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증예(症例) : 대량의 무통성 복수로 발현된 전신성 홍반성 루푸스 1예
이신은 ( Shin Eun Lee ),선인오 ( In O Sun ),최진화 ( Jin Hwa Choi ),이영재 ( Young Jai Lee ),최혜은 ( Hye Eun Choi ),박승민 ( Seung Min Park ),이용웅 ( Yong Ung Lee ),황민호 ( Min Ho Hwang ) 전북대학교 의과학연구소 2005 全北醫大論文集 Vol.29 No.2
저자들은 대량의 무통성 복수를 주 증상으로 내원한 젊은 여자환자에서 다른 기저 질환없이 대량의 복수로 발현된 전신성 홍반성 루푸스를 진단할 수 있었고, Prednisolone 투여로 복수가 조절되고 증세 호전 보인 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Systemic lupus erythematosus (SLE) can affect virtually any organ system. So, clinical manifestation and initial presenting manifestation is variable. But ascites is uncommon in SLE initially. Ascites occurs clinically in 8-11% of patients with SLE, usually associated with nephritic syndrome, protein-losing enteropathy, congestive heart failure, liver cirrhosis, Budd-Chiari syndrome, tuberculosis peritonitis. Lupus peritonitis alone does not cause significant ascites. We describe a patient in whom massive, painless ascites was the initial presenting and major manifestation in SLE.
교통안전법 개정에 따른 서울시 교통사고원인조사 체계정립에 관한 연구
이신해 ( Shin Hae Lee ),김원호 ( Won Ho Kim ),김승준 ( Seung Jun Kim ),박지훈 ( Ji Hun Park ) 서울시정개발연구원 2008 연구보고서 Vol.2008 No.51
The Traffic Safety Act was legislated in 1979, motivated by I-li station explosion which occurred in 1977, and wholly revised to make up for the week points in the government`s traffic safety system in December 28, 2006. The objective of the revision is to make improvements and general reorganization, because the Traffic Safety Act does not function properly so that Korea lags behind badly in the field of traffic safety. As the revised Traffic Safety Act obligates an administrative district (city or state government) to make every effort to improve traffic safety conditions, Seoul Metropolitan Government also enters upon a new phase in the traffic safety. Especially, Seoul City regarding traffic safety surroundings is quite different from other cities, it needs to re-interpret the intent of the Act and find the better way to achieve the goal. Investigated Traffic Safety Act revision and Seoul traffic safety work, and focused on the need of additional inquiry about Traffic Accident Cause Investigation and progressed study. A Traffic Accident Cause Investigation, regulated by the Act, is a necessary step to determine the cause of accidents so corrective actions can be taken to prevent recurrence. However, the current standards on doing an accident investigation are not enough to identify the cause. Therefore, this study is to provide three suggestions which are related to the standard or organization in the traffic accident investigation. The first is to extend the standard of Traffic Accident Cause Investigation. According to the current law, only the roads having 3 dead accidents at least are considered as the investigation site. However, the roads having more than 3 dead accidents are rarely found in Seoul. Therefore, the current standard on selecting the roads, where an investigation should be carried out, should be changed to the one that have more than 1 pedestrian dead accident or have more than 3 serious accidents. Additionally, in the case of urban highway, the spot having more than 1 dead accident is considered as an investigation site. The second is to extend the range of Traffic Accident Cause Investigation. The current law, which standardizes the range of Traffic Accident Cause Investigation as 50m, does not reflect the actual road features of Seoul. Since Seoul has various-sized roads, the range of investigation should be flexible according to the size of roads. As vehicle approaching speed and crosswalk distance depend on the number of lanes in general, the investigation range around intersections should be extended over 50m between intersection and crosswalk according to the minimum standard. In case of the urban highway, one kilometer can be used as an investigation range, because it has high operating speed and its influence zone is longer than an arterial when accidents occur. The third suggestion is to establish and operate a Traffic Accident Cause Investigation Analysis Division. This new division might help an effective performance of Traffic Accident Cause Investigation under the supervision of Seoul Metropolitan City or related research institute. It will include an Investigation Team and an Analysis Team, which will produce an outline map of accident point/a summary of accident, accident-type map/structure analysis table/accident chart, field study, reporting, improvement plan, presuming improvement plan result, and monitoring.
