결핵성 흉막염 환자에서 흉수가 폐기능에 미치는 영향에 대한 연구

임정윤 ( Jeong Yoon Yim ),이기현 ( Kee Hyun Lee ),정혜경 ( Hye Kyung Jung ),장중현 ( Jung Hyun Chang ),천선희 ( Seon Hee Cheon ) 대한결핵 및 호흡기학회 1996 Tuberculosis and Respiratory Diseases Vol.43 No.4

건강 검진자에서의 Helicobacter pylori 혈청학적 유병률

임정윤 ( Jeong Yoon Yim ),최승호 ( Seung Ho Choi ),박민정 ( Min Jeong Park ),김영선 ( Young Sun Kim ),임선희 ( Sun Hie Lim ),조경란 ( Keong Ran Choi ),김동희 ( Dong Hie Kim ),김충현 ( Chung Hyun Kim ),정인경 ( In Keong Jung ),최 대한내과학회 2006 대한내과학회지 Vol.70 No.6

목적: 최근 H. pylori 제균 치료가 비교적 흔히 이루어지고 있고, 사회경제적 요소가 향상되고 있어 H. pylori 양성률에 감소가 있을 것으로 예상 된다. 이에 성인 건강 검진자를 대상으로 H. pylori 혈청학적 양성률 및 이에 관련된 인자에 대해 분석해보고자 하였다. 방법: 2004년 11월부터 2005년 6월까지 8개월간 서울대학교병원 강남센터에 건강 검진을 목적으로 내원한 20세 이상의 성인 남녀를 대상으로 하여 H. pylori에 대한 Background: H. pylori-associated gastrointestinal diseases have been widely recognized. The aim of this study was to investigate the seropositivity of H. pylori in health check-up subjects and to find out the relating factors. Methods: From November 2004 t

기관지에서 발견된 점액상피양암 일례

임정윤 ( Jeong Yoon Yim ),손혜영 ( Hye Young Son ),박기령 ( Ki Ryung Park ),이기현 ( Kee Hyun Lee ),신미승 ( Mi Seung Shin ),장중현 ( Jung Hyun Chang ),김광호 ( Kyang Ho Kim ) 대한결핵 및 호흡기학회 1997 Tuberculosis and Respiratory Diseases Vol.44 No.5

Lactobacillus 가 함유된 발효유에 의한 인체 위점막에서의 Helicobacter pylori 억제효과

박민정(Min Jung Park),김주성(Joo Sung Kim),임정윤(Jeong Yoon Yim),정현채(Hyun Chae Jung),송인성(In Sung Song),유은실(Eun Sil Yu),이정준(Jeong Jun Lee),허철성(Chul Sung Huh),백영진(Young Jin Baek) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.4

Background/Aims: The eradication rates of regimens for Helicobacter pylori (H. pylori) infections are still around 85%. Lactobacilli have been demonstrated to have in vivo and in vitro inhibitory effects on H. pylori infection. We aimed to evaluate the inhibitory effect of Lactobacillus on H. pylori in human stomach. Methods: Forty H. pylori-infected volunteers (21-44 yr, F:M=9:31) were randomized into two groups which were treated with 100 mL of fermented milk containing lactobacilli (Lactobacillus acidophilus, Lactobacillus casei) q.I.d. or 100 mL of placebo q.I.d. for 4 weeks. Before and after treatment, they underwent 13C-urea breath tests (13C-UBTs) and endoscopies with biopsies for rapid urease test and histological evaluation. The compliance evaluated via daily checking questionnaire was considered acceptable if they took 90% of assigned treatment. Results: All patients were compliant and the H. pylori density of antrum tended to decrease in treatment group compared with placebo group (p=0.072). Δ13CO2 analyzed by Wilcoxon rank sum test showed a significant decrease in treatment group compared with placebo group (p=0.0064). Three cases in treatment group were noted for negative conversions of both rapid urease test and 13C-UBT. Conclusions: A fermented milk containing lactobacilli may have an inhibitory effect of H. pylori infection and can be an adjunct to the standard anti-H.pylori regimen. (Korean J Gastroenterol 2001;38:233-240)

