SWAT 모형을 이용한 만대천 유역의 비점오염 예측과 초생대 수질 개선 효과 분석

이지원,엄재성,김범철,장원석,류지철,강현우,김기성,임경재,Lee, Ji-Won,Eom, Jae-Sung,Kim, Bom-Chul,Jang, Won-Seok,Ryu, Ji-Chul,Kang, Hyun-Woo,Kim, Ki-Sung,Lim, Kyoung-Jae 한국농공학회 2011 한국농공학회논문집 Vol.53 No.1

Mandae watershed in Gangwon province has been known as one of soil erosion hot spot watersheds within Hanggang basin. Thus numerous efforts have been made to reduce soil erosion and pollutant loads into receiving watershed. However, proper best management practices have not been suggested because no monitoring flow and water quality data were available. Thus, modeling technique could not be utilized to evaluate water quality issue properly at Mandae watershed to develop and implement the best management practices. In this study, the SWAT model was applied to the Mandae watershed, Gangwon province to evaluate the SWAT prediction ability and water quality improvement with vegetated filter strip (VFS) in this study. The Nash-Sutcliffe model efficiency (NSE) and Coefficient of determination ($R^2$) values for flow simulation were 0.715 and 0.802, respectively, and the NSE and $R^2$ values were 0.903 and 0.920 for T-P simulation indicating the SWAT can be used to simulate flow and T-P with acceptable accuracies. The SWAT model, calibrated for flow and T-P, was used to evaluate water quality improvement with the VFS in agricultural fields. It was found that approximately 56.19 % of T-P could be reduced with vegetated filter strip of 5 m at the edge of agricultural fields within the watershed (34.86 % reduction with VFS of 1m, 48.29 % with VFS of 3 m). As shown in this study, the T-P, which plays key roles in eutrophication in the waterbodies, can be reduced with proper installation of the VFS.

복분자(Rubus coreanus Miquel) 추출물이 MC3T3-E1 조골세포의 활성과 분화에 미치는 영향

이지원,이인선,Lee Ji-Won,Lee In-Seon 한국생명과학회 2004 생명과학회지 Vol.14 No.6

골조직은 골아세포, 파골세포, 골세포 등으로 구성되며, 골개조시 여러 인자가 세포증식, 분화, 활성화 및 골대사 조절에 관여한다. 이때 조골세포의 활성은 골형성에 중요하므로, 본 연구에서는 MC3T3-E1 조골세포주를 이용하여 식용자원인 복분자의 조골세포의 증식과 분화활성에 미치는 영향을 조사하였다. 복분자 추출물이 조골세포의 성장에 미치는 영향을 MTT 검색법으로 조사한 결과, 복분자 추출물 $10\;{\mu}g/mL$ 처리시 대조군과 비교하여 $142\%$ 증가하여 조골세포에 대해 높은 성장률을 보였다. 복분자 추출물이 ALP 효소 활성에 미치는 영향을 3일 간격으로 배지교환 및 시료처리를 하면서 27일 동안 배양시간에 따른 변화를 측정하여 조사하였다. 그 결과, 농도 1, 10, $100\;{\mu}g/mL$ 처리시 $100\;{\mu}g/mL$을 제외한 나머지 분획물들이 시간이 지남에 따라 ALP 활성을 증가시켰고, $10\;{\mu}g/mL$ 농도의 추출물은 27일째에 대조군에 비해 약 2.6배 이상, 양성대조군에 비해 약 1.5배 이상 ALP 활성을 증가시켰다. 복분자 추출물은 다시 ALP 효소 염색법과 Alizarin Red 염색으로 조골세포의 ALP활성유도, 분화와 석회화 형성능을 재확인하였으며 골기질 유전자의 발현의 변화도 확인하였다. 따라서 종래의 골질환에 좋다고 알려진 식품인 복분자 추출물이 양성대조군에 비해 빠르게 세포 증식과 분화를 유도하고 있어 앞으로 복분자에 대한 좀 더 깊은 분자생물학 수준 등의 구체적인 연구들과 기작연구가 지속적으로 이루어져야 할 것이라 추측된다. The osteoblastic cell activity is important for born formation, thus, this study was performed to investigation of that the effect of edible sources, Rubus coreanus Miquel (RCM), on the proliferation and differentiation of MC3T3-E1 osteoblastic like cell. The effects of RCM extract on cell proliferation were measured by MIT assay. At 1, $10\;{\mu}g/mL$ of RCM extract treated, that were elevated of cell proliferation to 103 and $142\%$ via control, respectively. And the cell differentiation were measured as alkaline phosphatase (ALP) activity at 3, 9, 18, and 27 days. As the results, the $10\;{\mu}g/mL$ was increased ALP activity more than 2.6 times compared with control, 1.4 times via positive control at 27th day (p<0.05). The optical concentration of RC extract was rechecked by ALP staining and Alizarin Red staining for investigation of the induction of ALP activity, nodule formation by mineralization. mRNA expression analysis showed that the RCM $(10\;{\mu}g/mL)$ increased in SOX9 as well as ALP in MC3T3-E1 cells. These results suggest that RC extract was stimulates the MC3T3-E1 cell proliferation and differentiation.

