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錦江上流地域에 있어서 肝吸蟲의 感染實態 및 Embay8440(praziquantel)의 治療效果에 關한 硏究
張大允 충남대학교 의과대학 지역사회의학연구소 1979 충남의대잡지 Vol.6 No.2
The present studies have been undertaken to the epidemiological aspects and chemotherapeutic effects on the Clonorchiasis in upper and middle areas in Gum river. Fecal specimens were collected from all inhabitants of Buri, Jewon Myun, Gum san Gun, Dongi Myun, okchun Gun, Sintanjin, Dae duk Gun in Gum river. The 28 patients were selected from inhabitants of Dongi Myun, Ok chun Gun and had medicated Embay 8440, 3 x 25mg/day for 1 day or 2 days, and had checked therapeutic effects by stool examination at 30 days and 60 days after Embay 8440 medication. The results are as follow : 1. Among the sureveyed area, the prevalence rate of Helminthic infection was shown as 86.6% and Clonorchis sinensis (50.7%), Trichuris trichiura (45.5%) and Ascaris lumbricoides (36.8%) were noted. 2. Geographical prevalence rates of Clonorchis infection was shown as Gum san Gun (43.9%), Okchun Gun(58.9%) and Dae duk Gun(47.9%). Prevalence rates of Male had been 2∼3 times more than female. 3. By age distribution, there was more prevalence rate of C. sinensis with growing age and peak rate was 5th decade(62.4%). 4. The degree of the intensity of Clonorchis infection by EPG count in the surveyed area was distributed by most, light(1-999), next number, mild (1000-4999), heavy (10,000 or over), moderate(5,000-9,999) infection groups. 5. Cure rates were 2 days group(91.6%), 1 day group(87.5%) of praziquantel medication. 6. Hematological and biochemical tests showed no abnormal findings after therapy which might be due to the medication 7. The assessment of tolerance recorded only a few side effects such as itching sensation & erythema, headache, nausea, numbness. It was evidently shown that the human clonorchiasis cou'd be successfully treated with a few doses of praziquantel without any serious side effect. Therefore, Praziquantel is the most promising drug for the treatment against Clonorchis sinensis infection.
Aspergillus fumigatus 감염진단을 위한 Enzyme-linked-Immunosorbent-Assay 법의 유용성에 관한연구
장대윤,안승운 충남대학교 의과대학 지역사회의학연구소 1983 충남의대잡지 Vol.10 No.1
In the past decades a number of techniques have been applied for diagnosing Aspergillus fumigatus infection. Indeed the correct diagnosis of Aspergillus infection is made by isolation and identification of the organism from biopsied specimen in the lesion, but it is fairly hard to achieve successfully. Recently serological studies are being applied to this fungal infection. However none of them was fully satisfactory in the sense of specificity, sensitivity, reproducibility and applicability for laboratory and field trial. In the present study ELISA are carried out with minor modification of Voller's microplate method for diagnosis of Aspergillus fumigatus infection, where Aspergillus metabolite as antigen, peroxidase conjugated antihuman globulin (IgG) as conjugated enzyme and H_2O_2-OPD as substrate is used. The results obtained are as follows: 1. The optimal dilution of conjugate, metabolite antigen and serum are 1/10,000, 60㎍/ml and 1/200 respectively. 2. One to two common precipitation is observed on double gel immunodiffusion using metabolite antigen. 3. The ELISA values for aspergillosis is significantly higher than other group, that is, aspergillosis; 0.788±0.296, healthy group; 0.131±0.078, asthma; 0.158±0.034, pulmonary tuberculosis; 0.184±0.066, bacterial pneumonia; 0.117±0.057, paragonimiasis; 0.231±0.020, (P<0.001). 4. The specificity of ELISA using Aspergillus metabolite antigen as a diagnostic tool is 97.3%. From the above results it is suggested that the ELISA using Aspergillus metabolite antigen is a useful serologic tool for diagnosis of Aspergillus infection since the technique has high specificity, sensitivity and reproducibility.
金武剛,金鍾煥,張大允 충남대학교 의과대학 지역사회의학연구소 1980 충남의대잡지 Vol.7 No.2
A Survey of zoonoses such as the Taeniasis and Cysticercosis were carried out among the dairy farmers in the some areas of Chung cheong nam Do. The results are summerized as follows : 1. Past history of Taenia infection rate was 23.1% by the 1584 Questionnaires (male 1038, female 546). Among of them the worm recovery rate was 5.1%. By the sex difference, the positive rates of Taeniasis showed that 26.3% in male and 17.0% in female and the recovery rates of the worm were 5.2% in male and 2.6% in female, and the increasing tendency of Taenia infection was found in the above 20 age group. 2. Both bovine and swine raw meat or raw visceral organs, liver and intestine, eating history from the rural inhabitants was found almost every case, and the eating place was in home, in the restaurant and in the tavern in order. 3. Incidence of human intestinal helminths was 78.6% from the 435 stool specimens examined, and the rate in Dae duck area was found higher rate than that of the Seosan, and the Taenia infection rate 6.5% in Daeduck residents and 0.9% in Seosan. 4. A total of 111 of Taeniasis cases were treated with Niclosamide, the worms, scolices and, or proglottids were expelled from 81 of the treated cases. The species identification with the 87 removed worms was performed, among of them 70 was T. saginata and 17 was T. solium. the ratio of both species was 4.7 : 1. 5. Examination of human cysticercosis from the out patient clinic of Chungnam National University Hospital as well as the local several clinics in Daejeon was observed in 17 cases. Subcutaneaus cysticercosis occurred all of the cases, and epileptic symptomes caused presumably by cerebral cysticercosis were also observed in 14 cases among of them, and Ocular cysticercosis occurred in the 3 cases out of 17 cases. 6. The incidences of Cysticercosis in the bovine was 5(0.6%) out of 803 slaughtered animals and 9(0.6%) out of 1522 slaughtered swine from the Daejeon and Dae duck public abattoir.