Multi-Electrode Array를 이용한 뇌 해마의 Total Activity 추산

이정찬,김지은,조정연,손민숙,박경모,박지호,Lee, Jeong-Chan,Kim, Ji-Eun,Cho, Chung-Yearn,Son, Min-Sook,Park, Kyung-Mo,Park, Ji-Ho 대한의용생체공학회 2006 의공학회지 Vol.27 No.6

Research on neural circuit is a difficult area due to complexity and inaccessibility. Due to recent developments, the research using multi-electrode array of cells or tissues has become an important research area. However, there are some difficulties to decode the submerged meaning from huge and complex neural data. Moreover, it needs a harmonic collaboration between informatics and bioscience. In this paper, we have developed a custom-designed signal processing technique for multi-electrode array measured neural responses induced by electrical stimuli to the hippocampal tissue slices of the rat brain. The raw data from hippocampal slice using the multi-electrode array system were saved in a computer. Then we estimated characteristic points in each channel and calculated the total activity. To estimate the points, we used the Polynomial Fitting Approximation Method. Using the calculated total activity, we could provide the histogram or pseudo-image matrix to help interpretation of results.

저온 O_sub2 어닐링 공정을 통한 HfSi_xO_y의 전기적 특성 개선

이정찬,김광숙,정석원,노용한,Lee, Jung-Chan,Kim, Kwang-Sook,Jeong, Seok-Won,Roh, Yong-Han 한국전기전자재료학회 2011 전기전자재료학회논문지 Vol.24 No.5

We investigated the effects of low temperature ($500^{\circ}C$) $O_2$ annealing on the characteristics of hafnium silicate ($HfSi_xO_y$) films deposited on a Si substrate by atomic layer deposition (ALD). We found that the post deposition annealing under oxidizing ambient causes the oxidation of residual Hf metal components, resulting in the improvement of electrical characteristics such as flat band voltage shift (${\Delta}V_{fb}$) by hysteresis without oxide capacitance reduction. We suggest that post deposition annealing under oxidizing ambient is necessary to improve the electrical characteristics of $HfSi_xO_y$ films deposited by ALD.

대편(大便)을 중심(中心)으로 한 사상(四象) 체질(體質) 병증(病證)에 대(對)한 고찰(考察)

이정찬,김달래,Lee, Jeong-Chan,Kim, Dal-Rae 사상체질의학회 1992 사상체질의학회지 Vol.4 No.1

무릎 골관절염에서의 펄스 전자기장 치료의 효과

이정찬 ( Jung Chan Lee ),박정진 ( Jeong Jin Park ),신동혁 ( Dong Hyuk Sheen ),최영미 ( Young Mi Choi ),박남규 ( Nam Gyu Park ),김우규 ( Woo Kyu Kim ),이윤종 ( Yun Jong Lee ),이은봉 ( Eun Bong Lee ),송영욱 ( Yeong Wook Song ) 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.2

Objective: To determine the effectiveness of pulsed electromagnetic fields (PEMF) in the treatment of knee osteoarthritis (OA). Methods: In this randomized, placebo-controlled, double-blind trial, 51 patients with knee OA, diagnosed according to the criteria of the American College of Rheumatology, were treated with PEMF or placebo. Eleven patients failed to attend after screening and were excluded from analysis. Treatment consisted of 3 half-hour periods of exposure per week over 6 weeks in a specially designed cylindrical device that emits low-frequency pulsed electromagnetic fields (25 gauss, 12 Hz). The primary outcome measure was reduction in pain on movement using a 10 cm visual analog scale. Secondary outcome measures included joint swelling and tenderness, the Lequesne index, and overall evaluations of improvement by the patient and examining physician. Evaluations were made at baseline, 3 week and 6 week during treatment and 4 weeks after finishing treatment. Results: There were no significant differences between PEMF and placebo groups in respect of any outcome measures after treatment. Range of motion and knee swelling tended to be improved in the PEMF group. There were no clinically relevant adverse effects attributable to PEMF treatment. Conclusion: These results suggest that the PEMF treatment has no clinically significant benefits in patients with knee OA resistant to conventional treatment. The larger studies are needed to confirm the efficacy of PEMF therapy in knee OA.

