간유(肝兪).풍지(風池)와 음릉천(陰陵泉) 자침(刺針)의 비만유발(肥滿誘發) 흰쥐의 지질강하(脂質降下) 및 항산화효과(抗酸化效果)에 대한 비교연구 -생화학적(生化學的) 및 분자생물학적(分子生物學的) 검토(檢討)를 중심으로-

이준무,임관일,Lee, Joon-Moo,Lim, Kwan-II 대한약침학회 2002 Journal of pharmacopuncture Vol.5 No.2

The lipid lowering and antioxidant effects of Gansoo(BL18), Pungji(GB20) and Eumnungcheun(SP9) acupuncture in rats fed high fat diet were analyzed in biochemical and molecular biological aspects. The results obtained from this study are as follows : 1. In the body weight reduction, all acupuncture groups showed a high reduction compared to those of control group and in acupuncture groups, Gansoo(BL18) and Pungji(GB20) acupuncture groups showed a high reduction. 2. The concentration of plasma triglyceride, total cholesterol and LDL-cholesterol with acupuncture groups showed a little decrease and in acupuncture groups, Gansoo(BL18) and Pungji(GB20) groups showed a low values compared to those of other acupuncture groups. However, the tendency of HDL-cholesterol concentration showed no significant different. 3. The concentration of plasma ${\beta}-lipoprotein$ and free fatty acids showed a lowest values in the Gansoo(BL18) and Pungji(GB20) acupuncture groups and the glucose concentration showed to decrease in all treated acupuncture groups. 4. The concentration of liver total cholesterol and triglyceride in Gansoo(BL18) and Pungji(GB20) acupuncture groups showed a lower values than those of control group. 5. In all the acupuncture groups, the plasma glutamic oxaloacetic transaminase(GOT) activity showed a little decrease. In the glutamic pyruvate activity(GPT), Gansoo(BL18) and Pungji(GB20) acupuncture groups showed a lower values than those of control groups. However the values of eumneungcheun acupuncture only group showed no significant difference to those of control group. 6. The plasma and liver Thiobabituric acid reactive substance (TBARS) concentration in Gansoo(BL18) and Pungji(GB20) acupuncture groups were a lower than those of control group. However the values of eumneungcheun acupuncture group showed no significant difference to control group. 7. The superoxide dismutase (SOD) activity in Gansoo(BL18) acupuncture group and Glutathione peroxidase (GSH-Px) activity in Gansoo(BL18) and Pungji(GB20) acupuncture groups showed a high values. The catalase (CAT) activity in all the acupuncture groups showed a higher values than those of control group. 8. In acupuncture groups, DNA expression of Apo-B and Apo-E showed a tendency to decrease, however DNA expression of leptin showed no significant difference in all treatment groups. DNA expression of $TNF-{\alpha}$ showed a increase in acupuncture groups. These results indicate that Gansoo(BL18) and Pungji(GB20) (especially Gansoo(BL18)) acupuncture affect the lipid metabolism and showed possibility of lowering adipose tissue mass and lipid peroxidation.

새로 개발한 한방 피부소양증 치료제에 관한 연구

이준무,Lee, Joon-Moo 대한한방안이비인후피부과학회 2008 한방안이비인후피부과학회지 Vol.21 No.3

Objectives : There have been few studies on external treatment for itching. A clinical study was performed to evaluate the effect of a newly developed herbal ointment. Methods : A newly developed herbal ointment made from Rumex japonicus Houtt, Prunus persica(Linne) Batsch, Sesamum indicum L., and Sus scrota domestics Brisson., was given to 49 participants with itching to administer for approximately a month. Demographic characteristics, treatment experiences, symptom change, and other comments were self-reported on a pre-defined questionnaire. Results : Most frequent complaint was itching (24.01%), followed by sensitivity (19.60%), dryness(18.62%), frustration (13.72%) and insomnia (12.25%). Of 41 participants who had been given treatment for itching, around a half of them (n=21) have been treated with Korean Medicine, but all of them tried Western Medicine as well. The effect of the ointment was evaluated as excellent or good/fair (67.32%). Continuity was reported as excellent or good/fair (51.0%) and fragrance (73.44%) and color (75.48%) was reported as excellent or good/fair. Convenience, however, was assessed as good/fair (67.32%) and as inconvenient (22.4%). Conclusion : The newly developed herbal ointment seems promising for relieving itching and further research to standardize and develop this kind of ointment is warranted.

마황약침이 부신피질기능부전증에 미치는 영향

이준무,Lee, Joon-Moo 대한약침학회 2007 Journal of pharmacopuncture Vol.10 No.2

Effects of mahwang(Ephedrae herba) aqua-acupuncture at sinsoo (B-23)and Jisil(B-52)on adrenal cortical insufficiency were investigated in dexamethasone treated rats. Concentration of serum cortisol was decreased in dexamethasone treated rats. However, these values showed a tendency to increase in mahwang(Ephedrae herba) aqua-acupuncture groups. Concentration of serum total protein was increased in dexamethasone treated rats. However, these values were decreased by the mahwang(Ephedrae herba) aqua-acupuncture. The portion of neutrophils was decreased and the portion of lymphocytes and eosinophils were increased in dexamethasone treated rats. However, in mahwang(Ephedrae herba) aqua-acupuncture groups, the portion of neutrophils showed a tendency to increase and the portion of lymphocytes and eosinophils showed a tendency to decrease. In dexamethasone treated rats, the weight of adrenal glands were decreased, however these values were increased in mahwang(Ephedrae herba) aqua-acupuncture groups.

