서울시 아파트의 매매가와 전세가 사이의 스프레드값 분석에 관한 연구

이충한(Choong Han Lee),이상엽(Sang Youb Lee) 서울연구원 2015 서울도시연구 Vol.16 No.3

경부 결핵성 임파선염

김중규(Joong Kyu Kim),이충한(Choong Han Lee) 대한두경부종양학회 1995 대한두경부 종양학회지 Vol.11 No.1

Tuberculous cervical lymphadenitis is one of common cause of neck mass in young adult in Korea. Tuberculous cervical lymphadenitis known as scrofula was being treated by the 'Royal Touch' in the 5th century and by surgery in the 17th century, yet the principle of the treatment is still controversal. We report the clinical evaluation and therapeutic result about 121 tuberculous cervical lymphadenitis. The result were as follows: 1) The annual incidence(1985-1994) was 30.5 % (37 cases: 1985-1986), 17.7 % (21 cases: 1990-1992). 19.8%(24 cases: 1994). 2) The age of highest incidence was 20-29 year old age group in 41.3% (50 cases) and female predominated over male by 1.8 : 1. 3) The duration of disease was less than 6 months, in 85.9% (104 cases). 4) The most commonly involved LN group was superficial cervical group in 69.4% (84 cases), and difference between Rt & Lt, was not significant. 5) The most common symptom and local finding(P/E) were, painless swelling of LN in 74.3 % (90 cases) and single mass in 59.5 % (72 cases). 6) In seasonal variation, 85.9% (104 cases) was spring and summer. 7) Procedures except biopsy for evaluation were chest PA, AFB smear & culture(sputum), Mantoux test, USG, CT and, Associated extracervical tuberculous lesions were lung, axilla, breast. 8) In operation method (involving biopsy), Excision was 68.5 % (83 cases), neck dissection was 6.6% (8 cases). 9) The Modality, Duration and side effect of antituberculous medication: INH-Rifampin­Ethambutol was 66.1 % (88 cases), duration was 1 year in 84.3% (102 cases), side effects were severe GI trouble (24.8%), liver function damage (3.3%). 10) 3 cases recurred on the same site after 2 yrs(2 cases) and 4 months(1 case) and its treatment was curretage or I & D, with antituberculous medication.

노인을 위한 4주간의 저산소 훈련이 혈구세포 및 혈중지질 변인에 미치는 효과

김만겸(Kim Man Kyum),이충한(Lee Choong Han) 한국노년학회 2008 한국노년학 Vol.28 No.3

본 연구는 65세 이상의 노인들을 대상으로 저산소 훈련이 혈구세포 및 혈중지질 변인에 미치는 영향을 분석하여 노인들을 위한 효과적인 저산소 트레이닝을 처방하는데에 있어 과학적인 근거를 제공하고자 하는데 그 목적이 있다.저산소 훈련이 65세 이상 노인의 혈구세포 성분변화에 미치는 영향을 알아보기 위해 실험집단과 통제집단의 운동량은 자전거 에르고메터를 이용한 유산소운동 30분과 웨이트트레이닝 10분으로 동일하게 하였으며, 실험집단은 유산소운동시 산소농도조절장치(Altitrainer200, Sports & Medical Tech., Swiss)를 이용하여 고도 2,300~2,500m에 해당하는 저산소환경을 만들어 주었으며, 통제집단은 해수면 수준에서 실시했다. 모든 연구대상자들은 운동프로그램 실시 전ㆍ후, 그리고 종료 4주 후에 혈액검사를 실시하였으며 혈구세포 성분변인 관찰을 위해 적혈구(RBC), 헤모글로빈(Hb), 헤마토크리트(Hct) 수치를 측정하였으며, 각 변인 모두 저산소 훈련 4주 후 실험군에서 통제군보다 유의하게 증가하였다. 혈중 지질 변인의 변화를 관찰하기 위해 총콜레스테롤과 저밀도지단백콜레스테롤, 고밀도지단백콜레스테롤, 중성지방 수준을 관찰하였으며, 총콜레스테롤과 저밀도지단백콜레스테롤은 실험군에서 운동 4주후 유의한 감소가 나타났으나 통제군에서는 유의한 변화가 나타나지 않았다. 결론적으로, 노인에서 저산소 훈련은 혈액의 세포성분인 적혈구, 헤모글로빈, 헤마토크리트 수치를 개선하여 운동수행능력을 높여 줄 가능성이 높고, 혈중 지질성분 중 총콜레스테롤과 저밀도지단백콜레스테롤의 감소에 긍정적인 영향을 미쳐 심장질환의 발병을 예방하는데 효과적인 방법이라는 결론을 내릴 수 있다 The purpose of this study was to evaluate the effects of hypoxia training on blood cell components and lipid profiles in elderly. Subjects were eighteen healthy elderly people who were over 65 years, members of seniors tower at Song-do hospital and didn't have any history in cardiovascular disease. The hypoxia exercise program for experimental group consisted of a 10-minute warm-up, 40-minute workout(30-minute bicycle ergometer with 50%VO2max and 10-minute weight training), and 10-minute cool down. Exercise frequency was 5days/a week and duration was 4weeks. Weight training was performed 15 times(15RM) by 2sets using the Leg extension, Leg curl, Chest press, Biceps curl, Lat pull down and Sit-up with machine. The results of this study were as follows; First, there were significant difference in RBC, Hemoglobin and Hematocrit between experimental and control group after hypoxia exercise. Experimental group increased significantly after hypoxia training, whereas control group was unchanged. At 4weeks after completion of experiment, Experimental groups had a high level more than control group. Second, there were significant difference in TC, LDL-C, TG between experimental and control group after hypoxia training. and Experimental group increased significantly after training, whereas control group was unchanged. At 4weeks after completion of experiment, experimental group had a high level more than control group. But there was no significant difference in HDL-C between experimental and control group after exercise. As a result, active hypoxia training is more efficient and safety method to improve blood cell components and lipid profiles concerning preventing heart disease and improving aerobic capacity in elderly.

