봉약침(Bee Venom)과 Sweet Bee Venom의 Allergy 반응에 대한 비교연구

이진선,이종영,권기록,이희춘,Lee, Jin-Seon,Lee, Jong-Young,Kwon, Ki-Rok,Lee, Hee-Choon 대한약침학회 2006 Journal of pharmacopuncture Vol.9 No.3

Objectives : Sweet bee venom is made by removing allergen from the bee venom through gel filtration chromatography and propionic acid/urea polyacrylamide gel electrophoresis. The aim of this study was to verify allergy inhibitory action in Sweet Bee Venom in which the allergy causing enzyme is removed. Methods : 95 healthy adult men and women were selected through a survey whom had never received the bee venom therapy in the past. The concentration of bee venom pharmacopuncture and Sweet BV pharmacopuncture was equally at 0.1mg/ml and the experiment was conducted as the double blind test. Experiment groups were classified into low dosage groups(0.1ml for both bee venom pharmacopuncture and Sweet BV) and high dosage groups where 0.4ml of respective administrations were rendered made observations for allergic responses. Results : Participants of the study was comprised of 71 men and 24 women with the average age of 29.0 years. According to results of the low dosage groups, Sweet BV group showed significant reduction in pain after 4 hours and 24 hours compared to the bee venom pharmacopuncture group. Other allergic responses were insignificant between the groups. For the high dosage groups, Sweet bee venom group showed reduction in pain after 30 minutes and 4 hours. Other allergic responses such as edema, itchiness, dizziness from hypersensitivity, and fatigue were significantly lower in the Sweet bee venom administered group after 30 minutes. Conclusions : As a result of removed allergen, Sweet bee venom significantly inhibits allergic responses both locally and throughout the body. This indicates wider and easier application of Sweet bee venom for the symptoms applicable to the bee venom pharmacopuncture. Further comparative studies should be conducted to yield more objective verification.

회원작품 - 누하당(樓下堂)

이진선,Lee, Jinsun 대한건축사협회 2018 建築士 Vol.586 No.-

전기영동법(Electrophoresis)을 이용한 봉약침의 주요 성분에 관한 연구

이진선,권기록,이승배,Lee, Jin-Seon,Kwon, Gi-Rok,Lee, Seung-Bae 대한약침학회 2000 Journal of pharmacopuncture Vol.3 No.2

This study was designed to study on major components of various Bee Venom(Bee Venom by electrical stimulation in Korea; K-BV I, Bee Venom by Microwave stimulation in Korea; K -BV II, 0.5rng/ml, Fu Yu Pharmaceutical Factory, China; C-BV, 1mg /ml, Monmouth Pain Institute, Inc., U.S.A.; A-BV) using Electrophoresis. The results were summarized as follows: 1. In 1:4000 Bee Venom solution rate, the band was not displayed distinctly usmg Electrophoresis. But in 1: 1000, the band showed clearly. 2. The results of Electrophoresis at solution rate 1:1000, K-BV I and K-BVII showed similar band. 3. The molecular weight of Phospholipase $A_2$ was known as 19,000 but its band was seen at 17,000 in Electrophoresis. 4. Protein concentration of Bee Venom by Lowry method was different at solution rate 1:4000 ; C-BV was $250{wmu}g/ml,\;K-BV\;I\;was\;190{wmu}g/ml,\;K-BVII\;was\;160{wmu}/ml\;and\;C-BV\;was\;45{wmu}/ml5$. Electrophoresis method was unuseful for analysis of Bee Venom when solution rate is above 1:4000 but Protein concentration of Bee Venom by Lowry method was possible. These data from the study can be applied to establish the standard measurement of Bee Venom and prevent pure bee venom from mixing of another components. I think it is desirable to study more about safety of Bee Venom as time goes by.

