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- 저자 : 임혜림(Hye Rim Lim) (검색결과 18 건)
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연구논문 : 인체구강모델을 이용한 구강점막자극 동물대체시험법 개발
임혜림 ( Hye Rim Lim ),이정선 ( Jung Sun Yi ),김태성 ( Tae Sung Kim ),고경육 ( Kyung Yuk Ko ),안일영 ( Il Young Ahn ),김주환 ( Joo Hwan Kim ),이진하 ( Jin Ha Lee ),양송이 ( Song Yi Yang ),김광만 ( Kwang Mahn Kim ),손수정 ( Soo Jun 한국동물실험대체법학회 2015 동물실험대체법학회지 Vol.9 No.1
Ensuring the biological safety of dental materials is important, because people of all ages use them and they stay inside the mouth of a person for years once they are put into it. However, current oral irritation tests bring pain to animals, and there are no internationally accepted alternative test methods. In this study, we have developed a new method to test for oral irritation using three-dimensional (3D) human oral mucosal models in the light of growing needs for alternatives to animal testing in order to ensure the safety of dental materials. The commercially available 3D human oral mucosal models (EpiOral™, HOM™) were cultured, using normal oral epithelial cells, and histologically and phenotypically similar to native buccal tissues. Two controls and three dental materials that are widely used in dentistry were selected for testing. These included a polyethylene film (negative control), 1% Triton X-100 (positive control), resin, denture base resin and impression materials. These three dental materials were prepared according to manufacturers’ instructions, and were turned into 0.7-cm discs in diameter. And then, we directly placed the controls and the three dental materials on the top of each human oral mucosal model for 24 hours and measured tissue viability via the MTT assay and cytokine secretion. When cell viability is less than 50% or cytokine secretion is more than 250 pg/ml, a test material is evaluated as an irritant. The negative control, resin and denture base resin turned out non-irritants while the positive control and the impression materials irritants. Since the results of the oral mucosal irritation test of dental materials using human oral mucosal models matched those of existing cytotoxicity tests, it seems that the oral mucosal test can be a good alternative method. The results of this study suggest that the oral mucosal irritation test employing the 3D human oral mucosal models can be an alternative test method for dental materials. And further validation studies are required in order to take advantage of this method in the future.
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임혜림 ( Hye-rim Lim ),전서영 ( Seo-young Jeon ),조교희 ( Koy-hee Jo ),주아인 ( A-in Ju ),김설희 ( Seol-hee Kim ) 한국치위생과학회 2016 치위생과학회지 Vol.16 No.4
스트레스, 구강건강, 구강건강관련 삶의 질 연관성 분석을 위해 2016년 6월 2주 동안 D지역 대학생 452명을 대상으로 조사한 결과 다음과 같은 결론을 얻었다. 스트레스는 여학 생이 남학생보다 높게 조사되었고(p<0.05), 스트레스 상위 군이 하위군보다 구강건조증, 구취, TMJ 통증 인식이 높게 조사되었으며(p<0.05), 스트레스 상위군이 하위군보다 OIDP에 부정적 영향을 경험하는 것으로 조사되었다(p<0.05). 스트레스와 구강건강, OIDP 상관관계 분석결과 스트레스는 구강건조증, 구취, TMJ 통증과 통계적으로 유의한 양의상관관계가 있었고, OIDP는 구강건조증, 구취, TMJ 통증, 스트레스와 통계적으로 유의한 양의 상관관계가 있었다. 이와 같이 스트레스는 구강건강, 구강건강관련 삶의 질에 부정적 영향을 미치는 것으로 조사되었다. 그러므로 대학생들의 스트레스 대처능력과 자가구강관리능력을 향상시켜 심신이 건강한 사회인으로 성장할 수 있도록 교육이 이루어져야 할 것이다. The purpose of this study was to investigate the relationship between stress and oral symptoms, and quality of life in university students. This survey was performed on 452 university students in the Daejeon area. The research was conducted during 2 weeks in June 2016 using a self-reported questionnaire. The data were analyzed by PASW Statistics ver. 18.0. According to the findings of the study, higher levels of stress were detected in girls than in boys (p<0.05). Stress had a significant impact on the symptoms of dry mouth, bad breath, and temporomandibular pain (p<0.05). The high-stress group experienced a negative impact on oral impacts on daily performance (OIDP) scores as compared to the group with lower stress. Stress had a significantly positive correlation with dry mouth, bad breath, temporomandibular joint (TMJ). OIDP was a significant positive correlation with dry mouth, bad breath, TMJ and stress. The findings of the study showed that stress exerted a significant influence on the oral symptoms and quality of life in university student.
