주성분 분석을 이용한 펄스형 전자기장 자극을 통해 DNCB로 유발된 아토피성 피부염의 개선 효과 분석

이지영,김준영,이예린,김고은,이용흠,양세정,Lee, Jiyoung,Kim, Jun-Yong,Lee, Yerin,Kim, Ko Eun,Lee, Yongheum,Yang, Sejung 대한의용생체공학회 2021 의공학회지 Vol.42 No.3

Atopic dermatitis (AD), a chronic inflammatory skin disease, is characterized by itchy and age-dependent lesions. Previous studies have shown that pulsed electromagnetic field (PEMF) significantly improved chronic ulcers and ununited fractures, providing an evidence for the application of PEMF in resolving inflammation caused by AD. This study investigated the anti-inflammatory effect of PEMF on DNCB-induced AD in animal models. Five male hairless mice (6 weeks old) per group were assigned to a normal group, a sham group, and two PEMF groups (15Hz, 75Hz). Mice were treated with 2,4-Dinitrochlorobenzene (DNCB) to induce uniform AD among all groups excluding a normal group. To examine the inflammatory progress and the improvement of AD after the PEMF stimulation, images are taken with various cameras for non-invasive evaluation and the results are expressed using principal component analysis (PCA) for visualization. The results of this study demonstrated that PEMF effectively improved skin lesions without the use of drugs.

대용량 에너지 저장장치용 2세대 고온 초전도 코일의 특성해석

이지영,이세연,김영일,박상호,최경달,이지광,김우석,Lee, Ji-Young,Lee, Seyeon,Kim, Yungil,Park, Sang Ho,Choi, Kyeongdal,Lee, Ji-Kwang,Kim, Woo-Seok 한국전력공사 2015 KEPCO Journal on electric power and energy Vol.1 No.1

대용량 초전도 에너지저장장치(Superconducting Magnetic Energy Storage, SMES)용 초전도 권선을 제작하기 위해서는 높은 자장특성을 가고 있는 2세대 고온초전도 (2nd Generation High-Temperature Superconductor, 2G HTS) 선재를 사용하는 것이 효율적이다. 자기에너지 저장 밀도를 높이기 위해서는 권선에 높은 전류밀도를 인가해야 하는데, 도체의 평면에 수직 방향으로 인가되는 자속밀도가 커지면 임계전류가 작아지는 2세대 HTS 선재의 특성상 토로이드 형태의 권선을 구성하는 것이 일반적이다. 이러한 고온초전도 권선을 설계하기 위해서는 권선 특성의 정확한 해석이 필요한데 이를 위해 유한요소법을 사용한 프로그램을 이용하여 해석이 가능하나 토로이드 형태의 권선은 대칭성의 문제로 3차원 해석을 해야만 하며, 이는 모델링에 많은 어려움과 높은 컴퓨터 사양, 그리고 매우 긴 계산 소요시간이 필요함을 의미한다. 본 논문에서는 이러한 문제점을 해결하기 위해 분석적이고 통계적으로 고온 초전도 코일에서 작용하는 최대 수직자장과 저장된 에너지를 결정하는데 이해하기 쉽고 효율적으로 계산하는 방법을 제시했다. 이 방법은 현저한 시간단축과 효율적인 설계를 할 수 있는 새로운 계산 방법으로 기존의 유한요소법에 의해 소요되는 계산 시간에 비해 1/1000정도로 계산시간 단축을 할 수 있었다. Large scale superconducting magnetic energy storage (SMES) system requires very high magnetic energy density in its superconducting coils to enhance the energy capacity and efficiency of the system. The recent high temperature superconducting (HTS) conductors, so called 2G conductors, show very good performance under very high magnetic field so that they seem to be perfect materials for the large scale SMES coils. A general shape of the coil system with the 2G HTS conductor has been a tor oid, because the magnetic field applied perpendicularly to the surface of the 2G HTS conductor could be minimized in this shape of coil. However, a toroid coil requires a 3-dimensional computation to acquire the characteristics of its critical current density - magnetic field relations which needs very complicated numerical calculation, very high computer specification, and long calculation time. In this paper, we suggested an analytic and statistical calculation method to acquire the maximum magnetic flux density applied perpendicularly to the surface of the 2G HTS conductor and the stored energy in the toroid coil system. Although the result with this method includes some errors but we could reduce these errors within 5 percent to get a reasonable estimation of the important parameters for design process of the HTS toroid coil system. As a result, the calculation time by the suggested method could be reduced to 0.1 percent of that by the 3-dimensional numerical calculation.

