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이윤정,김언국,김혜윰,윤정주,이소민,이용표,이건목,강대길,이호섭,Lee, Yun Jung,Kim, Eon Kuk,Kim, Hye Yoom,Yoon, Jung Joo,Lee, So Min,Lee, Yong-Pyo,Lee, Geon Mok,Kang, Dae Gill,Lee, Ho Sub 대한한의학방제학회 2013 大韓韓醫學方劑學會誌 Vol.21 No.1
Objectives : Diabetes mellitus is the leading cause for vascular complications such as atherosclerosis. The present study is to investigate whether Doinseunggi-tang (DST) improves diabetic vascular dysfunction in type II diabetes. Methods : The db/db mice were treated with high fat/high cholesterol diet and DST (200 mg/kg/day) for 8 weeks. Results : DST significantly lowered blood glucose and systolic blood pressure. In addition, DST also markedly decreased total plasma cholesterol, triglyceride, and LDL-cholesterol, whereas increased the HDL-cholesterol. Vascular relaxation of aortic rings by acetylcholine or SNP was ameliorated by DST in a dose-dependent manner. Damage of vascular intima and hypertrophic of media was improved by DST. Immunohistological study revealed that DST attenuated the increase of ICAM-1, VCAM-1, and ET-1 expression in thoracic aorta. Conclusions : Taken together, DST suppressed hyperglycemia and diabetic vascular dysfunction in type II db/db mice. The present data suggests that Doinseunggi-tang may be prevent a development of diabetic atherosclerosis.
고지혈증 동물모델에서 홍삼과 천마 혼합투여에 의한 혈관 염증 개선연구
이윤정,김혜윰,윤정주,이소민,고정현,이호섭,최경민,강대길,Lee, Yun-Jung,Kim, Hye-Yoom,Yoon, Jung-Joo,Lee, So-Min,Kho, Joung-Hyun,Lee, Ho-Sub,Choi, Kyung-Min,Kang, Dae-Gill 대한한의학방제학회 2012 大韓韓醫學方劑學會誌 Vol.20 No.1
Objectives : This experimental study was designed to investigate the inhibitory effects of combination with Korean red ginseng and Gastrodia rhizoma on vascular dysfunction in high-fat/cholesterol diet-induced hyperlipidemia. Methods : Sprague-Dawley rats were fed with 7.5% cocoa butter and 1.25% cholesterol for 10 weeks, with Panax ginseng (PG), and mixtures of Panax ginseng and Gastrodia rhizoma (PGM), respectively. Results : Chronic treatment with PG and PGM significantly decreased body weight. The aortic expression of cell adhesion molecules such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin were markedly increased in hyperlipidemia rats. Interestingly, PGM significantly decreased cell adhesion molecules expression. However, there was no significant decrease in PG group. In addition, PG and PGM group inhibited high-fat/cholesterol diet-induced cytokine such as monocyte chemoattractant protein (MCP-1) mRNA expression. Furthermore, PG and PGM group significantly decreased c-reactive protein protein (CRP) level. Especially, PGM significantly accentuated the decrease of MCP-1 mRNA expression and CRP level. Conclusions : the present study provides an evidence that combination with Panax ginseng and Gastrodia rhizoma enhances anti-vascular protective effects through suppression of vascular inflammation in hyperlipidemic rats.
Salmonella typhimurium 에서 무산소 환경 유도유전자들에 대한 조절유전자들의 특성 및 클로닝
이윤정,방일수,이인수,이영록,박용근 ( Yun Joung Lee,Iel Soo Bang,In Soo Lee,Yung Nok Lee,Yong Keun Park ) 한국환경생물학회 1993 환경생물 : 환경생물학회지 Vol.11 No.2
New regulatory loci which participate in the anaerobic environment inducible gene(ani) expression in Salmonella typhimurium were identified. These regulators (oxr) showed negative regulatory effect on the anaerobiosis inducible operon fusions of this organism in aerobic environment (oxr 107 and oxr 108 to ani 2001, oxr 109 to ani 2007). They were identified as the trans-acting regulators, and increased β-galactosidase activity of ani-lacZ fusion strains up to about 10-240 fold in aerobic environment. By using the library of S. typhimurium chromosomal DNA, two negative regulators (oxr 101 and oxr 109) were cloned. The insert fragment of each clone, pPK32 for oxr 101 and pPK33 to oxr 109 were 7.8Kb and 9.3Kb, respectively. The recombinant plasmid pPK32 didn`t complement the mutation effect of oxr 101 on minimal media but rich media, pPK33 complemented the mutation effect of oxr 109 on both minimal and rich media.