신유(腎兪), 지실(志室)의 팔미지황탕약침처리(八味地黃湯藥鍼處理)가 토끼, 기니어 픽 및 Rat의 혈액상(血液象)에 미치는 영향(影響)

이준무,권기록,Lee, Joon-Moo,Kwon, Gi-Rok 대한약침학회 1999 Journal of pharmacopuncture Vol.2 No.1

Counts of RBC and proportion of packed cell volume(PCV) showdc no difference among treatment groups. the values of hemoglobin in rat showed a tendeuy to increase in herbal-acupuncture group, however the values of hemoglobin in guineapig and rabbit showed no significant difference in the treatnent groups. the count of WBC showed high in the chishiI(BL52) herbal-acupuncture group. The proprtion of neutrophils showed no significant difference in rabbit, however the values in guinea-pig and rat showed a tendency to increased in herbal-acupuncture groups. The proportion of lymphocytes in rabbit and guinea-pig showed a tendency to decreast in herbal-acupuncture groups, however the values in rat showed no significant difference. The proportion of Eosinophils and monocytes showed no significant difference in all the treated groups. Results from this study indicated that shinsu(BL23) and chishil(BL52) herbal-acupuncture with palmijihwangtang elivate the biglogical function in Rabbit Guinea-pig and Rat.

간유(肝兪) 및 일월(日月) 청호약침(靑蒿藥鍼)이 고지방(高脂肪) 급여(給與) 흰쥐의 혈청(血淸) 지질구성(脂質構成)에 미치는 영향(影響)

이준무,Lee Joon-Moo 경락경혈학회 2003 대한침구의학회지 Vol.20 No.3

Effects of cheungho aqua-acupuncture at gansoo$(BL_{18})$ and illweul$(GB_{14})$ on plasma lipid composition were investigated in rat fed high fat diet. Body weight gain showed a tendency to decrease in aqua-acupuncture groups and in aqua-acupuncture groups, gansoo and illweul join aqua-acupuncture group showed a lower values than other aqua-acupuncture groups. Concentrations of plasma triglyceride, free fatty acids, lipoprotein and glucose showed a tendency to decreasea in the aqua-acupuncture groups. However in aqua-acupuncture groups, these values showed no significantly different. In plasma lipid composition, total cholesterol and LDL- cholesterol showed a tendency to decrease in aqua-acupuncture groups, however the values of LDL-cholesterol showed no significantly different in the aqua-acupuncture groups. HDL-cholesterol concentration showed a tendency to increase in aqua-acupuncture groups and in aqua-acupuncture groups, gansoo aqua-acupuncture group showed a high value.

동의보감(東醫寶鑑)의 복통분류(腹痛分類)에 따른 침구치료(鍼灸治療)의 문헌연구(文獻硏究)

이준무,지준환,Lee, Joon-Moo,Ji, Jun-Hwan 대한약침학회 2005 Journal of pharmacopuncture Vol.8 No.1

Objectives : The purpose of this study is as follows. We classify belly-ache into six kinds as mentioned in DongUiBoGam (東醫寶鑑), and are going to present each acupuncture & moxibustion treatment. Methods : For the purpose of looking for each treatment, we referred to a large number of literature for belly-ache treatment from ancient to malearn. Results : The six kinds of belly-ache have each treatment above all, in treatment of belly-ache due to cold-belly-ache (寒腹痛) and hotbelly-ache (熱腹痛) have pain in the formable of ache part. Therefore, general point such as CVl2, CV8, ST36, Extra Meridian are used in turn. Also bad-blood-belly ache and many kinds of belly-ache such as BL18, BL17, LR2 are mainly used much in turn. Especially CV is in common use. Conclusions : we conclude that six kinds of belly-ache have each different acupuncture & moxibustion points and treatment, so if we follow each treatment we might obtain more higher treatment rate of belly-ache.

