의약품의 생물학적 동등성시험에관한 연구 ( Ⅰ); 라니티딘에 대하여

이창기(C . K . Lee),한익수(I . S . Han),최광식(K . S . Choi),최기환(K . H . Choi),홍재선(J . S . Hong),심창구(C . K . Shim),이학중(H . J . Lee),김재백(J . B . Kim) 한국약제학회 1988 Journal of Pharmaceutical Investigation Vol.18 No.4

N/A

기외수축후 T 파변화에 관한 임상적 관찰

강희태 ( H. T. Kang ),이동용 ( D. Y. Lee ),이학중 ( H. C. Lee ),박용재 ( Y. J. Park ),김화숙 ( H. S. Kim ) 대한내과학회 1975 대한내과학회지 Vol.18 No.6

본태성 및 신성고혈압증에 대한 Propranolol (Inderal) 의 강압효과

이봉재 ( B. J. Lee ),강희태 ( H. T. Kang ),김화숙 ( H. S. Kim ),이동용 ( D. Y. Lee ),김효석 ( H. S. Kim ),이학중 ( H. C. Lee ) 대한내과학회 1974 대한내과학회지 Vol.17 No.1

혈관 확장 및 체액량 변화에 따른 혈장 ANP ( Atrial natriuretic peptide ) 농도의 변화

양인석(I . S . Yang),김수경(S . K . Kim),장규만(K . M . Jang),김종연(J . Y . Kim),유병희(B . H . Yu),이홍순(H . S . Lee),이학중(H . C . Lee) 대한내과학회 1988 대한내과학회지 Vol.35 No.3

N/A 1) In hypertensive patients, the plasma atria natriuretic peptide (ANP) level was significantly increased in comparison with healthy controls (p<0.025). 2) The plasma ANP level, after normalization of blood pressure by vasodilator therapy, was significantly decreased in comparison with the pre-treatment level, (p<0.01). There was no significant discrepancy in plasma ANP levels between the healthy controls and the post-treatment hypertension groups (p>0.1). 3) In CRF patients, the plasma ANP level was significantly decreased after ultrafiltration in comparison with pre-ultrafiltration (p<0.025). However, the plasma ANP level after ultrafiltration was significantly higher than in the healthy controls (p< 0.005).

혈중 갑상선자극홀몬 측정의 진단적 의의에 관한 연구

이종석,이학중,문성수,석광호,박우한,한창순 대한핵의학회 1980 핵의학 분자영상 Vol.14 No.2

저자들은 혈중 TSH의 방사면역측정을 정상인과 각종 갑상선질환 환자들에게 실시하여 의미있는 결과를 얻었기에 이에 보고하는 바이다. 환자들은 1978년 1월부터 1980년 8월까지 국립경찰병원 내과에 내원한 각종 갑상선환자 41예와 정상인 22예를 대상으로 하였다. 1) 정상인 22예의 혈충 TSH치는 평균 4.2∼1.7μU/ml이고, 그 범위는 1.9∼7.4μU/ml이었다. 2) 원발성 갑상선기능저하증 9예에 있는 혈중 TSH의 평균치가 97.1±116.4μU/ml이고 그 범위는 14.0±300μU/ml였다. 3) Graves씨병 17예는 혈중 TSH치의 평균이 1.5±0.6μU/ml였다. 4) 갑상선염 8예는 갑상선기능상태에 따라 혈중 TSH치의 변화가 많았으며 그 범위는 1.6∼220μU/ml이었다. 5) 갑상선결절 7예는 혈중 TSH치의 평균이 2.4±2.0μU/ml이었다. 6) Graves씨병에 Taoazole치료후 TSH치가 상승하는 것을 볼 수 있었고, 이것이 병경과를 판정하는데 아주 유용하였다. 이상의 결과로써 혈중 TSH의 측정은 갑상선질환의 진단뿐 아니라 치료경과를 판정하는데도 좋은 수단이 될 수 있다고 하겠다. The radioimmunoassay of TSH (human thyrotropin) was performed by utilizing anti-h-TSH antibody and purified human thyrotropin supplied from Daiichi from Jan. 1978 through Aug. 1980 the serum concentration of TSH was measured on 41 cases with various thyroid diseases, and 22 normal persons. Among 41 cases, 9(22%) were primary hypothyroitlism, 17(41%) Graves' disease, 8(20%) subacute or chronic lymphocytic thyroiditis, and 7(17%) nodular goiter. The results were as follows:1) The normal values of serum TSH in 22 cases of control group were 4.2±1.7μU/ml, (1.9∼7.4μU/ml), which were within normal range in kit used in this study. 2) The serum TSH concentration in 9 cases with primary hypoehroidism were 97.1±116.4μU/ml(14. 0∼300μU/ml), which were significantly elevated as compared, with normal control values. 3) The serum TSH concentration in 17 cases with Graves' disease were 1.5±0.6μU/ml(1.0∼2.5μU/ml), which were below than normal control. 4) The serum TSH concentration in 8 cases with subacute or chrotic thyroiditis revealed wide ranges(1.6∼220μU/ml), according to the state of thyroid function. 5) The serum TSH values in 7 cases with nodular goiters were 2.3±2.0μU/ml, which were strictly within normal levels. 6) The serum TSH levels were elevated during prolonged treatment with Tapazole(Methimazole) without serial check of the serum TSH concentration in Graves' disease, so the serial measurement of serum TSH concentration was considered of available index of thyroid states.

