대한임상독성학회지에 발표된 연구 문헌의 통계적 분석

이진혁 ( Jin Hyuck Lee ),임태호 ( Tae Ho Lim ),김원희 ( Won Hee Kim ),김창선 ( Chang Sun Kim ),오재훈 ( Jae Hoon Oh ),강형구 ( Hyung Goo Kang ),최혁중 ( Hyuk Joong Choi ),강보승 ( Bo Seung Kang ) 대한임상독성학회 2013 대한임상독성학회지 Vol.11 No.2

Purpose: The purpose of this study was to examine the research characteristics and the trend of the Journal of the Korean Society of Clinical Toxicology by bibliometric analysis. Methods: This study was a retrospective quantitative literature review of the publications. We collected data from the internet homepage of the Korean Society of Clinical Toxicology. Among 228 publications, a total of 225 articles were included in this analysis. The data were analyzed from different perspectives, including article types, study design, number of authors, type of toxic material, and the top five ranking prolific authors and the affiliated organization were identified. Results: A total of 225 articles were analyzed; 98(43.6%) were original articles, 115(51.1%) were case reports, and 12(5.3%) were reviews. Among the original articles, nine were prospective studies and 89 were retrospective studies, which were assorted according to study design; there were two(2.0%) cross sectional studies, 93(94.9%) cohort studies, and three(3.1%) etc. The median number of authors per article was five and the top five ranking authors and affiliated organizations published 31.1% and 32.8% of total articles, respectively. The most abundant topic was pesticides, followed by natural poisons and poisons encountered in the work place. Conclusion: Since its foundation, the Journal of the Korean Society of Clinical Toxicology has published 19 issues and 228 articles and has played a key role in development of toxicology research in Korea. However, low ratio of original articles and a decrease in the number of recent articles indicates that greater effort is needed in clinical research. In addition, further interest of many experts and various institutions is necessary.

산삼복합약침과 한약을 병행한 식이요법이 체성분 변화에 미치는 영향: 후향적 연구

이진혁(Jin-Hyuck Lee),김선종(Seon-Jong Kim),임정아(Jung-A Lim),신정민(Jung-Min Shin) 한방비만학회 2022 한방비만학회지 Vol.22 No.1

The purpose of this study was to investigate the effects of dietary therapy with Korean herbal medicine and cultivated wild ginseng pharmacopuncture on change of body composition retrospectively. We analyzed the medical records of 26 patients, who carried out dietary therapy with Korean herbal medicine and cultivated wild ginseng pharmacopuncture at Moemfit Clinic, Charmjin Oriental Medicine for 8-12 weeks. And exercise and nutrition were recommended self-developed food, Moemfit Shake, Moemfit Hankki and walking exercise for one hour a day. The body composition values (body weight, body mass index, body fat mass, skeletal muscle mass, waist-hip ratio, visceral fat area, percent body fat) decreased after dietary therapy with Korean herbal medicine and cultivated wild ginseng pharmacopuncture significantly. But, percent skeletal muscle increased significantly. Results from this investigation showed that dietary therapy Korean with herbal medicine and cultivated wild ginseng pharmacopuncture has positive effects on changes of body compositions.

배합사료의 크기, 사육밀도 및 용존산소 농도가 넙치 (Paralichthys olivaceus)의 성장에 미치는 영향

김성삼 ( Sung Sam Kim ),이진혁 ( Jin Hyuck Lee ),김강웅 ( Kang Woong Kim ),김경덕 ( Kyoung Duck Kim ),이봉주 ( Bong Joo Lee ),이경준 ( Kyeong Jun Lee ) 한국수산과학회 2015 한국수산과학회지 Vol.48 No.3