특별세션 2 - 한국하천협회-한국수자원학회 공동주최 하천문화강연회 후기

이지원,Lee, Ji-Won 한국하천협회 2014 하천과 문화 Vol.10 No.1

정보자원의 개방과 연계를 위한 SRU, SRU Record Update 프로토콜 연구

이지원,Lee, Ji-Won 한국도서관정보학회 2009 한국도서관정보학회지 Vol.40 No.3

다양한 가상공간에 산재하는 많은 분산자원들을 보다 효과적으로 활용하기 위하여 여러 프로토콜들이 개발되어 왔다. 이 연구는 분산 정보자원 검색과 갱신을 위한 SRU, SRU Record Update 프로토콜의 개발 배경, 기능, 구성 요소 등을 살펴봄으로 새로운 표준 프로토콜에 대한 이해를 넓히기 위함이다. 또한 다른 프로토콜과의 비교 및 실제 구현 사례 등을 통하여 자관의 정보자원을 외부에 효과적으로 제공하고, 외부 정보자원을 적절히 활용하려는 도서관 및 정보서비스 기관들에게 상호운용성 보장을 위한 실제적인 방안을 제시하기 위함이다. Several protocols have been developed to efficiently utilize a great number of distributed resources. This paper investigated the background, operations and elements of SRU and SRU Record Update protocol, compared them with other protocols, and reviewed their implementation cases. The purpose of this pager is to broaden the understanding of the two new standards and to provide a practical guide to ensure their interoperability for libraries and information service centers which want to expose their own contents and to access to external resources.

학령후기 아동의 건강개념 및 건강행위에 관한 서술적 연구

이지원,Lee Ji Won 한국아동간호학회 1999 Child Health Nursing Research Vol.5 No.1

The purpose of this study was to explore the late schooler's health concept and health behavior. The research was a descriptive method using a self-report questionaire which include semi open-ended questions. the subjects were 458 late schooler's from 4 to 6 grade. The results were as follows : 1. Perceived health concepts were ‘having no illness’ ‘having normal physical feature and strength’ ‘eating food well’ ‘take exercise’ ‘having a bright mind’ ‘having good interpersonal relationships’‘having strong will’ ‘recovering well’. 2. Perceived health behaviors to maintain health were ‘taking proper exercise’ ‘eating proper food’ ‘maintaining cleanliness’ ‘taking sufficient rest and sleep’ ‘having a vigor life and positive thought’ ‘having good interterpersonal relationships’ ‘receiving health check and immunization’. 3. Health behaviors carried out at present were ‘taking proper exercise’ ‘eating proper food’ ‘having a vigor life and positive thought’ ‘receiving health check an immunization’ ‘taking supplementary drugs’ ‘having a regular life’ ‘maintaining cleanliness’ ‘maintaining warmth’. 4. Perceived causes of illness were ‘taking inproper food’ ‘uncleanliness’ ‘insufficient warmth or environment’ ‘lack of exercise or overexertion’ ‘irregular life habits’ ‘contact with germs’ ‘mental stress’. 5. Perceived treatments of illness were ‘having sufficient rest and sleep’ ‘mental relaxation’ ‘eating food’ ‘ maintinging cleanliness’ ‘ maintaining warmth’ ‘taking supplementary drug’ ‘receiving medical treatment’.