한국인 비알코올성 지방간 질환 환자에서 P2/MS 및 기타 비침습적 섬유화 지표의 유효성

유수종 ( Su Jong Yu ),김동희 ( Dong Hee Kim ),이정훈 ( Jeong Hoon Lee ),정고은 ( Goh Eun Chung ),임정윤 ( Jeong Yoon Yim ),박민정 ( Min Jung Park ),김윤준 ( Yoon Jun Kim ),윤정환 ( Jung Hwan Yoon ),장자준 ( Ja June Jang ),이효석 ( 대한소화기학회 2011 대한소화기학회지 Vol.57 No.1

Background/Aims: P2/MS is a noninvasive marker for detecting hepatic fibrosis in patients with viral hepatitis. However, the applicability of P2/MS in patients with nonalcoholic fatty liver disease (NAFLD) has not yet been validated. This study aimed to validate P2/MS and compare it to other noninvasive fibrosis scoring systems in Korean patients with NAFLD. Methods: Consecutive patients who underwent liver biopsy between January 2002 and December 2009 at Seoul National University Hospital, Seoul, Korea were enrolled in this study. Fibrosis stage was determined using the METAVIR scoring system. Results: A total of 235 patients were included in the study: advanced fibrosis (METAVIR F3-F4) was present in 7 patients. No patient was over-staged among 162 patients with a P2/MS score above the high cut-off (95), resulting in a high negative predictive value (NPV) of 100% (95% confidence interval, 97.1-100). There was no significant difference between the area under the receiver-operating characteristic curve (AUROC) of the FIB-4 (0.964) and the AUROC of the NAFLD fibrosis score (0.964) or P2/MS (0.940) for detecting advanced fibrosis. If P2/MS was implemented in the Korean patients with NAFLD, 68.9% of liver biopsies might be avoided. Conclusions: P2/MS has a high NPV for excluding advanced fibrosis in Korean patients with NAFLD, and can reduce the burden of liver biopsy in the majority of cases. Since there were few patients with advanced fibrosis, further studies are warranted in a cohort including more patients with advanced fibrosis to validate the low cut-off value. (Korean J Gastroenterol 2011;57:19-27)

여성에서 우울이 위장관 증상에 미치는 영향

조경란 ( Kyung Ran Cho ),이오영 ( Oh Young Lee ),윤대현 ( Dae Hyun Yoon ),임선희 ( Seon Hee Lim ),박민정 ( Min Jung Park ),임정윤 ( Jeong Yoon Yim ),김영선 ( Young Sun Kim ),김충현 ( Chung Hyeon Kim ),김동희 ( Dong Hee Kim ),양선 대한소화기기능성질환·운동학회 2007 Journal of Neurogastroenterology and Motility (JNM Vol.13 No.2