Shin-Hae Lee(이신해),Mi-Sun Hwang(황미선),Yoon-Jeong Choi(최윤정),Young-Shin Kim(김영신),Miae Yu(유미애) 한국생명과학회 2012 생명과학회지 Vol.22 No.12
Matrix metalloproteinase (MMP)는 세포외골격의 주요 조절효소로, 배아발생, 혈관생성, 상처치료 및 조직 재생과정에 중요한 인자로 알려져 있다. MMP의 조절 이상은 비정상적 세포외골격 분해로 인해 암 전이와 같은 질병을 일으킨다. 따라서, MMP의 발현과 활성은 엄격하게 조절되고 있다. 최근, 초파리 Mmp1이 소화기관에서 강하게 발현되며, 장줄기세포의 비정상적인 활성을 억제하여 장의 항상성 유지에 중요함을 밝혔다. 하지만, 장조직에서 Mmp1의 발현 조절 기전은 아직 밝혀지지 않았다. 본 연구에서는, 장조직에서 Mmp1의 발현이 장 발생과 항상성 유지에 중요한 Caudal homeobox 유전자에 의해 조절되는지를 연구하였다. GAL4/UAS 조절계를 이용하여 장조직 특이적으로 Caudal의 발현을 감소시켰을 때, Mmp1의 발현이 감소함을 확인하였으며, Caudal을 과발현 시켰을 때, Mmp1의 발현이 증가함을 in vitro와 in vivo 실험 모두에서 확인하였다. 또한, Mmp1 promoter에 Caudal 전사인자 결합 부위가 존재하며, 이 부위가 Mmp1 발현에 중요한 역할을 함을 확인하였다. 이상의 본 연구는, 정상적 혹은 암화 과정에서 Mmp1이 Caudal의 표적 유전자일 수 있음을 의미한다. The matrix metalloproteinase (MMP) family plays essential roles in physiological processes such as embryonic development, angiogenesis, wound healing, and tissue omeostasis as a consequence of MMPr capacity for breaking down many types of extracellular matrix proteins. Imbalanced regulation of MMP expression can also lead to pathological conditions such as tumor progression. We recently reported that the Drosophila Mmp1 gene is highly expressed in the digestive tract and is required for the maintenance of intestinal homeostasis such as by restriction of uncontrolled intestinal stem cell proliferation. However, the regulatory mechanisms of MMP gene expression in the intestine remain unclear. In this study, we determined that the expression of Mmp1 is regulated by the homeodomain transcription factor Caudal. Experiments using the targeted expression of Caudal under the regulation of Gal4-UAS system indicated that endogenous Caudal is required for the Mmp1 gene expression in the adult Drosophila intestine and that exogenous Caudal induces Mmp1 expression. Transient transfection experiments indicated that Caudal can activate the promoter activity of Mmp1 and that several putative Caudal binding sites in the 5´-flanking region of the Mmp1 gene may be critical to the upregulation by Caudal. Our data suggest that Mmp1 is one of the target genes of Caudal in physiological normal condition and in tumorigenesis.
고령 혈액투석 환자에서 바이오임피던스법으로 측정한 체수분량 상태
이신아 ( Shin A Lee ),안혜림 ( Hye Rim An ),류정화 ( Jung Hwa Ryu ),유민아 ( Min A Yu ),류동열 ( Dong Ryeol Ryu ),김승정 ( Seung Jung Kim ),강덕희 ( Duk Hee Kang ),최규복 ( Kyu Bok Choi ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.6
Purpose: This study was aimed to compare hydration status between young and elderly end-stage renal disease (ESRD) patients on hemodialysis (HD) and to analyze factors related to overhydration. Methods: We measured fluid status before a mid-week HD session in clinically stable 47 patients on maintenance HD using bioimpedance spectroscopy (BIS) device. In addition, weight and blood pressure (BP) were recorded during the treatment. Results: Participants were divided into young (<65 years, n=32) and elderly (65 years, n=15) patients.≥In elderly patients, pre-HD diastolic BP, intracellular water (ICW), and lean tissue index (LTI) were significantly lower and extracellular water (ECW)/total body water (TBW) was significantly higher than in young patients. However, there were no differences in pre-HD body mass index (BMI), ultrafiltration volume, pre-HD systolic BP, TBW, ECW, and fat tissue index between the two groups. ECW/TBW ratio and LTI were significantly correlated with age. In a multivariate regression analysis, age and pre-HD pulse pressure were significantly associated with ECW/TBW. Conclusion: Although BMI and TBW of elderly ESRD patients were similar to those of young patients, ICW and LTI were lower and ECW/TBW was higher in elderly patients than in young patients. Therefore, clinical manifestations related to overhydration may develop more frequently in elderly patients compared with young patients.