이윤정,정인준,우균,Lee, Yun-Jung,Jung, In-Jun,Woo, Gyun 한국정보처리학회 2012 정보처리학회논문지D Vol.19 No.1
Today, Internet users can easily create and share the digital contents with others through various online content sharing services such as YouTube. So, many portal sites are flooded with lots of user created contents (UCC) in various media such as texts and videos. Estimating popularity of UCC is a crucial concern to both users and the site administrators. This paper proposes a method to predict the popularity of Internet articles, a kind of UCC, using the dynamics of the online contents themselves. To analyze the dynamics, we regarded the access counts of Internet posts as the popularity of them and analyzed the variation of the access counts. We derived a model to predict the popularity of a post represented by the time series of access counts, which is based on an exponential function. According to the experimental results, the difference between the actual access counts and the predicted ones is not more than 10 for 20,532 posts, which cover about 90.7% of the test set. 오늘날 인터넷 사용자들은 유튜브(YouTube)와 같은 온라인 콘텐츠 공유 사이트를 통해 손쉽게 자신의 콘텐츠를 만들고 다른 사람들과 공유하고 있다. 그로 인해 하루에도 엄청난 양의 온라인 콘텐츠들이 쏟아지고 있다. 온라인 콘텐츠들의 홍수 속에서 어떤 콘텐츠가 향후에 인기가 있을 것인지를 예측하는 문제는 일반 이용자들이나 콘텐츠 공유 사이트 운영자들 모두가 관심을 가지는 문제이다. 본 논문에서는 인터넷 토론 게시판에 등록된 게시물들의 인기도를 예측하는 방법을 제안한다. 본 논문에서는 인터넷 토론 게시판에 등록된 게시물들의 인기도를 예측하기 위해 게시물의 조회수를 인기 척도로 간주하고 각 게시물의 조회수 변화량을 분석하였다. 게시물의 최종 조회수를 예측하기 위하여 관찰된 조회수 시계열 데이터를 이용하여 지수 함수를 기반으로 하는 조회수 증가 모델을 제안한다. 다음 아고라 게시판의 게시물을 대상으로 한 실험에서 전체 실험 게시물 중 약 90.7%인 20,532개의 게시물이 예측 오차가 10개 이하로 나타났다.
경계 차감 클러스터링에 기반한 클러스터 개수 추정 화자식별
이윤정,최민정,서창우,한헌수,Lee, Youn-Jeong,Choi, Min-Jung,Seo, Chang-Woo,Hahn, Hern-Soo 한국음향학회 2007 韓國音響學會誌 Vol.26 No.5
본 논문에서는 화자식별을 위한 특징벡터의 새로운 클러스터링 방법을 제안한다. 제안된 방법은 클러스터 센터에 대한 초기값 설정과 클러스터 개수에 대한 사전 정보 없이 클러스터링이 가능하다. 각 클러스터 센터는 경계 차감 클러스터링 알고리즘으로 한 번에 한 개의 클러스터 센터가 추가됨으로써 순차적으로 구해지며, 클러스터 개수는 클러스터간의 상호관계를 조사하여 결정된다. 인공 생성 데이터 및 TIMIT 음성을 이용하여 실험한 결과로부터 제안된 방법이 기존의 방법보다 우수함을 확인하였다. In this paper we propose a new clustering algorithm that performs clustering the feature vectors for the speaker identification. Unlike typical clustering approaches, the proposed method performs the clustering without the initial guesses of locations of the cluster centers and a priori information about the number of clusters. Cluster centers are obtained incrementally by adding one cluster center at a time through the boundary subtractive clustering algorithm. The number of clusters is obtained from investigating the mutual relationship between clusters. The experimental results for artificial datum and TIMIT DB show the effectiveness of the proposed algorithm as compared with the conventional methods.
집합주택단지의 옥외공간에 있어서 고령자 이바쇼(居場所)의 특징고찰 - 일본 치바현(千葉縣)의 카시와시(柏市) 토요시키다이(豊四季台)단지를 대상으로 -
이윤정,변경화,유창균,Lee, Yunjeong,Byun, Kyeonghwa,Yoo, Changgeun 한국주거학회 2015 한국주거학회 논문집 Vol.26 No.6
The purpose of this study is to analyze the characteristics of exterior spaces used by the elderly of housing complex. The exterior spaces are used for going out in everyday life with the view point that the elderly have to go out from the inside home in order to prevent isolating the elderly from local community. For that Toyoshikidai housing complex in Kashiwa city of Chiba prefecture, Japan is selected and carried out questionnaire survey and field survey targeting residents. The results are following as. For spatial characteristics, the location installed benches, location occupied in one part by roof, wall, or plants, place connecting to moving flow of the aged, and an open expanse getting safety from vehicle are taken advantages for the elderly. For using benches, the elderly of 70.1% do not have experience using benches installed in all those places. The the biggest reason is that they are not tired. However, 36.8% of the elderly are using benches in order to take a rest and 20.8% of them are using benches in order to talk with the other people. Bench is ibasho of the elderly.