카메라 렌즈 평가용으로 제작된 nodal slide식 실시간 OTF 측정 장치

이지영,송종섭,조재흥,장수,임천석,이윤우,이인원,Lee, Ji-Young,Song, Jong-Sup,Jo, jae-Heung,Chang, Soo,Rim, Cheon-Seog,Lee, Yun-Woo,lee, In-Won 한국광학회 2002 한국광학회지 Vol.13 No.2

A real-time OTF (optical transfer function) measuring system with on- and off-axis nodal slide bench type for the camera lens is fabricated and evaluated. It consists of a nodal slide bench including a T-bar for the OTF measurement of an off-axis object, two dimensional CCD (charge coupled device) with pixel of 9.9${\mu}{\textrm}{m}$$\times$9.6${\mu}{\textrm}{m}$ for real-time OTF measurment, and a collimating lens of focal length of 300 mm for the optimization of this system. The OTF system is corrected by using the OTF of a SIRA lens of fnumber of F/8 and focal length 50 mm. In order to confirm the reliability of the OTF system, two MTFs (modulus transfer functions) of CCTV & VIDEO lens (JAPAN, AVENIR-SE 2514) of focal length of 25mm and field of view 10.6$^{\circ}$are measured by the camera bench type OTF system of reference OTF system and the nodal slide bench type OTF system and compared with each other. As a result, these two values are agree well with each other within 4% from 0 1p/mm to 100 1p/mm. 초측정 할 수 있는 nodal slide식 실시간 OTF 측정 장치를 제작하였다. 비축 물체를 측정하기 위하여 nodal slide와 T-bar를 사용하고, 실시간 측정을 위하여 화소 간격이 가로 9.9$\mu\textrm{m}$와 세로 9.6$\mu\textrm{m}$인 2차원 CCD(charge coupled device)를 사용하며, 초점 길이 300mm의 시준 렌즈를 사용하여 장치를 소형화하였다. 그리고 F/8, 초점 길이 50 mm인 SIRA사의 표준 렌즈를 이용하여 측정 장치의 정확도를 평가하고 보정하였다. 본 장치의 신뢰도를 위하여 시야각이 10.6$^{\circ}$이고, 초점 길이가 25.0mm인 CCTV & VIDEO 렌즈(JAPAN, AVENIR-SE 2514)의 MTF를 측정하여 카메라 벤취(bench)형 OTF측정 장치로부터 구한 MTF 값들과 상호 비교한 결과 대부분의 공간주파수에서 4% 이내로 일치하였다.

Developing Data Fusion Method for Indoor Space Modeling based on IndoorGML Core Module

이지영,강혜영,김윤지,Lee, Jiyeong,Kang, Hye Young,Kim, Yun Ji Korea Spatial Information Society 2014 한국공간정보학회지 Vol.22 No.2