자하거(紫河車) 약침이 흰쥐의 혈액성상과 항산화효소의 활성에 미치는 영향

이준무 ( Joon Moo Lee ) 대한경락경혈학회 2009 Korean Journal of Acupuncture Vol.26 No.2

Objectives: To investigate the effects of Hominis placenta pharmacopuncture on the blood picture and antioxidative activity in rats. Methods: Sprague-Dawley rats were divided into 3 groups; normal control (n=5), pharmacopuncture at CV12 (CV12 group, n=5), and pharmacopuncture at ST36 (ST36 group, n=5) once every other day for 4 weeks. Blood cell counting was performed and liver superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities were analyzed. Results: Values of red blood cell and plasma cell volume were significantly higher in the ST36 group than the normal control. Values of hematocrit, total protein, and albumin were not significantly different among groups. White blood cell count and the percentage of neutrophils, lymphocytes, and eosinophils were not significantly different among groups. However, monocytes and basophils were significantly increased in the ST36, and CV12 groups, respectively. SOD and CAT in the CV12 and ST36 groups were significantly activated than in the normal control group, while the activity of GSH-Px showed no significant difference among groups. Conclusions: Based on the findings of this study, Hominis placenta pharmacopuncture may have positive impact on antioxidative capacity, thus activate various functions of the body.

중완 (中脘) 천추혈 (天樞穴) 애구가 진통 및 혈색소량에 미치는 영향

이준무(Joon Moo Lee),임종국(Jong Kook Lim) 대구한의대학교 제한동의학술원 1981 東西醫學 Vol.6 No.2

N/A N/A

동씨침(董氏鍼)의 혈위(穴位)에 관한 고찰(1) -수지부(手指部)에 있는 혈(穴)-

이준무 ( Joon Moo Lee ),김택률 ( Taek Ryul Kim ) 대한경락경혈학회 2004 Korean Journal of Acupuncture Vol.21 No.3

Objective: The purpose of this study is to find out differences of the points locations of Dongshi-Acupuncture described in some related books. Methods: This study was carried out by means of comparing the different locational descriptions on the same acupoint in those books: Dong Shi Ji Xue Zhen Jiu Xue(董氏奇穴鍼灸學). Shi Yong Dong Shi Zhen Jiu Ji Xue Quan Ji(實用董氏鍼灸奇穴全集), Dong Shi Zhen Jiu Ji Xue Jing Yan Lu(董氏鍼灸奇穴經驗錄), Dong Shi Leng Zhen Cheng Xue Xue(董氏稜鍼徵穴學), Dong Shi Ji Xue Tu Pu Zhi Llao Xue(董氏奇穴圖譜治療學), Tel Wan Dong Shi Zhen Jiu Jing Xue Xue (臺灣董氏鍼灸經穴學). Results: There are disagreement on the number, locations, cuns of acupuncture points among the books: the numbers of 11 kinds of points, locations of 2 points and cun of 15 points. Conclusions: The authors can be grouped by the opinions on the acupuncture points. One group consists of Yang Wei Jie(楊維傑). Iai Jin Xiong(賴金雄) and Hu Bing Quan(胡丙權) and Hu Wen Zhi(胡文智), Liu Jian Zhong(陸建中) and Li Guo Zheng(李國政) form the other.

침자극(鍼刺戟)이 고지방식이(高脂肪食餌)를 급여(給與)한 흰쥐의 체지질구성(體脂質構成)에 미치는 영향(影響)

이준무 ( Joon Moo Lee ),오세웅 ( Se Woong Oh ),이은 ( Eun Lee ) 대한경락경혈학회 2001 Korean Journal of Acupuncture Vol.18 No.1

Effects of LR3(太衝), GB39(懸鍾) and SP4(公孫) acupuncture on lipid composition were investigated in rat fed high fat diet. The results obtained from this study are as follows: 1. In the all treatment groups, the body weight values after feeding the basal diet for 4 weeks were significantly decreased compared to the initial body weight. However the decrement of body weight showed a high in acupuncture groups compared to those of control group. In the acupuncture groups, the decrement of body weight showed a high in the LR3 acupuncture groups. 2. The contents of plasma β-lipoprotein and free fatty acids showed a tendency to decrease in the acupuncture groups compared to those of control group and the values of LR3 acupuncture groups showed a low in the acupuncture groups. 3. The contents of plasma triglyceride showed a low values in the complex treatment group of LR3, GB39 and SP4. However among the other treatment groups, this values showed no significantly different. The contents of liver triglyceride showed a tendency to decrease in all acupuncture groups except to the complex treatment group of GB39 and SP4 acupuncture and in the acupuncture groups, LR3 acupuncture groups were lower than GB39 and SP4 acupuncture groups. 4. The contents of plasma glucose showed a tendency to decrease by the acupuncture treatment and LR3 acupuncture groups showed a lower values than other acupuncture groups. 5. In the values of plasma glutamic oxaloacetate transferase activity, LR3 acupuncture group and the complex treatment group of LR3, GB39 and SP4 acupuncture were a lower values than other treatment groups and among the other treatment groups showed no significantly different. The values of plasma glutamic pyruvate transferase activity showed no significantly different among all the treatment groups. 6. Contents of plasma and liver total cholesterol showed a tendency to decrease in LR3 acupuncture 1) groups. However those of the other groups showed no significantly different. 7. In the contents of plasma LDL-cholesterol, LR3 acupuncture groups were a lower values than other groups, however among the other groups showed no significantly different. The contents of plasma HDL-cholesterol showed a tendency to increase in the acupuncture groups, however these values showed no significantly different.