적토룡 추출 단백분획의 프로테나제 유도 수용체-2의 활성화 및 형행개선 효과

이철규,신장식,최영근,임채곤,조일환,김철,Lee, Chul-Kyu,Shin, Jang-Sik,Choi, Young-Keun,Lim, Chae-Kon,Cho, Il-Hwan,Kim, Chul 대한약학회 1997 약학회지 Vol.41 No.2

The proteinase-activated receptor (PAR-2) belongs to the family of seven transmembrane region receptors, like the thrombin receptor, it is activated by specific proteolytic clea vage of its extracellular amino terminus and a synthetic peptide (SLIGRL). The earthworm protein fraction (EPF) extracted from Lumbricus rubellus elicted dose- and endothelium-dependent relaxations in phenylephrine-contracted rat thoracic aorta, whereas heat inactivated EPF (0.5 ${\mu}g$ /ml) had no effect. In the presence of the nitric oxide synthase inhibitor NG-methyl-L-arginine (1.8 micro M), EPF (0.5 ${\mu}g$ /ml)-induced relaxations were partially inhibited. Furthermore, EPF (0.5 ${\mu}g$ /ml) dramatically caused relaxation of thrombin-desenstized rat thoracic aorta. These results indicate that EPF activates PAR-2 in vascular endothelial cell. Intravenous injection of EPF (20 mg/kg, bolus) into anesthetized rats produced a marked depressor response. EPF (0 ~ 80 ${\mu}g$ /ml, gradient) was very effective on increasing of perfusion volume in rabbit ear vessel preparations. These results imply the usefulness of EPF as a vascular smooth muscle relaxant and indicate that the activation of PAR-2 may be a mechanism of EPF on hemokinetic improvement.

Multi Axis DOAS를 이용한 대기미량 물질 원격 측정

이철규 ( Chul Kyu Lee ),김영준 ( Young Joon Kim ) 大韓遠隔探査學會 2006 大韓遠隔探査學會誌 Vol.22 No.2

태양광을 광원으로 하고 천정방향을 포함한 다양한 고도각을 이용하는 자외선/가시광선영역에서의 흡수분광학이 최근에 지상용 대기원격 측정에 개발되어오고 있다. 이를 이용하여 지표부근에 존재하는 대기 미량 물질의 공간적 분포가 유추될 수 있다. 대기질 측정기술 중 하나인 MAX-DOAS (Multi-axis Differential Optical Absorption Spectroscopy) 기술은 광원으로서 태양산란광을 이용하고, 다양한 고도각에서 태양산란광을 기록하고 분석을 통하여 대기 중 미량 물질을 측정한다. 광주과학기술원 환경모니터링신기술 연구센터에서 개발된 MAX-DOAS 시스템은 2004년 1월, 5월, 10월에 각각 도시대기, 화산플룸, 화력발전소 플룸의 측정에 적용되었다. 각각의 경우에 SO2, NO2, BrO, O4를 정량분석하기 위하여 기록된 MAX-DOAS 스펙트럼은 자외선/가시광선 영역에서의 고유 흡수스펙트럼을 이용한 DOAS 기술을 이용하여 분석 되었다. 그 결과는 Slant Column Density (SCD)로 표현되었다. 플룸 측정의 경우에서는 플룸 속에 포함된 NO2, SO2의 공간적 분포를 파악하기 위하여 플룸의 진행방향과 수직적인 방향에서 MAX-DOAS 스캔이 이루어졌다. 이를 통하여 얻은 단면적을 토대로 SO2, NO2 농도가 계산되었다. 화산플룸에서 SO2는 580ppbv, 화력발전소 플룸에서 NO2는 337ppbv, SO2는 227 ppbv로 계산되었다. UV-visible absorption measurement techniques using several horizone viewing directions in addition to the traditional zenith-sky pointing have been recently developed in ground-based remote sensing of atmospheric constituents. The spatial distribution of various trace gases close to the instrument can be derived by combing several viewing directions. Multi-axis differential optical absorption spectroscopy (MAX-DOAS) technique, one of the remote sensing techniques for air quality measurements, uses the scattered sunlight as a light source and measures it at various elevation angles (corresponding to the viewing directions) by sequential scanning with a stepper motor. A MAX-DOAS system developed by GIST/ADEMRC has been applied to measuring trace gases in urban air and plumes of the volcano and fossil fuel power plant in January, May, and October 2004, respectively. MAX-DOAS spectra were analyzed to identify and quantify SO2, NO2, BrO, and O4 (based on Slant Column Densities, SCD) in the urban air, volcanic plume, and fossil fuel power plant utilizing theirs specific structured absorption features in the UV-visible region. Vertical scan through the multiple elevation angles was performed at different directions perpendicular to the plume dispersion to retrieve cross-sectional distribution of SO2 or NO2 in the plumes of the volcano and fossil fuel power plant. Based on the estimated cross sections of the plumes the mixing ratios were estimated to 580 SO2 ppbv in the volcanic plume, and 337 NO2 and 227 SO2 ppbv in the plume of the fossil fuel power plant, respectively.