According to the purpose of applications, the application program will utilize the most suitable data model and 3D modeling data would be generated based on the selected data model. In these reasons, there are various data sets to represent the same geographical features. The duplicated data sets bring serious problems in system interoperability and data compatibility issues, as well in finance issues of geo-spatial information industries. In order to overcome the problems, this study proposes a spatial data fusion method using topological relationships among spatial objects in the feature classes, called Topological Relation Model (TRM). The TRM is a spatial data fusion method implemented in application-level, which means that the geometric data generated by two different data models are used directly without any data exchange or conversion processes in an application system to provide indoor LBSs. The topological relationships are defined and described by the basic concepts of IndoorGML. After describing the concepts of TRM, experimental implementations of the proposed data fusion method in 3D GIS are presented. In the final section, the limitations of this study and further research are summarized. 응용프로그램은 그 목적에 따라 최적의 데이터 모델을 활용하며, 이러한 응용프로그램을 위한 3차원 모델링 데이터는 선택된 데이터 모델을 기반으로 생성된다. 이러한 이유로, 동일한 공간의 지형지물을 표현하기 위해 다양한 데이터 셋이 존재한다. 그러한 중복된 데이터 셋은 공간정보 산업의 재정적 측면에서 문제를 가져올 뿐만 아니라, 시스템호환성과 데이터 비교가능성에서도 심각한 문제를 야기한다. 이러한 문제를 극복하기 위하여, 본 연구에서는 항목클래스내의 공간객체들 간의 위상적 관계를 이용하여 TRM (Topological Relation Method)이라고 하는 공간데이터융합 방법을 제안한다. TRM은 응용프로그램 수준에서 구현되는 공간데이터 융합방법으로써, 서로 다른 데이터 모델에 의해 생성된 기하데이터들을 응용시스템에서 어떠한 데이터 변환이나 교환 과정을 거치지 않고, 직접적으로 실내공간 위치기반 서비스에 제공하기 위해 사용된다. 이러한 위상관계는 IndoorGML의 기본 개념으로 정의 및 기술된다. TRM의 개념을 기술한 후, 3D GIS상에서 제안된 데이터 융합방법의 실험적 구현을 보여준다. 마지막으로서 본 연구의 한계와 향후 연구에 대해 정리한다.

도라지(Platycodon grandiflorum DC) 추출 성분의 암세포 증식 억제효과

이지영,황우익,임승택,Lee, Ji-Young,Hwang, Woo-Ik,Lim, Seung-Taik 한국식품과학회 1998 한국식품과학회지 Vol.30 No.1

도라지의 물과 석유에테르 추출물의 세포 증식 억제효과를 mouse DBA/2 strain유래의 백혈병성 임파모세포인 L1210과 인체 결장 암세포인 HCT-48 및 직장암세포인 HRT-18를 대상으로 분석하였다. 수용성 추출물보다는 석유에텔 추출물이 모든 항암세포에 대하여 현저히 높은 항암효과를 나타내었다. 도라지 석유에테르 추출물을 실리카겔 컬럼크로마토그라피에서 석유에테르과 에틸에테르 혼합을(7:3)로 얻은 분획은 더욱 높은 활성을 나타냈으며 L1210에서는 0.3mg/mL, HCT-48는 1.2mg/mL의 농도에서 대조군에 비해 -99%, -55%의 증식억제효과를 보였다. To investigate the cytotoxic effect of Platycodon grandiflorum DC, petroleum ether extract of Platycodon grandiflorum DC was partially purified by a silica gel column chromatography. Among several fractions, fraction D which was obtained under the elution with a 7:3 mixture of petroleum ether and ethyl ether, showed patent cytotoxicity against mouse leukemia cell line (L1210), human rectum cancer cell line (HRT-18) and human colon cancer cell lint (HCT-48).

해암단이 수종의 암세포에 미치는 항암 효과

이지영,오혜경,류한성,김남재,정원용,오현아,최혁재,윤성우,류봉하,Lee, Jee Young,Oh, Hye Kyung,Ryu, Han Sung,Kim, Nam Jae,Jung, Won-Yong,Oh, Hyun-A,Choi, Hyuck Jai,Yoon, Seong Woo,Ryu, Bong-Ha 대한암한의학회 2015 大韓癌韓醫學會誌 Vol.20 No.2

Objective : The objective of this study was to investigate the anti-tumor activity of the complexed herbal formula, Haeamdan (HAD). Methods : Seven Cancer cell lines, LoVo, MCF-7, AGS, Sarcoma 180, HL-60, NCI-H69, LL/2, were prepared and the cytotoxicity was assessed by 3-(4,5-dimethylthiazol-2yl)-2,5-dephenyl tetrazolium bromide (MTT) assay. HAD was applied with various concentrations from 0.1 to 1.0 mg/ml to figure out the appropriate dosage. ICR male mice were intraperitoneally implanted with Sarcoma 180 and divided into 8 species for each group. Control group was treated with normal saline, positive control group was treated with cyclophosphamide 8mg/kg, and experimental group was treated with HAD 1g/kg. Results : Among seven cancer cell lines, HAD exhibited strong cytotoxic activities to followed four cancer cell lines, that is, Sarcoma 180, HL-60, NCI-H69, and LL/2. These cytotoxic activity was expressed under 0.50 mg/ml of IC50 under 0.1~1mg/ml of OBW. When Sarcoma 180 cancer cell was implanted in ICR male mice and treated with the HAD, HAD prolonged the median overall survival for 3.6 days, from 17.5 to 21.1 days. Conclusion : HAD showed strong cytotoxicity to the cancer cells, Sarcoma 180, HL-60, NCI-H69, on in vitro study and it showed anti-tumor activity in vivo with the peritoneal cancer mice by prolonging the median survival for 3.6 days. Further researches would be expected to support the anti-tumor efficacy of HAD.

