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이태후 ( Tae Hoo Yi ),박히준 ( Hi Joon Park ),임사비나 ( Sa Bi Na Lim ) 대한경락경혈학회 2004 Korean Journal of Acupuncture Vol.20 No.2
목적: 본 연구는 염증유발 내독소인 LPS 자극을 통한 면역 스트레스에 대한 약침의 치료효과와 기전을 알아보기 위해 설계되었다. LPS를 통한 염증반응은 다양한 기전을 통해 이루어지는 데 특히, 산화질소 (NO)를 생성하는 효소인 iNOS의 활성은 시상하부에서 NO의 생성을 촉진함으로써 염증반응을 발현시키는 중요한 역할을 하는데 약침이 LPS로 인해 활성화된 iNOS의 발현에 어떠한 영향을 미치는지 알아보고자 하였다. 실험방법: 흰쥐에 LPS를 투여하고 2시간 경과한 후 약침 (소염방, 대한약침학회)을 경혈 (합곡, 족삼리)에 좌,우 각각 0.2cc 씩 피하 투여하고 RT-PCR 방법을 통하여 면역활성에 중요한 역할을 하는 시상하부에서의 iNOS의 mRNA 발현을 알아 보았다. 실험결과: LPS 투여로 인하여 증가하였던 iNOS mRNA가 약침치료를 통해 현저하게 감소하였다. 그러나 비경혈점 (미추부위 임의혈)에 약침을 투여한 군과 경혈점에 생리식염수를 투여한 군에서는 iNOS mRNA 가 감소하지 않았다. 이는 약침이 LPS를 투여한 흰쥐의 시상하부에서 iNOS의 mRNA 발현에 조절 작용을 가지고 있는 것을 보여주는 결과로 약침이 면역활성에 중요한 역할을 하는 NO의 생성을 억제함으로써 면역 스트레스에 치료효과를 나타내는 것으로 보여진다. 결론: 본 연구는 약침치료가 면역반응의 중추기관인 시상하부에서 면역반응의 중요한 조절인자인 NO의 생성을 조절하는 기전을 통해 그 치료효과를 나타내는 것을 밝혔고 더 나아가 약침에 대한 현대과학적 연구에 중요한 발판을 마련했다는 점에서 그 의의를 가지고 있다고 사료된다.
이태후,문정배,안경애,이혜정,Yi, Tae-Hoo,Moon, Jung-Bae,An, Kyung-Eh,Lee, Hye-Jung 대한한방체열의학회 2006 대한한방체열의학회지 Vol.5 No.1
Objectives: To examine any potential relationships between the types of alopecia and the facial heat distribution in patients with alopecia Methods: 183 patients with alopecia participated in this study to provide facial heat distribution measured by the Infrared Thermography Scanner (ITS, Nec San-ei Instruments Ltd, Japan). The thermography scan was used in a light-and heat-protected room after 20 minutes’of resting period. 1.5m of distance maintained between the patients and ITS. Results: Specificity in the type of facial heat distribution was found as follow. 1. Types of facial heat distribution can be classified as T-type and diffused patterns. 2. There was a significant difference in the pattern of facial heat distribution among different types of alopecia (p=0.002): facial heat distribution appeared T-type in Androgenic Alopecia, Alopecia Areata, and Telogen Effluvium (71.3%, 85.7%, 70.4%), whereas diffused pattern was dominant in Seborrheic Alopecia(55.6%). 3. There was a significant difference in the pattern of facialheat distribution between men and women (p<0.001): While the T-type and diffused type were equally appeared in men (50.6%: 49.4%), T-type was dominant in women (88.0% vs. 12.0%). Conclusions: We conclude that the pattern of facial heat distribution differs depends on the types of alopecia and gender. These differences may provide useful information for the diagnosis and clinical therapy for this population.