자화 벡터 분포를 고려한 CPM의 3차원 자계 분포 해석 및 설계

李喆圭(Chul-Kyu Lee),權丙一(Byung-Il Kwon),朴勝燦(Seung-Chan Park),禹炅一(Kyung-Il Woo) 대한전기학회 2002 전기학회논문지 B Vol.51 No.10

연구논문 : CO2 흡착을 위한 Ethylenediamine 함침 MCM41의 특성 분석

이철규 ( Chul Kyu Lee ),최성우 ( Sung Woo Choi ) 한국환경과학회 2012 한국환경과학회지 Vol.21 No.6

Adsorption experiment of carbon dioxide was performed on MCM41 silica with a 30 wt % EDA (ethylenediamine) loading at different CO2 inlet concentration and various adsorption temperature, The surface characteristics of CO2 capturing agent were carried out using BET analysis, X-ray diffraction and FT-IR, The results of BET showed 781 m2/g for MCM41 and 464 m2/g for EDA/MCM41, X-ray diffraction results reveled typical hexagonal pore system, The higher sorption capacity of EDA/MCM41 was about 80 mgco2/gsorbent with 50% CO2 inlet concentration and 303 K adsorption temperature, The isosteric heat of adsorption in 303-353 K ranged from -25.47 to -28.24 KJ/mole for EDA/MCM41, which indicates CO2-EDA/MCM41 interaction with exothermic adsorption process. Finally, the performance of EDA/MCM41 in 10 consecutive sorption-desorption runs was a stable with only a minor drop in its sorption capacity.

화력발전소 가동에 따른 PM10 분포특성 및 영향연구

이철규(Chul-Kyu Lee),최성우(Sung-Woo Choi),정동진(Dong-Jin Jung) 계명대학교 낙동강환경원 2012 環境科學論集 Vol.16 No.1

In this study, based on existing plant operations, distribution characteristics of PM10 and their impact to the surrounding area are predicted by CALPUFF air model, so results are presented and analyzed. As a result of air pollution analysis, environmental concentrations in the area surrounding the power plant and those of Incheon national background levels environmental concentrations show similar trend seasonally and monthly, indicating that the seasonal weather effect is more significant than power plant operation. Especially PM10 concentrations is proportional to yellow sand period According to theresults of air modeling, the predicted concentrations and the measured concentrations compared with the correlation coefficient R = 0.762. Along with plant operation, the average contribution concentration for 24hours contribution are PM10 is 1~5 ㎍/㎥. In addition, annual major wind direction is west-north-west(WNW), so most of air pollutants is move to east-south-east(ESE). As a result of air dust modelling, the average contribution concentration for 24hours is 1.5~4.5 ㎍/㎥, the health impact in surrounding are seems to be insignificant.

