폐암환자의 객담 및 암 조직에서 MAGE A 1-6와 SSX 1-9 유전자의 발현

이연재 ( Yeun Jae Lee ),이장훈 ( Jang Hoon Lee ),이정철 ( Jung Cheul Lee ),이관호 ( Kwan Ho Lee ),LungNeoplasmsGenes 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.70 No.4

Background: A variety of diagnostic modalities for lung cancer have been developed. To achieve efficient and early detection of lung cancer, we tried to measure the expression rates of the melanoma associated gene (MAGE) and synovial sarcoma on X chromosome (SSX) genes. Methods: We designed primers for the SSX gene. In addition to the pre-developed MAGE A primer, using an SSX gene primer was attempted to increase the detection rate. We obtained cancer tissues and cancer-free lung tissues from resected lung, sputum from lung cancer patients who had not undergone surgery, and sputum from healthy people and patients with benign intrathoracic diseases. Results: The sensitivity of the MAGE or SSX gene RT-PCR to identifying cancer tissue of the 69 lung cancer patients was 95.2% for squamous cell carcinoma (scc), 87.0% for adenocarcinoma, and 100% for small cell carcinoma. The mean sensitivity value was 94.2% (p=0.001). For adenocarcinoma, the additional use of the SSX gene resulted in a higher expression rate than MAGE alone (87% vs. 69.6%). The expression rate for the cancer-free lung tissue was 14.3% in scc, 17.4% in adenocarcinoma, and 25.0% in small cell carcinoma. In the induced sputum of 49 lung cancer patients who had not undergone surgery, the expression rate for one of the two genes was 65.5%. The expression rate for the sputum of healthy people and benign intrathoracic diseases by MAGE or SSX gene reverse transcription polymerase chain reaction (RT-PCR) was 3.8% and 17.7%. Conclusion: Detecting lung cancer using the expression of MAGE and SSX genes in lung cancer tissue has high sensitivity.

종격동내 혼합 생식 세포종과 폐전이를 동반한 혈관육종이 동시에 존재한 중복암

류헌모 ( Hon Mo Ryu ),최희진 ( Hee Jin Choi ),신경철 ( Ghung Cheul Shin ),정진홍 ( Jin Hong Chung ),이관호 ( Kuan Ho Lee ),이현우 ( Hyen Woo Lee ),이동혁 ( Dong Hyunp Lee ),이정철 ( Jung Cheul Lee ),한승세 ( Sung Sae Han ),심영란 대한결핵 및 호흡기학회 1994 Tuberculosis and Respiratory Diseases Vol.41 No.4

수부 다한증에서 흉부교감신경 절제술의 성적

이장훈,이정철,Lee, Jang-Hoon,Lee, Jung-Cheul 대한흉부심장혈관외과학회 2008 Journal of Chest Surgery (J Chest Surg) Vol.41 No.1