비골골절 정복술 후 커진 지방육아종의 치험례

이지원,최재일,하원,양완석,김선영,Lee, Ji Won,Choi, Jae Il,Ha, Won,Yang, Wan Suk,Kim, Sun Young 대한두개안면성형외과학회 2012 Archives of Craniofacial Surgery Vol.13 No.1

Purpose: Lipogranuloma is the reaction of adipose tissue to various oils, paraffin, and other hydrocarbons injected into subcutaneous tissue for cosmetic or other reasons. The authors experienced a case of sclerosing lipogranuloma on the nasal dorsum. Methods: A 42-year-old female, without a history of the injection of any foreign materials, was admitted on our hospital for a painless, irregular, and firm mass located on her nasal dorsum with step-off deformity. It was considered that the mass had developed after augmentation rhinoplasty. The size of mass had been increased after closed reduction of nasal bone fracture. On April 2011, under general anesthesia, the mass was removed by open rhinoplasty technique. In addition, a pathologic examination was performed. After the mass extirpation, dermofat graft was performed for the correction of depression deformity. Results: The histopathological findings demonstrated a Swiss cheese pattern with variably-sized vacuoles, which corresponded to lipid removed with tissue processing, and variable foreign body giant cell reaction, fat necrosis, and hyalinized fibrous tissue. The pathologic diagnosis is lipogranuloma replacing nasalis muscle. It has been considered that sclerosing lipogranuloma is caused by nerve injury during augmentation rhinoplasty and the ointment used after the closed reduction of nasal bone fracture, which infiltrated through the injured mucosa. Conclusion: During the treatment of rhinoplasty or nasal bone fracture, the nerve injury or the ointment use can lead to lipogranuloma. Therefore, careful dissection for avoidance of the nerve injury and limited use of ointment seems to be helpful in decreasing incidence of lipogranuloma.

안와골절에서 결막절개를 통한 Medpor 내고정술의 합병증 분석과 치료

이지원,최재일,하원,양완석,Lee, Ji Won,Choi, Jae Il,Ha, Won,Yang, Wan Suk 대한두개안면성형외과학회 2012 Archives of Craniofacial Surgery Vol.13 No.1

Purpose: In accordance to an increased interest in facial appearance and the popularization of computed tomography scanning, the number of diagnosis and treatment of blowout fractures has been increased. The purpose of this article is to review pure blowout fracture surgery through transconjunctival incision focusing on complications and their management. Methods: In this retrospective study, 583 patients, who had been treated for pure blowout fracture through transconjunctival incision from 2000 to 2009, were evaluated. Their hospital records were reviewed according to their sex, age, fracture site, preoperative presentations, time interval between trauma and surgery, and postoperative complications. Results: According to postoperative follow-up results, there were early complications that included wound dehiscence and infection (0.2%), hematoma (insomuch as extraocular movement is limited) (0.7%), lacriminal duct injury (0.5%), and periorbital nerve injury (0.7%). In addition, there were late complications that lasted more than 6 months, that included persistent diplopia (1.7%), extraocular movement limitation (0.9%), enophthalmos (1.0%), periorbital sensation abnormalities (1.0%), and entropion (0.5%). Conclusion: We propose the following guidelines for prevention of postoperative complications: layer by layer closure; bleeding control with the epinephrine gauzes, Tachocomb, and Tisseel; conjunctival incision 2 to 3 mm away from punctum; avoidance of excessive traction; performing surgical decompression and high dose corticosteroid therapy upon confirmation of nerve injury; atraumatic dissection and insertion of Medpor Barrier implant after securing a clear view of posterior ledge; using Medpor block stacking technique and BioSorb FX screw fixation; performing a complete resection of the anterior ethmoidal nerve during medial wall dissection; and making an incision 2 to 3 mm below the tarsal plate.

가와사끼병에서 고용량 정맥용 면역글로불린 투여 후 생화학 지표들의 변화

이지원,이경일,Lee, Ji-Won,Lee, Kyung-Yil 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.8

