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당뇨 환자에서 활차 운동 후 혈중 t-PA 및 PAI-1 의 변화
최정혜(Jung Hye Choi),김순길(Sun Gil Kim),이응수(Woong Soo Lee),김태화(Tae Wha Kim),김태영(Tae Young Kim),신진호(Jin Ho Shin),이재웅(Jae Ung Lee),김경수(Kyung Soo Kim),김정현(Jeong Hyun Kim),임헌길(Heon Kim Lim),이방헌(Bang Hun Lee) 대한내과학회 1999 대한내과학회지 Vol.56 No.5
N/A Objectives : Plasma fibrinolytic activity is determined by the balance between plasmonogen activators and their inhibitors. The aim of this study was to compare the fibrinolytic activity before and after exercise of the type 2 diabetic patients with control group. Methods : We measured plasma tissue-plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) antigen before and after standardized treadmill exercise in 21 type 2 diabetic patients (14 men, 11 women, ages 46.2±5.6 years) and 21 sex and age- matched control group (10 men, 11 women, ages 48.6±5.4 years). Results : 1) Post exercise t-PA antigen increased in both diabetic group (from 7.36±3.89 to 10.62±4.81 ng/ml, p<0.05) and control group (from 8.30±3.99 to 10.99±5.52 ng/ml, p<0.05). But the rise in t-PA antigen with exercise was similar in both group. 2) Both base line and post exercise PAI-1 antigen levels were similar between the diabetic group (from 29.46±10.35 to 31.48±12.94 ng/ml, p>0.05) and control group (from 30.04±10.40 ng/ml to 31.06±10.88 ng/ml, p>0.05). 3) In diabetic group, significant correlations between base line PAI-1 antigen levels and serum triglyceride levels were observed. And post exercise PAI-1 antigen levels were correlated with systolic blood pressure. Conclusion : The results show that plasma t-PA antigen level is increased after vigorous exercise in patients with type 2 diabetes mellitus and plasma PAI-1 antigen level is not changed. The increment of plasma t-PA level is not different with healthy subjects.
Bacillus sphaericus ts-U311의 단백질 합성변화의 전기영동적 분석
임헌길,황성희,이형환 建國大學校基礎科學硏究所 1992 理學論集 Vol.17 No.-
Bacillus sphaercus 1593 K-5와 ts-U311의 총 세포 단백질을 전기영동적인 방법으로 비교했다. 1. B. sphaercus 1593 K-5와 ts-U311의 총 단백질간에는 분자량과 등전점에서 많은 차이가 있었으나,동일 균주에서는 성장온도 변화에 따른 단백질 양상에서 거의 차이가 없었다. 2.B.sphaericus 1593 K-5는 분자량이 최고 225Kd에서 최저 13Kd에 걸쳐 총 26개 밴드가 분리되었고,ts-U311 은 최고 220K 달톤에서 최저 13.5K달톤까지 24개 밴드가 분리되었드며, 두 균주의 단백질은 분자량이 150,94,77,57,40,32,19Kd인 곳에서 존재유무와 양에 차이가 있었다. 3. B.sphaericus 1593 K-5 ts-U311은 pH 4.2에서 pH 4.8 사이에서 등전점을 가지는 단백질이 이차원젤상에 나타나지 않았으나, B.sphaericus 1593 K-5는 진하게 염색된 4번과 5번 단백질 점이 나타났다. 4. 이차원젤 상에서 두 균주의 단백질 종류의 차이점은 다음과 같다. 4번,5번,12번,19번,20번,21번은 B.sphaericus 1593 K-5에 존재하나 ts-U311에는 없었고, 36번,37번,38번,39번은 ts-U311에는 존재하지만 B.sphaericus 1593 K-5에는 없었다. 또한,3번,6번,27번,28번,29번,35번은 단백질의 양에서 차이가 있었고,여러 곳에서 전개위치가 약간씩 다르게 나타났다. 5.B.sphaericus 1593 K-5의 단백질 중에서 분자량이 150Kd인 것이 독소인 것으로 확인되었고 ts-U311에서는 이 단백질이 없었다. 생체검정시험에서도 B.sphaericus 1593 K-5는 강력한 독성을 보였지만 ts-U311은 전혀 독성이 없었다. Protein syntheses by B. sphaericus 1593 wild type strain and ts-U311 mutant were studied by gel electrophoretic analysis. The protein patterns of the two strains were different in the molecular weight bands of 150,94,77,57,40,32 and 19 kilodaltons by SDS-polyacryl-amide gel electrophoresis analysis. In the isoelectric-focusing the proteins from B. sphaericus ts-U311 were not banded in the pH ranges 4.2 to 4.8 In the analysis of two-dimentional polyacrylamide gel electrophoresis the wild type strain had number 4,5,12,19,20 and 21 sptted proteins, but the ts-U311 did not. Number 36,37,38 and 39 spotted proteins were produced from the proteins of ts-U311,but the wild type strain did not. The 150 Kd protein from B.sphaericus wild type strain was toxic to the larvae of Culex pipiens, but it was not produced from the B.sphaericus ts-U311.
김종표,김순길,오승일,박준성,김동욱,이재형,이 상,이재웅,김경수,이철범,김정현,임헌길,이방헌 한양대학교 의과대학 2002 한양의대 학술지 Vol.22 No.2
Hemorrhages are the main complications associated with oral anticoagulant therapy. Spontaneous intramural small bowel hemorrhage is considered to be a rare but clinically serious problem. The exact pathogenesis of these complications is unknown. Neither the clinical nor the laboratory and radiologic features are in themselves diagnostic of intramural hematoma, but if a patient receiving anticoagulant therapy is suspicious to have hemorrhagic complications, then radiological workup of the patient including abdominal ultrasound and a CT scan should be considered. The management of patients with proved or suspected anticoagulation associated intramural hemorrhage of the small intestine is conservative, but surgery should be contemplated if the patient's condition does not improve when the anticoagulant is withdrawn. A 75-year-old female patient who received anticoagulant therapy with warfarin due to atrial fibrillation, mitral stenosis and aortic regurgitation was admitted to our hospital because of abdominal pain. A pre-contrast abdominal CT scan revealed intramural hematoma of small intestine. After immidiate cessation of the anticoagulant and conservative treatment with transfusion, the patient was improved. Therefore, we report the clinical course of the patient and review literatures.
홍택원,김순길,김태엽,정재면,고동희,이재웅,김경수,김정현,임헌길,이방헌,이철범 한양대학교 의과대학 2002 한양의대 학술지 Vol.22 No.2
Spontaneous coronary artery dissection is a rare cause of myocardial infarction. It occurs in relatively young people with a striking predilection for women, mainly during or after prognancy. The optimal management of spontaneous coronary artery dissection has not been established yet and may vary, depending upon the presence of intimal versus extramural compromise. Coronary artery bypass, stenting, and thrombolysis may have been successful and also may have failed, owing to extension of dissection. We describe a case of acute myocardial infarction caused by spontaneous coronary artery dissection which occurs in a 51-year old man. The coronary angiography showed a spiral dissection of right coronary artery, from the origin of conus branch to the distal portion of right coronary artery. An intimal plaque with 35% obstruction and normal (TIMI 3) flow was demonstrated. The patient was functionally recovered after conventional midical treatment including heparin, beta blockers and long acting nitrates. Four months later, follow up coronary angiography showed stabilization of coronary lesion and improvement of stenosis.