목적 : 기질적인 요인으로 설명이 어려운 위장관 증상이 있는 경우 정신적 질환과의 관련성이 있다고 알려져 있다. 그러나, 대부분 연구에서 병원을 방문한 환자들을 대상으로 하여 정신사회학적 요인이 병원 방문의 주요 요소로서 작용할 수 있다는 선택편향을 배제하지 못했다. 본 연구는 일반인을 대상으로 시행한 건강검진에서 우울 증상을 가진 여성들의 위장관 내시경 소견의 특징을 알아보고 우울과 위장관 증상과의 연관성을 알아보고자 하였다. 대상 및 방법 : 2004년 10월 1일부터 2007년 3월 31일까지 건강 검진자들 중 설문에 응한 여성 8169명을 대상으로 상부 및 하부 내시경을 시행하고 Beck 우울 척도(Beck Depression Inventory, BDI) 및 13개 위장관 증상을 설문하였다. BDI 점수에 따라 우울 증상의 정도를 정상(<10점), 경도(10~15점), 중등도(16~23점) 및 중증(>23점)으로 나누었고 16점 이상인 집단을 우울군으로, 그 미만인 경우를 비우울군으로 하여 위장관 내시경 소견과 위장관 증상을 비교하였다. 결과 : 우울군은 1460명(17.9%)이었고 비우울군은 6709명(82.1%)이었다. 상부 및 하부 내시경 소견은 모두 두 군 간 차이가 없었다. 우울군(77.2%)에서 비우울군(56.9%)보다 위장관 증상 호소가 많았고 우울 점수가 높을수록 위장관 증상 호소가 많았다. 또한, 각각의 위장관 증상의 호소도 우울 점수가 높을수록 많았다(정상 51.0%, 경도 69.0%, 중등도 76.9%, 중증 79.0%, p<0.001). 위장관 증상 호소는 우울군에서 비우울군보다 2.6배 많았다(CI 2.3-3.0, p<0.001). 결론 : 우울 성향을 보이는 여성들은 특정 내시경 소견과는 관련 없으나 우울하지 않은 경우보다 위장관 증상 호소가 많고 우울 정도에 따라 증상 호소도 증가했다. 우울이 병원으로 내원하게 만드는 요인일 뿐 아니라 위장관 증상 호소에 중요한 영향을 미친다고 할 수 있어 위장관 증상을 보이는 여성들의 관리에 정신사회학적인 접근이 중요하다 하겠다. Background/Aims: Patients with unexplained gastrointestinal symptoms often have psychiatric diseases, but most of the studies about the association of gastrointestinal symptoms and psychiatric illness were undertaken in the clinical setting of referred hospital. The aim of this study was to determine the relationship between depression and gastrointestinal symptoms in addition to endoscopic findings in women of healthcare screening. Methods: Total 8169 women were included in this study with either an upper or lower endoscopy for a health check-up and completed questionnaires including Beck Depression Inventory (BDI) for evaluation of depression and a list of 13 gastrointestinal symptoms. BDI score ≥16 was defined as depressed and <16, as non-depressed. Results: Among them, 1460 women were depressed, and 6709 women were non-depressed. There were no significant differences in upper and lower endoscopic findings between two groups. Depressed women complained of gastrointestinal symptoms more frequently compared to non-depressed women (77.2% vs. 56.9%) and this difference was observed in all 13 gastrointestinal symptoms. The incidence of women complaining of gastrointestinal symptoms increased as BDI score increased; Fifty-one percent of them had gastrointestinal symptoms in BDI score <10, 69% in 10~15, 77% in 16~23, and 78% in ≥24. Depressed women had more chance of having gastrointestinal symptoms by 2.6 folds compared to non-depressed women (CI 2.3-3.0). Conclusions: Although depressed women did not have specific endoscopic findings compared with non-depressed women, they complained of gastrointestinal symptoms more frequently, according to the severity of depression. (Kor J Neurogastroenterol Motil 2007;13:146-151)

비만과 흡연이 한국인 성인에서 기관지과민성의 발생에 미치는 영향

김선신 ( Sun Sin Kim ),최승호 ( Seung Ho Choi ),박민정 ( Min Jeoung Park ),김영선 ( Young Sun Kim ),임정윤 ( Jeong Yoon Yim ),임선희 ( Seon Hee Lim ),장윤석 ( Yoon Seok Chang ),김윤근 ( Yoon Keun Kim ),신찬수 ( Chan Soo Shin ) 대한천식알레르기학회 2005 천식 및 알레르기 Vol.25 No.3

건강검진 수진자들에서 성별, 나이 및 체질량지수에 따른 간효소치의 상세 분포 연구

최승호 ( Seung Ho Choi ),양종인 ( Jong In Yang ),이창현 ( Changhyun Lee ),변희진 ( Hee Jin Byun ),강정묵 ( Jung Mook Kang ),김세룡 ( Se Young Kim ),임정윤 ( Jeong Yoon Yim ) 대한소화기학회 2014 대한소화기학회지 Vol.64 No.4

