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      • SCOPUSKCI등재

        파목신 캅셀(아목시실린 500 mg)에 대한 곰실린 캅셀의 생물학적동등성

        이윤영,최미희,이경률,이희주,Lee, Yun-Young,Choi, Mee-Hee,Lee, Kyung-Ryul,Lee, Hee-Joo 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.4

        A bioequivalence study of $Gomcillin^{TM}$ capsules (DAEWOONG Pharmaceutical Co., Korea) to $Famoxin^{TM}$ capsules (Dong Wha Pharm. Ind. Co., Korea) was conducted according to the guideline of Korea Food and Drug Administration (KFDA). Twenty four healthy male Korean volunteers received each medicine at the amoxicillin dose of 500 mg in a $2{\times}2$ crossover study. There was a one-week wash out period between the doses. Plasma concentrations of amoxicillin were monitored by a high-performance liquid chromatography for over a period of 8 hours after the administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 8 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Gomcillin^{TM}/Famoxin^{TM}$ were $log0.91\;{\sim}\;log1.03$ and $;log0.93\;{\sim}\;log1.10$, respectively. These values were within the acceptable bioequivalence intervals of $log0.80\;{\sim}\;log1.25$. Thus, our study demonstrated the bioequivalence of $Gomcillin^{TM}$ and $Famoxin^{TM}$ with respect to the rate and extent of absorption.

      • SCOPUSKCI등재

        박사르<sup>®</sup>정 4 밀리그램(라시디핀 4 mg)에 대한 라니디엠<sup>®</sup>정 4 밀리그램의 생물학적동등성

        이윤영,김혜진,나숙희,조경희,장문선,박영준,이희주,Lee, Yun-Young,Kim, Hye-Jin,La, Sookie,Cho, Kyung-Hee,Jang, Moon-Sun,Park, Young-Joon,Lee, Hee-Joo 한국약제학회 2010 Journal of Pharmaceutical Investigation Vol.40 No.2

        A bioequivalence study of LANIDIEM$^{(R)}$ tablet 4 mg (Samil. Co., Ltd.) to Vaxar$^{(R)}$ tablet 4 mg (GlaxoSmithKline Co., Ltd.) was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). Forty healthy male Korean volunteers were enrolled in the study and thirty six volunteers completed the study according to the protocol. Thirty six volunteers received each medicine at the lacidipine dose of 4 mg in a $2{\times}2$ crossover study. There was one week wash-out period between the doses. Plasma concentrations of lacidipine were monitored by a high performance liquid chromatography - tandem mass spectrometry (LC-MS/MS) for over a period of 24 hours after drug administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 24 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for LANIDIEM$^{(R)}$/Vaxar$^{(R)}$ were log 0.8102~log 1.0417 and log 0.8493~log 1.1439, respectively. These values were within the acceptable bioequivalence intervals of log 0.80~log 1.25. Thus, our study demonstrated the bioequivalence of LANIDIEM$^{(R)}$ tablet 4 mg and Vaxar$^{(R)}$ tablet 4 mg with respect to the rate and extent of absorption.

      • KCI등재

        SSL 프로토콜의 CipherSuite 설정 문제점과 해결 방안

        이윤영,허순행,박상주,신동휘,원동호,김승주,Lee, Yun-Young,Hur, Soon-Haeng,Park, Sang-Joo,Shin, Dong-Hwi,Won, Dong-Ho,Kim, Seung-Joo 한국정보처리학회 2008 정보처리학회논문지 C : 정보통신,정보보안 Vol.15 No.5

