 그러나 다양한 정보와 서비스가 정형화되어 있지 않고 정상적인 가격경쟁의 불가 등 의료 서비스 제공으로 인한 문제점이 대두되고 있는 실정이다. 이렇게 정형화 되지 않은 의료 서비스 제공으로 인한 문제점이 대두되고 있으며, 이를 개선하기 위해 본 논문에서는 의료 생태계 조사를 통하여 ICT 기반 한국형 의료관광 서비스 모델을 설계하였다. 우선적으로 국내외 의료 생태계 현황 분석을 진행하여 국내 시장에서의 의료관광 문제점을 파악하고 개선을 위한 주요한 방향성을 제시하여 전략을 수립하였다. 이를 반영하여 국내 실정에 맞으며 고객이 접근 가능하고 편리한 ICT 기반 의료관광 서비스 모델, 클라우드, O2O 서비스 기반 역경매 시스템, 빅데이터 기반 라이프사이클 관리 그리고 모바일 중심 헬퍼 서비스를 설계하였다. 본 논문에서 제안한 의료관광 서비스 모델은 고객에게 편리함을 제공하며 향후 한국 의료관광 문제점들을 해결하고 활성화에 기여하며 산업적으로도 파급력 있는 효과를 기대한다. The market for medical tourism services in the world is steadily increasing and the medical tourism market in the South Korea is also showing high growth. However, they have also problem such as informal various information and services, irregularity price competition etc. In order to solve this problem, We have designed a medical tourism service model based on ICT specific on domestic medical ecosystem. First, analysis trends of domestic and overseas medical ecosystem and identify current problem of medical tourism. In order to solve existed problem we also have designed a medical tourism strategy. Based on the strategy, we have designed business service model based on ICT platform for as fit as Korea medical tourism status. The proposed medical tourism business service model can provide usability to customer and also can solve current medical tourism problem. We expect industrial effect and contribution to the activation.

궤양성 대장염에서 점소 당항원 sTn 과 Tn 의 발현에 관한 연구

장무선(Moo Sun Chang),도재혁(Jae Hyuk Do),김형준(Hyung Jun Kim),유경금(Kyung Kum Yoo),박수정(Soo Jeong Park),문철(Cheol Moon),허철행(Cheol Heang Heo),김재규(Jae Gyu Kim),장세경(Sae Kyung Chang),박실무(Sil Moo Park),김미경(Mi Kyung K 대한내과학회 1997 대한내과학회지 Vol.52 No.1

N/A Objectives: Long standing observation, which may relate either to the causes or the effects of UC, reveals that there is a pronounced alteration of mucin such as quantitative and qualitative abnormalities of mucin glycoprotein. But recently in situ hybridization technique showed no specific difference in the expression of apomucin mRNA in UC. Therefore we investigated whether abnormality of mucin was originated from defect in glycosylation. And we also tried to find differences in the expression of Tn and sTn antigens between Korean and Jewish patients with UC. Methods: We performed the immunohistochemical staining using the monoclonal antibody of mucin carbohydrate antigens Tn and sTn in 19 patients with UC. Results: Tn and sTn antigens were not expressed throughout the crypt and surface epithelium in normal colon but both of mucin carbohydrates antigens were well expressed in mild UC, Tn antigen was seen in the surface epithelium with perinuclear pattern and sTn antigen was shown not only in surface but also in crypt epithelium. In severe UC, Tn antigen was well expressed, but sTn antigen was not expressed. Tn antigen seemed to be ex-pressed more frequently than sTn antigen with severity of inflammation. These results were similar in Korean and Jewish patients with UC. Conclusion: These results suggest that inflammatory bowel disease has some deterioration in the step of glycosylation in the cytoplasm and there was no racial difference in the expression of Tn and sTn antigen in Korean and Jewish patients with UC.

