소손 주상변압기 교체를 위한 임시송전시스템 개발에 관한 연구

이정균(Jung-kyun Lee),윤영모(Young-Mo Yun),전시식(Si-Sik Jeun),이재헌(Jae-Heon Lee),정동주(Dong-Ju Jeong),박용범(Yong-Beom Park),김점식(Jeom-Sik Kim),조성문(Seong-Mun Jo),Hyung-geun Lee 한국조명·전기설비학회 2009 한국조명·전기설비학회 학술대회논문집 Vol.2009 No.10월

3기 위암에서 수술후 보조 면역화학요법

이정균(Jeong Kyun Lee),오정택(Jung Taeck Oh) 대한외과학회 2000 Annals of Surgical Treatment and Research Vol.58 No.1

위암에서 Methylenetetrahydrofolate Reductase C677T의 유전자 다형성

서원,박원철,이정균,김정중,Seo Won,Park Won Cheol,Lee Jeong Kyun,Kim Jeong Jung 대한위암학회 2005 대한위암학회지 Vol.5 No.1

Purpose: Recently the role of vitamins, folate in particular, has been emphasized in the maintenance of health. Folate deficiency is known to give rise to developmental delay, immature vascular disease, neural tube defect, acute leukemia, atherosclerotic vascular disease, delivery defects, breast cancer, and particularly gastrointestinal neoplasia. Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme in folate metaboism, and influences DNA synthesis and DNA methylation. Generally, folate deficiency is associated with gastrointestinal neoplasms. The amino-acid- changing and enzyme-activity-reducing nucleotide polymorphism (766C$\rightarrow$T/ Ala222Val) has been described in the MTHFR polymorphism and leads to low enzyme activity that may reduce the capacity of DNA methylation and possibly uracil mis-incorporation into DNA. These processes may be critical in the oncogenic transformation of human cells, especially in colorectal carcinomas. We investigated the relationship between the MTHFR polymorphism in gastric cancer and the tumor site, the smoking history, and the alcoholic history. Materials and Methods: Ninety-six (96) individuals with gastric cancer and 287 healthy persons were analyzed. Blood sampling was performed, PCR-RFLP was analyzed, and MTHFR polymorphism genotypes of C/C, C/T, and T/T were obtained and analyzed statistically for their correlation. Results: In the gastric cancer group there were 69 ($72\%$) males and 27 ($28\%$) females. There were also 58 cases ($60\%$) involving the gastric lower body, 20 cases ($21\%$) the gastric mid-body, and 18 cases ($19\%$) the gastric upper body. In the control group there were 169 ($59\%$) males and 118 ($41\%$) females. Among the gastric cancer, 56 ($61\%$) smoking patients, 40 ($39\%$) non-smoking patients, 45($47\%$) alcoholic patients, 51 ($53\%$) non-alcoholic patients. In the gastric cancer group, MTHER polymorphisms were C/C in 18 ($19\%$) cases, C/T in 59 ($61\%$) cases, T/T in 19 ($20\%$) cases. In the control