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임혜림 ( Hye Rim Lim ),이정선 ( Jung Sun Yi ),김태성 ( Tae Sung Kim ),고경육 ( Kyung Yuk Ko ),안일영 ( Il Young Ahn ),김주환 ( Joo Hwan Kim ),이진하 ( Jin Ha Lee ),양송이 ( Song Yi Yang ),김광만 ( Kwang Mahn Kim ),손수정 ( Soo Jun 한국동물실험대체법학회 2015 동물실험대체법학회지 Vol.9 No.1
Ensuring the biological safety of dental materials is important, because people of all ages use them and they stay inside the mouth of a person for years once they are put into it. However, current oral irritation tests bring pain to animals, and there are no internationally accepted alternative test methods. In this study, we have developed a new method to test for oral irritation using three-dimensional (3D) human oral mucosal models in the light of growing needs for alternatives to animal testing in order to ensure the safety of dental materials. The commercially available 3D human oral mucosal models (EpiOral™, HOM™) were cultured, using normal oral epithelial cells, and histologically and phenotypically similar to native buccal tissues. Two controls and three dental materials that are widely used in dentistry were selected for testing. These included a polyethylene film (negative control), 1% Triton X-100 (positive control), resin, denture base resin and impression materials. These three dental materials were prepared according to manufacturers’ instructions, and were turned into 0.7-cm discs in diameter. And then, we directly placed the controls and the three dental materials on the top of each human oral mucosal model for 24 hours and measured tissue viability via the MTT assay and cytokine secretion. When cell viability is less than 50% or cytokine secretion is more than 250 pg/ml, a test material is evaluated as an irritant. The negative control, resin and denture base resin turned out non-irritants while the positive control and the impression materials irritants. Since the results of the oral mucosal irritation test of dental materials using human oral mucosal models matched those of existing cytotoxicity tests, it seems that the oral mucosal test can be a good alternative method. The results of this study suggest that the oral mucosal irritation test employing the 3D human oral mucosal models can be an alternative test method for dental materials. And further validation studies are required in order to take advantage of this method in the future.
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태블릿PC 어플리케이션을 이용한 인지훈련이 뇌졸중 환자의 인지 기능과 우울 및 불안에 미치는 영향
임이원 ( Lim Lee-won ),김윤성 ( Kim Yoon-seong ),김예지 ( Kim Ye-ji ),윤혜영 ( Yun Hye-young ),추선경 ( Chu Sun-kyoung ),최혜림 ( Choi Hye-rim ) 대한인지재활학회 2019 대한인지재활학회지 Vol.8 No.2
본 연구는 태블릿PC 어플리케이션을 이용한 인지훈련이 뇌졸중 환자의 인지와 우울 및 불안에 미치는 효과에 대해 알아보고자 하였다. 재활치료를 받는 뇌졸중 환자 5명을 대상으로 태블릿PC 어플리케이션은 6주간, 주 3회, 1일 30분 동안 실시하였으며, 연구자 1인의 진행 하에 초기 평가 이후 6주 후에 재평가가 이루어졌으며, 본 연구의 모든 평가는 연구자 1인이 단독으로 실시하여 일관성을 유지하도록 하였다. 태블릿 PC를 이용한 인지훈련 실시 전과 후의 한국형간이 정신 상태 검사(MMSE-K)의 점수를 비교한 결과 실시 전 22.40±0.55점에서 실시 후 24.40±0.55점으로 통계적으로 유의미한 증가를 보였다(p= 0.04, p<.05). 한국판 노인형 기호잇기검사(Korean Trail Making Test for the Elderly A; K-TMT-e A)의 점수를 비교한 결과 실시 전 64.63±11.62초에서 실시 후 52.80±11.91초로 통계적으로 유의미한 감소를 보였다(p= 0.04, p<.05). 한국판 노인형 기호잇기검사(Korean Trail Making Test for the Elderly B; K-TMT-e B)의 점수를 비교한 결과 실시 전 136.06±17.65초에서 실시 후 120.65±17.13초로 통계적으로 유의미한 감소를 보였다(p= 0.04, p< .05). 숫자 외우기 검사(Digit Span; DS)의 점수를 비교한 결과 실시 전 3.40±0.55점에서 실시 후 3.80±0.45점으로 점수의 변화는 있었으나 통계적으로 유의미하지 않았다(p= 0.16, p >.05). 벡의 우울 척도 검사(Beck Depression Inventory; BDI) 점수를 비교한 결과 실시 전 21.80±12.19점에서 실시후 20.00±11.33점으로 통계적으로 유의한 감소를 보였다(p= 0.04, p<.05). 벡 불안 척도(Beck Anxiety Inventory; BAI)의 점수를 비교한 결과 실시 전 34.40±13.96점에서 실시 후 29.20±12.97점으로 통계적으로 유의한 감소를 보였다 (p= 0.04, p<.05). 