http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
랫트에 있어서 페노바르비탈 전처리가 딜티아젬의 생체내 동태에 미치는 영향
이용복,고익배,이민화,Lee, Yong-Bok,Koh, Ik-Bae,Lee, Min-Hwa 한국약제학회 1992 Journal of Pharmaceutical Investigation Vol.22 No.3
The influence of phenobarbital (PB) pretreatment (75 mg/kg/day, i.p. for 4 days) on the pharmacokinetics of diltiazem (DTZ) and its metabolite, desacetyldiltiazem (DAD), was investigated in rats. DTZ was injected via femoral (3 mg/kg) or portal (10 mg/kg) vein to the control and PB-pretreated rats. DAD was also injected separately via femoral (3 mg/kg) vein to both groups of rats. The intrinsic hepatic plasma clearance of DTZ was found to be significantly increased (6.8-fold) by the PB pretreatment. However, the fraction of an intravenous DTZ dose converted to DAD $(F_mi)$ was only slightly (6%) increased and calculated metabolic rate constant of DTZ to DAD was not affected by the pretreatment. On the other hand, plasma free fraction of DTZ was increased (1.8-fold) from $4.24{\pm}0.25%$ to $7.45{\pm}0.54%$ by the pretreatment. However, the l.8-fold increase in the free fraction of DTZ would not explain the 6.8-fold increase in the hepatic intrinsic clearance of DTZ. Therefore, the increase in either the hepatic blood flow or the metabolism other than to DAD was expected as the probable mechanism(s) of the increased hepatic clearance of DTZ. Sequential metabolism of DAD to further metabolites, however, would be a more potential cause of the apparently unchanged metabolism of DTZ to DAD by the PB-pretreatment.
나프록센의 비선형 체내동태에 미치는 페노바르비탈의 영향
이용복,채명애,고익배 ( Yong Bok Lee,Myung Ae Chae,Ik Bae Koh ) 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.2
N/A In order to elucidate the effect of phenobarbital (PB) on the nonlinear pharmacokinetic behavior of naproxen (NAP), we compared the dose dependent hepatic intrinsic clearance, biliary excretion and protein binding of NAP in control rats to those in the PB-pretreated rats which were intraperitoneally pretreated with PB sodium (75 ㎎/㎏) once a day for four days. NAP was injected via femoral (1.5 ㎎/㎏) and portal(0.25, 0.5, 1.5, 15 and 30 ㎎/㎏) vein to the control and PB-pretreated rats, respectively. And also. we measured the plasma free fraction of NAP with the equilibrium dialysis method and the biliary excreted total amounts of NAP in both rats. Plasma free fraction of NAP was decreased in lower concentration than 150 ㎍/㎖ of NAP due to PB pretreatment. In higher concentration, however, plasma free fraction was increased. These in vitro results suggest that the total protein concentration was increased but the total binding capacity of NAP to protein was decreased by PB-pretreatment. The total plasma clearance and the hepatic intrinsic clearance of NAP had similar values in both groups, respectively. And, both clearances of NAP were significantly increased by PB-pretreatment. Even though the plasma free fractions of NAP in both groups were constantly remained within the concentration range according to the increase of administration dose, the hepatic intrinsic clearances of NAP were significantly increased in both groups with the increased dose. And, the biliary excreted total amounts of NAP were significantly increased by PB-pretreatment at the lower dose, but decreased at the higher dose. These in vivo results suggest that NAP represents the uncommon nonlinear pharmacokinetic behavior that the hepatic intrinsic clearance was enhanced with the increased dose, and that PB enhances further the hepatic intrinsic clearance of NAP with the increased dose due to its enzyme induction effect.
SM45C용접부에서 회전굽힘시험에 의한 피로 및 파단면의 특성
이용복,Lee, Yong-Bok 한국생산제조학회 2010 한국생산제조학회지 Vol.25 No.3
SM45C steel rods using generally for machine components were selected and welded by butt-GMA welding method for this study. And then they were studied about characteristics of fatigue behavior and fracture surfaces by rotary bending test. Fatigue strength in weld zone present highly in order of the boundary between deposited metal zone and heat affected zone, deposited metal zone, heat affected zone. The region of infinite life by Haigh diagram present highly in order of the boundary between deposited metal zone and heat affected zone, deposited metal zone, heat affected zone. Fatigue cracks in unnotched specimens of base metal and weld zone introduce simultaneously from extensive out-side of circumferential cross-section and propagate to the other side indicating beach markings and dimples according to consolidation of fatigue cracks. Fatigue cracks in all of notched specimens introduce simultaneously in out-side of circumferential cross-section by high stresses and propagate to center of it indicating beach markings.
이용복,김태윤,정진성,최지훈,Lee, Yong-Bok,Kim, Tae-Yun,Jeong, Jin-Seong,Choe, Ji-Hun 대한기계학회 2000 大韓機械學會論文集A Vol.24 No.3
Mechanical press joining has been used in sheet metal joining processes because of its simple process and possibility of joining dissimilar metals, such as steel and aluminum. The strength of mechanical press joining varies with joining conditions. The optimum joining conditions considering tensile-shear and peel-tension strength have to be established to assure the reliability in the joining strength. Therefore, optimization of joining conditions has been investigated for improving joining strength of sheet metal. It is possible to obtain optimum strength from improvement on the joining strength of peel-tension mechanical press joint under multiaxial stress states.
유제화에 의한 경구용 항암제인 테가푸르의 장관 임파수송
이용복,남권호,장우익,오인준,고익배,Lee, Yong-Bok,Nam, Kweon-Ho,Chang, Woo-Ik,Oh, In-Joon,Koh, Ik-Bae 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.1
W/O and O/W emulsions of tegafur (50 mg/5 ml/kg) were orally administered to rats to compare with their mesenteric lymphatic delivery effects. And also in order to demonstrate the lymph targeting associated to the oral route, it was deemed necessary to investigate the fate of solution after oral administration as a control. Lymph and plasma samples were periodically taken from each subject of mesenteric lymphatic duct cannulated rats. Then, lymph and plasma levels of tegafur and its active metabolite, 5-FU, were simultaneously observed. Also pharmacokinetic parameters were compared with each others. On the other hand, most previous studies of lymphatic transport have not addressed the question of whether an increase in mesenteric or thoracic lymph transport by the manipulation of a suspected variable was due to a selective delivery to the intestinal lymphatics or an overall increase availability. Therefore, based on a physiologically based pharmacokinetic model which represents the characteristics of lymphatic systems, we are also going to determine the contributions of mesenteric lymph transport versus thoracic lymph transport of tegafur reported in reference(13). In comparison with tegafur solution, AUC and mean residence time of plasma tegafur were significantly increased in W/O emulsion but significantly decreased in O/W emulsion. Lymph flow rates were similar in both solution and W/O emulsion but half in O/W emulsion. AUC of tegafur in mesenteric lymph and in plasma for W/O emulsion were 3.7 times and 2.9 times more than those for O/W emulsion, respectively. And AUC of 5-FU in thoracic lymph for W/O emulsion was 3.7 times more than that for O/W emulsion. These results suggested that lymphatic delivery or tegafur by W/O emulsion was more effective than that by on emulsion due to its differences or formation ability of chylomicrons.