group polymorphisms were C/C 116 ($40\%$) cases, C/T 103 ($36\%$) cases, and T/T 68 ($24\%$) cases (P=0.045). In cases of lower gastric body cancer, polymorphisms were C/C in 16 ($24\%$) C/C in 16 ($24\%$) cases and C/T or T/T in 42 ($72\%$) cases. In cases of upper and mid-body cancer, polymorphisms were C/C in 2 ($5\%$) cases and C/T or T/T 36 ($95\%$) cases (P=0.006). In the non-smoking patient group, polymorphisms were C/C in 5 (12%) cases and C/T or T/T in 35 ($88\%$) cases. In the smoking patient group, C/C in 13 ($23\%$) cases and C/T or T/T in 43 ($77\%$) cases (P=0.189). In the non-alcoholic patient group, polymorphisms were C/C in 6 ($12\%$) cases and C/T or T/T in 45 ($88\%$) cases. In the alcoholic patient group, polymorphisms were C/C in 12 ($26\%$) cases and C/T or T/T in 33 ($74\%$) cases (P=0.063) Conclusion: MTHFR polymorphisms are associated with gastric cancer and tumor site, but not with smoking and alcohol drinking. 목적: 건강을 유지하는 데 비타민, 특히 엽산의 중요성이 근래에 강조되고 있다. 엽산의 결핍은 발달 지연을 일으켜 신생아에서 미성숙 혈관질환이나 신경관 결손 등의 중추 신경계 질환 등을 일으킬 수 있고, 급성 백혈병 같은 혈액학적 질환과도 연관된다. 또한, 과호모시스테인혈증과 연관되어 여러 폐색성 혈관성 질환 등을 유발하고, 출산 결손이나 다른 임신성 합병증을 유발하기도 한다. 특히 최근에는 위장관 신생 종양의 발생과도 연관된다고 보고되고 있다. Methylenetetrahydrofolate Reductase(MGHFR)는 엽산 대사에서 DNA 합성과 메틸화에 영향을 주는 필수 효소이다. MTHFR의 유전자 다형성은 아미노산의 변화와 효소 활성을 감소시키는 핵산의 유전자 다형성(677C $\rightarrow$T/Ala222Val)으로 정의되는데, 이때 효소 자체의 활성을 감소시켜 DNA 합성 저하와 저메틸화로 이어져 생체 내에서 발암성 변이를 일으켜 위장관계 종양과 연관된다. 우리는 MTHFR의 유전자 다형성과 위암의 발생 위험과의 관련성을 알아보기 위하여 본 연구를 시행하였다. 대상 및 방법: 2003년 7월부터 2004년 6월까지 위암으로 진단 받은 환자군 96명과 건강 검진에서 정상으로 판정 받은 대조군 287명의 혈청 표본으로 PCR-RFLP방법으로 MTHFR의 유전자 다형성을 구하여 위암에서의 연관성을 비교하였고, 환자군 내에서 암의 발생 위치와 낮은 체내 엽산 농도에 영향을 미치는 흡연력과 음주력에 대해 비교 하였다. 결과: 위암 환자 중 남자 69명($72\%$), 여자 27명($28\%$)이었고, 위 하부 58예($60\%$), 위 중부 20예($21\%$), 위 상부 18예($9\%$)였다. 위암 환자 중 흡연력이 있는 경우는 56명, 없는 경우는 40명이었고, 음주력이 있는 경우는 45명, 없는 경우는 51명이었다. 환자군에서 MTHFR의 유전자 다형성은 C/C 18($19\%$), C/T 59($61\%$), T/T 19($20\%$)였고, 대조군에서는 C/C 116($40\%$), C/T 103$40\%$), T/T 68($24\%$)이었다(P=0.045). 암의 위치에 따른 MTHFR유전자형의 분포는 위 하부에서 C/C 16($28\%$), C/T & T/T 42($77\%$)이었고, 위 중부 및 상부에서 C/C 2($5\%$), C/T & T/T 36($75\%$) 이었다(P=0.006). 환자군 내에서 흡연력 유무에 따른 MTHFR유전 자형의 분포는 흡연력이 있을 때 C/C 13($23\%$), C/T & T/T 43($77\%$)이었고, 흡연력이 없을 때 C/C 5($12\%$), C/T & T/T 35 ($88\%$)였다(P=0.189). 환자군 내에서 음주력 유무에 따른 MTHFR유전자형의 분포는 음주력이 있을 때 C/C 12($26\%$), C/T & T/T 33($74\%$)이었고, 음주력이 없을 때 C/C 6($12\%$), CT & T/T 45($88\%$)였다.(P=0.063). 결론: 본 연구에서는 MTHFR C/T & T/T 유전자 다형성이 위암의 발생과 그 위치에 대해 관련이 있는 것으로 여겨지고, 흡연력, 음주력과는 관련이 없는 것으로 여겨진다.