갑상선기능항진증에 있어서 T3RU 및 T4에 관한 임상적 연구

이종석,문언수,박요한,조창호,박인수,이학중 대한핵의학회 1978 핵의학 분자영상 Vol.12 No.2

1) 갑상선기능항진증환자의 연령 및 성별 분포를 보면 10대 4례(4.26%), 20대 27례(28.72%), 30대 28례(29.79%), 40대 17례(18.09%), 50대 13례(13.83%) 및 60대 5례(5.31%)로써 20대와 40대 사이에서 76.60%를 찾이하였다. 성별분포를 보면 남자 19례(20.2%), 여자 75례(79.79%)로써 여자에서 높은 빈도를 보였다. 2) 갑상선기능항진증환자에서 호소하는 중요증상을 열거하면 심계항진 77례(81.92%), 체중감소 60례(63.83%), 식욕항진 62례(65.96%), 내서성저하 54례(57.4%), 발한 64례(68.09%), 신경질 75례(79.79%) 등을 보였다. 3) 갑상선기능항진증환자에서 이학적소견을 보면 손떨림 54례(57.16%), 빈맥증 45례(47.63%), 넓은 맥압력 38례(40.17%), 수축기심잡음 29례(35.86%), 안구돌출 34례(35.86%), 따뜻한 피부 44례(46.33%) 등의 순이었다. 4) 갑상선기능항진증환자를 갑상선중독증, 선종양갑상선중독증 및 결절성갑상선종으로 분류하여 T3 resin 섭취율과 T4치의 성적을 보면, 갑상선중독증에서는 T3 RU 49.15±9.94%, T4 21.29±7.04μg/dι이고, 선종양갑상선중독증에서는 T3 RU 40.32±13.08%, T4 15.47±8.25μg/dι였고, 결절성갑상선종에서는 T3 RU 32.47±6.74%, T4 11.03±5.0μg/dι였다. 5) 갑상선크기를 중심으로 하여 갑상선중독증, 선종양갑상선중독증 및 결절성갑상선종을 비교하여 보면, 갑상선중독증에서 우엽의 장축과 폭은 6.91±1.85cm, 2.72±0.89cm, 우엽은 각각 6.51±1.5cm, 2.67±0.58cm였다. Hyperthyroidism may be defined as those clinical conditions which result from an increase in the circulating levels of one or both thyroid hormones. Hyperthyroidism in broad sense could be classified with toxic diffuse goiter, toxic adenomatous goiter, and toxic multinodular goiter on the basis of the circulating thyroid hormone levels. For this study, the subject included 94 cases with hyperthyroidism were presented in 77 with toxic diffuse goiter, 8 with toxic adenomatous goiter, and 9 with toxic multinodular goiter on the levels of 125IT3 resin uptake rate and serum thyroxine (T4). The observed results were as follows: 1) In the cases of hyperthyroidism including toxic diffuse goiter, toxic adenomatous goiter, and toxic multinodular goiter, 20.21% of the patients were male and 79.79% female. The majority of the patients were in 2nd to 4th decades of their lives. 2) There were objective signs clearly manifested in hyperthyroidism including toxic diffuse goiter and toxic adenomatous goiter which were rare in the multinodular goiter. The clinical signs in toxic diffuse and toxic adenomatous goiter included wide pulse pressure, tachycardia, systolic murmur, exophthalmos, tremor and warm skin etc. (Table 3.) 3) The most freauent complaints of the patients with hyperthyroidism were palpitation, weight loss, increased appetite, perspiration, heat intolerance, nervousness, exertional dyspnea, and menstrual disturbance etc. (Table 4.) There was no clear difference in the incidence of symptoms between toxic diffuse goiter and toxic adenomatous goiter, but there was clear difference between toxic multinodular goiter. 4) Considering of results of 125IT3 resin uptake rate and serum T4 level in toxic diffuse goiter, toxic adenomatous goiter and toxic multinodular goiter, 125I T3 regin uptake rate was 49.15±9.94% (mean) and serum T4 21.29±7.04 ug/dl (mean) in toxic diffuse goiter. In toxic multinodular goiter, 125I T3 resin uptake rate was 32.47±6.74% (mean) and serum T4 level 11.03±5.0 ug/dl, and then there was clear dience in the results of 125I T3 resin uptake rate and serum T4 between toxic diffuse goiter and toxic multinodular goiter. The levels of 125I T3 uptake rate and serum T4 in toxic adenomatous goiter were 40.32±13.08% (mean), 15.47±8.25 ug/dl (mean) respectively, so there was no clear difference between toxic diffuse goiter and toxic adenomatous goiter. 5) There was no significant differnece in length and width performed width thyroid scanning in toxic diffuse goiter, toxic adenomatous goiter, and toxic multinodular goiter.