따라서 스마트 기기를 활용한 어플리케이션 기반의 인지훈련이 인지 기능을 향상시킨다는 선행연구에 추가적인 증거를 제공하였을 뿐만 아니라 나아가 뇌졸중 환자의 우울 및 불안과 같은 정서적인 문제에 태블릿 PC가 효과적으로 사용될 수 있을 것으로 사료된다. This study aimed to investigate the effects of cognitive training using a tablet PC application on cognition, depression and anxiety in patients with stroke. In this study, five patients with stroke undergoing rehabilitation received cognitive training using a tablet PC application for 30 minutes per session, three times per week during 6 weeks. An initial evaluation was conducted by one researcher, and then a reevaluation was made six weeks later. All evaluations in this study were conducted by one single researcher to ensure consistency in the evaluation. The results of comparing the MMSE-K scores before and after the cognitive training using a tablet PC application showed that there was a statistically significant increase in the MMSE-K score from 22.40 ± 0.55 points before the intervention to 24.40 ± 0.55 points after the intervention (p=0.04, p <.05). The results of comparing the scores of the Korean version of the Trail Marking Test-A for elderly persons before and after the intervention showed that there was a statistically significant decrease in from 64.63±11.62 seconds before the intervention to 52.80±11.91 seconds after the intervention (p=0.04, p<.05). The results of comparing the scores of the Korean version of the Trail Marking Test-B for elderly persons before and after the intervention showed that there was a statistically significant decrease in from 136.06±17.65 seconds before the intervention to 120.65±17.13 seconds after the intervention (p=0.04, p< .05). The results of comparing the Digit Span (DS) scores before and after the intervention showed that there was a change in score from 3.40 ± 0.55 point before the intervention to 3.80 ± 0.45 point after the intervention, but it was not statistically significant (p=0.16, p >.05). The results of comparing the Beck Depression Inventory (BDI) scores before and after the intervention showed that there was a statistically significant decrease in BDI score from 21.80 ± 12.19 points before the intervention to 20.00 ± 11.33 points after the intervention (p= 0.04, p<.05). The results of comparing of comparing Beck Anxiety Inventory (BAI) before and after the intervention showed that there was a statistically significant decrease in BAI score from 34.40±13.96 to 29.20±12.97 (p= 0.04, p<.05). Therefore, the results of this study provided additional evidence to previous studies revealing that smart device application-based cognitive training improved cognitive function. Furthermore, it is thought that tablet PCs can be effectively used for emotional problems such as depression and anxiety in stroke patients.
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임병인 ( Lim Byung-in ),서혜림 ( Seo Hye-rim ) 한국보건사회연구원 2021 保健社會硏究 Vol.41 No.2
본 연구에서는 미혼 여성의 결혼의향, 기혼여성의 출산, 추가출산의향에 결혼, 자녀, 성역할 가치관이 미치는 효과를 2015년과 2018년의 『전국 출산력 및 가족보건, 복지실태조사』를 사용하여 로지스틱 회귀분석으로 실증하였다. 분석결과, 첫째, 2015년 이후 3년 동안 미혼 여성의 결혼의향과 자녀가 있는 기혼여성의 추가출산의향이 모두 통계적으로 유의하게 낮아졌다. 둘째, 미혼 여성과 자녀가 없는 기혼여성은 취업한 경우 결혼, 출산의향에 긍정적이고, 자녀가 있는 기혼여성은 결혼 당시 자가에 거주할 경우 추가출산의향이 더 높았다. 이는 첫 자녀출산 결정에는 취업여부, 첫 자녀 이후 추가출산 결정에는 주거상황이 영향을 줄 수 있음을 보여준다. 셋째, 미혼 여성은 전통적 가족가치관에 긍정적일수록 결혼의향이 높았지만, 기혼여성의 출산의향에 가치관이 주는 방향은 일관되지 않고 혼재되어 있다. 넷째, 국가의 결혼, 출산, 육아에 관한 지원정책이 필요하다고 생각하는 미혼 여성과 기혼여성이 증가하였고, 더 나아가 국가의 적극적인 지원정책이 결혼의향과 추가 출산의향을 높이는 것으로 나타났다. 