Mini-gel을 이용한 비방사성 SSCP의 위암 p53유전자 변이 검출

유경금(Kyung Kum Yoo),도재혁(Jae Hyuk Do),허철행(Cheol Heang Heo),문철(Cheol Moon),김형준(Hyung Jun Kim),이태진(Tae Jin Lee),유재형(Jae Hyeng Yoo),장진수(Jin Soo Chang),이상재(Sang Jea Lee),장세경(Sae Kyung Chang),박실무(Sill Moo Pa 대한소화기학회 1997 대한소화기학회지 Vol.29 No.5

N/A Background/Aims: p53 mutation was reported in many studies, but conventional PCR-SSCP protocol using radiolabeled PCR primers or nucleotides to generate a radioactive PCR products is cumbersome to handle. With the aim of a rapid and safe method for single-strand conformation polymorphism(SSCP) analysis of PCR products, we used Mini-SSCP method to detect the mutation of p53 gene of gastric cancer. Methods: In 27 pair of gastric cancer and normal tissues, PCR-SSCP was done with Mini-SSCP, and then Silver sequencing was done. Results: The p53 gene mutation of gastric cancer was found in 10 of 27(37%). Mutation of exon 4, 5 were 2, 5 cases and tnutation of exon 6, 7 mutation were 0, 3 cases respectively. Mutation rate was similar with other reports. P53 mutation was not correlated with stage, lymph node involvement and histological differentiation. Conclusions: Mini-SSCP method, modification of Cold-SSCP, greately increased our accessibility to detect polymorphisms with easiness and safeness. So, it is a useful method to detect genetic mutation. (Korean J Gastroenterol 1997;29:601-609)

폐색성 담관질환자의 장투과성의 변화

김정욱 ( Jeong Wook Kim ),전우규 ( Woo Kyu Jeon ),장세경 ( Sae Kyung Chang ),이정안 ( Jung Ahn Lee ),박동일 ( Dong Il Park ),조용균 ( Yong Kyun Cho ),성인경 ( In Kyung Sung ),손정일 ( Chung Il Sohn ),김병익 ( Byung Ik Kim ),김은정 대한내과학회 2004 대한내과학회지 Vol.67 No.6

목적 : 장관장벽 이상은 폐색성 담관질환에서 발생하며 장내세균전위나 장관내독소혈증과 같은 감염성 합병증을 유발 한다. 본 연구에서는 폐색성 담관질환에서 장관장벽 이상과 임상양상과의 관계를 알아보았다. 방법 : 건강대조군 18명, 양성질환에 의한 폐색성 담관질환자 20명, 악성질환에 의한 폐색성 담관질환자 21명에서 장투과성 검사를 실시하였으며 질환군간 차이와 각종 임상양상과 연관성을 비교하였다. 장투과성 검사는 51Cr-EDTA (51Cr-ethylen Background : Gut barrier dysfunction occurs in experimental models and humans of obstructive biliary disease. This phenomenon promotes infectious complications including bacterial translocation and intestinal endotoxemia. The aims of this study were to ex

5 - Aminosalicylic Acid 와 Sulfasalazine 이 Deoxycholic Acid 를 투여한 백서의 대장점막의 Superoxide Radical 과 항산화 효소에 미치는 영향

김종숙(Chong Sook Kim),장세경(Sae Kyung Chang),이호심(Ho Sim Lee),김호정(Ho Jung Kim) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.1

N/A Effect of 5-Aminosalicylic acid and sulfasalazine in ulcerative colitis was known to suppress the production of prostaglandins and leukotrienes. However, during the oxygenation of arachidonic acid, superoxide and other oxygen moieties are formed which have been implicated in mediators of intestinal mucosal injury. We study the effect of 5-ASA and sulfasalazine on their ability to scavenge superoxide radical and effect on CuZu-SOD, Mn-SOD and catalase in deoxycholic acid induced injured rat colonic mucosa. The result was as follows. 1) DOC and normal saline group showed significant increase in superoxide radical compared with normal saline only group (p<0.005). 2) The experimental groups which were administered 5-ASA and sulfasalazine showed significant decrease in superoxide radical compared with DOC only treated group (p<0.05, p<0,005). 3) Sulfasalazine treated group shovecl increasc in CuZn-SOD compared with DOC onily treated proup (p<0.05). 4) In Mn-SOD, 5-ASA and sulfasalazine treated group showed signnificant increase than that of DOC only treated group (p<0.05). 5) There was no significant difference in the activity of catalase in each experiimiental group.