제1발표장 : 정보처리 및 복합기술 분야 ; 고품질 계란공급을 위한 혈란 선별시스템 개발

이홍석 ( Hong Suck Lee ),이충한 ( Choong Han Lee ),장동일 ( Dong Il Chang ),조병관 ( Byoung Kwan Cho ) 한국농업기계학회 2013 한국농업기계학회 학술발표논문집 Vol.18 No.1

위암 환자에서 위아전절제술후 재건 방법에 따른 술후 체중 변화의 비교 연구

이승도(Sung Do Lee),신동훈(Dong Hoon Shin),최경현(Kyung Hyun Choi),백승언(Seung Uhn Baek),이충한(Choong Han Lee) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.6

N/A Weight. loss and malnutrition are common complications after subtotal gastrectomy. The authors campared weight changes, Visick grade and performance status according to reconstructing method after subtotal gastrectomy. The reconstruction methods were Roux-en-Y gastrojejunostomy and jejunojejenostomy (R-Y method) or Billorth-II gastrojejunostomy and Braun jejunojejunostomy (B-II method) after subtotal gastrectomy. The results were as follow; In stage I stomach cancer, weight recovery period were significantly decreased in R- Y method than B-II method in male and female. In stage llI stomach cancer, weight recovery period were no significant differences between R- Y method and B-II method in male and female. There were no significant differences in body weight change during 2 years after subtotal gastrectomy between R-Y method and B-II method in stage I and III stomach cancer. There were no significant differences in Visick grade and performance status during 2 years after subtotal gastrectomy between R - Y method and B- II method in stage I and III stomach cancer. Our conclusion was that weight reovery period was shortened in R-Y method than B-II method in stage I stomach cancer.

간 스캔을 이용한 간경변증 환자의 평가

배상균(Sang Kyun Bae),이석모(Seok-Mo Lee),신동훈(Dong Hoon Shin),이상욱(Sang Uk Lee),이충한(Choong Han Lee) 한국간담췌외과학회 2002 한국간담췌외과학회지 Vol.6 No.2

소장의 Malignant Fibrous Histiocytoma 1예

유대우(Dae Woo Yoo),신동훈(Dong Hoon Shin),박명선(Myeng Sun Park),허방(Bang Hur),이충한(Choong Han Lee) 대한외과학회 2001 Annals of Surgical Treatment and Research Vol.60 No.5

갑상선 여포상 선종과 암종의 감별진단에서 p27KIP1, MIB-1, bcl-2, p53 발현의 유용성에 대한 연구

강미선(Mi Seon Kang),윤혜경(Hye Kyoung Yoon),김상효(Sang Hyo Kim),윤기영(Ki Young Yoon),이충한(Choong Han Lee),최경현(Kyung Hyun Choi),허방(Bang Hur),노미숙(Mi Sook Roh),홍숙희(Sook Hee Hong) 대한두경부종양학회 2001 대한두경부 종양학회지 Vol.17 No.2