찹쌀가루와 멥쌀가루의 첨가량에 따른 호박죽의 품질 특성

이철규(Chul Kyu Lee),윤혜현(Hye Hyun Yoon) 한국조리학회 2017 한국조리학회지 Vol.23 No.3

ISC3 모델을 이용한 대구광역시 대기오염 자동측정망의 적절성 평가

이철규(Chul-Kyu Lee),이중범(Jung-Bom Lee),최성우(Sung-Woo Choi) 계명대학교 낙동강환경원 2010 環境科學論集 Vol.14 No.1

Air Quality monitoring networks is established in order to evaluate present level of air pollution, to make future prediction, to provide input data of air quality model, and to assess compliance with the standards. Environmental level is determined by regional environmental factors, that affected by complex urban environment. therefore, accurate measurement of environmental level has top priority to establish and promote appropriate environmental policies. Air quality monitoring network of Deagu, consisting of 13 stations, was allocated under unscientific and irrational principles. therefore, this study was aimed at presenting improvement directions for the efficent network relocation base on the present problems obtained by ISC3 model. From the result of SO2, CO, NO2, PM-10 concentration prediction classified into high value 2 point, medium value 4 point, low value 5 point. Air Quality monitoring networks was arranged properly. The maximum concentrations in regions is 28 grid, 29 grid, 36 grid, 37 grid, 38 grid, 45 grid, Air Quality monitoring networks did not exist and Therefore Air Quality monitoring networks is necessart to and rearrangement or new installation

CO₂ 흡착을 위한 EDA 함침 메조실리카의 특성분석

이철규(Chul-Kyu Lee),최성우(Sung-Woo Choi) 계명대학교 낙동강환경원 2012 環境科學論集 Vol.16 No.1

Adsorption experiment of carbon dioxide was performed on MCM41 silica impregnated with EDA(ethylenediamine). The prepared adsorbents were characterized by BET surface area, X-ray diffraction. The CO2capture study was investigated in a U type packed column with GC/TCD. The results of XRD for MCM-41 and EDA-impregnated MCM41 showed typical the hexagonal pore system. BET results showed the MCM 41 impregnated amine to have a surface area of 141 ㎡/g to 595 ㎡/g. The CO₂ adsorption capacity on EDA was as follow: EDA30/MCM41 > EDA40/MCM41 > EDA20/MCM4 > EDA50/MCM41 1> EDA10/MCM. The EDA30/MCM41 showed the highest adsorption capacity due to physical adsorption and chemical adsorption by amino-group content. Also, as CO₂ inlet concentration was increased, the breakthrough time was decreased. The lower adsorption temperature lead to a good adsorption capacity. In the multiple cycle test of 10 times, MCM-41 impregnated with 30% of EDA show a constant adsorption capacity.

대구지역 PM10 물질의 총량규제를 위한 배출량 분석과 대기환경용량 산정에 관한 연구

이철규(Chul-Kyu Lee),최성우(Sung-Woo Choi) 계명대학교 낙동강환경원 2007 環境科學論集 Vol.12 No.1

The purpose of this study lies in improving the quality of the atmosphere through the introduction of Total Emission Standard Regulations System(TESRS). This system is put into act after calculating the environmental critical loads of the atmosphere for PM10, a based on the current research for air pollutant emission rate in Daegu. The data for the output amounts has been collected from Clean Air Policy Support System(CAPSS) in the year of 2003 through 2004. For the effective management of air quality in Daegu area, point source and non-point pollution source of PM10 were calculated, the point pollution source calculated in terms of each output facility. The atmospheric environmental amount of PM10 was estimated by ISCLT3(Industrial Source Complex Long Term Dispersion Model). To improve PM10 concentration through emissions reduction policies, it was found that emissions reduction for the on-road mobile source would be the most effective in Daegu.

인체에 유해하지 않은 원소를 사용환 Ti계 벌크 비정질 합금 개발

이철규 ( Chul Kyu Lee ),이승훈 ( Seong Hoon Yi ) 한국주조공학회 2012 한국주조공학회지 Vol.32 No.4

Ti-based bulk metallic glasses with high glass forming ability were developed through a systematic alloy design technique. The main alloy design strategy was the selection of alloying elements that may not be toxic in the human body. The Ti450Cu401Zr127Si23 alloy could be cast into an amorphous rod with the diameter of 3 mm by a suction casting technique using Cu mold. The compressive strength of the amorphous rod was measured as 1826MPa. Since the Ti-based amorphous alloys consist of non-toxic elements, they can be widely used as bio-materials and ele-materials with unique and beneficial properties.