위 임파종과 십이지장 선암이 병발한 중복암

김영수(Young Soo Kim),장세경(Sae Kyung Chang),박기룡(Ki Ryong Park),김호정(Ho Jeong Kim),신순현(Sun Hyun Shinn),김종숙(Jong Suk Kim),박용욱(Yong Ook Park) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2

Double prirnary cancer is defined as the case of primary malignant tumors of different site origins, which are different histologically in each other. The absolute number of reported cases of double primary malignant tumors has increased in recent years by means of more developed diagnostic procedure. But the occurrence of multiple primary malignant tumors is relatively rare. We have experienced a case with double primary malignant tumors of different site origins such as gastric lymphoma and duodenal adenocarcinoma, which were diagnosed by biopsies with gastric fiberoptic endoscopy. For its great rarity, we report this case with review of literatures.

Somatostatin ( SMS 201 - 995 ) 이 흰쥐의 위액과 위점막 당단백질에 미치는 영향

김종숙(Chong Sook Kim),장세경(Sae Kyung Chang),이병직(Byung Jik Lee) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2

Somatostatin, a peptide present in hypothalamus, gastric mucosa, and pancreas suppress several gastrointestinal functions. Its short half life of two or three minutes prevents its clinical use. According to the report that subcutaneous administration of the synthetic SMS analogue SMS 201-995 produced a marked inhibition of pentagastrin-stimulated acid secretion, we have therefre evaluated the effect of SMS 201-995 to glycoprotein of gastric juice and mucus in rats. The results obtained were as follows. 1) Somatostatin increased sialic acid concentration in gastric juice and mucus significantly. 2) When somatostatin and indomethacin were given, the sialic acid concentration was lower compared with somatostatin given alone in gastric juice. 3) The sialic acid concentration after indomethacin alone was not significantly different from the control in gastric juice and soluble mucus.

당뇨병 유무와 치료 방법에 따른 대장 선종의 빈도

김상중 ( Sang Jung Kim ),최창환 ( Chang Hwan Choi ),문홍주 ( Hong Ju Moon ),문장식 ( Jang Sik Mun ),이현웅 ( Hyun Woong Lee ),김형준 ( Hyung Joon Kim ),도재혁 ( Jae Hyuk Do ),장세경 ( Sae Kyung Chang ) 대한장연구학회 2008 Intestinal Research Vol.6 No.1

Background/Aims: Diabetes mellitus (DM) is associated with an increased incidence of colon cancer. However, the relationship between DM and colorectal adenoma is not definite. In this study, we sought to determine the association between DM and the prevalence of colorectal adenoma. Methods: We enrolled 606 patients with DM and 606 asymptomatic adults who underwent colonoscopy for routine health evaluations from June 2003 to June 2007. The frequency and characteristics of the colorectal adenomas were analyzed and compared between the two groups. Results: The sex ratio and mean age were 1.67:1 (M:F) and 58.1±10.6 years, respectively, in patients with DM, and 1.68:1 and 57.6±8.9 years, respectively, in patients without DM, and these values were similar. The frequency of colorectal adenoma was 33.2% for the patients with DM and 32.3% for the patients without DM. The frequency, location, number, size and histopathologic findings of the colorectal adenomas were not different between the two groups. Among the patients with DM, the frequency of colorectal adenoma was 35.7% in the patients treated with oral hypoglycemic agents and 31.4% in the patients treated with insulin. Also, the other characteristics of the colorectal adenomas were not different according to the treatment method. Conclusions: The frequency and characteristics of colorectal adenomas were not different between the patients with and without DM. (Intest Res 2008;6:50-55)

건강 검진자에서 과민성 장 증후군의 빈도 및 연관 인자

황상연 ( Sang Yon Hwang ),최창환 ( Chang Hwan Choi ),이수연 ( Su Yeon Rhie ),도미영 ( Mi Young Do ),이승현 ( Seong Hyun Lee ),김형준 ( Hyung Joon Kim ),김정욱 ( Jung Uk Kim ),김재규 ( Jae Kyu Kim ),장세경 ( Sae Kyung Chang ),박실 대한소화기기능성질환·운동학회 2006 Journal of Neurogastroenterology and Motility (JNM Vol.12 No.2

