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허창재 ( Chang Jae Hur ),민보람 ( Bo Ram Min ),이유진 ( Yoo Jin Lee ),장병국 ( Byung Kuk Jang ),황재석 ( Jae Seok Hwang ),김은수 ( Eun Soo Kim ),박경식 ( Kyung Sik Park ),조광범 ( Kwang Bum Cho ),강유나 ( Yu Na Kang ),정우진 ( Woo 대한소화기학회 2015 대한소화기학회지 Vol.65 No.4
Background/Aims: Hepatic angiosarcoma, a rare and aggressive liver malignancy, is difficult to diagnose because of a lack of specific clinical features. The clinical and radiological features of patients with histologically confirmed hepatic angiosarcoma were examined. Methods: Among 2,336 patients diagnosed with primary hepatic carcinoma at Keimyung University Dongsan Medical Center (Daegu, Korea) between May 2002 and February 2012, eight (0.03%) with histologically confirmed primary hepatic angiosarcoma were included. The patterns of disease diagnosis, tumor characteristics, treatment responses, and prognoses were reviewed retrospectively. Results: Median age was 66 years-old (range, 41-80 years). Four patients were male. Five patients were compulsive drinkers. All patients had no HBsAg and anti-HCV. Initial radiologic diagnoses revealed primary hepatic angiosarcoma (n=2), hepatocellular carcinoma (n=2), hemangioma (n=2), and hepatic metastatic carcinoma (n=2). Definitive diagnoses were made by percutaneous needle biopsies in seven patients and surgical resection in one patient. At the time of the initial diagnosis, extrahepatic metastases were detected in three patients (37.5%). Metastatic sites included the spleen and lung, pericardium, and bone, in one patient each. Two patients underwent conservative treatments. The remaining patients underwent surgical resection (n=1), transcatheter arterial chemoembolization (n=1), and systemic chemotherapy (n=4). The median survival period was 214 days (range, 21-431 days). Conclusions: Hepatic angiosarcoma is a highly progressive disease with a poor prognosis. Detailed studies including histological examinations are essential to facilitate early diagnosis of the disease. (Korean J Gastroenterol 2015;65:229-235)
만성 B형간염에 의한 간경변증 환자에서의 Sweet 증후군
박창욱 ( Chang Wook Park ),김윤정 ( Yoon Jung Kim ),서혜진 ( Hye Jin Seo ),이경인 ( Kyung In Lee ),장병국 ( Byung Kuk Jang,),황재석 ( Jae Seok Hwang ),정우진 ( Woo Jin Chung ) 대한소화기학회 2012 대한소화기학회지 Vol.59 No.6
Sweet`s syndrome (SS), also known as acute febrile neutrophilic dermatosis, is characterized by the sudden onset of painful erythematous skin lesions together with fever and neutrophilia. SS can be associated with several disorders, such as malignancy, autoimmune disease, and infections. However, SS associated with liver cirrhosis is uncommon. We report a case of SS in a patient who was diagnosed with liver cirrhosis caused by chronic hepatitis B. (Korean J Gastroenterol 2012;59:441-444)
윤영호,정우진,안성훈,황재석,장병국,정영호,권순대,강영우,허정욱,박승국 대한소화기내시경학회 1998 Clinical Endoscopy Vol.18 No.6
Menetrier's disease is a rare, characterized by the presence of large rugal folds involving part or all of the stomach. Patients with hypertrophic gastropathy often have distressing abdominal symptoms, weight loss, and edema due to gastric protem loss. A 64 year old male patient was admitted with the chief complaint of epigastric discomfort. Endoscopic, radiologic and histologic examination, revealed characteristic findings of Menetrier's disease. A case of Menetrier's disease is reported with a brief review of literature.
운동장애성 소화불량 환자에서 물 섭취가 포만감과 위전도에 미치는 영향
강영우,손수상,박승국,황재석,장병국 대한소화기학회 1999 대한소화기학회지 Vol.33 No.4
Background/Aims: The aim of this study was to evaluate the influence of water ingestion on electrogastrographic findings and epigastric fullness in patients with dysmotility-like functional dyspepsia (DLFD). Methods: The study was performed on 15 patients with DLFD and 17 normal controls Abdominal surface electrogastrography was applied for 30 min in fasting state and for 30 min afte water ingestion to bring epigastric fullness. Results: Patients with DLFD showed higher scale of epigastric fullness in fasting, postprandial 20 min and postprandial 30 min, compared with norma controls. There was no difference between the patients and controls in the amount of ingested wate which brought epigastric fullness. Significant differences were found in the percentage of fed 3 cpm wave and the percentage of fed bradygastria. No significant differences were found in the percentage of fed tachygastria, fasting electrogastrographic findings and power ratio. No correlation was found between the percentage of 3 cpm slow wave and the scale of epigastric fullness. Conclusions: Pati ents with DLFD showed higher percentage of 3 cpm wave after ingestion of water. The amount o ingested water to bring epigastric fullness was similar in the patients and normal controls.
Helicobacter pylori가 소화성 궤양 출혈에 미치는 영향
강영우,안성훈,박승국,황재석,허정욱,장병국 대한소화기학회 1999 대한소화기학회지 Vol.34 No.3
Background/Aims: Helicobacter pylori (H. pylori) infection is deeply involved in pathogenesis of peptic ulcer. However, the role of H. pylori infection on the peptic ulcer bleeding is not established. We investigated the effect of H. pylori infection on ulcer bleeding by comparision of the incidence of H. pylori infection in patients with bleeding ulcer or non bleeding ulcer. Methods: We surveyed 101 patients who were diagnosed as bleeding and non bleeding peptic ulcer by gastroscopy from September, 1997 to June, 1998. We obtained biopsy specimen within 5 cm from pylorus by jumbo biopsy forcep and performed CLO test and Cresyl-Violet stain. Results: The positive rate of H. pylori infection in the patients with bleeding gastric ulcer was 55% (11 of 20), which was significantly lower than that of patients with non bleeding gastric ulcer, 84% (27 of 32)(p$lt;0.05). The positive rate of H. pylori infection in patients with bleeding duodenal ulcer was 69% (11 of 16), which was not significantly lower than that of patients with non bleeding duodenal ulcer, 81% (27 of 33). Conclusions: Our results suggested that H. pylori infection did not have any effect on bleeding in patients with peptic ulcer, especially gastric ulcer.