뇌질환 연구 동향 조사 및 턱관절 장애 관련 뇌질환 기전 연구의 필요성

이세은,이민지,이병호,임세현,조수인,Lee, Se-Eun,Lee, Min Ji,Lee, Byoungho,Lim, Sehyun,Cho, Suin 턱관절균형의학회 2018 턱관절균형의학회지 Vol.8 No.1

Recently, clinical efficacies of the intraoral balancing appliance therapy have been reported by several researchers, and it has been found that there are various kinds of diseases that can be effectively applied. However, studies on cerebrovascular disease, one of the main diseases with a high mortality rate, are still poorly reported, and studies of temporomandibular joint disorder (TMD)-induced changes in brain function suggest that cerebrovascular disease is more appropriate as an adaptive disorder of the temporomandibular joint (TMJ) balancing device. In the developed countries, the importance of research on the structure and function of the brain has been recognized and spurred on the related research. In Korea, the research on brain function and cognitive disorders should have promoted more massively. In order to regain its former reputation in the Korean medicine in the field of cerebrovascular disease, it should be spurred on basic research and clinical case studies. In addition, extensive and in-depth studies including animal studies are needed to establish the basis of underlying mechanisms of the TMJ balancing therapies.

일본의 쌀 가공 기술

이세은,Lee, Se-Eun 한국식품연구원 2011 食品技術 Vol.24 No.2

본 내용은 일본에서 개최한 동경 제과 및 제빵 박람회(MOBAC SHOW 2011)에 참관하여 제품 기술개발 현황 조사와 교토, 오사카 지역의 쌀 가공식품 판매현장 방문을 통한 조사 업무를 통하여 쌀을 이용한 식품 현황 파악, 개발 제품의 사업화 방향 등 향후 연구에 반영하고자 한다.

세계 소금산업의 현황

이세은,Lee, Se-Eun 한국식품연구원 2009 食品技術 Vol.22 No.4

저산소 농도가 식품의 유통기간에 미치는 영향

이세은,Lee, Se-Eun 한국식품연구원 2011 食品技術 Vol.24 No.1

Characteristics of $[^3H]$-Choline Uptake into Synaptosomes from Rat Hippocampus

이세은,홍성길,최림순,Lee, Se-Eun,Hong, Seong-Gil,Choe, Rim-Sun The Korean Society for Integrative Biology 1998 Korean journal of biological sciences Vol.2 No.2

Certain basic characteristics of choline uptake in nerve terminals were studied with synaptosomes from rat hippocampus. Synaptosomal $[^3H]$-choline uptake was clarified as specific and high affinity by low Km value(2.2 uM), Na+-dependency and high sensitivity to hemicholinium-3, a competitive inhibitor of choline uptake. Choline uptake into synaptosomes was linearlys related to Na+ concentration and membrane potential. Extracellular Ca2+ modulated the choline uptake, but probably not through increase of intracellular $Ca^{2+}$, because this modulation was not affected the by high $K^+$-depolarization. EGTA (2mM) added for $Ca^{2+}$-free condition had a peculiar effect of decreasing choline uptake. These results suggest that Ca2+ may play an important role in regulating the metabolism of acetylcholine in the nerve terminals directly through the increase of acetylcholine release.

캄보디아의 벼 수확 후 처리기술

이세은,Lee, Se-Eun 한국식품연구원 2010 食品技術 Vol.23 No.4

본 내용은 한국농촌경제연구원의 2010년 국제농업협력 기획사업인 '캄보디아 쌀 산업 일관체계 구축지원사업'의 일환으로 추진 중인 캄보디아의 시범 RPC 가능지역 선정을 위한 현지 추진조사와 관련하여 RPC 전문가로서 캄보디아 프놈펜과 Battambang주의 벼 수확 후 처리기술 및 시설 현지 조사 업무 수행을 하였다.

소아 복막 투석 환자에서 발생한 복막염: 단일기관에서 10년간의 경험

이세은,한경희,정윤혜,이현경,강희경,정해일,하일수,Lee, Se-Eun,Han, Kyoung-Hee,Jung, Yun-Hye,Lee, Hyun-Kyung,Kang, Hee-Gyung,Cheong, Hae-Il,Ha, Il-Soo 대한소아신장학회 2010 Childhood kidney diseases Vol.14 No.2