이승민 ( Seung Min Lee ),이태후 ( Tae Hoo Yi ),금동호 ( Dong Ho Keum ) 한방재활의학과학회 2005 한방재활의학과학회지 Vol.15 No.2
Objectives : This study was planned to evaluate clinical status of the alopecia patients who had visited oriental medicine clinic. Methods : 80 patients with alopecia, who had visited oriental medicine clinic from January 2004 to August 2004, were examined. Results & Conclusions : 1. The kinds and incidences of Alopecia : androgenetic alopecia 57.5%(46/80), alopecia areata 20.0%(16/80), telogen effluvium 16.3%(13/80), seborrheic alopecia 6.3%(5/80). 2. In distribution of sex, the rate of male to female was 1:1 and most patients belonged to 20-30 year old group. 3. The most common onset of age was adolescence(63.8%) and the most common duration of hair loss was 1 to 3 years. 4. Among the 30 male androgenetic alopecia patients, Hamilton`s type 4 was most common and among the 16 female androgenetic alopecia patients, Ludwig`s type Ⅱand Ⅲ were most common. 5. Family history of baldness in Androgenetic alpoecia and alopecia areata were 56.5% and 25.0%, respectively. 6. Self-conscious causes of hair loss : stress(48.8%), irregular eating habits (21.3%), and lack of sleep (20.0%). 7. Associated diseases with alopecia patients : chronic neck pain(58.8%), temporomandibular disorders(55.0%) and seborrheic dermatitis (20.0%). 8. Associated symptoms with alopecia Patients : stress(78.8%), sleep disorders(68.8%), irregular eating habits(55.0%), Hot flush (43.8%), Stool disorders (43.8%), cold hands and feet(37.5%) and menstruation disorders(31.3%). 9. The most common scalp type was oily scalp(70.0%) and the symptoms of scalp were iching, dandruff, pain, inflammation. 10. Bian zheng(辨證) of alopecia patients : xue-re-feng-zau(血熱風燥) (25.0%), gan-shen-bu-zu(肝腎不足) (23.8%), shi-re-shang-zheng (濕熱上蒸) (16.3%), xue-re-sheng-feng(血熱生風) (13.8%), xue-xu-feng-zau(血虛風燥) (13.8%), yu-xue-zu-luo(瘀血阻絡) (7.5%)
피부로 침투된 양자점 나노입자의 분포와 전자현미경 분석 시 발견되는 오스뮴산 결합물과의 구분
최기주,박상용,이정민,신헌섭,양정은,이돈길,이태후,Choi, Ki-Ju,Park, Sang-Yong,Lee, Jeong-Min,Shin, Heon-Sub,Yang, Jung-Eun,Lee, Don-Gil,Mavonov, Garfurjon T.,Yi, Tae-Hoo 한국현미경학회 2012 Applied microscopy Vol.42 No.1
나노입자의 가능성은 의생물학 분야의 연구자들에 의해 열띤 토론이 되어지고 있다. 우리는 일종의 추적자인 양자점(quantum dots)을 이용하여 피부로 침투된 나노입자의 분포를 전자현미경으로 확인하는 과정에서 나타나는 문제점과 이를 해결하기 위한 방법을 제안해 보고자 하였다. 나노입자는 피부의 각질층과 모공을 통한 일부 피지세포 내부까지 침투되는 것을 확인하였다. 이 과정에서 오스뮴산이 세포 내 지방산과의 결합에 의해 나노입자 형태의 축적물이 생성되는 것을 확인할 수 있었고, 이것은 의도한 나노입자(양자점)의 분포를 확인하는데 간섭을 주는 요인이 되는 문제점을 발견하였다. 이를 해결하기 위해, 양자점과 오스뮴산을 달리 처리하는 방법을 통하여 각각의 사진에서 나타나는 나노입자의 진위 여부를 비교하므로 의도한 나노입자의 정확한 분포를 확인할 수 있었다. 이러한 결과는 의생물 분야에서 생체내 나노입자의 분포를 확인하기 위한 연구 시 오차를 감소시키고, 보다 정확한 분석을 제공할 수 있을 것으로 기대해 본다. The possibility of nanoparticles (NPs) in biotechnology had been discussed by biomedical investigators. Here we report to suggest a solution and problems when using electron microscopy to determine the distribution of quantum dots (QDs) nanoparticles that penetrate skin. The results of this study showed that NPs were able to penetrate stratum corneum (SC) and sebocyte via hair follicle. However, we have found artifacts such as nanoparticles that are produced from combination of free fatty acid and osmium tetroxide during specimen preparation. It is usually difficult to identify NPs. Therefore, we tried to resolve these problems by comparing the cross-correlation image pattern that are derived from the images of sample that had been processed differently. This method can contribute to more accurate interpretation and minimal errors during the analysis using quantum dot as tracer.
