http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
원저 : LC-MS/MS를 이용한 돈육에서 퀴놀론계 약물의 동시 잔류 분석법
임채미 ( Chae Mi Lim ),권현정 ( Hyun Jeong Kwon ),조병훈 ( Byung Hoon Cho ),박수정 ( Su Jeong Park ),정갑수 ( Gap Su Chung ),손성완 ( Seong Wan Som ) 한국수의공중보건학회 2010 예방수의학회지 Vol.34 No.4
A reversed-phase high-performance liquid chromatography with tandem mass-spectrometric detection was developed and validated for the simultaneous analysis of 13 quinolones (orbifloxacin, sarafloxacin, marbofloxacin, ofloxacin, enrofloxacin, danofloxacin, pefloxacin, ciprofloxacin, norfloxacin, difloxacin, oxolinic acid, flumequine, nalidixic acid) in pork. The drugs were extracted from homogenized sample using acidic buffer (2% trichloracetic acid) and acetonitrile with ethyl acetate. Analysis was performed by liquid chromatograph with tandem mass spectrometry (LC-MS/MS) in positive mode for all quinolones. Mass spectral acquisition was performed in the multi reaction monitoring mode (MRM), selecting two structurally significant transitions per compound. Good linear relationship (R2=0.999) was observed at 6 concentrations of 2.5~100 ng/g. Satisfied recoveries (73.3~105.4%) of all quinolones were demonstrated in spiked pork at three levels from 5 to 20 ng/g. The limits of quantitation (LOQs) for quinolones ranged from 0.25 to 5.0 ng/g.
LC-MS/MS를 이용한 우유 중 설파제의 동시 잔류 분석법
임채미 ( Chae Mi Lim ),권현정 ( Hyun Jeong Kwon ),조병훈 ( Byung Hoon Cho ),박수정 ( Su Jeong Park ),정갑수 ( Gap Su Chung ),손성완 ( Seong Wan Son ) 한국수의공중보건학회 2010 예방수의학회지 Vol.34 No.3
A simple, selective and sensitive procedure for the confirmation of 14 sulfonamide antibacterials in milk was developed. The milk samples were homogenized, extracted and deproteinized by acetonitrile and defatted by n-hexane. Analysis was performed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) in positive mode for all 14 analytes. Mass spectral acquisition was performed in the multi reaction monitoring mode (MRM), selecting two structurally significant transitions per compound. The calibrations were performed in sample matrixes and the interference effect of sample matrixes on the ionization was effectively eliminated. Good linear relationship (R2=0.992~0.999) were observed at 6 concentrations of 2.5~100 ng/g. Satisfied recoveries (86.3~110.2%) of all sulfonamides were demonstrated in spiked milk at three levels from 5 to 20 ng/g. The limits of quantitation (LOQs) for sulfonamides ranged from 0.25~2.1 ng/g.
LC-MS/MS를 이용한 돼지 근육 및 신장에서 8종 페니실린계 항생물질의 동시잔류분석법
임채미 ( Chae Mi Lim ),권현정 ( Hyun Jeong Kwon ),조병훈 ( Byung Hoon Cho ),박수정 ( Su Jeong Park ),정갑수 ( Gap Su Chung ),손성완 ( Seong Wan Son ) 한국예방수의학회(구 한국수의공중보건학회) 2011 예방수의학회지 Vol.35 No.4
A rapid, simple and reliable LC-MS/MS method, which can be used on a routine basis, was developed for the simultaneous detection of 8 penicillin antibiotics (amoxicillin, ampicillin, penicillin-G, penicillin-V, oxacillin, cloxacillin, nafcillin and dicloxacillin) in swine muscle and kidney. The antibiotics were extracted from samples with water and methanol. The extract was centrifuged, filtered and analyzed by liquid chromatography coupled with a tandem mass spectrometer (LC-MS/MS), using a C18 reversed phase column with water/acetonitrile gradient containing 0.05 % formic acid. Mass spectral acquisition was achieved in an electrospray positive ion mode by applying multiple reaction monitoring (MRM) of 2 fragment ion transitions to provide a high degree of sensitivity and specificity. The ion rations were consistent and could be used for confirmation of identity of the penicillin antibiotics. Recoveries of eight penicillins at three fortification levels (10, 20 and 40㎍/㎏) ranged from 79.8 to 102.4% and 72.8 to 103.4% in swine muscle and kidney, respectively. The coefficient of variation was than 9% in all samples. The estimated limits of quantification (LOQs) ranged from 1.0 to 3.2㎍/㎏in swine muscle and kidney, respectively. The LOQs of this method are below the MRLs of penicillin antibiotics in animal tissues established in Korea and other countries.
