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Clomiphene Citrate와 FSH 또는 Clomiphene Citrate와 hMG의 연속병합에 의한 배란유도주기에서 인공수정 후 임신율의 비교
정구성,홍기언,유승환,이현숙,이종인,허영문,전은숙,윤정임,홍정의,이지삼,Jung, Goo-Sung,Hong, Ki-Eon,You, Seung-Hwan,Lee, Hyeon-Sook,Lee, Jong-In,Hur, Young-Mun,Jeon, Eun-Suk,Yoon, Jeong-Im,Hong, Jeong-Eui,Lee, Ji-Sam 대한생식의학회 1999 Clinical and Experimental Reproductive Medicine Vol.26 No.3
Objective: To evaluate the effectiveness of CC+FSH or CC+hMG in intrauterine insemination (IUI) cycles for the treatment of infertility. Method: Patients received daily 100 mg of clomiphene citrate (CC) for 5 days followed by hMG or FSH. A single IUI was performed at 36 h after hCG. Clinical pregnancy was classified if a gestational sac or fetal cardiac activity was seen on ultrasound. Results: The overall clinical pregnancy rate was 19.1% per cycle (17/89) and 21.5% per patient (17/79). More clinical pregnancies were recorded in CC+FSH (23.1%, 6/26) than CC+ hMG cycles (17.5%, 11/63), but this difference was not statistically significant. No differences were found in age, duration of infertility, follicle size, levels of estradiol ($E_2$) on the day of hCG injection and total motile sperm counts between pregnant and non-pregnant groups. However, more ampules of gonadotropins were used in pregnant group than non-pregnant group (p<0.05). Conclusion: Combination of CC and hMG may economically be more effective to induce ovulation for IUI compared to CC and FSH.