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당귀 추출물 정맥 주사가 Middle Cerebral Artery Occlusion 모델 흰쥐에서 Gliosis 억제에 미치는 영향
송봉근,전용철,김선애,심안나,성기문,이언정,Song, Bong-Keun,Jeon, Yong-Cheol,Kim, Sun-Ae,Shim, An-Na,Seong, Kee-Moon,Lee, Eon-Jeon 대한약침학회 2011 Journal of pharmacopuncture Vol.14 No.3
Objectives : Gliosis becomes physical and mechanical barrier to axonal regeneration. Reactive gliosis induced by middle cerebral artery occlusion is involved with up-regulation of CD81 and GFAP (Glial fibrillary acidic protein). The current study is to examine the effect of the Angelica gigas Nakai(intravenous injection. 100 mg/kg twice in a day) on CD81 and GFAP of the rat in the brain after middle cerebral artery occlusion. Methods : Cerebral infarction was induced by middle cerebral artery occlusion. And after intravenous injection of water extract of Angelica gigas Nakai, the size of cerebral infarction was measured. Examination of optical microscope were also used to detect the expression of CD81 and GFAP in the brain of the rat. Results : The following results were obtained : We found that size of cerebral infarcion induced by MCAO (Middle Cerebral Artery Occlusion) in rats were decreased after intravenous injection of Angelica gigas Nakai. We injected the extract of Angelica gigas Nakai to the MCAO in rats, and the optical microscope study showed that Angelica gigas Nakai had effect on protecting the cells of hippocampus. We found that GFAP, CD81 and ERK of the brain in rats with cerebral infarction after MCAO were meaningfully decreased after intravenous injecting Angelica gigas Nakai. We found that c-Fos expression of the brain in rats with cerebral infarction after MCAO were significantly increased after intravenous injecting Angelica gigas Nakai. Conclusions : These results indicate that Angelica gigas Nakai could suppress the reactive gliosis, which disturbs the astrocyte regeneration in the brain of the rat with cerebral infarction after MCAO by controlling the expression of CD81 and GFAP. And the effect may be modulated by the up-regulation of c-Fos and ERK.
이언정,김형균,신선호,김동웅,신학수,양재훈,최진영,한명아,한상칠,최우정 대한동의생리학회,대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.6
Aconitum carmichaeli Debx(附子) is one of widely used herbal. But, sometimes toxicosis such as general and local paralysis, falling of blood pressure, vertigo, cramp, nausea, vomitting, difficulty of breathing is arised from carelessness in use. This paper is about one patient of acute cardiac shock caused by Acontitum carmichaeli Debx poisoning who admitted to Department of Internal Medicine, Wonkwang University Oriental Medicine Hospital in Jeonju. We treated by means of oriental medicine, such as Gamdutanggamibang(甘豆湯加味方), Saengmaegsangamibang(生脈散加味方), Sophorae Radix (苦蔘), sufficient fluid theraphy, Dopamine injection and O_2 supply. We hope that this case report could help to wide the territory of oriental medicine and more systemic effort could be bone for treatment of acute cardiac Shock caused by Aconitum carmichaeli Debx poisoning.
左歸飮과 六味地黃湯 煎湯液 투여가 家兎腎機能 및 혈장Aldosterone농도에 미치는 영향
최우정,이언정,김형균,이광석,이대용,정대영 대한동의생리학회,대한동의병리학회 2002 동의생리병리학회지 Vol.16 No.6
To evaluate the effect of Choakwiyeum(CKY) and Yukmijihwang-tang(YJT) water extract on the renal function and the levels of plasma aldosterone, this experiment was performed in the rabbbits. These result indicate that increase in urine volume(UV) after administration of CKY and YJT water extract is related to increase in glomerular filtration rate(GFR), free water clearance(FWC) and renal plasma flow(RPF) and also to decrease in plasma aldosterone concentration(PAC), which seems to be affected by renin-angiotensin-aldosterone system, and that reduced blood pressure seems to be caused by reduced peripheral resistance.