Background/Aims: The aim of this study was to examine the distribution of range of liver enzymes according to age and BMI in each gender using large-scale data. Methods: Data were gathered from 65,715 subjects who underwent a routine health check-up and did not have HBsAg and anti-HCV. Boxplot analysis was used to examine the distribution of range of liver enzymes according to age and BMI in each gender. Multivariate linear regression analysis was performed for assessment of the association of liver enzymes with age and BMI, and to determine whether the range of liver enzymes was affected by risk factors for metabolic syndrome in each gender. Results: ALT, AST, and GGT levels showed significant association with BMI in both male and female after adjusting for age. The range of ALT, AST, and GGT levels varied more widely according to the increase in BMI in males than in females, and this finding was more prominent in younger subjects than in older subjects. All risk factors for metabolic syndrome were shown to affect liver enzyme levels in male subjects. However, although most risk factors for metabolic syndrome affected liver enzyme levels, there might be weak or no effect of fasting hyperglycemia on AST, and low serum HDL-cholesterol level on GGT in female subjects. Conclusions: Age, BMI, and other risk factors for metabolic syndrome had a significant effect on the distribution of range of liver enzymes in each gender, even in this study conducted from Korean health checkup subjects. (Korean J Gastroenterol 2014;64:213-223)

위장관 ; 대장 선종 환자의 식이 위험요인에 관한 연구

양선영 ( Sun Young Yang ),김영선 ( Young Sun Kim ),송지현 ( Ji Hyun Song ),정수진 ( Su Jin Chung ),이인희 ( In Hee Lee ),홍경주 ( Kyoung Ju Hong ),이은정 ( Eun Jung Lee ),김동희 ( Donghee Kim ),임정윤 ( Jeong Yoon Yim ),박민정 ( M 대한소화기학회 2012 대한소화기학회지 Vol.60 No.2

Background/Aims: The role of dietary risk factors in colorectal carcinogenesis remains unclear. We investigated the association between dietary intakes and colorectal adenomas who visited a health promotion center for a routine health check-up colonoscopy. Methods: We conducted a retrospective case-control study using data from individuals who had colonoscopy at Seoul National University Hospital Healthcare System Gangnam Center from October 2003 to December 2007. The subjects were 242 patients (162 males and 80 females) with histopathologically confirmed colorectal adenoma, and 464 (272 males and 192 females) controls. Dietary data were obtained via 24 hour dietary recall, assisted by a registered dietitian. The student`s t-test and the chi-square test were performed for the statistical comparison of means and proportions among groups. Multivariate analyses using logistic regression were performed to assess the relation between dietary intake and colorectal adenoma. Results: The total average energy intake of the patients (male: 2,407.5±429.2 kcal, female: 1,901.3±316.9 kcal) was higher than the controls (male: 2,249.6±430.4 kcal, female: 1,752.4±275.0 kcal; p=0.001). High energy intake (male: OR=4.13, 95% CI=1.70-10.05, p=0.002; female: OR=4.00, 95% CI=1.51-10.61, p=0.005) and animal protein intake (male: OR=3.97, 95% CI=1.66-9.49, p=0.002; female: OR=5.76, 95% CI=1.99-16.169, p=0.001) were found to be associated with the risk of colorectal adenoma after adjusting for confounders such as age, BMI, waist circumference, metabolic syndrome and smoking. Conclusions: In summary, high energy intake and animal protein were associated with colorectal adenoma. (Korean J Gastroenterol 2012;60:102-108)