Lim, Chae-Mi(임채미),Lee, Jieun(이지은),Lim, Heejin(임희진) 한국소비문화학회 2009 소비문화연구 Vol.12 No.1
본 연구의 목적은 technology market에서 소비자들의 라이프스타일에 기반한 세분집단을 규명하는 것이다. 다단계 군집분석(multi-step cluster analysis)을 사용하여 1,186명의 응답자들을 4개의 차별화된 소비자라이프스타일집단- Smart shoppers, Trendy shoppers, Tech-laggards, and Apathetic shoppers-로 세분화하였다. 4개의 군집 집단들은 가격 의식, 브랜드 의식, 패션 의식 및 기술 혁신성 등의 소비자라이프스타일 변수에서 의미 있는 차이를 보였다. 또한 세분집단간에 다양한 쇼핑관련 태도와 행동을 비교함으로써 소비자라이프스타일 세분화의 타당성을 입증하였다. 분석 결과 각각의 소비자라이프스타일 군집에 속하는 응답자간에 다양한 쇼핑 채널에 대한 인식, 충동구매행동, 그리고 혁신적인 기술 제품들의 소유여부에 차이가 있는 것으로 밝혀졌다. 본 연구의 결과에 기반하여 마케터들을 위한 전략적 시사점이 도출되었다. This study identifies consumer lifestyle segments among consumers of technology market. By using multi-step cluster analysis, this study categorizes respondents (n=1,186) into four distinct consumer lifestyle groups Smart shoppers, Trendy shoppers, Tech-laggards, and Apathetic shoppers. Overall, four cluster groups show significant differences in lifestyle variables such as priceconsciousness, brand-consciousness, fashion consciousness, and technology innovativeness. Consumer lifestyle segmentation is validated by comparing various shopping-related attitudes and behavior across segments. Findings show that respondents in four consumer lifestyle clusters significantly differ from each other in terms of perception of different shopping channels, impulse buying behavior, and ownership of innovative technology products. Based on the results, strategic implications for marketers are discussed.
신동호,임채미,김재하,Shin, Dong-ho,Lim, Chae-mi,Kim, Jae-ha 대한수의학회 1995 大韓獸醫學會誌 Vol.35 No.2
Amitraz frequently causes the side effect of intestinal stasis or bloat in mammals. It is very similar to the side effect of xylazine or clonidine which produce the inhibition of intestinal motility through the stimulation of ${\alpha}_2$ adrenoceptor. Therefore, we examined whether amitraz causes intestinal stasis or bloat through the inhibition of intestinal motility or whether amitraz produces the inhibition of intestinal motility through the stimulation of ${\alpha}_2$ adrenopceptor. Amitraz inhibited the intestinal motility in a dose-dependent manner in isolated rabbit jejunum and isolated pig ileum. These inhibitory effects of amitraz were blocked by yohimbine but not by prazosin. The effect of intestinal contraction of carbachol or high-potassium was not affected by the pretreatment of amitraz. However, the con-traction of histamine was inhibited by the pretreatment of amitraz. It is concluded that amitraz mainly inhibits the intestinal motility through the stimulation of ${\alpha}_2$-adrenoceptor although partially antihistaminic action of amitraz can be involved.