http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
간장 ( 肝腸 ) 및 담도 ( 膽道 ) : B형 활동성 간염 환자에서 단기 Prednisolone과 ARA - AMP 겸용 치료의 경과에 따른 면역 지표의 변화에 관한 연구
민영일(Young Il Min),장린(Rin Chang),김병호(Byung Ho Kim),장영운(Young Woon Chang),이정일(Joung Il Lee),황이숙(Yi Sook Hwang),김정원(Jeong Won Kim),김효종(Hyo Jong Kim) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.3
N/A Withdrawal of corticosteroids in patients with chronic type B hepatitis is frequently associated with enhanced cellular immune response to hepatitis B virus. This immunolgic rebound generally results in a transient reduction in levels of HBV-DNA and DNA polymerase, and seldom results in clearance of HBeAg. There was a pilot study that the combination of a short course of prednisone followed by ARA-AMP was potentially synergistic. The object of this study was to determine the effect of short term prednisolone followed by ARA-AMP on the immune system in patients with chronic active ltepatitis-B. Patients were started 40 mg of prednisolone daily for 4 weeks. After prednisolone therapy was discontinued, patients received no medication for 2 weeks. ARA-AMP was then given for 4 weeks at a dose of 500 mg daily. Immune parameters such as T cell subsets, IL, production, NK cell activeity, and LAK cell activity were tested before and during treatement period. The resullts were as follows. 1) Basal IL2 production in CAH-B (71.3 unit/ml) was lower than that of normal control (p<0.025). Basal NK activity, T4/T8 ratio and LAK activity of CAH-B were similar to those of normal control. 2) After prednisolone treatment, IL2 production, NK cell activity and LAK cell activity were significantly lower than those of basal value. 3) After induction of immune rebound, IL, production increased to 84.8 unit/ml (basal 71.3 unit/ml,
궤양성 대장염 수술 방법으로써 회장낭-항문문합술과 영구회장조성술 후 경과와 삶의 질에 대한 비교
정용희 ( Yong Hee Joung ),김효종 ( Hyo Jong Kim ),이길연 ( Kil Yeon Lee ),이병욱 ( Byoung Wook Lee ),한요셉 ( Yo Seb Han ),동석호 ( Seok Ho Dong ),김병호 ( Byung Ho Kim ),장영운 ( Young Woon Chang ),이정일 ( Joung Il Lee ),장린 ( 대한장연구학회 2003 Intestinal Research Vol.1 No.1
Background/Aims: Ileostomy (IL) and ileal-pouch anal anastomosis (IPAA) are treatment of choice in ulcerative colitis. We investigate the complications and quality of life after operation according to the operative methods. Methods: We analyzed patients experienced total proctocolectomy. We divided them in two groups according to the operation methods. We analyzed the characteristics and outcomes after IL or IPAA group for evaluation quality of life and evaluated the characteristics of patients preoperative and postoperative state retrospectively. Results: Fourteen patients were enrolled this study. IPAA was done at eight of them and IL was done at the six of them. There were no difference in sex, age, frequency of use of immunosuppressive agent, duration of medication of steroid and duration of ulcerative colitis according to the operation methods. Most common indication of operation was medical intractability. Similar incidence of postoperative complication in both operation methods. According to the questionnares for evaluating of quality of life, we compared both operation method. There was no difference. But in IPAA, antidiarrheal medication was more needed. Conclusions: In IL and IPAA, quality of life was improved. There was no difference in quality of life in IL and IPAA. (Intestinal Research 2003;1:39-44)
SV40 T 항원의 온도조건부 변이형 유전자가 포함된 Amphotropic Retrovirus 에 의한 사람 태아 간세포의 불멸화
이정일(Joung Il Lee),동석호(Seok Ho Dong),김효종(Hyo Jong Kim),김병호(Byung Ho Kim),장영운(Young Woon Chang),장린(Rin Chang),성세라(Se Ra Seong),박재경(Jae Kyung Park),김승보(Seung Bo Kim),이상목(Sang Mok Lee) 대한내과학회 1999 대한내과학회지 Vol.57 No.1