배경: 수부 다한증의 치료로 3번 늑골 위 교감신경 절제술이 널리 이용된다. 본 연구에서는 수부 다한증으로 3번 늑골 위 교감신경 절단술을 받은 환자들의 중장기 성적을 추적하여 환자의 만족도를 연구하고자 하였다. 대상 및 방법: 2001년 1월부터 2006년 12월까지 3번 늑골위 교감신경 절단술을 시행받은 환자 225명 중 의무기록 관찰과 전화 설문 조사가 가능한 환자 200명을 대상으로 하였다. 평균 추적기간은 51.7개월($11{\sim}80$개월)이었다. 수술 후 손에 땀이 나는 정도를 알기 위해 손이 너무 마른다(grade 1), 적당하다(grade 2), 땀이 나지만 술 전보다 감소했다(grade 3), 수술 전과 비슷하게 땀이 다시 난다(grade 4)로 나누어 조사하였다. 보상성 다한증의 발생과 일상생활에 불편이 있는지를 알아보기 위해 보상성 다한증이 없다(grade 0), 약간 있지만 생활에 불편은 없다(grade 1), 생활에 조금 불편을 느낀다(grade 2), 생활에 불편함이 크다(grade 3)로 나누어 조사하였다. 수술 후 만족도에 대해서는 매우 만족(very good), 만족(good), 보통(regular), 불만족(deficient)의 4가지로 나누어 조사하였다. 결과: 보상성 다한증이 발생한 군과 발생하지 않은 군 사이에 임상적 지표는 유의한 차이가 없었다. 보상성 다한증의 발생률은 83.5%였고 체간과 하지에 많은 분포를 보였다. 보상성 다한증의 정도는 환자의 body mass index와 유의한 관련이 있었고 계절과 주위 온도에 영향을 받으며 정신적 긴장이 보상성 다한증을 악화시키는 것으로 밝혀졌다. 결론: 수술 결과에 대한 만족도는 61.5%로 기대 이하의 만족도를 나타내었다. 술 후 만족도는 보상성 다한증의 발생과 정도에 밀접한 관계가 있는 것으로 나타나 보상성 다한증을 줄이는 것이 환자의 만족도를 높이는 방법이라 생각된다.표준 어음청력검사표의 완성등 적절한 조치가 이루어져야할 것으로 촉구되었다.사항의 응답재료를 검토한 바 있기에 보고하는 바이다.시도는 우리나라 광양만 내에 존재하는 해양 바이러스의 생태적 분포 연구를 다루는 첫 번째 실험으로 사료된다.탄산염암 지역은 Ca-$HCO_3$형, 혼펠스 지역은 Na-K형과 $CO_3+HCO_3$형이 우세한 것으로 나타났다. 본 연구를 통해 달천 폐광산 지역의 광미적재지에서 $Ca^{2+},\;Mg^{2+}$ 및 $SO_4^{2-}$ 성분이 지하수에 다량 용해되어 지하수의 주 흐름 방향에 위치한 기반암 지하수에 유입되었음을 알 수 있었다.tic monks could not wear. to express their deep faith. So the rules of the samgha has been distorted. The samgha has enlarged day by day as a great huge religious association. There are many different shapes of Kasaya. The Buddhist samgha need to establish a minute and rigid rules of Kasaya to order living of monks and to teach the moral and educational life to ordinary people. That book of rule is Vinaya pitaka(율장) . There are many kinds of Vinaya pitaka. This paper surveys the rules of Kasaya from Southern Vinaya pitaka(남전율장). This study will be the basic ground to research the Korean Buddhist Background: Thoracoscopic R3 sympathicotomy can effectively treat palmar hyperhidrosis. Here, we evaluated post-operative outcomes of patients receiving a thoracoscopic R3 sympathicotomy due to palmar hyperhidrosis. Material and Method: From January 2001 to December 2006, 225 patients were treated with a R3 sympathicotomy, and follow up was completed for 200 patients, with an average follow up period of 51.7 ($11{\sim}80$) months. We measured postoperative hand sweating according to four grades; dry (grade 1), proper (grade 2), light sweating (grade 3), heavy sweating (grade 4) and evaluated patient satisfaction using 4 grades: very good (grade 0), good (grade1), regular (grade 2), and deficient (grade 3). Result: There were no differences in clinical parameters between the compensatory sweating group and the non-compensatory sweating group. There was a 83.5% compensatory sweating rate. The degree of compensatory sweating related to the patient's body mass index and was influenced by the season, environmental temperature, and emotional stress. Conclusion: The satisfaction rate was 61.5%, and the degree of satisfaction related to the development of compensatory sweating. Therefore, reducing compensatory sweating would increase patient satisfaction with R3 sympathicotomies.

편평상피세포암종과 선암종이 동반된 복합형 소세포암종 (Combined Small Cell Carcinoma)

박혜정 ( Hye Jung Park ),문영철 ( Yeung Chul Mun ),유성근 ( Sung Keun Yu ),신경철 ( Kyeong Cheol Shin ),정진홍 ( Jin Hong Chung ),이관호 ( Kwan Ho Lee ),김미진 ( Mi Jin Kim ),이정철 ( Jung Cheul Lee ) 대한결핵 및 호흡기학회 2000 Tuberculosis and Respiratory Diseases Vol.48 No.1

