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박승하 ( Seung Ha Park ),이승세 ( Seung Sei Lee ) 대한내과학회 2002 대한내과학회지 Vol.63 No.6
목적: VEGF는 혈관신생의 중요한 조절인자이다. 다양한 악성 종양에서 혈청 VEGF 농도가 증가되어 있음이 기존의 많은 연구에서 보고되었으나 임상적인 예후와의 연관성에 대한 연구는 부족하였다. 본 연구는 폐암환자에서 혈청 VEGF 농도가 생물학적 예후인자로 이용될 수 있는지를 규명하고자 하였다. 방법: 조직학적으로 폐암을 진단 받은 환자 86명을 대상으로 ELI SA kit를 이용하여 혈청 VEGF 농도를 측정하였다. 대상 환자의 혈청 VEGF 농도의 Background: Vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis and vascular permeability. Increased serum VEGF concentrations (sVEGF) have been reported in various types of human cancer. In the current study, we assessed s
위장관 ( 胃腸管 ) : 원발성 위악성 임파종의 임상적 관찰
이상종(Sang Jong Lee),박영철(Young Chul Park),이승세(Seung Sei Lee),정을순(Eul Soon Jung),권순호(Soon Ho Kwon),이화영(Hwa Young Lee) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.3
N/A Primary gastric lymphoma represents 1 to 6% of all gastric cancer and anatomically is the most common type of extranodal lymphoma. We present the clinicopathologic findings in 9 patients with primary gastric lymphoma between Jaunary 1984 and March 1990 in the this hospital. 1) The mean age of patients was 46.0 years with a male to female ratio 3.5:l. 2) The most common initial symptom was epigastric pain among these patients. 3) Fiberoptic gastroscopy was performed in 9 patients, who revealed ulceroinfiltrative lesion in 4 cases, ulcerative lesion in 3 cases, infiltrative lesion in 2 cases, respectively. Pathologic findings of biopsy specimens elicited gastric lymphoma in 8 cases and adenocarcinom in 1 case respectively. 4) All were non-Hodgkins lymphoma, and histologic classification by the Rappaport system was possible in all cases including 4 cases of diffuse histiocytic type, 3 cases of diffuse mixed histiocytic and lymphocytic, 2 cases of diffuse lymphocytic poorly differeatiated type respectively. 5) According to modified TMN staging system, 3 cases were stage I, 2 cases stage II, 2 cases stage III and 2 cases unknown in our series. 6) Surgical resection was done on 7 patients, of whom 5 patients received chemotherapy and 2 patients both combined chemotherapy and radiotheyapy. The 2-years survival rate of our seriea was 55.6%.
원발성 간암과 췌장암에 있어서의 αFP , TATI 및 CA 19 - 9 의 임상적 의의
이상종(Sang Jong Lee),이만호(Man Ho Lee),이승세(Seung Sei Lee),서영주(Young Joo Suh),채종찬(Jong Chan Chae),정을순(Eul Soon Jung) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.3
N/A The aim of this study was to evaluate the usefulness of measuring more than two tumor markers including TATI in the diagnosis of pancreatic cancer and hepatoma. Pancreatic cancer patients (10); The range of serum CA 19-9 concentration was 55.01-231 U/ml. All of 10 (100%) had increased value (>33U/ml). Nine of 10 patients (90%) had CA 19-9 values above the cancer diagnostic cut off level (>100U/ml). Serum TATI concentration were raised (range 26.47-450 pg/,L ) in 80% (8/10) of the patients. Serum TATI concentration was above cut off level (40pg/I ) in 5 patients (50%). One patient, who had non diagnostic CA19-9 level (42.9 U/ml), had 413.47 pg/Lof serum TATI concentration. Thus when the two tumor markers (CA19-9, TATI) were used together, all of 10 pancreatic cancer patients (100%) had diagnostic cut off level. Primary hepatoma patients (22); Serum aFP value were raised in 86.36% (19/22) of the patients (range 14.26-2014 pg/ml). Six patients had value of non diagnostic range (14.26-237 pg/ml), so that 59. 09% (13/22) of the patients had a diagnostic aFP value (>400pg/ml). Serum TATI values were raised in 77.2% (17/22) of the patients. 59% (13/22) of the patients had serum TATI value above the cut off level. Of the 6 patients who had non diagnostic a FP level, three patients had serum TATI value above cut off level. When serum n FP and TATI were measured together, 81.8% (18/22) of the patients had at least one of the value above cut off level. So if the two tumor markers were used together (CA19-9 and TATI in pancreatic cancer, aFP and TATI in primary hepatoma) it might be helpful in some patients in the diagnosis of malignancy. But accounting economical and other factors, we think it needs further evaluation.