Objectives: The most important differential point of follicular carcinoma from adenoma is capsular invasion or angioinvasion of follicular cells. Serial sections for examination of levels of tumor margins are necessary to watch the invasion. However, the interpretation of capsular invasion or angioinvasion is sometimes not feasible on the routine staining of tumor tissue. The aim of this study is to evaluate the clinical significance of expressions of p27KIP1, MIB-1, bcl-2 and p53 in differential diagnosis of follicular adenoma and carcinoma. Materials and Methods: 16 cases of follicular carcinoma and 26 cases of follicular adenoma were entered on study of immunohistochemical stains for p27KIP1, MIB-1, bcl-2 and p53. In carcinoma cases, correlation between the above markers, patient's age, tumor size, infiltration pattern and metastasis was studied. Results: p27KIP1 labelling index (LI) of follicular carcinoma and adenoma was 4.89±6.92 and 14.52±9.17, respectively, but there was no significant difference between adenoma and carcinoma (p=0.2560). MIB-1 LI of carcinoma and adenoma was 4.11±3.89 and 0.80±0.75, respectively, and MIB-1 LI was significantly higher in carcinoma (p=0.0000). bcl-2 expression was seen in 2(12.5%) of 16 carcinoma cases and 130(50.0%) of 26 adenoma cases, and bcl-2 expression rate was higher in adenoma than in carcinoma(p=0.014). In one adenoma and one carcinoma case, p53 expression was noted. In follicular adenoma with atypia compared to adenoma without atypia, lower p27KIP1 LI, higher MIB-1 LI and lower bcl-2 expression rate were seen. In follicular carcinoma, MIB-1 LI was significantly higher in invasive carcinoma(p=0.045) and was relatively increased in tumors larger than 3.0cm, showing angioinvasion and distant metastasis. But p27KIP1 LI was higher in cases over 40 years old(p=0.008) and with conspicuous capsular invasion. There were no positive correlations between expressions of MIB-1, bcl-2 and p53. Conclusion: MIB-1 labelling index and bcl-2 expression could be helpful for differential diagnosis of follicular adenoma and carcinoma, but p53 showed very low expression rate and no significance in differential diagnosis. p27KIP1 labelling index reveals decreasing tendency in carcinoma compared with adenoma, MIB-1 LI was considered as a poor prognostic marker in follicular carcinoma, but p27KIP1 LI was higher in carcinoma cases over 40 years old with showing conspicuous capsular invasion. Further study for the significance of p27KIP1 labelling index in follicular neoplasms is necessary to evaluate diagnostic value of follicular carcinoma.

원발성 간세포암의 육종성 변화

신동훈(Dong Hoon Shin),강원근(Won Geun Kang),윤명희(Mung Hi Yoon),천봉권(Bong Kwon Chun),오경승(Keyng Seung Oh),이충한(Choong Han Lee) 한국간담췌외과학회 2001 한국간담췌외과학회지 Vol.5 No.2

Dimethylformamide 취급 근로자에서의 CYP2E1, GSTM1, GSTT1 유전자 다형성과 N-methylformamide 배설량간의 관련성

김재일,이충한,이용환 KOSIN UNIVERSITY COLLEGE OF MEDICINE 2006 高神大學校 醫學部 論文集 Vol.21 No.1

Background: N,N-dimethylformamide (DMF) has excellent solvent properties and is used intensively in the production of synthetic leather and resins. It has known to induce hepatotoxicity in human and animal by absorbing it through the lungs and skin. The metabolic transformation of DMF takes place mainly in the liver, with the aid of microsomal enzyme systems including cytochrome P450 (CYP), and glutathione S-transferase (GST). In metabolic studies and biological monitoring, urinary concentrations of metabolites are measured and expressed as N-methylformamide (NMF). This study examined the associations of the genetic polmorphism of CYP2E1. GSTM1 and GSTT1 with DMF metabolism. Methods: The subjects were 30 workers who exposed to DMF in a synthetic leather factory. Their urinary samples were collected and NMF concentrations were measured. Also, DMF concentrations in air were measured by personal air sampler during thier work. Genotypes of CYP2E1, GSTM1 and GSTT1 were investigated using PCR-RFLP or multiolex PCR methods with DNA extracted from venous blood. Effects of the polymorphisms of CYP2E1, GSTM1 and GSTT1 on DMF metabolism were analyzed. Results: The frequency of c1/c1 and c1/c2 genotypes for CYP2E1 were 76.6% and 23.3%, respectively. GSTM1 was deleted in 53.3% and GSTT1 deletion rate was 40.0%. In the group of GSTM1 deletion, mean urinary NMF concentrations (95.2 mg/g creatinine) were significantly higher than the undeleted group (45.3 mg/g creatinine, p=0.042). There were no significant differences of mean urinary NMF concentrations in the groups with the defferent genotypes of CYP2E1 and GSTT1. The distribution of CYP2E1, GSTM1 and GSTT1 genotypes by urinary NMF concentrations had not statistical significance. Conclusions: In GSTM1 deleted workers who exposed to DMF, mean urinary NMF concentration was higher than undeleted cases. GSTM1 deleted workers are seemed to be more susceptible to DMF toxicity. It is necessary to screen whether the workers have GSTM1 deleted genotype or not when they are arranged to their work place.