기술위험 거버넌스에서의 역할분담: 영국과 한국의 방사성폐기물 관리 공론화 사례
이윤정,Lee, Yun Jeong 기술경영경제학회 2016 Journal of Technology Innovation Vol.24 No.4
과학기술 전문가가 근거를 제시하고 정책관료가 결정을 내리던 기존의 정책결정체계와는 달리, 불확실성과 이해관계 대립으로 특징지어지는 기술위험 영역에서 참여적 의사결정방법이 바람직한 모델로 상정되어왔다. 이어 여러 가지 정책실험이 이루어졌다. 그러나 의사결정과정에 있어서 '누가 어떤 역할을 할 것인가'에 대해서는 여전히 다양한 견해가 존재한다. 본 연구는 기술위험 거버넌스에 대한 사회적 배경이 다른 두 나라인 영국과 한국에서 각각 수행된 방사성폐기물 관리방안 모색을 위한 공론화 프로그램을 역할분담의 관점에서 분석한다. 본고는 영국과 한국의 공론화 프로그램이 전개되는 과정에서 다양한 참여자 그룹이 어떻게 정의되고, 어떠한 근거로 역할이 상정되며, 적용된 의사결정방법은 무엇인지에 관해 논의한다. 공론화과정의 사례연구를 통해 많은 기술선진 민주주의 사회에서 지지 받고 있는 '참여를 통한 의사결정'이라는 기술위험 거버넌스의 규범이자 방법론이 실제 각기 다른 정치사회 환경에서 어떻게 구현되는 지를 살펴본다. 방사성폐기물 관리와 공론화에 대한 오랜 경험을 가진 영국과의 비교분석은 한국의 방사성폐기물 관리정책과 나아가 기술위험 거버넌스를 위한 정책도구를 정교화 하는 데 기여할 것이다. In order to deal with uncertainty and conflicting interests in technological risk policy-making, various participatory decision-making models have been practiced. This participatory approach is an alterative to the traditional process of science and technology policy-making where scientific experts provide evidence and government officials make decisions. However, there still remain different opinions on who should play what kind of role in decision-making process. Therefore this paper examines the division of labour in the public deliberations for radioactive waste management policy carried out in the UK and Korea. It discusses the ways in which various actors are defined, and the rationales are employed for allocating actors to certain roles and participatory methods. In so doing, this paper unfolds the ways in which the participatory decision-making process for risk governance is delivered in real policy context. Similarities and differences revealed in the division of labour of two cases contribute to development of radioactive waste management policy and the policy instruments for risk governance.
이윤정,Lee Young Ah,Kim Jae Hyun,Chung Hye Rim,Gu Min Jeong,Kim Ji Young,Shin Choong Ho 대한소아내분비학회 2020 Annals of Pediatirc Endocrinology & Metabolism Vol.25 No.4
Purpose: Despite the prevalent use of insulin pump therapy worldwide, few studies have been conducted among young patients with type 1 diabetes (T1D) in Korea. We investigated the durability and effectiveness of insulin pump therapy among Korean pediatric and young adult patients with T1D. Methods: This study included 54 patients with T1D diagnosed at pediatric ages (range, 1.1–14.1 years) who initiated insulin pump therapy during 2016–2019 at Seoul National University Children's Hospital and Seoul National University Bundang Hospital. Clinical and biochemical data, including anthropometric measurements, insulin dose, and glycated hemoglobin (HbA1c) levels were obtained from T1D diagnosis to last follow-up. Results: Forty-four patients (81.5%) continued insulin pump therapy with a median pump use duration of 2.9 years (range, 0.2–3.5 years); 10 discontinued the therapy within 12 months (<1 month, n=6; 1–6 months, n=1; and 6–12 months, n=3) due to physical interferences or financial problems. Older age (≥10 years of age) and longer diabetes duration (≥2 years) at the initiation of pump therapy were associated with discontinuation (P<0.05 for both). For patients continuing pump therapy, HbA1c levels significantly decreased after 1 year of therapy (from 8.9% to 8.1%, P<0.001) without changes in the body mass index z-scores or insulin dose. Although 4 patients experienced diabetic ketoacidosis, all recovered without complications. Conclusion: Insulin pump therapy was effective in improving glycemic control in T1D patients during 12 months of treatment. Early initiation of insulin pump therapy after T1D diagnosis was helpful for continuing therapy.