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RISS 인기검색어
- 검색키워드
- 저자 : 임국환(Kook Hwan Rhim) (검색결과 61 건)
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Thiamine 이 水銀中毒白鼠의 各職器에 미치는 影響
林國煥(Kook Hwan Rhim) 한국환경보건학회 1986 한국환경보건학회지 Vol.12 No.2
Th,e purpose of this study is to determine the antidotal effects of thiamine in phenylmercury poisoning rats. Sixty-six rats were divided into six groups ; the control group, the 40 r thiamine -only osed group. the 6 ppm phenylmercury잉nly-dosed group, the simultaneously-dosed-group with 6 ppm mercury & 20 r thiamine, and with 6 ppm mercury & 40 r thiamine, and with 6 ppm mercury & 80 r thiamine. πle thiamíne was put into pellet by various concentrations, and phenylmercury was mixed in drinking water by 6 ppm concentration. πle rats were sacrificed for observing the histopatholo밍ca1 changes of brain, liver and kidney. The results summarized are as follows ; 1. In the group dosed with only 40 r thiamine, the tissues of brain, liver and kidney did not show any abnorma1 architecture. 2. The phenylmercury-only-dosed group and the simultaneoulsy-dosed group with mercury and 20 r thiamine showed remarkable degenerative or necrotic hepatic cells. In addition, a remarkable swelling and necrosis on epithelium of proxima1 tubules in kidney were found. 3. Th(~ simultaneously-dosed group with mercury and 40 r thiamine sllOwed moderate degeneratioll and necrosis of Purkinje cells in cerebellum. A moderate necrosis and swelling on epi1thelium of pro성ma1 tubules and a large amount of tubular casts were found as well. 4. The simultaneously-dosed group with mercury and 80r tamine showed a slight degenerative change of Purki띠 e cells. A slight degenerative change on epithelium of proximal tubules and a small amount of tubular casts were also found.
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키토산이 실험적 대장암의 전암단계병변에 미치는 영향에 관한 연구
임국환(Kook Hwan Rhim) 한국환경보건학회 1999 한국환경보건학회지 Vol.25 No.4
An investigation was conducted to assess the chemopreventive effects of chitosan in a rat preneoplastic colorectal carcinogenesis induced by azoxymethane (AOM). Thirty, 5-week-old, male F344 rats were divided into three groups. CRF-1 diet containing 2% chitosan and control diet were fed to the rats of group 1 and 2, respectively, for 12 weeks. AOM (15 mg/kg body weight, subcutaneously) were given to the rats three times for 2 weeks from week 2. The treatment regimen to the rats of group 3 were same to the group 1 except that saline was given instead of AOM initiation. Animals were sacrificed at week 12 to examine the development of aberrant crypt foci (ACF). A decreasing tendency was observed in the total number of ACF and sum of aberrant crypts in group 1 comparing with those of group 2. These results indicate that chitosan may have inhibiting effects to the development of preneoplastic lesions by azoxymethane and be a potential chemopreventive food component.
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의약분업 실시 이후 의료이용자들의 의료이용 행태 및 만족도
임국환(Kook Hwan Rhim),김진희(Jin Hee Kim),최만규(Man Kyu Choi) 고려대학교 보건과학연구소 2006 보건과학논집 Vol.32 No.2
The separation of prescription and dispensation has been implemented with a purpose to restrict efficiently the overuse or misuse of drugs by attributing the roles of diagnosis and prescription just to the doctor and the roles of the preparation and administration of the medicine to the pharmacist. In spite of the benefits of this system, this separation system has resulted in several problems and immediately raised complaints from the patients and their family. Therefore, in order to evaluate the success of the new system, it is important to check how to minimize the inconveniences and to maintain the quality of the health services. The purpose of this study is to produce baseline data from the viewpoint of the healthcare consumers in order to improve the problems of the separation system of prescription and dispensation. For this, we interviewed 500 patients or families who visited pharmacies with a prescription. The survey was conducted from June 18, 2006 to July 7, 2006. The results of the study are as follows : First, half of the patients received one copy of the prescription from the hospitals in contrast to two copies - one for the pharmacy and one for the patient to keep. Also, only half of the patients received a receipt of the treatment from the medical institutions, which implies that many hospitals do not issue receipts to their patients. Second, some patients had to visit numerous pharmacies in order to receive the proper medication prescribed by their doctor. The main reasons for this were that certain pharmacies did not carry out the prescribed medication and that there were too many patients waiting in line in the pharmacies. Third, 61.2% of the patients said that they experienced no difference in their habits in taking medicine. 6.1% said that they even take more medicine than before. Fourth, 61.7% more than twice as many patients answered that they find it more complicated to get proper medicines after the separation system than before. The main reason was the troubles they take in going from the hospital to a pharmacy. Others include the complicated procedure from prescription to dispensation and lack of medication in certain pharmacies. The satisfaction of the consumers of hospitals and pharmacies is one of the important contributing factors in the stability and success of the separation policy. The problems identified by this study must be solved immediately.
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임국환(Kook Hwan Rhim) 한국환경보건학회 1998 한국환경보건학회지 Vol.24 No.4
The purpose of this paper is to develop the implementation strategies for improving the management system of infectious wastes. At present the management system is controlled by several separate departments, causing inefficiency. I propose that the management system should be operated by one unified system. The suggestions made in this paper are as follows : 1. Only professional personnel who have been trained should be employed and be in charge of the management of disposal systems in the medical institutes above the hospital-level and treatment com panies as well. 2. The regional treatment system of the infectious wastes is needed for the efficiency of treatment and the reduction of the treatment expenses. 3. A multilevel system should be introduced for easy confirmation of proper treatment by the institutes which produced infectious wastes and by the management surveillance institutes as well. 4. A special management committee for managing infectious wastes which is composed of government officials, representatives of the source institutes, should be organized. They take the responsibility for establishing the legal and systematic methods for effective and reasonable management of the disposal system.
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임국환(Kook-Hwan Rhim),민선영(Sun-Young Min),이정경(Jung-Kyung Lee),김판기(Pan-Gyi Kim) 고려대학교 보건과학연구소 2004 보건과학논집 Vol.30 No.1
It is known that tobacco generates about 4,000 kinds of toxic materials through the reaction of thermal decomposition, thermal composition, distillation, oxidation, hydration and dehydration when it is combusted. Among them such chemicals as tar, nicotine, carbon-monoxide, nitrogen-dioxide are especially noted as major hazardous materials. This study was conducted to examine if jade filter pipe reduce the amount of various hazardous material and found out that it could reduce about 10% of harmful materials in average.<BR> The results obtained were as follows.<BR> There was no great difference in reduction rate of hazardous material by jade filter pipe between high nicotine level tobacco (American) and low nicotine level tobacco (Korean).<BR> The reduction rate of tar, was 16.56% in American tobacco and 12.92% in Korean tobacco. Nicotine was removed by 15.00% and 15.88% in American and Korean tobacco respectively. Carbon monoxide was removed by 4.60% and 5.33% in American and Korean tobacco respectively. Nitrogen dioxide was removed by 10.94% and 10.91% in American and Korean tobacco respectively.<BR> The reduction effectiveness of repeated using jade filter pipe was no significant difference of reduction rate of tar and nicotine. Jade filter pipe could reduced total contents of toxic materials generated from tobacco about 4.6~16.5%.
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