HPLC를 이용한 봉약침의 주요 성분에 관한 연구

이진선,권기록,최호영,Lee, Jin-Seon,Kwon, Gi-Rok,Choi, Ho-Young 대한침구의학회 2000 대한침구의학회지 Vol.17 No.4

This study was designed to study on major components of various Bee Venom(Bee Venom by electrical stimulation in Korea; K-BV I, Bee Venom by Microwave stimulation in Korea; K-BV II, 0.5mg/ml, Fu Yu Pharmaceutical Factory, China; C-BV, 1mg/ml, Monmouth Pain Institute, Inc., U.S.A.; A-BV) using HPLC(High performance liquid chromatography). The results were summarized as follows : 1. HPLC method is useful for analysis of Bee Venom when solution rate is above 1:4000. 2. Analysis of Apamin using HPLC, the Retention time was 8.7min, and standard measurement curve was a function of y=4E+06x+21245. 3. Analysis of Melittin using HPLC, the Retention time was 29.0 min, and standard measurement curve was a function of y=4E+06x+23015. 4. Concentration of Melittin was about 297times than Apamin in K-BV I, and about 329times in K-BV II at same 1:500 solution rate, abnormally about 12 times in C-BV at 1:4000 solution rate. 5. Chinese Bee Venom using HPLC, the point from 5 to 7min(Retention time) showed a big extraordinary peak. These data from the study can be applied to establish the standard measurement of Bee Venom and prevent pure bee venom from mixing of another components. I think it is desirable to study more about safety of Bee Venom as time goes by.

지진시 동토압을 받는 역 T형 옹벽의 접지압 산정에 관한 연구

이진선,Lee, Jin-Sun 한국지진공학회 2012 한국지진공학회논문집 Vol.16 No.2

본 논문에서는 지진시 역 T형 옹벽에 작용하는 기초 접지압의 변화를 Mononobe-Okabe공식을 이용하는 기존의 유사정적 설계기법과, 지반의 비선형 부지증폭현상 고려한 유한차분해석을 이용하여 살펴 보았다. 옹벽 설계에 있어서 높이 10m를 초과하는 역 T형 옹벽의 경우 상시 안정조건을 만족함에도 불구하고 지진시 지지력 안정조건을 만족하지 못하는 경우가 발생한다. 안정조건을 만족시키지 못하는 주요 원인은 동토압으로 야기되는 편심하중 증가로 인한 기초 유효저면적의 감소이다. 본 논문에서는 역 T형 옹벽의 지진시 유효저면적의 변화를 유한차분해석프로그램(FLAC)을 이용하여 살펴보았으며, 그 결과로부터 동적지지력 계수의 설계 적용성을 검토하였다. Pseudo static analysis using the Mononobe-Okabe method and numerical analysis considering a small strain nonlinearity from the soil were performed to determine the bearing pressure changes of the inverted T-type retaining wall subjected to earthquake motions. In many cases, an inverted 'T' type retaining wall of more than 10 m shows bearing capacity failure under earthquake conditions, despite showing sufficient bearing capacity during normal conditions. The most important reason for this is the change of the effective base area during an earthquake. In this paper, the change of the effective base area of an inverted 'T' type wall is analyzed by using finite difference element code (FLAC). In addition, the effect of dynamic bearing capacity coefficients (which has been suggested by several researchers but not adopted in current design codes and procedures) was verified.

대용량 분류에서 SVM과 신경망의 성능 비교

이진선,김영원,오일석,Lee Jin-Seon,Kim Young-Won,Oh Il-Seok 한국정보처리학회 2005 정보처리학회논문지B Vol.12 No.1

이 논문은 대용량 분류 문제를 위한 모듈러 신경망(modular feedforward MLP)과 SVM(Support Vector Machine)의 성능을 비교 분석하였다. 전반적으로 SVM이 상당한 성능 차이로 우수함을 확인하였다. 또한 부류 수가 많아짐에 따라 SVM이 신경망보다 완만하게 성능 저하가 있음도 확인하였다. 또한 기각에 따른 정인식률 추이를 분석하였고, 대용량 분류에 적합한 SVM 파라메터(kernel 함수와 관련 변수들)를 도출하였다. In this paper, we analyzed and compared the performances of modular FFMLP(feedforward multilayer perceptron) and SVUT(Support Vector Machine) for the large-set classification problems. Overall, SVM dominated modular FFMLP in the correct recognition rate and other aspects Additionally, the recognition rate of SVM degraded more slowly than neural network as the number of classes increases. The trend of the recognition rates depending on the rejection rate has been analyzed. The parameter set of SVM(kernel functions and related variables) has been identified for the large-set classification problems.