        인터넷과 정보통신기술의 사용이 일반화되면서 인터넷 상에서 중요한 데이터를 안전하게 전송해야 함에 따라 SSL 프로토콜의 사용은 필수요소가 되었다. SSL 프로토콜은 메시지 위/변조 공격과 같은 능동적인 공격에 안전하도록 설계가 되었지만 CipherSuite 설정 변경은 별다른 제약 없이 수정이 가능하다. 공격자가 Client의 시스템의 오작동을 유도하여 CipherSuite 설정을 키 길이가 낮은 대칭키 알고리즘으로 변경한다면 도청하여 데이터를 해독할 수 있다. 본 논문은 키 길이가 낮은 대칭키 알고리즘 설정에 대한 국내 웹사이트의 보안세션 생성 조사 및 CipherSuite 설정 문제점에 대한 해결책을 제시한다. As the use of Internet and information communication technology is being generalized, the SSL protocol is essential in Internet because the important data should be transferred securely. While the SSL protocol is designed to defend from active attack such as message forgery and message alteration, the cipher suite setting can be easily modified. If the attacker draw on a malfunction of the client system and modify the cipher suite setting to the symmetric key algorithm which has short key length, he should eavesdrop and cryptanalysis the encrypt data. In this paper, we examine the domestic web site whether they generate the security session through the symmetric key algorithm which has short key length and propose the solution of the cipher suite setting problem.

      • 복합자극으로 유발되는 감성측정 기술에 관한 연구

        이윤영 ( Yun Young Lee ),백은주 ( Eun Joo Baik ),김한수 ( Han Soo Kim ),문창현 ( Chang Hyun Moon ),서형제 ( Hyeong Je Seo ),김영경 ( Young Kyung Kim ) 한국감성과학회 1999 추계학술대회 Vol.1999 No.-

        최근들어 제품개발에 앞서 제품으로 인해 유발되는 감성을 측정하기 위한 시도가 늘고 있다. 그러나 제품을 사용하면서 나타나는 행동의 변화는 많은 영향 요소를 포함하고 있어 이를 해석하기가 어렵다. 본 연구는 안정을 유도하는 Herb차를 개발하거나 치약과 같이 사용으로 인한 감성유발 효과를 보고싶어하는 요구에 따라 시행하였다. 우선 실험전 피검자의 불안 척도, 기본 check list에 따라 피검자를 선택하였다. 또한 객관적 감성 지표로는 Fz, FpI, Cz, Oz에서 뇌파를 측정하였고 EOG를 시행하여 noise를 제거하였다. 자율신경계 반응으로 galvanic skin resistance(GSR), 피부온도, 심박수등을 동시에 측정하였다. 이들 제품 사용으로 인한 객관적 감성 변화의 대조군으로는 행동 시행전에 측정하였다. 제품 사용 후 10분 간격으로 30-60분까지 나타나는 변화를 측정하였으며, 이들 제품들은안정 효과를 유도하고자 기획되었으므로 대조군으로 00 X 0의 복잡한 계산문제를 주어 stress로 인한 감성, 걷는 동작, 손 씻는 행위등을 나누어 측정하였다. 본 연구의 결과에 의하면, 제품 사용으로 인한 감성의 변화는 GSR에서 가장 잘 반영되었고 또한 계산 문제로 인한 자극에서도 역시 GSR의 변화가 가장 뚜렷하였다. Herb차인 경우 기호도에 따른 차이가 나타났음을 알 수 있었다.