이상에서 미혼여성과 자녀가 없는 기혼여성에게는 고용안정에 대한 실효성 있는 정책, 자녀가 있는 기혼여성에게는 현재의 주거안정정책을 보완, 강화할 필요가 있다는 정책적 시사점을 도출할 수 있다. We examined if the values women have of marriage, childbirth, and gender role affect their intention to marry and to have children. For our analysis, we used logistic regression estimation and multiple regression on data from the 『National Survey on Fertility and Family Health and Welfare』 of 2015 and 2018. Empirical findings are as follows: first, both unmarried women’s intention to marry and married women’s intention to have an additional childbirth has declined to a statistically significant extent since 2015. Second, in both unmarried women and married women without children, being in employment positively affected the intention both to marry and to have a child. Among married women with children, being in employment did not affect the intention to have another child. Having a home of one’s own was associated with increased intention to have a child. Third, the more positive unmarried women were about family values in the traditional sense, the higher their intention to get married. Married women, however, appeared to have inconsistent and mixed values affecting their intention to give birth. Fourth, an increasing proportion of unmarried or married women were found to think that promoting marriage and childbirth should require the increased support from the government. In conclusion, effective policies for job security are needed for both unmarried women and married women without children. For married women with children, there is a need for strengthening on-going housing policies.
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5·31 교육개혁이 남녀 대학생 수에 미친 차별적 효과분석
임병인 ( Byung In Lim ),서혜림 ( Hye Rim Seo ) 한국경제통상학회 2021 경제연구 Vol.39 No.3
본 연구는 1980년도부터 2018년도까지 총 39개년의 시계열 자료를 ARDL-UECM 모형에 적용하여 5·31 교육개혁으로 도입된 교육정책(대학설립준칙주의, 수시 전형)과 다른 사회경제적인 변수들이 남녀 대학생 수에 미친 장기관계를 추정하여 그 결과들을 분석하였다. 추정결과, 첫째, 대학 설립준칙주의 시행과 수시 전형제도는 남녀 대학생 수에 모두 양(+)의 영향을 미치나, 여자 대학생에게 더 큰 양(+)의 영향을 끼쳤다. 이로써 5.31 교육개혁으로 인해 도입된 대학설립 준칙주의와 수시 전형제도는 여자 대학생에게 더 큰 혜택으로 돌아갔음을 알 수 있다. 둘째, 가구원 수가 줄어들수록, 실질 가구소득이 증가할수록 남녀 대학생 수가 증가하였지만, 여자 대학생 수에 더 큰 영향을 주었다. 이는 남아 선호 인식 약화와 자녀 수 감소와 소득증가로 성별과 무관하게 자녀에 대한 교육 투자를 증가시켰기 때문이라고 보인다. 이상에서 5.31 교육개혁으로 인해 도입된 두 정책과 사회경제적인 변화가 남녀 대학생의 증가에 기여하였지만, 여자 대학생에게 상대적으로 더 유리하여 여자의 대학진학률이 1990년대 후반부터 급격하게 증가하여 2005년 남자를 추월한 뒤 그 추세를 유지하고 있는 현상을 설명해준다. 또한, 5.31 교육개혁 수혜자 집단으로서의 여자 대학생 증가가 2000년대 이후 여성의 경제활동 참가율 증가에 기여하면서 경제 활동 참가율의 남녀 격차 축소에 일정 정도 기여하고 있다는 정책적인 시사점을 도출할 수 있다. This study applies the 39 years time-series data(1980-2018) to the ARDL-UECM model, and estimates the long-term relationship if two educational policies, i.e., the university establishment rules and the early admission introduced by the 5.31 education reform, have an impact on the number of male and female university students. Empirical findings are as follows: first, the 5.31 education reform policy benefits female university students bigger than male students. Second, the less the number of households, the more the household income, the higher the number of both male and female university students, also meaning that these have greater impact on the number of female university students than male. It results from weakening the perception of preference for boys, a decrease in the number of children, and an increase in income. In these contexts, it can be said that both two policies and socio-economic changes are also beneficial to female university students, and further, the reason why women's university enrollment rate has increased rapidly since the late 1990s, overtaking male students’ rate in 2005 and then maintained those trends. In addition, we derive another following policy implication: more female students have entered the labor market since the 5.31 education reform than before, and thus led to the participation rate of women in economic activity higher, and then contributed to narrowing the gap between male and female’s participation rate.
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