We performed three sets of feeding trials to establish the optimal feed size (Exp-I), stocking density (Exp-II), and dis-solved oxygen level (DO) (Exp-III) for olive flounder Paralichthys olivaceus. In Exp-1, four replicate groups of fish (53.6±0.9 g) were fed commercial diets with three particle sizes (small, medium, and large). In Exp-II, fish (30.0±0.1 g) were reared at four stocking densities (1.8, 3.5, 5.3, and 7.1 kg/m3). In Exp-III, fish (187±1.48 g) were reared under two different DO levels (2-3 and 6-7 mg/L). In Exp-I, fish fed the large-particle diet gained significantly more weight and had a lower feed conversion ratio than fish fed the small- and medium-particle diets. In Exp-II, fish reared at 1.8 and 3.5 kg/m3 gained slightly more weight and had lower feed conversion ratios than fish reared at 5.3 and 7.1 kg/m3, although these differences were not significant. In Exp-III, negative effects were observed in the low DO groups. Therefore, under our experimental conditions, the optimal feed particle size, stocking density, and DO level for olive flounder were 9-9.4 mm, 3.5 kg/m3, and 6-7 mg/L, respectively.

등속성 검사를 통한 견관절 전방 불안정 환자와 정상인의 회전력 비교

이동기(Dong-Ki Lee),김태권(Tae-Kwon Kim),이진혁(Jin-Hyuck Lee),이대희(Dae-Hee Lee),정웅교(Woong-Kyo Jung) 대한견주관절의학회 2012 대한견주관절의학회지 Vol.15 No.2

목적: 견관절 전방불안정 환자는 탈구에 대한 불안감 및 탈구시의 통증 등 다양한 원인으로 정상적인 운동 및 활동을 하지 못할 것으로 예상할 수 있으나 이에 대한 연구는 미미한 실정이다. 본 연구에서는 견관절 전방불안정 환자와 정상인 사이의 내회전 및 외회전력에 대해 등속성 근력 검사를 시행하여 전방불안정 환자에서 나타나는 회전력의 변화를 살펴보고자 하였다. 대상 및 방법: 2009년 3월부터 2010년 2월까지 우측 우세수의 견관절 전방 불안정 진단 하에 수술적 치료를 시행한 환자 중 수술 전 등속성 근력 검사를 시행한 환자 13명을 대상으로 하였고, 견관절의 전방불안정 증상이 없는 정상 성인 15명을 대조군으로 설정하였다. 대상군 및 대조군 모두 남성이었으며 두 군간의 평균 연령, 신장, 체중, 체질량 등의 차이는 없었다. 등속성 근력검사는 Biodex system (Biodex Medical Systems, Shirley, NY, USA)을 사용하여 60 deg/sec, 180 deg/sec 의 각속도로 견관절의 외회전력 및 내회전력의 체중보정 최대우력 (peak torque)과 총 일량을 측정하였고, 외회전, 내회전 최대우력비율 및 운동피로도를 계산하였다. 두 군간에 각 측정치를 비교하여 전방 불안정 환자의 회전력의 특징을 분석하였다. 결과: 불안정증이 없는 좌측 견관절의 등속성 회전근력은 양군 사이에 모든 측정치에서 차이가 없었다. 우측 견관절의 등속성 근력 검사결과 내회전력은 전방 불안정환자와 정상 대조군 간 모든 각속도에서 최대우력 및 총 일량 사이에 유의한 차이가 없었다. 외회전력의 체중보정 최대우력과 총 일량은 전방불안정 환자에서 60 deg/sec 및 180 deg/sec 두 각속도에서 모두 정상 대조군에 비하여 감소되었고, 외회전력/내회전력의 최대우력비율 역시 통계적 차이가 있었다. 운동피로도는 외회전력, 내회전력 모두 양 군간에 의미 있는 차이는 없었다. 결론: 견관절 전방불안정 환자는 견관절의 외회전력이 감소되어 있고 내회전-외회전력의 균형이 소실되어 있으나 근피로도는 정상으로 판단되며 이는 견관절 탈구 환자의 보존적 치료나 재활에 있어 고려해야 할 것으로 생각된다. Objective: It has been expected that patient with posttraumatic recurrent anterior shoulder dislocation might have limited daily life activity because of pain and apprehension of dislocation. But there have been only a small number of investigations regarding the rotator strength in this patient. The aim of this study is to find the characteristics about rotator strength of patient with posttraumatic recurrent anterior shoulder dislocation using an isokinetic testing. Method: We enrolled thirteen patients with posttraumatic recurrent anterior shoulder dislocation and fifteen sex, age-matched healthy nonathletic subjects in this controlled study. All participants were male and there were no significant differences between the two groups in age, height, weight, BMI. Isokinetic internal rotator and external rotator strength was evaluated with a Biodex Isokinetic Testing machine (Biodex Medical Systems, Shirley, NY, USA), tests were performed at 60 deg/sec and 180 deg/sec for both sides. Peak torque normalized to body weight, external rotator to internal rotator ratio, total work and fatigue were calculated for each angular velocity. The association between internal rotator and external rotator strength and shoulder instability was analyzed by comparisons with a control group. Results: Any notable differences could not be found between the two groups given all data from no symptomatic left shoulder. There were no significant differences between the two groups statistically in internal rotation strength of right shoulder. However, there has been a tendency that at all angular velocities, external rotator peak torque to body weight, total work and external rotator to internal rotator ratio were significantly lower in the anterior instability group than the control group at all angular velocities. There was no substantial difference between those groups with respect to the fatigue of external rotator and internal rotator in our study. Conclusion: The prominent characteristics of posttraumatic recurrent anterior shoulder dislocation are external rotator weakness and loss of balance with external rotator and internal rotator. Therefore selective training using this information rotator might be helpful in conservative treatment and rehabilitation.