우하복부 통증 환자에서 충수 전산화 단층촬영의 유용성

유지만(Jee Man You),이정균(Jeung Kyun Lee),박원철(Won Cheul Park),강동백(Dong Baek Kang),윤성언(Sung eun Yoon),윤기중(Ki Jung Yoon) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.72 No.2

Purpose: This study was performed to evaluate the contribution of appendiceal computed tomography (CT) in the more accurate diagnosis of acute appendicitis and decrease in the rate of negative appendectomies. Methods: Between May and August 2005, 146 patients with right lower quadrant (RLQ) abdominal pain and tenderness were diagnosed using appendiceal CT. The appendiceal CT scans were performed with contrast media in the abdominal and pelvic areas. 7 ㎜ slice scans were taken both before and after the contrast media injection, with a time delay. The control group was comprised of 99 patients, who were also checked by abdominal CT or ultrasonography, between December 2004 and April 2005, with the data analyzed retrospectively. Results: In the study group, 85 of the 146 cases were diagnosed with acute appendicitis on appendiceal CT, and had undergone an appendectomy, including 42 men (mean age 39.9 yr) and 43 women (mean age 44.6 yr). The sensitivity and specificity of appendiceal CT in acute appendicitis were 95.3 and 98.4%, respectively. There were 4 (4.7%) negative appendectomy cases; 2 in men and 2 in women. The control group conprised of 47 men and 52 women. There were 13 (13.1%) negative appendectomy cases; 4 in men and 9 in women. Conclusion: The routine use of appendiceal CT, in patients with RLQ abdominal pain and tenderness, resulted in a significant decrease in the negative appendectomy rate.

림프절 전이가 없는 위암에서 CD44v6 과발현의 의의

김승호 ( Seung Ho Kim ),이정균 ( Jeong Kyun Lee ),윤기중 ( Ki Jung Yun ) 대한소화기학회 2003 대한소화기학회지 Vol.41 No.5

Background/Aims: The CD44 serves as an adhesion-molecule in cell-to-cell and cell-to-matrix interactions and is involved in lymphocyte homing, cell migration, and cancer metastasis. This study was performed to investigate the relationship between CD44v6 overexpression and histologic prognostic factors such as the depth of invasion, histologic differentiation, and lymphovascular invasion, and to evaluate the clinical value as a prognostic factor of CD44v6 in node-negative gastric cancer. Methods: Immunohistochemical staining of CD44v6 was performed in 78 patients with node-negative gastric cancer who underwent radical gastrectomy. The case that over half of carcinoma cells was stained, was regarded as overexpression, and the case that less than half was stained, was regarded as low expression. The relationship between CD44v6 overexpression and the depth of invasion, histologic differentiation, lymphovascular invasion, and 5-year survival rate of patients was analysed. Results: The CD44v6 overexpression was found in 17 cases (21.8%) of the 78 patients. There was no significant correlation between CD44v6 overexpression and the depth of invasion, histologic differentiation, and lymphovascular invasion. However, 5-year survival rate was lower in 17 cases of CD44v6 overexpression (64.7%) than in 61 cases of CD44v6 low expression (86.9%). Conclusions: These results suggest that CD44v6 overexpression could be useful as a prognostic factor in node-negative gastric cancer. (Korean J Gastroenterol 2003;41:343-350)

급성 침윤성 장관 고래회충유충증에 의한 소장폐쇄

강동백 ( Dong Baek Kang ),오정택 ( Jung Taek Oh ),박원철 ( Won Cheol Park ),이정균 ( Jeong Kyun Lee ) 대한소화기학회 2010 대한소화기학회지 Vol.56 No.3

Anisakiasis usually occurs in the stomach and can easily be diagnosed by digestive tract endoscopy as opposed to enteric anisakiasis which is very rare and difficult to be diagnosed definitively. The most important and useful tool in diagnosing enteric anisakiasis is obtaining an accurate patient history of having eaten raw fish before the onset of symptoms. We report a case of small bowel obstruction caused by acute invasive enteric anisakiasis. A 60-year-old woman visited the emergency room suffering from sudden abdominal pain. She had eaten raw fish 1 day before the onset of symptom. Radiologic studies showed small bowel obstruction. However, no definitive cause could be found. An emergency laparotomy revealed edematous and dilated proximal jejunum and a focal stenosis of the distal jejunum. Segmental resection of the jejunum was performed, and histopathological examination revealed enteric anisakiasis. The patient was discharged on the 7th day after surgery following an uneventful course of recovery. (Korean J Gastroenterol 2010;56:192-195)