폐암과 염증성 폐질환에 있어서 전폐절제술 후의 경과 비교

이장훈 ( Jang Hoon Lee ),이정철 ( Jung Cheul Lee ) 영남대학교 기초/임상의학연구소 2007 Yeungnam University Journal of Medicine Vol.24 No.2S

Background:Pneumonectomy has been known with higher rate of morbidity and mortality. Thereby, we evaluated patients who received pneumonectomy for lung cancer and infectious lung disease related to postoperative morbidity and mortality. Materials and methods:The retrospective study was undertaken in 55 patients who had undergone pneumonectomy at Yeungnam University Hospital from January 1996 to December 2004. We devided into two groups, lung cancer group (group A, n=40) and infectious lung disease group (group B, n=15) and then compared and analyzed. 1) Results:The mean age was higher in group A and there was statistical significance (60.8 9.4 vs 45.7 12.1, p<0.001). With preoperative pulmonary function test, FEV1, FVC were higher in group A and there were statistical significane (p<0.001, p=0.006). With preoperative lung perfusion scan, the perfusion ratio of affected lung and postoperative predicted FEV1 were higher in group A and there were statistical significance (p<0.001, p=0.007). According to MRC dyspnea scale, change of respiratory difficulty of group A had statistical significance (p<0.001). There were a total 20 postoperative complications (36.4%) of which arrhythmia 7, postoperative bleeding 5, empyema and/or bronchopleural fistula 3, pneumonia 2, adult respiratory distress syndrome 1, vocal cord palsy 1. The postoperative complication rate was no difference between two groups (37.5% vs 33.3%) but arrhythmia developed in group A only. There were 3 postoperative mortalities, all in group A. Conclusion:Preoperative pulmonary function test and postoperative predicted FEV1 were lower in group B, however, postoperative complication rate was no difference between two groups and mortality developed in group A only. Because of lesser resected lung volume and well adopted in long term diseased period, there was lesser hemodynamic change in infectious lung disease, So postoperative mortality not developed in infectious lung disease group due to arrhythmia and respiratory failure.

폐암의 임상적 고찰

이정철,이종태,김규태 慶北大學校 醫科大學 1985 慶北醫大誌 Vol.26 No.4

A clinical study was made on 72 cases of primary lung cancer operated in the department of thoracic & cardiovascular surgery, Kyungpook National University hospital from January 1975 to May 1985. The ratio of male to female was 13.4:1 and mean age was 53. Histologically, squamous cell carcinoma comprised 72.2% of 72 operated cases. Before admission to our hospital, the erroneous diagnoses were made at local clinics on the 43 cases(59.7%) and a large percentage of them was diagnosed as pulmonary tuberculosis. And then, total of 56 cases recieved inadequate treatment or delayed the operation. For the location of the tumor, right to left ratio is 1.2:1 and the right upper lobe was most often involved(23.6%). Operation was performed on the 72 cases and resection on the 59 cases(8.2%). Postsurgical staging showed that stage Ⅲ was found most frequently(59.4%) and T_2N_2M_0 was 28% of total cases. Two common surgical complications were bleeding in 7 and acute respiratory failure in 6 cases, and these 6 cases of acute respiratory failure were all died. On the basis of these experiences, we conclude that aggressive effort is needed for the early accurate diagnosis and adequate treatment of lung cancer.

승모판 협착증과 동반된 자유롭게 부유하는 좌심방 구형혈전 1례

이정철,김영조,김영진,한승세,이태일,이동협,홍은표,최교원,심봉섭,강승호,신동구,이현우 영남대학교 의과대학 1993 Yeungnam University Journal of Medicine Vol.10 No.1

저자들은 승모판 협착증과 동반된 자유롭고 부유하는 좌심방내의 구형혈전은 1례를 치험하였기에 그 희귀성에 비추어 문헌 고찰과 함께 보고하는바이다. A free-floating ball thrombus in the left atrium is a rare complication of the mitral valvular disease. A 53-year-old man was admitted for pain and paresthesia on both legs. On admission he had auscultatory sign of mitral stenosis and mitral regurgitation, and the roentgenogram of his chest revealed a slight pulmonary venous congestion, enlargement of the pulmonary conus and cardiomegaly. Laboratory findings including complete blood counts, coagulation studies and blood chemistry were normal. An echocardiographic examination revealed a mitral stenosis and a free-floating ball thrombus in the left atrium. We performed the emergent open heat surgery for removal of the ball thrombus and mitral replacement successfully with Duromedics 29 mm valve. The size of thrombus was 39 X 32 X 30 mm.