근대적 구두법(句讀法)이 읽기와 쓰기에 미친 영향 -근대 전환기를 중심으로-

이정찬 ( Jeong Chan Lee ) 한국작문학회 2008 작문연구 Vol.0 No.7

국문 글쓰기가 확립되어 가면서 근대적 구두법 역시 나타나기 시작했다. <독립신문>의 경우 일반 대중을 독자로 포섭하기 위한 장치로 띄어 쓰기를 사용하였는데 여기에는 음성문자로서의 국문에 대한 인식이 전제되어 있었다. 따라서 의미 단위와 소리 단위를 시각적 장치(space:공백)를 통해 나타내는 띄어쓰기는 읽는 이로 하여금 독서의 효율성을 높일 수있으며 이때의 ‘가상 독자’는 바로 일반 대중이었던 것이다. 다음으로 초창기 문인들은 ‘구어체’ 문장을 구현하는 데 있어 문장 부호를 사용하였다. 구어체란 서술자가 처해있는 당시 일반인들의 일상생활의 말을 그대로 기록해 낸 문장을 말한다. 즉, 문장을 기술하는 사람이 말을 행하는 사람의 입장을 취해서 그의 입장에서 사물을 인식하고, 그 인식된 사물을 그 사람의 말로 표현하는 것이다. 따라서 소설의 경우 다양한 인물이 그 인물의 말로 구현할 때 획득할 수 있는 것이다. 즉, 문장부호가 음성 언어가 지닌 어조, 음색, 속도, 고저, 억양 등을 문자 언어에서 구체화할 수 있도록 도움으로써 인물의 대사가 더욱 인물의 ‘음성’에 가깝도록 유도하는 것이다. 끝으로 이러한 일련의 변화는 독서 방식에 있어서도 ‘소리 내어 읽는’ 읽기에서 ‘눈으로 읽는’ 읽기로의 변화를 촉진시켰다. 이는 독자로 하여금 텍스트를 읽을 때 더 이상 타인이나 자신이 내는 소리에 영향을 받지 않고, 텍스트가 내는 ‘내면의 소리’에 귀를 기울이도록 하였다. A modern punctuation appeared by put Korean writing on a firm footing. In case of <The Independent>, it used a spacing in order to induce general people. A spacing, therefore, that distinguishes between meaning unit and phonetic unit can improve people`s readability. Next, The early writers used a modern punctuation to realize a colloquial style. A colloquial style is a writing through oral language in those days. In other words, a narrator thinks like a actor and speaks like a actor in a modern novel. Thus, a narrator has to take each actor`s voices and writer uses a punctuation to achieve the purpose. Because a punctuation help a literary expression get a tone, pace, pitch and intonation. Finally, These changes bring on the transition oral reading into silent reading. When a people reads, he need not be had influence on his voice or the other`s one and he only has to concentrate sound of text.

작문사(作文史)적인 관점에서 본 근대 초기 작문 교재 연구

이정찬(Lee Jeong-Chan) 한국언어문학회 2011 한국언어문학 Vol.79 No.-

This study aims to analyze the early modern Writing Text-book and reveal its interpretation and evaluation. Our writing history had been changed variously from 1894 that proclaimed Korean as the national characters. As adopted the Western culture, writing also mixed traditional and western or western replaced traditional one. In this period some one tried to negotiate each other’s differences and the other one emulated western. I choice representative writing text-books to analyze each writing features. There were three books- 〈Sil-Ji-Eung-Young Writing Mothods(實地應用作文法)〉(1909) by Choi Jea-Hak, 〈Sil-Young Writing Mothods(實用作文法)〉(1917) by Lee Gak-Jong and 〈Korean Writing in Middle School(中等朝鮮語作文)〉(1928) by Gang Mea. Each writing text-books had been appeared that how our writing history had been changed. The changes of early modern text-book represent a mode of differences. especially this problems are showed that this process are not universal and effective but sometimes result of compromise, following without critic and emulation. We, of cause, need not exclude this writing history. We must review and evaluate this writing history to seek more development of writing’s study.

침자극이 불안 환자와 정상 성인의 피부전도도에 미치는 영향

정명숙 ( Myeong Suk Jeong ),최우진 ( Woo Jin Choi ),이경원 ( Kyung Won Lee ),이승기 ( Seung Gi Lee ),김지은 ( Ji Eun Kim ),이정찬 ( Jeong Chan Lee ),박경모 ( Kyung Mo Park ) 대한한방신경정신과학회 2009 동의신경정신과학회지 Vol.20 No.2

Objectives: The purpose of this study was to investigate the effects of acupuncture on autonomic nervous system in anxiety patients and normal subjects by using SCR(Skin Conductance Response). Methods: The study group consists of 15 anxiety patients as the experimental group stimulated by verum acupuncture, 15 anxiety patients as the control group stimulated by sharm acupuncture, and 15 normal subjects stimulated by verum acupuncture. We measured GSR of experimental and control group, normal subjects during Working Memory Test and acupuncture stimulation. Results: 1. Measured value of SCR during Working Memory Test was significant different in control group, but it was not significant different in experimental group. 2. SCR value of three groups was significantly decreased during acupuncture stimulated. There was only significantly SCR value change during 0min.-5min. of first acupuncture. The section of the other groups was no significantly different. 3. STAI scores of experimental group and control group were significantly decreased. Conclusions: The study results suggest that acupuncture stimulation and sham acupuncture also effective on activity in the sympathetic nervous system and STAI scores.