신경망을 이용한 필기 숫자 인식에서 부류 분별에 기반한 특징 선택

이진선,Lee, Jin-Seon 한국정보처리학회 1999 정보처리논문지 Vol.6 No.2

The primary purposes in this paper are to analyze the class separation of features in handwritten numeral recognition and to make use of the results in feature selection. Using the Parzen window technique, we compute the class distributions and define the class separation to be the overlapping distance of two class distributions. The dimension of a feature vector is reduced by removing the void or redundant feature cells based on the class separation information. The experiments have been performed on the CENPARMI handwritten numeral database, and partial classification and full classification have been tested. The results show that the class separation is very effective for the feature selection in the 10-class handwritten numeral recognition problem since we could reduce the dimension of the original 256-dimensional feature vector by 22%. 본 논문의 목적은 필기 숫자 인식에서 특징의 부류 분별력을 분석하고, 이를 특징 선택에 활용하는 것이다. 부류 분별력을 측정하기 위하여 Parzen 윈도우를 이용하여 부류 분포를 추정하였고, 서로 다른 부류의 부류 분포간의 거리를 부류 분별로 정의하였다. 이렇게 계산된 부류 분별을 이용하여, 특징 벡터에서 쓸모 없거나 중복성을 갖는 특징을 제거하여 특징 벡터의 차원을 줄인다. 실험은 CENPARMI 필기 숫자에 대해 수행하였으며 10개 부류 전체 뿐 아니라 2개 부류에 대해서도 수행하였다. 실험 결과 10-부류 필기 숫자 인식에서 256-차원 원래 특징 벡터를 인식률 손실 없이 22% 줄일 수 있어, 부류 분별이 특징 선택을 위한 유용한 도구임을 보였다.

사독(蛇毒)에 대한 문헌적(文獻的) 고찰(考察)

이진선,권기록,Lee, Jin-Seon,Kwon, Gi-Rok 대한약침학회 1999 Journal of pharmacopuncture Vol.2 No.1

This study was carried out to invastigate the researches of Snake Venom and snakes which used in treatment 1. The fist literature that used the snake for treatment is Shin Nong Ben Cao Jing 2. Composition of Snake Venom is consist of Enzymatic proteins ; Phospholipase A(A1-2), Protease, L-amino acid oxidase etc, and Non-enzymatic proteins ; Crotamine(Cytolysin), Proteolytic factor(Hematoxin), Crotoxin(Neurotoxin) etc. 3. Main toxins in Snake Venom are Hematoxin, Cytolysin, Neurotoxin and Cardiotoxin. Lethal dose 50 value of Agkistrodon brevicaudus is $45.87{\mu}g$/18g, Agkistrodon saxatilis is $10.28{\mu}g$/18g, Agkistrodon ussuriensis is $8.68{\mu}g$/18g, therefore Agkistrodon ussuriensis has strongist Snake Venom of all in Korea. 4. Pharmacological actions of Snake Venom are anticoagulation, thrombolytic function, hypotensor etc. 5. Systemic syndromes and signs after snakebite are Dizziness(25.7%), Vomitting(23.1%), Fever(22%), Visual disturbance(18%), Headache(17.7%) and Dyspnea(17.6%), etc. 6. Local syndrome and sign after snakebite is Discoloration(54.2%), Bleeding(20.2%), Bullae(10.7%), Skinulcer(10.8%), etc. 7. Pathological syndromes after snakebite are WBC increase, Urine protein, Urine sugar, Haematuria and elevation of S-GDT, S-GPT etc. These syndromes are leaded by Hematoxin and Cytolysin. 8. Complication signs after snakebite are Cellulitis, Gastritis, Lympoma, Abscess etc. 9. Common function of Viperidae(Agkistrodon acutus or Zaocys dhumnades etc) is expelling the wind(祛風), removing obstruction in the channels(通絡), antipastic function(止痙). And it is used in order to cure hemiparesis, hemiplegia, facial palsy and CVA disease, etc. 10. Using way of snake for medical treatment is various like Herbal alchol therapy, pill, powder and injection etc. The Study on the Snake Venom should be carried out continuously for using of medical treatment.