목 적 : IVIG은 다양한 면역 질환에서 면역 조절제로 사용되고 있다. 가와사끼병에서 고용량의 IVIG 투여가 단백과 지질을 포함한 다양한 생화학적 지표에 미치는 영향을 알아보고자 하였다. 방 법 : IVIG(2 g/kg)을 투여받은 12 명의 가와사끼병 환아에 대해 IVIG 투여 전, 2시간, 24시간 및 7일 후에 혈청을 분리하고 $-20^{\circ}C$에 냉동보관하였다. 대조군으로 20명의 같은 연령군의 건강한 아동 혈청을 이용하였다. 결 과 : 알부민은 IVIG 투여 2시간 및 24시간 후 유의한 감소를 보였으며, 7일 후에는 투여 전 수준으로 회복되었다. 총 콜레스테롤과 트리글리세라이드는 7일 후 증가하는 경향을 보였다. HDL-콜레스테롤과 CRP 치는 IVIG 투여 2시간과 24시간 후 유의한 감소를 보였다. 결 론: 가와사끼병 환아에 투여된 고용량의 IVIG는 단시간 내에 단백 지표들과 HDL-콜레스테롤 치의 변화를 가져온다. HDL-콜레스테롤의 변화는 전신적인 단백 대사의 변화에 의할 것으로 보인다. Purpose : Intravenous immunoglobulin(IVIG) has been used as an immunomodulatory treatment for several immune-mediated diseases. The early effect of high-dose IVIG on biochemical profiles including lipids and proteins was evaluated in patients with Kawasaki disease(KD). Methods : Twelve children with KD(nine boys) were treated with IVIG of 2 g/kg over 12 hours. Serial sera were collected from the patients four times : before IVIG treatment and two hours, 24 hours and seven days after IVIG treatment. The samples were frozen at $-20^{\circ}C$ before biochemical analysis. Results : A significant decrease in albumin concentration was found two hours h and 24 hours after IVIG treatment, but this recovered to the pretreatment level after seven days. Total cholesterol and triglyceride increased slightly after seven day. A significant decrease in HDL-cholesterol and C-reactive protein was seen two hours and 24 hours after IVIG treatment. Conclusion : High-dose IVIG affects immediate changes in protein profiles and HDL-cholesterol in KD. Changes in HDL-cholesterol induced by IVIG may be the result of changes in systemic protein metabolism.

소양인(少陽人) 망음증(亡陰證)의 치방(治方)에 대한 고찰(考察)

이지원,이준희,고병희,이의주,Lee, Ji-Won,Lee, Jun-Hee,Koh, Byung-Hee,Lee, Eui-Ju 사상체질의학회 2011 사상체질의학회지 Vol.23 No.1

1. Background: This is the first documented study on the four medications for the Mangeum symptomatology (亡陰證) in the Soyangin disease category. The four medications, Hyeongbangsabaek-san (荊防瀉白散), Jeoryeongchajeonja-tang (猪?車前子湯), Hyeongbangjihwang-tang (荊防地黃湯), and Hwalseokgosam-tang (滑石苦蔘湯), were comparatively analyzed on their compositive principles and respective symptomatologies. 2. Methods: Previous literature, including classical works on earlier Sasang Constitutional Medicine (different editions of Donguisusebowon and Dongmuyugo), were reviewed for relevant material on the Mangeum medications. 3. Results and Conclusions: 1) Hyeongbangsabaek-san (荊防瀉白散) is used in pathologies of early stages of invasion of the internal heat in the lower-most burn-center (locus related to the Kidney system). 2) Jeoryeongchajeonja-tang (猪?車前子湯) is used when pathogenic dampness-heat invades the lower-most burn-center (locus related to the Kidney system). 3) Hyeongbangjihwang-tang (荊防地黃湯) is used to treat deficient heat involving injury of the lower-most burn-center (locus related to the Kidney system). 4) Hwalseokgosam-tang (滑石苦蔘湯) is used when the lower-most burn-center (locus related to the Kidney system) is in the early stages of exhaustion, expecially accompanied by concomitant dampness-heat. 5) The Mangeum symptomatology (亡陰證) was fully understood only after the completion of the 1901 Sinchuk edition (辛丑本) of Donguisusebowon (東醫壽世保元).

열다한소탕으로 호전된 태음인 호산구성대장염 환자 1례

이지원,김진영,오혜원,이의주,고병희,이준희,Lee, Ji-Won,Kim, Jin-Young,Oh, Hye-Won,Lee, Eui-Ju,Koh, Byung-Hee,Lee, Jun-Hee 사상체질의학회 2015 사상체질의학회지 Vol.27 No.4

Objectives The aim of this study was to report an improvement on the symptoms of Eosinophilic Colitis (EC) by Yeoldahanso-tang.Methods The patient was diagnosed with Taeumin Ganyeol-paeJo Symptomatology and treated with Yeoldahanso-tang. The gastroendoscopy and eosinophilic infitration of mucosa of colitis are investigated. Also patient's subjective symptom of abdominal pain was scored using the Numerical Rating Scale(NRS) during the treatment period. And the number of defecation in a day is also used to decide the degree of colitis.Results and Conclusions The patient had been treated from December 13, 2014 to August 8, 2015. Eosinophilic infiltration of colon was disappeared after the treatment although chronic inflammation still existed. Subjective pain of abdominal pain was measured as NRS 6~8 at the beginning of the remedy, but diminished through the treatment sessions and became NRS 0 in the end. The number of defecation was in average 3, and at the endpoint it became 1. In conclusion, this study suggests that Sasang constitutional Medicine used for treating EC of Taeumin may be effective.