성인의 심방중격 결손의 외과적 치료

이동협,이정철,한승세 영남대학교 의과대학 1992 Yeungnam University Journal of Medicine Vol.9 No.2

영남대학교 의과대학 흉부외과학 교실에서는 1985년 6월부터 1992년 8월까지 35세 이상의 성인 심방중격환자를 수술로 치험한 15례에서 다음과 같은 결과를 얻었다. 1. 수술은 11례(73%)에서 인조포편 및 자가심막을 사용하여 봉합하였다. 2. 단락정도와 수축기 폐동맥압과의 관계에서 특이한 상관관계가 없었다. 3. 술전의 뉴욕심장협회 기능분류 Ⅱ가 6명 Ⅲ이 8명이었는데 술 후 Ⅰ이 8명, Ⅱ가 6명으로 증상의 호전 있었다. 4. 심방세동 4례중 술후 3례에서 지속적으로 나타났고 1례에서는 정상리듬으로 돌아왔다. 5. 수술사망율은 없었고 수술결과는 만족하였다. The study consisted of all patients over 35years old undergoing surgical repair of atrial septal defect for the period from June 1985, to August 1992. The following results were observed. 1. ASD was closed with patch in 11(73%) patients. 2. The relationship of pulmonary artery systolic pressure to Qp/Qs ratio was not significant. 3. Before operation 6 patients were in NYHA functional class Ⅱ, 8 were in class Ⅲ, After operation 8 patients were in class Ⅰ, 6 were in class Ⅱ. 4. Atrial fibrillation has persisted in 3 patients and returned regular rhythm in 1 patient after surgery. 5. There was no operative mortality and we had good surgical results regardless of patient's age.

임산부에서 발생한 대동맥 박리(Aortic Dissection) 1례

이정철,김영조,이형민,신동구,한승세,심봉섭,이동협,홍은표 영남대학교 의과대학 1993 Yeungnam University Journal of Medicine Vol.10 No.1

본원에서는 출산 후 지속되는 호흡곤란, 전신부종을 주소로 내원한 환자에서 임신과 관계된 De Bakey유형Ⅱ의 대동맥해리를 진단하고 성공적으로 수술을 시행한 1례를 경험하였기에 보고하는 바이다. We have experienced a case of aortic dissecting aneurysm in pregnant woman. She felt initially severe chest pain which was radiated to the neck on the 3days before delivery. Thereafter dyspnea and generalized edema were developed for 1 month after delivery. She was diagnosed as aortic dissection, Debakey type Ⅱ. During cardiopulmonary bypass, the selective cerebral perfusion was done through the right and left commom carotid arteries. Aortic replacement with Hemashield vascular graft and reimplantation of innominate artery, resuspension of aortic valve, repair of intimal tear were performed. The postoperative course was uneventful.

기관지 유암종 2례

이관호,한승세,이동협,김성숙,이현우,이정철,최교원,정진홍,서정일 영남대학교 의과대학 1993 Yeungnam University Journal of Medicine Vol.10 No.2

전형 중심성 기관지 유암종과 비전형 기관지유암종을 기관지내시경하 생검 및 전산화 단층촬영하 생검으로 확진했으며 근치적 치료로 폐절제술을 시행한 치험 2례를 문헌 고찰과 아울러 보고하는 바이다. Bronchial carcinoid tumor was a low grade malignant and it was regarded as predictable clinical course and good survivality after surgical resection. But despite of its low grade malignant potentiality, bronchial carcinoid tumor was clearly capable of metastasizing and causing death. We present 2 cases of bronchial carcinoid tumors. One of them was typical carcinoid tumor in 44 year-old female and another was atypical carcinoid tumor in 53 year-old male patient. Currative therapeutic procedure was performed by lobectomy and wedge resection.