타피오카 전분을 이용한 넙치( Paralichthys olivaceus )용 고효율 배합사료 개발

김강웅 ( Kang Woong Kim ),이진혁 ( Jin Hyuck Lee ),배기민 ( Ki Min Bae ),김경덕 ( Kyoung Duck Kim ),이봉주 ( Bong Joo Lee ),한현섭 ( Hyon Sob Han ),이경준 ( Kyeong Jun Lee ),김성삼 ( Sung Sam Kim ) 한국수산과학회 2014 한국수산과학회지 Vol.47 No.6

This study compared the effects of feeding diets consisting of an experimental extruded pellet with tapioca starch (EEP), commercial extruded pellet (CEP), and raw-fish-based pellet (MP) on the growth, flesh quality, and apparent digestibility coefficient of the olive flounder Paralichthys olivaceus . Two replicated groups of 4,000 fish each (initial mean weight: 81.8±3.5 g) were fed one of the experimental diets for 5 months. After the feeding trial, the final mean weight, weight gain, specific growth rate, and feed efficiency of fish fed the EEP was significantly higher than those of fish fed the CEP and MP. Moisture content in the whole-body of fish fed MP was significantly higher than those of fish fed other diets. However, the highest crude protein in the whole-body was found in fish groups fed the EEP. Significantly higher contents of 24:1n-9, 20:5n-3, 22:6n-3 and lower 18:1n-7 was observed in fish fed the EEP compared with fish fed the MP. The amino acid contents in the whole-body showed significant differences in the composition depending on the feed, but the distribution of free amino acids showed similar patterns. Among amino acids, glutamic acid showed the highest content in all the experimental groups, and the threonine, cysteine, and lysine contents were significantly higher in the groups fed with EEP and CEP than in the group fed with MP. Digestibility of nutrients of the EEP was significantly higher than that of fish fed the CEP. This suggests that extruded pellets can be used to feed olive flounder without compromising growth and flesh quality in comparison to raw-fish-based moist pellets. Formulation of the EEP could be used as a practical feed for olive flounder.

