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各種 血液疾患의 Erythropoietin活性値에 關한 硏究
林學權 慶北大學校 醫科大學 1967 慶北醫大誌 Vol.8 No.2
Using incorporation of Fe^59 into erythrocytes of starved rats, erythropoietin activity was assayed in plasma of 10 normal male subjects serving as control and 115 patients with a variety of hematologic disorders. Highest activity was found in patients with aplasic anemia. Moderately high activity was observed in subjects with acute posthemorrhagic anemia, acute leukemia, splenic anemia and iron deficiency anemia. Assays in patients with hemolytic anemia and chronic myelogenous leukemia revealed slightly elevated levels. These studies demonstrated that as the severity of anemia increased, the activity of erythropoietin in plasma increased proportionately, and also as hemoglobin values decreased below 6 or 7 gm % patients with aplastic anemia, iron deficiency anemia as well as splenic anemia showed an abrupt and marked rise in erythropoietin activity. A log dose response relationship was noted between erythropoietin activity and marrow erythroid count of the rats infused with the plasma of the patients with iron deficiency anemia and aplastic anemia.
간세포암의 Type Ⅳ Collagen 및 Fibronectin의 분포에 관한 면역조직화학적 검색
허방,임학,허만하 고신대학교 의학부 1992 高神大學校 醫學部 論文集 Vol.8 No.1
It is well known that some of the basement membrane glycoproteins are sysnthesized and expressed in neoplastic hepatic tissue in spite of absence of an intact, organized basement membrane in the normal liver parenchyma. In an attempt to examine the distribution and expression patterns of basement membrane glycoproteins in hepatocellular carcinoma (HCC), immunohistochemical localization of type Ⅳ collagen and fibronectin is performed. Fifty cases of HCC are histologically analy zed and paraffin-embedded sections are immunostained with monoclonal antibodies to type Ⅳ collagen and fibronectin(Avidin-Biotin-Peroxidase Complex). Positive reactions to type Ⅳ collagen and fibronectin are obsewed in extracellular spaces. Intracellular expression of fibronectin in some cases is observed. The distribution patterns of these glycoproteins are categorized into four locations : pericsinusoidal(Pattern Ⅰ), periacinar(Pattern Ⅱ ), stromal(Pattem Ⅲ), and pericellular (Pattem Ⅳ) areas. patterns Ⅰ and Ⅱ are distributed throughout the lesion, while patterns Ⅲ and Ⅳ are observed in focal areas of the neoplastic tissues. These findings suggest that deposition of basement membrane glycoproteins in the extracellular matrix may be related to the histologic types of HCC. In well-differentiated neoplastic cells(Edmondson grades I and Ⅱ) organized in trabecular and/or acinar pattern, type Ⅳ collagen and fibronectin are always detected in the sinusoidal surface as pattern Ⅰand/or Ⅱ. In normal liver prenchyma, type Ⅱ collagen and fibronectin are also expressed in the sinusoidal surface. However, in less-differentiated neoplasms(Edmondson grades Ⅲ and Ⅳ), sinusoids are almost absent and only fibrotic stroma with vascularized connective tissue is reactive to type Ⅳ collagen and fibronectin. These findings suggest that the expression of basement membrane glycoproteins may be influnced by the degree of differentiation. Intracellular expression of fibronectin is noted in 30 cases of hepatocellular carcinoma(60% ), while it is not observed in normal liver cells. The expression modes can be classified into 3 patterns : 1) scattered, 2) stromal interface, or 3)mixed pattern. The stromal interface pattern is frequently observed in highly differentiated tumors and clear cell type of HCC. The significances of these findings are remained to be resolved.