온백원이 암세포에 미치는 항암활성 효과

이지영,오혜경,류한성,김남재,정원용,오현아,최혁재,윤성우,류봉하,Lee, Jee Young,Oh, Hye Kyung,Ryu, Han Sung,Kim, Nam Jae,Jung, Won-Yong,Oh, Hyun-A,Choi, Hyuck Jai,Yoon, Seong Woo,Ryu, Bong-Ha 대한암한의학회 2015 大韓癌韓醫學會誌 Vol.20 No.2

Objective : The objective of this study was to investigate the experimental efficacy of anti-tumor activity of the complexed herbal formula, Onbaekwon (OBW), which was derived from the literature of Traditional Korean Medicine, Dongeuibogam. Methods : Nine Cancer cell lines, LoVo, MCF-7, HepG2, AGS, A549, NCI-H69, HL-60, Sarcoma 180, LL/2, were prepared and the cytotoxicity was assessed by 3-(4,5-dimethylthiazol-2yl)-2,5-dephenyl tetrazolium bromide (MTT) assay. Four of them, NCI-H69, HL-60, Sarcoma 180, and LL/2, showed strong cytotoxic activities and they were additionally undergone flow cytometry to find out their effects on apoptosis. ICR male mice were implanted with Sarcoma 180 intraperitoneally and divided into 8 species for each group. Control group was treated with normal saline, positive control group was treated with cyclophosphamide 8mg/kg, and experimental group was treated with OBW 1 g/kg. Results : Among 9 cancer cell lines, NCI-H69, HL-60, Sarcoma 180, and LL/2, expressed less than 0.10 mg/ml of $IC_{50}$ under 0.1~1mg/ml of OBW. NCI-H69, HL-60, Sarcoma 180, and LL/2, showed dose-dependent efficacy of apoptosis. When Sarcoma 180 cancer cell was implanted in ICR male mice and treated with the OBW, they prolonged the median overall survival for 0.8 days, from 17.5 to 18.3. Conclusion : OBW showed strong cytotoxicity to some cancer cells, which are NCI-H69, HL-60, Sarcoma 180, and LL/2, and its apoptotic activity was dose-dependent. OBW prolonged the median survival of mice implanted with Sarcoma 180. Further researches would be expected to support the efficacy of OBW.

(Zn_1-xMg_x)₂SiO₄:mn 형광체의 제조와 발광특성

이지영,유일,Lee, Ji-Young,Yu, Il 한국전기전자재료학회 2009 전기전자재료학회논문지 Vol.22 No.5

$Zn_{2}SiO_{4}$:Mn green phosphors doped with Mg for PDP were synthesized by solid state reaction method. $Zn_{2}SiO_{4}$:Mn, Mg phosphors with increasing Mg concentration were changed from Rhombohedral to Orthorhombic structure. Photoluminescence intensity of $Zn_{2}SiO_{4}$:Mn phosphors doped with Mg 0.5 mol was definitely higher than that of Mg non-doped sample. The enhanced luminescence with doping Mg in the $Zn_{2}SiO_{4}$:Mn phosphors was interpreted by the increase of energy transfer from host to Mn ions with substitution Mg for Zn in the $Zn_{2}SiO_{4}$:Mn host.