간 Scintigram의 임상적 고찰

이종석,이학중,문성수,오경식,김열자,김영철 대한핵의학회 1980 핵의학 분자영상 Vol.14 No.2

저자들은 1978년 7월부터 1980년 8월말까지 국립의료원 일반내과에서 임상상, 검사실소견 또는 간생검소견으로 확진된 50예의 정상인과 150예의 간질환 환자 총 200예에 대하여교질형 방사성을 이용한 색채간주사를 실시하고 임의로 간기능 검사와 간주사 소견을 중심으로 해서 설정한 군의 기준을 적용하여 A군(정상), B군, C군, D군으로 구분하고 각군에 어떠한 간질환이 속하는가를 검토하여 다음과 같은 결론을 얻었다. 1) A군에는 남자 30예, 여자 20예로 간주사의 소견과 간기능검사상의 성적과 서로 일치하였다. 2) B군에 속한 예는 남자 33예, 여자 17예였고, 20대에서 40대 사이가 39예로 전체의 78%를 차지하였으며, 이군에 속한 질환은 급만성간염 35예(70%), 장티푸스 4예(8%), 간경변증 3예(6%), 기타가 3예(6%)였다. 3) C군에 속한 예는 남자 32예, 여자 18예였고 40대에서 50대 사이가 32예(64%)였으며, 이군에 속한 질환은 간경변증이 41예(82%)였고 만성 활동성간염 6예(12%), cholangiocarcinoma 1예(2%), 간결핵 1예(2%), 담당암 1예(2%)였다. 4) D군에 속한 예는 남자 45예, 여자 5예로 40대에서 60대 사이가 46예(92%)를 찾이하였고, 이군에 속하는 간질환은 원발성간암 26예(52%), 간경변증을 동반한 간암 7예(14%), 전이암 5예(10%), 간농양 10예(20%), 다발성낭종 1예(2%), Cystric duct의 선종 1예(2%)였다. Although primary application of radioisotope scanning technics to the liver has been of use in the detection of the intra-hepatic space occupying Iesion from the normal functioningliver parenchyme, there has been on increasing awareness of its use in evalution of Liver function. In this study, the diseases of the liver were classified into group A,B,C and D by the liver scanning findings, conventional liver function tests and clinical findings. Following were the results: 1) The colloidal radiogold liver scan appeared normal in the group A, also the albumin in serum alkaline phosphatase activity and prothrombin time were within normal levels in this group. 2) In the group B, there were acute hepatitis 24(48%), chronic hepatitis 5(10%), toxic hepatitis3(6%), subacute hepatic necrosis 3(6%), typhoid liver 4(8%), hepatic tuberculosis 2(4%), diabetes mellitus 3(6%) and others 3(6%). In this groups, SGOT and SGPT were increased predominantly as compared with group A, and the liver scan showed small amount of mottling of activity and faintly visualized spleen. 3) In the group C, there were postnecrotic liver cirrhosis 30(60%), Laennec eirrhosis 10(20%), cardiac cirrhosis 1(2%), cholangiocarcinoma 1(2%), chronic active hepatitis 6(12%), hepatic milliary tuberculosis 1(20%) and gall bladder cancer 1(2%). In this group, the albumin in serum and prothrombin time were lowered significantly and the live, scan showed severe mottling of activity with extra-hepatic uptake in the spleen and bone marrow along the vertebral column. 4) In the group D, there were primary hepatoma 26(52%), hepatoma with liver cirrhosis 7(14%), metastatic iiver cancer 5(10%), liver abscess 10(20%), muleiple livet cyst 1(2%) and cystic duct adenoma 1(2%), In this group, the alkaiine phosphatase activity was elevated with single or multiple intrahepatic space occupying lesion in the radiogold colloid liver scan.