공공부문 클라우드 사무환경 도입 방안에 관한 연구

이정찬(Lee Jung Chan),김정엽(Kim Jeong Yeop),송석현(Song Seok Hyun) 한국통신학회 2012 한국통신학회 학술대회논문집 Vol.2012 No.6

재발성 다발연골염 16예의 임상적 분석

박정진 ( Jeong Jin Park ),이정찬 ( Jung Chan Lee ),김진현 ( Jin Hyun Kim ),임철현 ( Churl Hyun Im ),강은하 ( Eun Ha Kang ),배영덕 ( Young Deok Bae ),이윤종 ( Yun Jong Lee ),이은봉 ( Eun Bong Lee ),송영욱 ( Yeong Wook Song ) 대한류마티스학회 2005 대한류마티스학회지 Vol.12 No.3

Objective: To investigate the clinical characteristics of relapsing polychondritis (RP) in Korea. Methods: We retrospectively reviewed 16 patients with RP who were diagnosed at Seoul National University Hospital and Gyeongsang National University Hospital in the period from July 1987 to August 2003. Results: There were 9 males and 7 females, the mean age was 45.4±12.8 years. The frequency of clinical manifestation was as follows; auricular chondritis (81.3%), nasal chondritis (68.8%), ocular inflammation (56.3%), respiratory tract involvement (56.3%), arthritis (50%) and audio-vestibular damage (25%). Westergren erythrocyte sedimentation rate (ESR) was elevated in 53.3% and antinuclear antibody (ANA) was positive in 20% of study patients. Rheumatoid factor was negative in all cases. Conclusion: Clinical manifestations were comparable to the reports of Western countries. However, the frequency of arthritis was lower in Korean patients with RP than Western reports.

환자중심서비스를 위한 온톨로지 기반의 u-Healthcare 시스템

정용규,이정찬,장은지,Jung, Yong Gyu,Lee, Jeong Chan,Jang, Eun Ji 서비스사이언스학회 2012 서비스연구 Vol.2 No.2

U-Healthcare는 홈 네트워크, 휴대용 장치 등에 기반한 정보통신기술과 의료시스템이 서로 융합되어 개인의 생체정보 등을 실시간으로 모니터링하고, 자동으로 병원 및 의사와 연결되어 시공간의 제약을 줄임으로써 언제 어디서나 건강을 관리하고 질병을 예방하는 새로운 형태의 의료서비스이다. 본 논문에서는 진료 중심에서 예방 중심으로 변화되어가고 있는 최근의 U-Healthcare 시스템의 기술 발전 추세에 맞추어 조기 대응이 가능한 Healthcare 정보시스템 구축을 위한 요구분석 사항들에 대해 정리하고, 이를 기반으로 u-Healthcare의 실현을 위한 기존의 단위 시스템인 PACS, OCS, EMR, 응급의료시스템을 통합한 환자중심의 클라이언트 시스템을 설계한다. 특히, 온톨로지는 특정분야의 정보 모델에 이용되어 그 분야에서 공통의 어휘를 제공하고, 그 용어의 의미와 용어간의 관계를 다양한 수준의 형식성을 가지고 제공한다. 본 논문에서는 이러한 온톨로지 및 무질서한 데이터에 대한 관계를 정의하고, 보다 체계적으로 데이터를 군집화하는 클러스터링의 개념을 포함한 환자중심의 서비스를 위한 온톨로지 기반의 시스템을 제안한다. U-healthcare is real-time monitoring of personal biometric information using by portable devices, home network and information and communication technology based healthcare systems, and fused together automatically to overcome the constraints of time and space are connected with hospitals and doctors. As u-healthcare gives health service in anytime and anywhere, it becomes to be a new type of medical services in patients management and disease prevention. In this paper, recent changes in prevention-oriented care is analyzed in becoming early response for Healthcare Information System by requirements analysis for technology development trend. According to the healthcare system, PACS, OCS, EMR and emergency medical system, U-healthcare is presenting the design of a patient-centered integrated client system. As the relationship between the meaning of the terms is used in the ontology, information models in the system is providing a common vocabulary with various levels of formality. In this paper, we propose an ontology-based system for patient-centered services, including the concept of clustering to clustering the data to define the relationship between these ontologies for more systematic data.