알츠하이머병 환자에서 행동심리증상의 성별차이

이지영,임우영,김현,이강준,Lee, Ji Young,Im, Woo-Young,Kim, Hyun,Lee, Kang Joon 한국정신신체의학회 2014 정신신체의학 Vol.22 No.2

연구목적 알츠하이머병 환자들의 행동심리증상(BPSD)은 임상적인 문제들을 일으켜 결국 기능의 감퇴, 간병인 스트레스, 입원, 사망률의 증가를 가져온다. 최근의 연구는 성별차이가 BPSD에서 중요한 역할을 한다고 보고하고 있으나, BPSD와 성별 사이 연관에 대한 국내 연구는 시행된 적이 없었다. 이에 본 연구는 알츠하이머병 환자들의 BPSD가 성별 차이에 의해 영향을 받는 것인지를 검증해 보고자 실시하였다. 방 법 면담과 인지기능평가를 통해 DSM-IV 진단기준에 의하여 알츠하이머병으로 진단받은 98명의 환자들이 본 연구에 참가하였다. 간이정신상태검사(MMSE), 임상치매평가척도(CDR), 전반적 퇴화척도(GDS), 한국형 신경정신행동검사(K-NPI)를 사용하여 인지기능 및 BPSD를 평가하였다. 성별 차이를 확인하기 위해서 독립 t 검증을 사용하여 분석하였으며, MMSE, CDR, GDS와 NPI 사이의 관련성을 살펴보기 위해 피어슨 상관분석을 사용하였다. 결 과 알츠하이머병 환자들의 BPSD에서 통계적으로 유의미한 성별 차이는 관찰되지 않았다. MMSE와 NPI 총점, 그리고 NPI 하위영역인 환각과 유의한 상관관계를 보였으며, CDR의 경우 NPI 총점, 무감동/무관심, 과민/불안정과, GDS의 경우 NPI 하위영역인 환각과 유의한 상관관계를 나타내었다. 결 론 본 연구결과 우리나라 알츠하이머병 환자들의 BPSD에서 성별의 차이는 나타나지 않았지만, 추후 알츠하이머형 치매의 BPSD가 성별 차이에 의한 것인지 혹은 개인 차에 의한 것인지를 더 명확하게 밝혀내기 위한 광범위하고 지속적인 연구가 필요할 것으로 생각된다. Objectives : Behavioral and psychological symptoms of dementia(BPSD) represent significant clinical problems, resulting in functional decline, caregiver distress, institutionalization and increased mortality. A recent study showed gender differences have important role in the development of BPSD, but relationship between BPSD and gender has never been studied in Korea. This study was designed to examine whether patients with Alzheimer's disease show gender differences in behavioral and psychological symptoms of dementia(BPSD). Methods : Ninety-eight subjects with Alzheimer's disease were included in this study. We carried out history taking and cognitive assessment for the diagnosis of Alzheimer's disease based on DSM-IV. Cognitive impairment and BPSD were measured using the Mini Mental State Examination(MMSE), Global Deterioration Scale (GDS), Clinical Dementia Rating(CDR) and the Korean Neuropsychiatric Inventory(K-NPI). Independent samples t-test was used to examine the differences across gender in BPSD. Correlation analysis between MMSE, CDR, GDS and NPI was performed using Pearson's correlation coefficient. Results : There were no significant gender differences between the gender in BPSD. We found statistically significant negative correlations between MMSE with NPI total score, and with scores of several sub-domains such as hallucination. Conclusions : This study showed that gender differences in BPSD are not significant. Further research is necessary to identify whether BPSD affect gender differences or individual differences.

Zn₂SiO₄:Mn,Al 녹색 형광체의 제조와 발광특성

이지영,유일,Lee, Ji-Young,Yu, Il 한국전기전자재료학회 2007 전기전자재료학회논문지 Vol.20 No.4

[ $Zn_2SiO_4:Mn$ ] green phosphors doped with $NH_4Cl$ and Al for PDP were synthesized by solid state reaction method. The luminescence of 532 nm in $Zn_2SiO_4:Mn$ phosphors was associated with $^4T_1{\to}^6A_1$ transition. Photoluminescence intensity of $Zn_2SiO_4:Mn$ doped with $NH_4Cl$ 15 mol% increased about two times as compared with that of $NH_4Cl$ non-doped sample. The color of the emission of Al-doped $Zn_2SiO_4:Mn$ phosphors changed to yellowish green.