목 적 : 복막염의 원인균과 항생제 감수성은 지역이나 병원에 따라 다양하다. 따라서 이에 대한 자료가 치료 지침의 수립에 반드시 필요하다. 본 연구는 최근 10년동안 복막 투석을 받은 소아 환자들에서 발생한 복막염의 발생 빈도와 원인균의 특성의 변화를 알아보기 위해 수행되었다. 방 법 : 2000년부터 2010년까지 서울대학교 어린이병원에서 복막 투석을 받은 110명의 소아 환자들을 대상으로 하여 의무기록을 후향적으로 분석하였다. 결 과 : 복막 투석을 받은 환자 110명 중 57명에서 140례의 복막염이 발생하였다. 복막염의 발생 빈도는 0.43회/환자 년이었고, 2003년 이후로는 비슷한 빈도로 발생하고 있다. 60%의 환자가 복막 투석 시작 후 첫 1년 이내에 복막염이 발생하였고, 1세 미만에 복막 투석을 시작한 환아 7명은 모두 복막염을 경험하였다. 원인균으로 그람 양성균, 그람 음성균, 진균이 각각 58%, 38%, 4.1% 였고, 배양 음성률은 13.6% 였다. 그람 양성균 중에는 Staphylococcus, 그람 음성균 중에는Pseudomonas와Acinetobacter가 가장 많이 동정되었다. 그람 양성균중 56%가에는 1세대 cephalosporin에 감수성을 보였고, 그람 음성균 중 91%가 ceftazidime에 감수성을 보였다. 결 론 : 앞으로 복막염의 빈도를 더욱 감소시키기 위한 새로운 돌파구가 필요하다. 영아에서 복막염이 더 잘 발생하였지만, methicillin에 대한 저항성은 2세 미만에서 유의하게 높지 않았다. 전국적인 공동연구를 통해 우리나라 실정에 맞는 경험적 항생제 사용 지침을 정하는 것이 필요하다고 생각된다. Purpose : The organisms causing peritonitis and their antibiotic sensitivities vary in different regions and centers, and these data are necessary to establish regional treatment guidelines. The aim of this study was to investigate the changes in incidence and characteristics of the organisms that cause peritonitis in children undergoing peritoneal dialysis (PD) during recent 10 years. Methods : We retrospectively collected and analyzed the data from medical records of 110 children on PD during the period from 2000 to 2010. Results : One hundred and forty episodes of peritonitis have occurred in 57 patients. The overall incidence of peritonitis was 0.43 episodes/patient year, and similar incidence have been maintained since 2003. Sixty percent of the patients experienced peritonitis within 1 year of PD, and all patients commencing PD in infancy experienced peritonitis. Gram positive (G (+)), gram negative (G (-)) organisms and fungi were cultured in 58%, 38%, and 4.1% respectively and cultures were negative in 13.6%. Staphylococcus was the most common G (+) organism, and Pseudomonas and Acinetobacter were 2 most frequent G (-) organisms isolated. Fifty-six percent of the G (+) organisms were sensitive to first generation cephalosporin and 91% of G (-) pathogens were sensitive to ceftazidime. Methicillin-resistance rate was not higher in children less than 2 years of age than in those more than 2 years. Conclusion : An additional breakthrough has to be made to further reduce the incidence of peritonitis. Treatment guideline customized for peritonitis in Korean children on PD need to be established through a nationwide co-work.

반응표면분석법을 이용한 결정화 공정의 최적화

이세은 ( Se Eun Lee ),김재경 ( Jae Kyeong Kim ),한상근 ( Sang Keun Han ),채주승 ( Joo Seung Chae ),이근득 ( Keun Duk Lee ),구기갑 ( Kee Kahb Koo ) 한국공업화학회 2015 공업화학 Vol.26 No.6

Cyclotrimethylene trinitramine (RDX) is a high explosive commonly used for military applications. Submicronization of RDX particles has been a critical issue in order to alleviate the unintended and accidental stimuli toward safer and more powerful performances. The purpose of this study is to optimize experimental variables for drowning-out crystallization applied to produce submicron RDX particles. Effects of RDX concentration, anti-solvent temperature and anti-solvent mass were analyzed by the central composite rotatable design. The adjusted determination coefficient of regression model was calculated to be 0.9984 having the p-value less than 0.01. Response surface plots based on the central composite rotatable design determined the optimum conditions such as RDX concentration of 3 wt%, anti-solvent temperature of 0.2 ℃ and anti-solvent mass of 266 g. The optimum and experimental diameters of RDX particles were measured to be 0.53 μm and 0.53 μm, respectively. The regression model satisfactorily predicts the average diameter of RDX particles prepared by drowning-out crystallization. Structure of RDX crystals was found to be α-form by X-ray diffraction analysis and FT-IR spectroscopy.

단삼(丹蔘) 추출물의 항산화 효과에 의한 RAW264.7 cell에서의 항염증 작용

이세은 ( Se-eun Lee ),조수인 ( Su-in Cho ) 대한본초학회 2015 大韓本草學會誌 Vol.30 No.4

Objectives: It had been reported that herbal medicines containing polyphenol and flavonoid have been shown to be associated with decreased the cause of aging and variety of disease such as reactive nitrogen species and reactive oxygen species in several recent studies. Salviae miltiorrhizae Radix, origined from Salvia miltiorrhiza BGE., is one of popular traditional herbal medicines that is commonly used by traditional medicine practitioners. To this date, Salviae miltiorrhizae Radix has more than 2000-year history of mature application. This study was conducted to investigate whether the Salviae miltiorrhizae Radix methanol extract has an inhibitory effect association with oxidation or inflammation. Methods: Cytotoxic activity of Salviae miltiorrhizae Radix methanol extract on RAW264.7 cells was evaluated by using 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide solution. Nitric oxide production was measured using griess reagent system. Western blot analysis and measurement for changes of protein expression, nitric oxide synthase and cyclooxygenase-2, also performed. Results: The medicinal plant, Salviae miltiorrhizae Radix, does not impair the cell viability in tested concentration (25-100 μg/ml). SMR showed anti-oxiative effects in vitro by decreasing electron donating ability, and also showed anti-inflammatory effects suppressing NO and COX-2 expressin in LPS induced RAW264.7 activation. SMR inhibited the generation of intracellular ROS production as dose dependant manner. Conclusions: These results indicate that Salviae miltiorrhizae Radix methanol extract has an anti-inflammatory activities via anti-oxidative effects, and the anti-inflammatory effect was presentedd as dose dependant manner.

무유쥬스 농축액의 Rheological Properties

이세은(Se-Eun Lee),이부용(Boo-Yong Lee),진재순(Jae-Soon Jin),김동만(Dong-Man Kim),김길환(Kil-Hwan Kim) 한국식품과학회 1992 한국식품과학회지 Vol.24 No.3