대장 신경초종

강동백(Dong Baek Kang),김승호(Seung Ho Kim),오정택(Jung Taek Oh),박원철(Won Cheul Park),이정균(Jeung Kyun Lee),김헌수(Hun Soo Kim) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.73 No.2

Schwannoma is a common soft tissue tumor, but it appears to be rare among the spindle cell mesencymal tumors of the gastrointestinal tract. Gastrointestinal Schwannomas (GIS) are rare and most of them originate in the stomach or the small bowel. GIS of the colon is extremely rare. The most important issue to be addressed for this type of tumor is the difficulty in making the correct preoperative diagnosis. Less than 10% of cases have been diagnosed as schwannoma preoperatively. A 58-year-old man was found to have a 3.5㎝ sized submucosal transverse colon tumor on the preoperative colonoscopy, abdominal CT and MRI. Wedge resection was done and the submucosal mass was diagnosed as schwannoma on the immunochemical staining. The immunochemical results were negative staining for CD 117(KIT) and CD 34 and positive staining for S-100 protein, which is all consistent with schwannoma. We report here on the first case of colonic schwannoma in Korea, along with a review of the literature.

도시림 이용객의 특성과 자원의 관리 평가

신원섭(Won Sop Shin),연평식(Poung Sik Yeoun),이정희(Jeong Hee Lee),이정균(Jung Kyun Lee),김경목(Kim KYung Mok) 한국산림휴양학회 2010 한국산림휴양학회지 Vol.14 No.1

도시숲은 도시민의 급격한 증가에 자원의 관리가 기인하기 때문에 최근 이슈화 되고 있다. 본 연구의 목적은 도시숲의 자원, 편의시설과 관리의 사용자 인식을 확인하고자 함이다. 최근 개발된 도시숲 4곳을 대상으로 541명의 응답자를 대상으로 데이터를 수집하였고, I.P.분석을 사용하였다. 분석 결과는 4개요인 속에‘우선 시정 필요’, ‘지속적 노력필요’, ‘저우선 순위’, ‘과잉노력 지양’속하며 관리에 제안된다. Urban forest is an emerging issue in resources management due to recent dramatic increase of urbanization. The purpose of this study was to identify users’ perception on resources, facility, and management of urban forests. To collect the data, 541 respondents were surveyed from four newly developed urban forest parks across the country. Using ‘Importance-Performance Analysis’, this study analyzed the data, and provided action grids for management actions. Based on the action grids, management suggestions were discussed under the four categorical components such as ‘concentrate here’, ‘keep up the good work’, ‘low priority’, and ‘possible overkill’.

혼합 간세포-담관암 환자에서 담관암에 의한 전이성 소장 천공

강동백(Dong Baek Kang),김승호(Seung Ho Kim),변승재(Seung Jae Byun),오정택(Jung Taek Oh),박원철(Won Cheol Park),김강득(Kang Deuk Kim),조향정(Hyang Jeong Jo),이정균(Jeong Kyun Lee) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.77 No.2

Advances in chemotherapy and radiation therapies for malignant tumors have resulted in the identifications of various novel features of intestinal metastasis. The common causes of small bowel metastasis are malignant melanoma and lung cancer, and this has also been rarely reported to uterine cervical cancer, malignant lymphoma of the larynx, malignant lymphoma of soft palate, and hepatocellular carcinoma (HCC). The Combined HCC cholangiocarcinoma (HCC-CC) is a rare primary liver malignancy, and is composed of cells with the histopathological features of both HCC and CC, but metastatic small bowel perforation by CC in a patient with combined HCC-CC has not been reported previously. The authors describe the case of a 51-year-old man with a metastatic small bowel perforation caused by an intrahepatic CC in combined HCC-CC with a review of the literature.

Stability of The Medium Chain Triglyceride As The Total Nutrient Admixtures

정상영 ( Sang Young Chung ),최수진나 ( Soo Jin Na Choi ),박현진 ( Hyun Jin Park ),조숙희 ( Sook Hee Cho ),기영순 ( Young Sun Ki ),이정균 ( Jung Kyun Lee ) 한국정맥경장영양학회 2002 한국정맥경장영양학회 학술대회집 Vol.2002 No.-