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이수곤 ( Soo Gon Lee ),전복현 ( Bok Hyun Jun ) 서울시립대학교 산업기술연구소 2006 산업기술연구소논문집 Vol.14 No.-
Recently, population increase and advanced economy let us reconstruct old freeways. To consider a better freeway shape, we must dig tunnels through mountains. But while tunnel excavation, the possibility of collapse is inclined to be higher. So the aim of this paper is to analyze forms and causes of the collapse for different geological conditions and applied reinforcement solutions from typical collapse sites during constructions. As all investigators described the collapse sites on their own ways, all data forms and methods are so different that it was difficult for me to use and analyze the collapse causes.
Solid Phase C1q ELISA 법을 이용한 혈중 면역복합체 측정에 관한 연구
이수곤(Soo Kon Lee),홍천수(Chein Soo Hong),허갑범(Kap Bum Huh),박기일(Ki Il Park) 대한내과학회 1987 대한내과학회지 Vol.33 No.6
N/A An assay for circulating immune complexes that is adaptable to a routine clinical laboratory is described. Solid phase C1q ELISA was performed using the serum of 35 SLE patients, 12 RA patients and 100 normal controls. The results are as follows; 1) The sensitivity of SP C1q ELISA for CIC ranged 0.48-30 ㎍/ml AHGG equivalents. 2) The method was reproducible with CV% (coefficient of variation) of <20% in the abnormal range. 3) Ninety-five percent of the sera from normal volunteers showed<25 ㎍/ml AHGG euqivalents. 4) 27 of 35 (77%) of sera from patients with systemic lupus erythematosus (SLE) showed elevated levels of immune complexes than controls. 5) The SP C1q ELISA activity correlated (r=0.68) with the clinical activity of SLE patients. In conclusion, SP C1q ELISA method is very sensitive and reproducible for detecting circulating immune complexes and valuable to evaluate the clinical activity of SLE patients.
류마토이드관절염 환자에 대한 재조합 Gamma - Interferon 의 효과에 대한 연구
이수곤(Soo Kon Lee),홍천수(Chein Soo Hong) 대한내과학회 1989 대한내과학회지 Vol.37 No.6
N/A An open non-randomized clinical trial was conducted to explore the efficacy and safety of recombinant gamma-interferon for patients with rheumatoid arthritis using the total daily dosage of 1×10(6) IU twice sub-cutaneously 4 weeks. The clinical assessment, made on weeks 0,1,2,3,4 of treatment, included the following: activities of daily living (ADL) questionnaires, severity of pain evaluated by the use of a 100 mm visual analogue pain scale, morning stiffness duration, articular indices including Richie, ARA and restricted joint index, and performance scales including grip strength, button test and 7.5 M walking time. The laboratory assessment, made on at the same time with clinical assessment, included following: hemoglobin, ervthrocyte sedimentation rate (ESR). CRP and rhumatoid factor titer. The results obtained were as follows; 1) Of the 15 patients enrolled, 13 patients (879) completed 4 weeks treatment. Treatment was evaluated as effective in 8 of 13 (62%) patients according to the criteria for treatment success. 2) There was no significant difference of demographic data or the clinical and laboratory variables mea- sured between responder and non-responder group. 3) All clinical variables, except 7.5 M walking time, button test, ARA joint index and duration of morning stiffness, were improved significantly. Of them, ADI. pain score (p=0.005) and restricted joint index (p=0.005) were the variables showed most significant improvement. 4) This clinical improvement was associated with decrease in biological parameters such as ESR (p=0.004) and CRP (P=0.036). 5) Side effects occurecd in 11 out of 15 (73%). In 8 (53%) out of these patients transient but manageable fever (38.5ºC) was recorded. Two patients were dropped out due to high spiking fever with chilling in one, and due to vomiting and diarrhea in another. In conclusion, recombinant gamma-interferon may be effective therapeutic agent in the treatment of rheumatoid arthritis. A controlled trial in rheumatoid arthritis patients appears mandatory.
이수곤(Lee Soo-Gon),김순철(Kim Soon-Chul),이강일(Lee Kang-Il),송창영(Song chang-Young) 한국구조물진단유지관리학회 2003 한국구조물진단학회 학술발표회논문집 Vol.- No.-
기둥의 부재축에 따른 휨강성 변화가 정현함수(sine function)로 표시되는 단층 2경간 골조의 임계하중을 유한요소법으로 산정하였다. 골조는 가새 골조와 비가새 골조로 구분하였으며 수치해석에서는 경간대 충고비(=β)와 보의 단면 2차 모멘트 대 기둥의 최대 2차 모멘트 비(=n)를 고려하였다. 또한 기둥 자체의 단면 2차 모멘트는 taper parameter (=α)와 sectional property parameter (=m)에 따라 변화하는 것으로 하였다. 수치해석으로 산정된 임계하중 계수의 변화는 매개변수의 대수함수식으로 표시하고 대수 함수식의 계수 값들은 희귀분석법으로 결정하였다. 끝으로 제안한 대수함수식을 이용하여 유효길이 계수식을 유도하였다. 등단면 기둥의 경우 제안한 대수식을 기본으로 한 유효길이 계수는 수정 처짐각법식을 이용한 계수보다는 크고 CM 66(또는 Alignment charts)을 적용하여 산정한 값보다는 작다.
자가면역질환 모델로서 류마티스관절염 활막조직에서 면역글로불린 유전자 이용에 관한 연구
이수곤 ( Soo Kon Lee ),송준현 ( Joon Hyun Song ) 대한류마티스학회 1994 대한류마티스학회지 Vol.1 No.2
Objective: To gain insights into structural characteristics of immunoglobulin kappa chain repertoire expressed in the inflammed synovium of rheumatoid arthritis (RA), we analyzed Vκ transcirpts expressed in the synovium of a patient with longstanding RA and compared to those expressed in the PBLs of RA and normal controls. Methods: RT-PCR was done to amplify kappa chain transcripts from RA synovial lymphocytes and the cDNA sequences were compared to those from PBL of RA patient or normal control. Results: Kappa chain repertoire from RA patient`s synovial lymphocytes or PBL revealed increased somatic mutation and unusually long complementarity determining region (CDR) 3 compared to normal control. Conclusions: These changes in kappa chain repertoire in RA patient are suggesting that the antibody repertoire expressed in the synovium or PBL is unique and may be related with systemic dysregulation of B cell development.