      • KCI등재

        영어신문 활용 수업에 대한 영어교사와 학습자의 인식 및 학습자의 읽기능력에 미치는 효과 연구

        이윤영 ( Yun Young Lee ),정양수 ( Yang Soo Jung ) 충남대학교 인문과학연구소 2013 인문학연구 Vol.44 No.2

        본 연구의 목적은 영어신문을 활용하여 학습자에게 읽기전략을 훈련시 켰을 경우, 학습자의 읽기능력과 태도에 어떤 영향을 미치는지를 살펴보는데 있으며, 또한 영어신문을 활용하는 영어수업에 대해 영어 교사들은 어떻게 인식하고 있는지를 알아보는데 있다. 본 연구를 위해 상위반 48명, 하위반 48명으로 나누어 영어신문을 활용하여 읽기전략을 훈련시켰으며, 27명의 영어교사가 설문조사에 참여하였다. 연구 결과에 의하면, 상위반 학습자들은 읽기능력과 흥미 및 태도에서 하위반 학습다들에 비해서 긍정적인 효과를 보여주었다. 그리고 영어신문을 활용한 영어수업의 효과에 대한 평가와 관련하여, 상위반 학습자들은 수업 참여에 적극적이었으며 또한 수업의 효과에 대해서도 긍정적으로 평가하였다. 또한 설문조사에 참여한 영어교사의 50%이상이 영자신문을 활용한 교육은 읽기수업에 적용하는데 적합하다고 답변하였다. 영어교사들은 ENIE가 학습자측면애서 영어문법과 어휘능력 향상, 문화에 대한 이해, 학습자의 흥미와 참여유발과 같은 부분에 효과적이라고 평가하였다. 그러나 ENIE에 필요한 자료준비 시간 부족, 교과수업 진도에 부담을 ENIE활용의 어려운 이유로 지적하였다. The purposes of this study are to examine how the reading strategies training using English newspaper influence on learners′ reading ability and their attitude toward English class, and to explore how English teachers perceive English class using English newspaper. For this study, 27 English teachers were participated in the questionnaire, and 96 vocational high school students were divided into two groups according to their reading proficiency level; the lower group and upper group. Before and after the experiment, reading comprehension test was conducted. And the questionnaires examining students'interest and attitude toward adopting ENIE in English class were administered after the experiment. As results of this study, followings were found. First, above 50% of English teachers answered that ENIE is a good way for teaching English reading, and above 60% of them answered they are willing to use ENIE in thee reading classes. English teachers also evaluated that using ENIE is an effective way to improve student' grammar and vocabulary ability, understanding of culture, and creating interest and motivation. But teachers say they are reluctant to apply ENIE due to lack of time preparing materials and burdens of teaching schedule. Second, by using ENIE in English class, students' English reading ability of the upper group learners was significantly improved. However, significant improvement of the lower group learners was significantly improved. However, significant improvement of the lower group learner` reading ability were not found. Third, the use of ENIE positively influenced on students' interest and motication for the upper group as well as lower group. In conclusion, the effect of using English newspapers in a reading class differs according to the different levels of learner proficiency. Different types of activities using English newspapers, therefore, should be developed appropriately for the both upper and lower level learners. Also, English teachers should be aware of the importance of ENIE and try to develop well-designed lesson plans the make the English class using ENIE successful.

      • KCI등재후보
      • KCI등재

        로타바이러스 백신 접종 유무 및 백신종류에 따른 창자겹침증 발병 연령의 비교: 단일기관 연구

        이윤영 ( Yun Young Lee ),이응빈 ( Eung Bin Lee ),최광해 ( Kwang Hae Choi ) 영남대학교 의과대학 2015 Yeungnam University Journal of Medicine Vol.32 No.2

        Background: Rotavirus is the most common cause of severe gastroenteritis in children <5 years of age. The first vaccine, RotaShield was developed, but withdrawn because of its association with increased risk of intussusception. Then, RotaTeq and Rotarix were developed. Although in pre-licensure studies, they were not associated with an increased risk of intussusceptions, in recent studies, it has been controversial. Regarding increased risk of intussusception, we studied the difference in the age of intussusception after rotavirus vaccination. Methods: A retrospective analysis was conducted on 136 patients diagnosed with intussusception at Yeungnam University Medical Center for 4 years in the pre-vaccination period (group A) and in the post vaccination period (group B). Sex, mean age and age distribution of intussusceptions were compared according to the type of rotavirus vaccine (group B-1, RotaTeq, group B-2, Rotarix). Results: The median ages of group A and group B were 18.8±19.6 months and 15.5±10.2 months, with no significant differences (p=0.23). The median ages of group B-1 and group B-2 were 15.3±9.3 months and 15.6±10.8 months, with no significant differences (p=0.91). And No significant difference in the distribution of onset age was observed between groups, and only 6 patients were diagnosed with intussusceptions within 1 month after vaccination. Conclusion: No difference was observed in the distribution of onset age of intussusception after rotavirus vaccination and according to the type of rotavirus vaccine. Our study has a limitation in that it was conducted in part of the Daegu area. Additional study is needed.

      • KCI등재

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