새로운 신속요소분해효소 검사인 HP™ 검사와 CLO™검사의 유용성 비교

임정윤,안영미,김도영,문일환 梨花女子大學校 醫科大學 醫科學硏究所 1999 EMJ (Ewha medical journal) Vol.22 No.4

신속분해요소 검사는 위장질환에서 H. pylori의 감염을 진단하는데 있어서 가장 흔하게 사용하는 기본적인 방법으로 여러 가지 제품들이 소개되고 있다. CLO^TM 키트는 우리나라에서 가장 흔하게 사용되는 제품이나 수입품으로 최근 국내에서(종근당) 이와 유사한 원리로 보다 신속하게 감염여부를 판별할 수 있으며 한 개의 키트로 2개의 조직을 검사할 수 있는 장점으로 소개된 HP^TM 키트가 출원되었다. 이에 저자들은 HP검사를 CLO검사와 비교하여 반응 속도를 관찰하고 위전정부 및 체부에서 동시에 검사는 것이 장점이 있는지 알아보고자 하였다. 내시경 검사를 시행받은 108명의 환자를 대상으로 하여 3개의 조직을 얻었는데 두 개는 위전정부 대만측의 서로 인접한 부위에서 얻어 HP검사와 CLO검사에 이용하였고 다른 한 개는 위체중부 소만측에서 얻어 HP검사를 시행하였다. 각각에서 20분, 1시간, 3시간 및 24시간에서 양성유무를 판정하여 다음과 같은 결과를 얻었다. 1) 위전정부에서 시행한 CLO검사의 양성률은 49.1%(53/108), HP검사는 49.1%(53/108)였고, 두 검사의 결과 일차율은 98.1%였다. 2) 시간별로 반응속도 관찰시 위전정부에서 시행한 CLO 검사와 HP검사의 3시간 양성률은각각 92.5%, 94.4%로서 유의한 차이가 없었다(p=0.696) 24시간까지 반응을 관찰한 결과 HP검사 3예(5.6%)에서 양성반응이 관찰되었고 CLO검사는 4예(7.5%)에서 양성이었다. 3) 위체부 HP검사의 양성율은 108명중 57예로 52.8%였다. 위전정부와 체부의 일치율은 94.5%였다. 위전정부는 양성이나 체부 음성은 1예(0.9%), 위선정부는 음성이나 위체부 양성은 5예(4~6%)였고 이 5예는 위전정부에서 시행한 CLO검사도 음성이었다. 이상의 결과로 국내에서도 최근 개발된 HP검사는 두개의 조직을 검사할 수 있는 장점으로 검체오류를 줄일수 있을 것이며 CLO검사와 유사한 반응속도로 뒤지지 않는 가치가 있으나 최종판독시간의 재검토가 필요하다고 생각된다. Although CLO test is one of the most commonly used rapid urease test for the diagnosis of Helicobacter(H.) pylori infection. Recently a Korean company, Jongkeundang, has succeeded in manufacturing the rapid urease test and named it as HP^TM test. The advantages of HP test are to have two agar gels in a plate and react faster in despite of same cost with CLO test. We performed this study to compare the results of the HP test with those of the CLO test and know if there is any advantage of using two biopsy samples instead of using only one sample. One hundred and eight patients underwent gastroscopy and two biopsy specimens from the greater curvature of the antrum was used for HP test and CLO test. Another biopsy specimen from lesser curvature of midbody was used for HP test. We read them at 20min, 1hour, 3hours, and 24hours. The positive rate of HP test in antrum was 49.1%(53/108) which was the same as CLO test in antrum. The concordance rate of the results of two tests in the same site(antrum) were 98.2%. In terms of a time change to a positive test, both tests were not significantly different with each other. ; 3hour positive rate of HP test was 94.4% and that of HP test was 92.5%. Four patients(5.6%) performed HP test had positive results after 2hours known final reading time. The positive rate of HP test in body was 52.8%(57/108) and that of HP test in antrum or body was 53.7%(58/108). The concordance rate of the results of antrum and body in HP test was 94.4%. Five of the negative HP test in antrum(4.7%) had positive results in gastric body. They were negative CLO test in antrum. In conclusion, HP test was thought to be as valuable as CLO test for the diagnosis of H. pylori infection and has a merit of decreasing sampling error by using two samples, even though it is a little. However, It had not quicker time to positivity than CLO test and might have false negative results if it were read at 2hours after reaction. So, Final reading time should be reevaluated.