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활동성 결핵의 중증도 및 병변 부위에 따른 전혈 인터페론 감마 분비능 측정의 민감도
김이영 ( Yi Young Kim ),이재희 ( Jae Hee Lee ),이윤지 ( Yoon Jee Lee ),이소연 ( So Yeon Lee ),이용훈 ( Yong Hun Lee ),최금주 ( Keum Ju Choi ),황보엽 ( Bo Yup Hwang ),차승익 ( Seung Ick Cha ),박재용 ( Jae Yong Park ),정태훈 ( Tae H 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.70 No.2
Background: The clinical manifestation of M. tuberculosis infection ranges from asymptomatic latent infection, to focal forms with minimal symptoms and low bacterial burdens, and finally to advanced tuberculosis (TB) with severe symptoms and high bacillary loads. We investigated the diagnostic sensitivity of the whole-blood interferon-y release assay according to the wide spectrum of clinical phenotypes. Methods: In patients diagnosed with active TB that underwent QuantiFERON(R) (QFT) testing, the QFT results were compared with patients known to be infected with pulmonary tuberculosis (P-TB) and extra-pulmonary TB (EP-TB). In addition, the results of the QFT test were further analyzed according to the radiographic extent of disease in patients with P-TB and the location of disease in patients with EP-TB. Results: There were no statistical differences in the overall distribution of QFT results between 177 patients with P-TB and 84 patients with EP-TB; the positive results of QFT test in patients with P-TB and EP-TB were 70.1% and 64.3%, respectively. Among patients with P-TB, patients with mild extents of disease showed higher frequency of positive results of QFT test than that of patients with severe form (75.2% vs. 57.1%, respectively; p=0.043) mainly due to an increase of indeterminate results in severe P-TB. Patients with TB pleurisy showed lower sensitivity by the QFT test than those with tuberculous lymphadenitis (48.8% vs. 78.8%, respectively; p=0.019). Conclusion: Although QFT test showed similar results between overall patients with P-TB and EP-TB, individual sensitivity was different according to the radiographic extent of disease in P-TB and the location of disease in EP-TB.
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분심기음(分心氣飮)이 고혈압 백서와 인간유래 혈관내피세포주(ECV 304)에 미치는 영향에 대한 연구
전연이,박창국,이소연,윤현덕,신오철,박치상,Jeon, Yeon-Yi,Park, Chang-Gook,Lee, So-Yeon,Yoon, Hyeon-Deok,Shin, Wo-Cheol,Park, Chi-Sang 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.1
Object : This study was designed to research whether the protection and inhibitory effects of cardiovascular diseases in L-NAME induced rat or ECV 304 cell lines through the Cell morphological pattern, Tunel assay, LDH activity, heart rate, blood pressure and immunohistochemistric analysis by Boonsimgieum water extract Methods : Nitric oxide(NO) play an important role in normal and pathophysiological cells including as a messenger molecule, neurotransmitter, microbiocidal agent, or dilator of blood vessels and artheriosclerosis, hypertension, myocardial infarction, respectively. Endothelial cell products can modulate the magnitude of a response to a vasoconstrictor, as evinced by the greater constriction after endothelium removal or NO synthesis blockade. To investigate that Boonsimgieum in the potential contribution of the levels of nitric oxide generated by endothelial nitric oxide synthase (eNOS) and the mechanisms of protection against NG-nitro-L-arginine methyl ester (L-NAME), human ECV 304 cells, which normally do not express eNOS, were expressed by L-NAME. L-NAME stimulated rat or cells were found to be resistant to injury and delayed death following the Boonsimgieum. Inhibition of nitric oxide synthesis abolished the protective effect against L-NAME, thrombin and collagen exposure. Interestingly, such effects have been observed during stimulation with agents such as phenylephrine and KCl on L-NAME mediate rats, were damaged by the NOS inhibitor L-NAME. Result : As the result of this study, In group, the anti-apoptosis and necrosis in the cardiovascular system have a potential capacity for prevented, protected and treating the diseases of cardiovascular system, against the necrosis of rat and ECV 304 cells with Caspase 3 and calpain expression by L-NAME is promoted. Conclusion : these results demonstrate neuroprotective and memory enhancing effects of ZIBU, suggesting its beneficial actions for the treatment of AD.