안면견갑상완형(Fascioscapulohumeral:FSH) 근이영양증 1례에 대한 증례보고

이진선,안창석,권기록,Lee, Jin-seon,An, Chang-suk,Kwon, Gi-rok 대한침구의학회 2001 대한침구의학회지 Vol.18 No.3

Objective : There was no report on the treatment of Fascioscapulohumeral (FSH) Muscular Dystrophy by Oriental medicine. But the treatment conducted on the patient admitted to the Sangji Oriental Medicine Hospital from January 9, 2001 to February 23, 2001, a significant treatment result was yielded and would like to suggest treatment plan for the future treatments. Methods : Under the assumption that Korean Bee-Venom Therapy may be affective for treating FSH Muscular Dystrophy, the following points were administered : SI10(노유), SI11(天宗), BL23(腎兪), BL26(關元兪), ST36(足三里), LI4(合谷), Liv3(太衝), SI9(肩貞). CFC(Carthami Flos;紅花 and Cervi Pantotrichum Cornu;鹿茸) herbal extract was treated on the other acupuncture points. Sa-Am(Four needle technique) Acupuncture (tonifying SI5 and ST42, sedating GB41 and ST43) was done every day. For herbal medicine, TaeEumIn ChoWiSeungChung-Tang was given based on the constitutional diagnosis. Results : After 7 weeks of treatment, a remarkable improvement was made for facial muscular movement and muscular strength of the scapular and another regions. Conclusions : 1. Significant improvement in the muscular strength for the case of FSH Muscular Dystrophy was obtained with through Korean Bee-Venom Therapy, Four needle technique, and herbal medication. 2. For progressive muscular dystrophy, it is necessary to practice muscular strength recovery exercise in conjunction with Korean Bee-Venom Therapy. 3. Although this case yielded favorable result, further observation and study must be made to concretely prove the effectiveness of Korean Bee-Venom Therapy for treating muscular dystrophies.

등고선 추출을 위한 효과적인 다음점 결정 방법

이진선,정성종,Lee, Jin-Seon,Jeong, Seong-Jong 한국정보처리학회 1994 정보처리논문지 Vol.1 No.3

고도행렬로부터 등고선을 추출하는데 있어, 가장 중요한 문제는 하나의 격자에 네개의 통과점이 발생하는 이상 상황(degenerate case)의 해결이다. 본 논문은 이상 상황 검사와 다음점 결정을 동시에 수행하는 방법을 기술한다. 이 방법은 최소 횟수 의 배열 인덱싱을 필요로 한다. 또한 통과점을 모서리점의 높이차에 따라 LOWER/ HIGHER로 표시하고, 이 정보를 이용하여 보다 적은 횟수의 배열 인덱싱을 필요로하는 방법을 제안한다. 그리고 통과점을 표시하고 이들을 추적하기에 적합한 자료구조를 구체적으로 기술한다. In extracting contours from elevation matrix, the most important problem is to solve the degenerate case where four cross point arise in a grid. This paper describes a technique which performs the checking of degenerate case and determination of next point simultaneously. It requires minimum number of array indexing. Also this paper proposes a technique which reduces the number of array indexing by using LOWER/HIGHER information of a cross point designated according to height difference of grid vertices. In addition, we describe a data structure which is proper for representing cross points and tracing them.