N/A Human cells are almost never spontaneously immortalized in vitro. We tried to immortalize human fetal hepatocytes (h-FH) and evaluate the differentiational status and its change. Methods : Hepatocytes were isolated from a liver fragment of 20 week old fetus and infected with amphotropic recombinant retrovirus containing a temperature- sensitive mutant of SV40 large T antigen and neomycin phosphotransferase gene. G418 resistant colonies were cloned and expanded. The cells which were able to divide more than 30 times were used to analyze various functions. Results : The immortalization rate was 3.3 x 10-8 and two cell lines (C11, D21) were established. C11-60, C11-80, D21-30 and D21-60 (suffix number means the cell division counts) were evaluated. D21-30 was thougt to be imcompletely immortalized because a considerable portion of cells died during culture. The morphology was similar to that of epithelial cells except for D21-30 which looked like fibroblast. The cells grew rapidly at 33oC but stopped growing at 39oC. T antigen and p53 was expressed at 33oC but disappeared at 39oC, which suggest that T antigen binds to p53. Chromosomal changes were so marked that it was impossible to discriminate exact number. Albumin was secreted as about 1/10 as that of h-FH, but alpha-fetoprotein secretion stopped after immortalization. Telomerase was activated in both cell lines except for the incompletely immortalized cells D21-30. Telomere was elongated in competely immortalized cell lines, but it was rather shortened in D21-30 compared to that of h-FH. Macroscopic colonies did not develop in soft agar assay. Conclusions : We successfully immortalized human fetal hepatocytes. Although the cells are not likely to have oncogenicity, the functions are not so good, possibly due to marked chromosomal changes which are thought to occur before telomerase is activated during immortalization step.
이정일(Jeong-Il Lee),김종원(Joung-Won Kim),오창석(Chang-Suk Oh) 한국엔터테인먼트산업학회 2008 한국엔터테인먼트산업학회논문지 Vol.2 No.2
최근 다양한 DDoS 공격 도구가 널리 확산되고 있을 뿐만 아니라 이를 이용한 DDoS 공격이 급속도로 증가되고 있기 때문에 이에 대한 효율적 탐지 기법이 요구된다. 이에 본 논문에서는 통계적 기법과 패턴 매칭 기법을 혼합하여 동적 임계값을 이용한 DDoS 공격 탐지 기법을 제안한다. 먼저, 관리 대상 시스템으로 유입되는 트래픽을 수집하고, 트래픽 카운터를 이용하여 동적 임계값과 임계값 유효시간을 계산한다. 다음으로 임계값에 따른 공격 가능 트래픽을 수집하고 공격 패턴을 분석하여 공격 유무를 판단한다. 마지막으로 공격으로 판단된 유해 트래픽의 IP 주소와 포트를 제어함으로써 공격을 차단한다. TCP flooding, UDP flooding, ICMP flooding 실험에서 제안한 알고리즘이 높은 DDoS 공격 탐지 성능을 보였다. Recently, owing to the spread of various DDoS attack tools on the network, the attacks using these tools have increased rapidly. For this reason, methods to efficiently detect them have been required. This paper proposes a method to efficiently detect DDoS attacks with dynamic threshold based on statistical methods and pattern matching methods. Firstly, dynamic threshold and its valid time are calculated after incoming traffics of a target system are collected. Next, with the threshold value calculated in the above step, attack-possible traffics are analyzed and harmful traffics are classified. Finally, DDoS attacks are cut off by controlling the IP addresses and ports of the harmful traffics. In the TCP, UDP and ICMP flooding experiments, proposed algorithm showed high performance to detect DDoS attacks.
트래픽 추이 분석을 통한 적응형 DDoS 공격 탐지 알고리즘
이정일(Jeong-Il Lee),김종원(Joung-Won Kim) 한국엔터테인먼트산업학회 2008 한국엔터테인먼트산업학회 학술대회 논문집 Vol.2 No.2
정보통신의 급속한 발전과 인터넷 서비스의 성장으로 www, FTP, Mail 등의 전통적인 인터넷 응용프로그램뿐만 아닌 peer-to-peer 파일 공유, 인터넷 게임, 인터넷 뱅킹, 음성과 이미지 스트리밍 등 많은 서비스와 응용 프로그램들이 인터넷 기반으로 운영됨에 따라 DDoS 공격은 과거에 비해 더욱더 치명적인 결과를 야기한다. 이에 본 논문에서는 정상 네트워크 환경에서의 트래픽 추이 값을 분석하여 실시간 트래픽 변화에 적응 가능한 임계값 설정 범위 변수 및 임계값 적응 시간 변수, 판단 자료 수집 시간 변수를 도출하고, 이를 적용한 DDoS 공격 탐지 알고리즘을 제안하였다.
