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임수빈 ( Soo-bin Lim ),김성남 ( Sung-nam Kim ) 한국미용예술경영학회 2013 미용예술경영연구 Vol.7 No.3
This study is to examine the origin of Geodumi a hair style of Naemyungbu in Joseon Dynasty. Geodumi is one of the most peculiar female hair styles in Joseon. But there have been no studies on from when and why it began to be used. So, the author tries to find out the clue of the shape in the Buddhist paintings, searching back from the photos of late Joseon. As the result, it was known that the basic style of Geodumi is to stick the lifted-up form on the back hair, which had been made of real hair before King Jeongjo but made of wood after his enthronement. And, according to the most ancient < Chaegniedogamuigue >, it was used as a part of decoration along with Daesu. Among the Buddhist paintings, there were some notable materials that satisfy this condition unexpectedly in early Joseon ones and even in Goryeo ones. The woman on < Suwolgwaneumdo > drawn in about early Joseon and late Goryeo turned to be Namyang Hongssi the daughter-in-law of King Jeongjong, and the Geodumi-type crown have received much attention from people. In the Buddhist painting of Goryeo paintings, queens frequently appear. On their heads, the Geodumi crowns are seen, having connection with those in Joseon Buddhist paintings. The women in Tunhuang paintings were from the noble class of Tang Dynasty, and their hair style must have been introduced to Gyeongju as a part of royal grant clothing from China after unification. The name was Ssanghwanmangseongye, reflecting the Sinseon(divine hermit) idea. After the unification of 3 kingdoms, the hair style of Tang women influenced on Korean women till the late Joseon and became a character of Korean classical hair style.
CTLA-4 항원의 세포막 도달 기작에서 친수성 N말단 아미노산 잔기의 역할
한지웅,이혜자,김진미,최은영,정현주,임수빈,최장원,정용훈,Han, Ji-Woong,Lee, Hye-Ja,Kim, Jin-Mi,Choi, Eun-Young,Chung, Hyun-Joo,Lim, Soo-Bin,Choi, Jang-Won,Chung, Yong-Hoon 대한면역학회 2002 Immune Network Vol.2 No.2
Background: This study was aimed to differentiate two forms of CTLA-4 (CD152) in activated peripheral blood lymphocyte and clarify the mechanism how cytoplasmic form of this molecule is targeted to cell surface. Methods: For this purpose we generated 2 different anti-human CD152 peptide antibodies and 5 different N'-terminal deletion mutant CTLA4Ig fusion proteins and carried out a series of Western blot and ELISA analyses. Antipeptide antibodies made in this study were anti-CTLA4pB and anti-CTLA4pN. The former recognized a region on extracellular single V-like domain and the latter recognized N'-terminal sequence of leader domain of human CD152. Results: In Western blot, the former antibody recognized recombinant human CTLA4Ig fusion protein as an antigen. And this recognition was completely blocked by preincubating antipeptide antibody with the peptide used for the antibody generation at the peptide concentration of 200 ug/ml. These antibodies were recognized human CD152 as a cytoplasmic sequestered- and a membrane bound- forms in phytohemagglutinin (PHA)-stimulated peripheral blood lymphocyte (PBL). These two forms of CD152 were further differentiated by using anti-CTLA4pN and anti-CTLA4pB antibodies such that former recognized cytosolic form only while latter recognized both cytoplasmic- and membraneforms of this molecule. Furthermore, in a transfection expression study of 5 different N'-terminal deletion mutant CTLA4Ig, mutated proteins were secreted out from transfected cell surface only when more than 6 amino acids from N'-terminal were deleted. Conclusion: Our results implies that cytosolic form of CTLA-4 has leader sequence while membrane form of this molecule does not. And also suggested is that at least N'-terminal 6 amino acid residues of human CTLA-4 are required for regulation of targeting this molecule from cytosolic- to membrane- area of activated human peripheral blood T lymphocyte.