名種 肝疾患에서 數種 肝檢査와 肝 Scintigram과의 比較觀察

李鍾錫,金洋一,朴善淑,曺昌鎬,李學重 中央醫學社 1976 中央醫學 Vol.30 No.1

In 12 normal cases and 88 liver disease cases, the radioactive colloidal gold liver scan, liver function test and liver biopsy were done at the Dept. of Internal Medicine. The results obtained were as follows: 1) Liver disease cases are classified according to the degree of splenic uptake and the degree of bone marrow uptake as seen along the vertebral column and there are high degree uptake 21 cases, moderate 3 cases, mild 35 cases of 100 cases. Decreased hepatic uptake and increased extrahepatic uptake (EHU) in the spleen and vertebral column are considered of an index of portal hypertension and collateral circulation. 2) Extrahepatic uptake of radioactive colloidal gold liver scan is increased at lower prothrombin level in 63 of 84 cases (75%). 3) The degree of splenic uptake and the degree of bone marrow uptake as seen along the vertebral column with mottling of the liver is high at lowered serum albumin and increased globulin level in 38 of 64 cases (59.4%). 4) Extrahepatic splenic and vertebral marrow visualization is noticed in cases of high serum alkaline phosphatase level but is not relationship between extrahepatic uptake rate and serum alkaline phosphatase level.

流行性出血熱患者에 있어서 치료전후의 電解質變動에 關한 硏究

李鍾錫,金文子,宋康正,李學重 최신의학사 1975 最新醫學 Vol.18 No.2

Study was made on 10 cases of electrolyte changes before and after treatment in hemorrhagic fever which were abserved at the National Medical Center from Sept. 1, 1973 to May 31, 1974. 1) On admission, the average serum sodium was 122.8mEq, potassium 5.8mEq, chloride 78.3 mEq and bicarbonate 16.OmEq per liter. The average serum creatinine was 9.15mg, urea nitrogen 79.4mg per 100m1. 2) The blood urea nitrogen 79.4mg per100ml before treatment decreased to 74. 2mg, 72. lmg, and 58.4mg per 100ml on the 2nd, 3rd and 7th day respectively. 3) The creatinine 9.15 per 100ml before treatment decreased to 7.6mg, 7.6mg and 3.97mg per 100ml on the 2nd, 3rd and 7th day respectively. 4) The potassium 5.8mEq per liter before treatment decreased to 4.93mEq, 4.93 mEq and 5.2mEq per liter on the 2nd, 3rd and 7th day respectively. 5) 2 cases were performed with peritoneal dialysis and then one case recovered, the other case expired in spite of peritoneal dialysis. The blood urea nitrogen 106mg, creatinine 12.2mg per 100ml decreased to 60mg(56.6%), 8.5mg (8. 24%) per 100ml after peritoneal dialysis in recovery case. The blood urea nitrogen 71.0mg, creatinine 15.4mg per lOOml on admission elevated to 90mg, 19.0mg per 100ml, and then the potassium 6.7mEq per liter elevated to 8. OmEq per liter in spite of peritoneal dialysis in expired case.