독성 간염이 동반된 Stevens - Johnson Syndrome 2예
이상종(Sang Jong Lee),박영철(Young Chul Park),김명숙(Myung Sook Kim),이승세(Seung Sei Lee),강진호(Jin Ho Kang),서영주(Young Joo Suh),이만호(nan Ho Lee),김계정(Kea Jeung Kim) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
Stevens-Johnson syndrome is a multisystemic inflammatory disorder associated with wide spread erythematous eruption that can result in deaths. Sulfonamides are one of the most common agent that produces drug eruptions including Stevens- Johnson Syndrome, However, we had also experienced two cases of Stevens-Johnson syndrome associated with ampicillin and aspirine, and penicilline. Moreover, these drugs caused drug induced hepatitis as well as Stevens-Johnson syndrome in these patients. This was unusual and had not been well documented. We treated them with large doses of steroid, and their mucocutanceous lesions and liver function test were improved.
급성 (急性) 바이러스성 간염에서 (肝炎) 혈청 (血淸 ) HBsAg / IgM 결합체의 (結合體) 임상적 (臨床的) 의의
정을순(Eul Soon Chung),이상종(Sang Jong Lee),이만호(Man Ho Lee),정인교(In Kyo Chung),김병호(Byoung Ho Kim),전우규(Woo Kyu Jeon),이승세(Seung Sei Lee) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1
N/A Circulating immune complexes are frequently found in the blood of patients with acute or chronic hepatitis type B. Recently, Palla and coworkers reported the apparent presence of HBsAg/IgMspecific anti-HBs complexes in acute and chronic hepatitis B and indicated that the presence of these immune complexes may function as prognostic indicators of chronic evolution. Therefore, we observed for the detection of HBsAg/IgM complexes and studied the significance of their presence in acute and chronic type B hepatitis. A total of 155 HBsAg-positive patients were carried out for this study from Mar, 1980 to Feb. 1986 in this hospital. They were included as 28 patients with asymptomatic hepatitis B carriers, 77 patients with acute hepatitis B, and 50 patients with chronic hepatitis B, respectively. The following results in this study were obtained: 1) Circulating HBsAg/IgM complexes were found in 15 out of 28 (54%) asymptomatic hepatitis B carriers, in 26 out of 77 (34%) acute hepatitis B patients, and in 26 out of 50 (52%) chronic hepatitis B patients, respectively. 2) Circulating HBsAg/IgM Complexes in patients with acute B hepatitis were either absent from the initial hospital day or disappeared from four weeks hospitalization, and recovered clinically within two months. 3) The acute hepatitis B patients, being detectable circulating HBsAg/IgM complexes, had persistent elevation of serum alanine transaminase at least six months period. It is suggested that circulating HBsAg/IgM complexes seem to be of important prognostic and diagnostic value in acute and chronic hepatitis B.
진행성 병기의 소세포폐암에 대한 Etoposide , Cisplatin 복합화학요법치료의 효과
서정열(Jung Yul Suh),정현식(Hyun Sik Jeong),이승세(Seung Sei Lee) 대한내과학회 2001 대한내과학회지 Vol.61 No.6
N/A Background : Small cell lung cancer (SCLC) disseminates early and has poor prognosis. However, SCLC is highly chemosensitive, thus chemotherapy has been established as the primary mode of treatment. This study evaluated the efficacy and toxicity of etoposide in combination with cisplatin in the treatment of extensive stage small cell lung cancer. Methods : Thirty four patients (28 males, 6 females) with previously untreated extensive stage small cell lung cancer were treated with etoposide at a dose of 100 mg/m2, IV on days 1-3 with cisplatin at 100 mg/m2, IV on day 1. The median age was 63 (range 41∼80). This combination chemotherapy was administered every 3-4 weeks. Response rate, response duration, survival, and toxicity were evaluated.Results : The response rate was 50%. The median survival time was 29 weeks. The median response duration was 17.2 weeks in responders. The toxicity was acceptable. Conclusion : This study illustrated that the combination of etoposide and cisplatin is effective in the treatment of extensive stage small cell lung cancer, and can be administered with acceptable toxicity. Although this study was not designed to be a formal comparative trial, the efficacy and toxicity observed with this regimen were found to be comparable to previous reports.(Korean J Med 61:590-596, 2001)
폐암 환자에서 혈청 Intercellular Adhesion Molecule-1 농도의 변화와 예후와의 관계
신헌섭 ( Hun Sub Shin ),정찬희 ( Chan Hee Jung ),박현덕 ( Hyun Duk Park ),이승세 ( Seung Sei Lee ) 대한내과학회 2003 대한내과학회지 Vol.64 No.4
목적 : 유착분자는 세포간에 서로 상호작용에 관여하고 있고, 염증작용에서도 중요한 역할을 하고 있다. 더욱이 종양세포와 주위세포 혹은 세포외의 기저물질(extra-cellular matrix)과의 유착상호작용은 종양의 성장에 중요한 역할을 하는 것으로 알려져 있다. 이러한 유착분자 중 하나인 ICAM-1은 대장암, 방광암, 폐암, 흑색종, 췌장암, 간암 등에서 증가되는 것으로 보고 되어 있다. 본 연구는 폐암환자에서 혈청 sICAM-1을 측정하여 조직학 Background : Adhesion molecule is related to cell-cell interaction and inflammatory interaction. In addition, adhesive interactions between tumor cells and adjacent cells and/or extracellular matrix are important role in the complex process of tumor growt