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실험연구 : 흰쥐의 포르말린 검사에서 척수강 내로 혼합 투여한 NMDA 수용체 길항제와 5-HT3 수용체 작동제의 상호 작용
한동우 ( Dong Woo Han ),권태동 ( Tae Dong Kweon ),이종석 ( Jong Seok Lee ),유영철 ( Young Chul Yoo ),이윤우 ( Youn Woo Lee ),김선종 ( Sun Chong Kim ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.52 No.6
Background: A single agent administered is not effective enough to block nociception. Combination of agents acting through different mechanisms may be one of the best ways for better analgesic methods. The purpose of this study was to investigate the spinally mediated analgesic interaction between 5-HT3 receptor agonist (m-CPBG) and NMDA receptor antagonist (MK801) in the rat formalin test. Methods: A polyethylene catheter was inserted in the atlanto-occipital membrane to the thoracolumbar level of the spinal cord. On postoperative 7 day, the normal saline (n = 6), m-CPBG (10, 30, 100μg: n = 18) and MK801 (0.1, 1, 10μg: n = 18) were injected intrathecally before subcutaneous injection of 5% formalin. The combinations of each 1/2ED50 + 1/2ED50, 1/4ED50 + 1/4ED50, 1/8ED50 + 1/8ED50 were tested and the ED50 of the combination was determined. The experimental ED50 values were compared with the theoretical additive values. Results: m-CPBG dose-dependently decreased the number of flinches in both phase 1 and 2. MK801 dose-dependently reduced the number of flinches in phase 2, but not in phase 1. The combination of m-CPBG and MK801 produced dose-dependent decreases of flinches on both phase 1 and 2. ED50 values (2.75μg for m-CPBG and 0.076μg for MK801) of phase 2 in the combination were significantly less than the calculated additive values (20.0μg for m-CPBG and 0.55μg for MK801)(P<0.01). Conclusions: Intrathecally administered m-CPBG and MK801 had synergistic analgesic effects on formalin-induced hyperalgesia as well as antinociceptive effects in phase 1 on the rat formalin test. (Korean J Anesthesiol 2007; 52: 694~701)
이민재,최일영,김석근,이종석,최재득,안기주 대한핵의학회 1968 핵의학 분자영상 Vol.2 No.1
단순성 갑상선종 환자 65예에 대하여 131I을 사용한 각종 갑상선기능검사법과 임상소견 및 생검법을 이용하여 퇴행형 (degenerative type), 증식형 (proliferative type), 「코로이드」형 (colloidal type) 그리고 낭포성 변질종 (cyst formation with degeneration)의 4형으로 분류하고 이에 대한 치료에 관해서 고찰하였다. $quot; Presented here are the results for clinical study on 65 cases of simple goiter the author treated during the period of 4 years and 10 months from jan. 1963 throught Oct. 1967 at the Seoul National University Hospital and Han-Il Hospital. It has been customary to classify simple goiter, according to the gross morphological characteristics of the thyroid gland, as diffuse and nodular type. This paper attempts to investigate the histopathological changes and treatment of simple goiter respectively. Sixty five cases of simple goiter were classified into 4 types; namely degenerative type was 20 cass (30.8%), proliferative type was 7 cases (10.8%), colloidal type was 24 cases (36.9%0 and cyst formation with degeneration was 14 cases (21.5%), on the basis of histopathological findings. Thus, it is essential that simple goiter should be differentiated from thyroid tumors as soon as practicable. The effectiveness of medical treatment with desicated thyroid and autohemotherapy for certain simple goiter are also discussed. $quot;