배합사료 및 습사료 공급에 따른 넙치( Paralichthys olivaceus )의 성장 및 어체성분 비교

김강웅 ( Kang Woong Kim ),이진혁 ( Jin Hyuck Lee ),배기민 ( Ki Min Bae ),김경덕 ( Kyoung Duck Kim ),이봉주 ( Bong Joo Lee ),한현섭 ( Hyon Sob Han ),김성삼 ( Sung Sam Kim ) 한국수산과학회 2014 한국수산과학회지 Vol.47 No.6

Two consecutive feeding trials were conducted to evaluate the effects of extruded pellet (EP) and raw fish-based moist pellet (MP) in the juvenile (experiment I) and sub-adult (experiment II) stages of olive flounder, Paralichthys olivaceus . The fish were distributed randomly to three aquarium tanks, as a group of 1,200 fish (initial mean weight 13.5±1.76 g) in experiment I, and as a group of 390 fish (initial mean weight 385±15.3 g) in experiment II. In experiment I, the weight gain, specific growth rate, feed efficiency, protein efficiency ratio, and survival of fish fed EP were all significantly higher than those of fish fed MP. In experiment II, no significant differences were observed in weight gain, specific growth rate and survival between the EP and MP groups. However, the feed efficiency and protein efficiency ratios of fish fed EP were significantly higher than those of fish fed MP. The results of this study indicate that EP could be developed to replace MP for market size production of olive flounder without any adverse effects on the growth performance. The dietary formulation used in this study could be used as an appropriate feed for olive flounder.

교통사고로 내원한 환자의 한방치료 전후의 삶의 질과 주관적 스트레스 변화

한창 ( Chang Han ),박종훈 ( Jong Hoon Park ),이진혁 ( Jin Hyuck Lee ),민관식 ( Kwan Sik Min ),한경완 ( Kyung Wan Han ) 대한한방신경정신과학회 2010 동의신경정신과학회지 Vol.21 No.2

Objectives: This study is to evaluate the quality of life and amount of stress after the treatment among the patients who visited hospital due to traffic accident. Methods: We evaluated 40 patients who have been treated by western medicine for 3 months but showed no improvements. We surveyed VNRS, SF-36 and IES-R-K scores before treatment began and treated patients twice a week for 4 weeks with acupuncture, chuna theraphy, herbal medicine. After 4 weeks of treatment, we surveyed VNRS, SF-36 and IES-R-K scores again and compared with the scores of before treatment. Results: VNRS score and SF-36 scale and IES-R-K scale showed significant improvement after the treatment, compared to the treatemt before. Conclusions: The amount of pain and stress, physical condition, all showed improvement among the patients who came to Oriental medicine hospital due to traffic accident.

사과 ‘히로사키’ 캘러스 추출물의 기능성 화장품 소재로서의 특성

고승희(Seunghee Ko),김영수(Young-Soo Kim),이진혁(Jin-Hyuck Lee),김일현(Il-Hyun Kim),김승범(Seungbeom Kim),노경백(Kyungbaeg Roh),신승우(Seungwoo Shin),정은선(Eunsun Jung),박덕훈(Deokhoon Park) 한국생물공학회 2013 KSBB Journal Vol.28 No.4

In order to investigate functional characterization of callus extracts of apple ‘Hirosaki’ for cosmetic materials, biological activities of its extracts including wrinkle improvement, hair growth, and anti-inflammatory effect were investigated. The callus extract showed similar activity with TGF-β used as positive control at 50 μg/mL in the test of collagen synthesis, and increased 40% of proliferation of hair follicle dermal papilla cells. Especially, in case of anti-inflammatory effect, callus extract inhibited about 50% of COX-2 expression which was known as response for intermediating inflammation, and about 70% of eotaxin-1 production which was increased by atopy dermatitis.

전단파 탄성초음파를 이용한 견관절 주변 근육 활성도의 비침습적 측정

황현정(Hyun Jeong Hwang),김슬기(Seul Ki Kim),장우영(Woo Young Jang),이진혁(Jin-Hyuck Lee),정웅교(Woong Kyo Jeong) 대한견주관절의학회 2017 대한견주관절학회 학술대회논문집 Vol.2017 No.3