김종원(Joung-Won Kim),이정일(Jeong-Il Lee) 한국엔터테인먼트산업학회 2008 한국엔터테인먼트산업학회 학술대회 논문집 Vol.2 No.2
본 논문에서는 점점 확대되고 있는 망 내에 유입되는 트래픽에 대하여 flow 기반으로 전체 트래픽의 점유율과 임계치를 적용하고, 요소별 연관성 분석을 통하여 공격시 경로상에 나타날 수 있는 다양한 증후들을 통해 유해트래픽을 탐지하고 서비스관점에서 분류 및 분석함으로서, 실시간 중앙 집중 관리식의 공격 탐지와 확장 및 연동 가능한 시스템을 설계함으로서, 효율적인 네트워크 유해 트래픽 탐지 기법을 제안하였다.
민영일(Young Il Min),장린(Rin Chang),장영운(Young Woon Chang),김병호(Byeong Ho Kim),이정일(Joung Il Lee) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.2
N/A A clinical study about II cases of spontaneous rupture of hepatoma who were operated at Kyung Hee University Hospital between January 1980 and December 1985 was done. The results of the clinical review were as follows; 1) Of 496 cases of hepatoma diagnosed during 6 years (from January, 1980 to December, 1985), 11 cases had spontaneous rupture (2.2%). Male to female ratio was 7:4. 2) 5 cases had single mass in left lobe of the liver, 3 in right lobe including 1 case who had multiple masses in right lobe. 2 cases had multiple masses in both lobe. 3) In most instances, the presenting symptom was abdominal pain and the diagnosis was very difficult without history of chronic liver disease. 4) 10 cases had rupture of tumor mass itself, and one case had rupture of normal liver tissue overlying tumor mass. 5) The association with liver cirrhosis was 73%. All cases of spontaneous rupture of hepatoma were accompanied by verying degree of hemoperitoneum. 6) Left lateral segmentectomy was performed in 4 cases, wedge resection in 2 cases, right lobectomy in 1 case and primary suture in 2 cases. Hepatic artery ligation was employed in 2 cases who had multiple masses or severe bleeding. 7) The postoperative follow-up period ranged from 17 days to 27 months and 2 cases died during hospital admission after surgery. The cause of death in these patients were intraperitoneal bleeding and hepatic failure.
특발성 세균성 복막염 진단에 복수의 산도 및 동맥혈 - 복수산도차 측정에 관한 연구
민영일(Young Il Min),장린(Rin Chang),김병호(Byung Ho Kim),장영운(Young Woon Chang),이정일(Joung Il Lee),정호연(Ho Yeon Chung),이석훈(Suk Hoon Lee) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.1
N/A To evaluate the diagnostic value of ascites pH and arterial-ascites pH gradient in patients with probable spontaneous bacterial peritonitis, we analyzed ascitic fluid in 27 patients. The results were as followed. 1) Mean ascites pH in probable spontaneous bacterial peritonitis was significantly lower than that of sterile ascties(P <0.01), but individual value showed many overlap. 2) Mean arterial-ascties pH gradient in probable spontaneous bacterial peritonitis was significantly higher than that of sterile ascties(P <0.01), but individual value also showed many overlap. 3) Mean ascites polymorphonuclear leukocytes count showed significant difference between sterile ascties and pobable spontaneous bacterial peritonitis(P <0.005). 4) Mean ascites protein concentration did not show significant difference between sterile ascites and probable spontaneous peritonitis. In conclusion, ascites polymorphonuclear leukocyte count may be more significant parameter than ascites pH or arterial-ascites pH gradient in differentiating probable spontaneous bacterial peritonitis from sterile ascies.