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김연규(Youn Kyu Kim),이소연(So-Yeon Yi),고산(San Ko),강상욱(Sang-Wook Kang),이주희(Joo-Hee Lee),최기혁(Gi-Hyuk Choi) 한국항공우주연구원 2008 항공우주산업기술동향 Vol.6 No.2
본 논문에서는 우주인 선발부터 발사/귀환까지 한국 우주인 배출 사업을 전체적으로 정리하고 아울러 사업 수행을 통해 얻은 기술 및 결과에 대해 자세히 소개될 것이다. 한국 우주인 배출 사업은 우주인 선발, 훈련, 우주실험 등과 관련된 유인우주기술을 습득하고 이 사업을 통해 국민들에게 과학과 우주에 대해 관심을 유도하여 과학문화를 확산하는 목적을 가지고 2005년 11월에 시작되었다. 2006년에는 우주인 선발 기준을 마련하고, 한국 우주인 배출을 위한 우주인 선발과정을 1차에서 4차까지 진행하여 우주인 2인을 최종 선발하였다. 그리고 2007년에는 우주인 2인이 러시아 가가린 훈련센터에서 우주인 훈련을 받았다. 그리고 한국 우주인이 국제우주정거장(ISS: International Space Station)에서 수행할 18가지의 우주과학실험과 3가지의 국제공동 실험을 개발하였다. 2008년 4월 한국 최초 우주인 이소연 박사가 카자흐스탄 바이코누르 발사장에서 소유즈 우주선을 타고 ISS로 올라가 계획된 우주실험 및 임무를 수행하고 무사히 귀환하였다. 위와 같이 본 논문에서는 이러한 일련의 과정(우주인 선발, 훈련, 우주실험 장비 개발 등)을 자세히 기술할 것이다. This paper entirely explains the Korean astronaut program from astronaut selection to launch and return and introduces technology and results through this program in detail. The Korean astronaut program launched Nov. 2005 with the objectives to develop the manned space technology such as astronaut selection, training and space experiment and to disseminate concerns to the public about the science and space. In 2006 to select the Korean astronauts, the standards for selecting astronauts were set and then the selection processes from 1st stage to 4th stage were performed. In 2007, the 2 Korean astronauts took the astronaut training and the 18 domestic science experiments and 3 international experiments which the Korean astronaut, Dr. Yi, performed in ISS last April were developed. In April 2008, the Korean astronaut was transported to ISS by Soyuz in Baikonur in Kazakhstan and returned to the ground with performing the mission and space experiments. This paper will explain these processes as the above(astronaut's selection, training, space experiment, etc.) in detail.
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국제우주정거장에서 수행된 한국우주식품 관능평가 결과분석
강상욱(Sang-Wook Kang),최기혁(Gi-Hyuk Choi),이소연(So-Yeon Yi),김성수(Sung-Soo Kim),송범석(Beom-Seok Song),김재훈(Jae-Hun Kim),이주운(Ju-Woon Lee) 한국항공우주학회 2009 韓國航空宇宙學會誌 Vol.37 No.8
본 논문에서는 한국우주인이 국제우주정거장에서 수행한 한국우주식품 10품목에 관한 관능평가결과를 분석하였다. 개인의 기호도 차이 때문에 관능평가 점수가 낮은 품목도 있었지만 대부분 높은 점수를 받았다. 해외우주인도 한국우주식품에 관하여 높은 평가를 하고 있어 향후 한국우주식품의 국제화 가능성도 확인할 수 있었다. 향후 유인우주탐사를 대비하여 한국우주식품의 품목 다양화와 우주에서 편리하게 사용할 수 있는 기능성을 갖춘 한국우주식품용 포장지 개발이 필요하다. We analyzed the result of sensory evaluation for the 10 items of Korean Space Foods performed by Korean astronaut in ISS. Although there were low score items because of the individual preference difference, Most items received the high score. Also, we can confirm the possibility of the internationalization of the Korean Space Foods because international astronauts gave the high valuation. we should develop the various space foods and food package which are easy to use in space for the human exploration in the future.
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