김치 유래 Lactiplantibacillus plantarum THK-j112의 Streptococcus mutans에 대한 항균효과 및 항생물막 효과
유두나(Du-Na Yu),이은지(Eun-Ji Yi),정제용(Je-Yong Jung),이태후(Tae-Hoo Yi),국무창(Moochang Kook) 한국유산균프로바이오틱스학회 2023 Current Topic in Lactic Acid Bacteria and Probioti Vol.9 No.1
Dental caries is an infectious disease accompanied by the destruction of teeth. It is a multifactorial disease caused by the interaction between microbes in dental plaque and food, with cariogenic Streptococcus mutans being one of the primary causes. In this study, the antimicrobial and antibiofilm activities of Lactiplantibacillus plantarum THK-j112 isolated from Kimchi, a traditional fermented food, against S. mutans were investigated. Furthermore, this paper also showed the possibility of developing this strain. After analyzing the 16S rRNA sequence, strain THK-j112 was named L. plantarum THK-j112 as it shared 99.93% similarity with L. plantarum ATCC 14917T. Both L. plantarum THK-j112 and L. plantarum ATCC 14917T demonstrated MIC values of 5 mg/mL and MBC values of 10 mg/mL against S. mutans KACC 16833T. The study confirmed that L. plantarum THK-j112 exhibited significant concentration-dependent inhibitory effects on biofilm formation, acid production, and glucosyltransferases(GTFs) production. Regarding hemolytic activity, Bacillus cereus ATCC 14579T, used as a positive control, was confirmed to cause hemolysis, whereas L. plantarum THK-j112 did not cause this phenomenon. Additionally, except for gentamicin, the antibiotic resistance test revealed a lower value than the MIC cut-off value for each antibiotic, indicating no resistance. Based on the findings, L. plantarum THK-j112 is expected to be useful in the food industry, such as functional food, as a lactic acid bacterium with antimicrobial and antibiofilm effects.
신헌섭 ( Heon Sub Shin ),이강진 ( Kang Jin Lee ),이태후 ( Tae Hoo Yi ) 한국두피ᆞ모발미용학회 2009 대한미용학회지 Vol.5 No.1
The hair cycle is divided 3 phases into anagen, catagen and telogen. Hair loss is the result of premature catagen caused by apoptotic signal. The process of apoptosis is controlled through the activation of many factors, such as inflammatory cytokines, p53, Bax and Bcl-2 family gene. Vitex rotundifolia has been used frequently as an indigenous medicine for curing headaches, colds, migraine, eye-pain, asthma, chronic bronchitis, and gastrointestinal infections. Recent studies have shown that the extracts from Vitex rotundifolia contain iridoids, flavonoids, and compounds with biochemical properties. In this study, C57BL/6 mice were treated topically on the depilated dorsal skin with Vitex rotundifolia extract dissolved in 70% EtOH. Moreover, treatment of Vitex rotundifolia extract onto hair cells induced more 20% growth of proliferation compared only control treated group. Also, the ratio of follicle number of anagen phase/total was increased. This result explains that Vitex rotundifolia extract has effect on prolong of anagen phase, so Vitex rotundifolia might be a potential new therapeutic source for the hair growth promotion.