목적: 우리나라에서 과민성 장 증후군의 빈도와 이와 연관된 인자를 알아보기 위하여 단일기관에서 건강 검진을 받는 사람들을 대상으로 설문조사를 시행하였다. 대상 및 방법: 2005년 3윌부터 2005년 8윌까지 관동대학교 의과대학 명지병원에서 건강 검진을 받는 사람들을 대상으로 하여, 미리 제작된 설문지를 작성하게 하였다. 설문지는 로마 기준 II를 우리말로 번역하여 질문형식으로 바꾸었으며 설사형, 변비형, 혼합형의 아형과 세부적인 증상을 확인할 수 있는 항목, 인구통계학적인 항목 등을 포함하였다. 기본적인 문진, 말초혈액검사, 혈청생화학검사, 갑상선가능검사, 대변잠혈검사, 상부소화관내시경검사, 복부초음파검사 등의 건강 검진 자료를 분석하여 기질적인 질환에 대한 평가를 하였으며, 과민성 장 증후군 발생과 연관된 인자를 분석하였다. 결과: 총 3083명의 대상자들 가운데 설문지 작성을 거부하거나 제외기준에 해당하는 사람을 제외하고 총 2,345명(76.1%)의 대상자가 연구에 포함되었다. 이 중 남자는 1,298명(55.4%), 여자는 1,047명(44.6%) 이었고 이들의 평균 연령은 49.0±13.6세였다. 로마기준 Ⅱ에 따른 과민성 장 증후군의 빈도는 8.3%였다. 증상에 따른 아형은 설사형 30.8%, 변비형 23.6%, 그라고 설사-변비 혼합형이 45.6%로 혼합형이 가장 많았다. 35세 미만의 젊은 연령에서 과민성 장 증후군의 빈도가 13.1%로 유의하게 높았고, 또한 체질량지수가 18.5 미만인 저체중에서의 빈도가 21.0%로 유의하게 높았다(p<0.01). 그러나 연령, 거주지역, 직업군, 흡연 및 음주력, 당뇨와 고혈압의 과거력, 빈혈의 유무, 혈액형, 역류성 식도염, 소화성궤양 및 지방간 유무, 그라고 헬리코박터 균 감염 유무에 따라서는 과민성 장 증후군 빈도에 차이가 없었다. 결론: 로마기준 II를 적용하여 건강 검진자를 대상으로 조사한 우리나라 과민성 장 증후군의 빈도는 8.3%이며, 35세 미만의 젊은 연령과 저체중에서 유의하게 빈도가 높았다. Background/Aims: Irritable bowel syndrome (IBS) is a common health problem affecting a substantial proportion of the population. The aims of this study were to evaluate the frequency of IBS that satisfied the ROME II criteria and to analyze the factors that could be associated with the frequency of IBS in subjects who underwent health check-ups in South Korea. Methods: We included a total of 2345 (76.1%) subjects among the 3083 subjects who visited the Health Promotion Center of Kwandong University College of Medicine, Myongji hospital from March 2005 through August 2005. They were interviewed by using a questionnaire that was comprised of the demographic features, the ROME II criteria and the probable associated factors. The frequency of IBS was analyzed according to various factors such as the demographic characteristics, the past history, the body mass indexes (BMI), blood tests and the endoscopic and abdominal sonographic findings. Results: The frequency of IBS was 8.3% (7.9% in males and 8.8% in females). Of the IBS patients, 30.8% had characteristics of diarrhea-predominance, 23.6% had characteristics of constipation-predominan while 45.6% had alternating symptoms. The most frequent symptom was a sense of incomplete evacuation (60.0%), followed by bloating or distention (54.9%), straining (36.9%), urgency (29.7%), and mucus in stool (9.2%). The frequency of IBS was significantly higher for the younger age subjects (age<35) and for the under-weight subjects (BMI<18.5), and these were the factors independently related with the presence of IBS on logistic regression analysis. The frequencies of IBS were not different in terms of gender, area of residence, occupation, smoking, alcohol intake, the diabetes mellitus and hypertension histories, anemia, ABO blood groups, Helicobacter pylori infection and the presence of reflux esophagitis, peptic ulcer or fatty liver disease. Conclusions: The frequency of IBS was 8.3%, according to the ROME II criteria, in the subjects who underwent health-check ups in our region. IBS was more common in the younger age subjects and the under-weight people. (Kor J Neurogastroenterol Motil 2006;12:136-143)