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임영권,정지아,윤철상,허광욱,이훈,김호철,김영란,조윤희,Lim, Young-Kwon,Jung, Ji-A,Yun, Cheol-Sang,Hur, Kwang-Wook,Lee, Hun,Kim, Ho-Chyul,Kim, Young-Ran,Cho, Yun-Hi 대한한방소아과학회 2006 대한한방소아과학회지 Vol.20 No.3
Objectives : The purpose of this study is to determine clinical efficacy of herbal medicine by evaluating SCORAD Index and total level of ceramaides in the skin of 13 children with atopic dermatitis Methods : Subjects are divided into two groups : Group 1(non-differentiation children treated with Saenghyeoryunbueom) and group 2(differentiation children treated with either pyungwisan, onchungum or gamitongsungsan). We determine SCORAD Index and total level of ceramaides in the skin of 13 children with atopic dermatitis before and after taking each of herbal treatment for 12 weeks. Results : After herbal prescription for 12 weeks, A SCORAD index of both group 1 and group 2 was decreased. However, the total level of ceramides in group 1 and group 2 was not altered after 12 weeks. When the correlation between the alteration of SCORAD index and ceramides levels was determined, the SCORAD index in group 1 was inversely correlated with the total level of ceramides(r=-0.994, p=0.006) In contrast, the alteration of SCORAD index in group 2 was not correlated with ceramide levels. Conclusions : The clinical efficacy of Saenghyeoryunbueom for non-differentiation children with atopic dermatitis is paralleled with the increased level of ceramides in skin. The clinical efficacy of pyungwisan, onchungum or gamitongsungsan for differentiation children with atopic dermatitis is not correlated with ceramide level in skin.
비.부비동염으로 내원한 소아환자들의 치료 유형별 만족도와 치료 평가
임영권,김현경,허광욱,정지아,이훈,윤철상,김호철,Lim, Young-Kwon,Kim, Hyun-Kyung,Hur, Kwang-Wook,Jung, Ji-A,Lee, Hun,Yun, Cheol-Sang,Kim, Ho-Cheol 대한한방소아과학회 2007 대한한방소아과학회지 Vol.21 No.3
Objectives The purpose of this study is to investigate the effects of simultaneous treatment with supplementary therapy and treatment interval for improving symptoms and satisfaction rate by treating child rhinitis or paranasal sinusitis patients. Methods 41 rhinitis or paranasal sinusitis patients who visited the clinic between April 2004 and April 2006 were involved for this study. The patients were classified into Group A(2 sessions per week, simultaneous supplementary therapy), Group B(1 session in 2 weeks, simultaneous supplementary therapy) and Group C(1 session in 2 weeks, no supplementary therapy). After the experiment, the improvement rates of symptoms and satisfaction rate were surveyed by the questionnaires. Supplementary therapies used in Group A and B were aroma spray, Saengbit-patch, cutaneous acupuncture, nebulizer and Chuna manipulation. Results From 41 of the rhinitis or paranasal sinusitis patients, the Group A(simultaneous treatment group, 2 sessions of intensive care per week with supplementary therapy) showed the remaining symptoms score of $12.1{\pm}10.0$ in average. This score was the lowest comparing with the average of $25.7{\pm}12.9$ in Group B(1 session in 2 weeks, simultaneous treatment group with supplementary therapy) and the average of $21.0{\pm}20.1$ in Group C(1 session in 2 weeks, no supplementary therapy). Nose symptoms and sleep scores were significantly lower in Group A(p<0.01). The satisfaction score was the highest in Group B that had the most remaining symptoms and it had no significant relationship with the symptom improvement. Additional analysis showed that among many factors such as treatment interval, treatment method, cost, accessibility of the clinic, family history and satisfaction with the doctor; the satisfaction with their doctor was the most closely related to the satisfaction rate of the patients. Conclusions In this study with 41 of rhinitis or paranasal sinusitis patients, the 2 sessions of intensive care group showed the best results in improving symptoms. Supplementary treatments were also used simultaneously; aroma spray, cutaneous acupuncture, Saengbit-patch, Chuna manipulation and nebulizer. The questionnaires showed that the satisfaction rate of the patients(care taker) was not related to the symptom improvement. Additional analysis of the factors that influence the satisfaction rate showed that it was more closely related to the satisfaction with their doctors.
수치방법(修治方法)에 따른 반하(半夏) 추출물(抽出物)의 마우스 단회투여독성실험(單回投與毒性實驗)
임영권 ( Young Kwon Lim ),이상남 ( Sang-nam Lee ),박지하 ( Ji-ha Park ) 한약응용학회 2020 한약응용학회지 Vol.20 No.2
Objective : The object of this study was to evaluate the single dose toxicity of Pinelliae Rhizoma(PR) according to processing methods in ICR mice. Methods : In order to observe the change of acute toxicity of PR according to the processing methods, Aqueous extracts of three different processing PR were administered to female and male ICR mice at dose levels of 2000 ㎎/㎏ (body weight) according to the recommendation of Korea Food and Drug Administration (KFDA) Guidelines (2009-116, 2009). The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after dosing, histopathological observations of 12 types of principle organs were examined. In addition, the changes on the serum biochemistry related to the hepatic damages - serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin and alkaline phosphatase (ALP) were also observed. Results : After single oral treatment of three different PR aqueous extracts, we could not find any mortality and toxicological evidences to 2000 ㎎/㎏ in both female and male mice, No remarkable changes on the serum AST, ALT, albumin and ALP levels were also demonstrated in this study. Conclusion : The results obtained in this study suggest that the toxicity of PR were also reduced by all three different processing methods used in this study. There were no evidences indicating the hepatic damages as well. However, previous study about the not processing PR showed hepatic toxicities. Therefore, it is recommended that the processing PR should be used in clinics as like as suggestions of traditional methods.