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진행성 위암에 대한 1차 요법으로 Docetaxel과 Cisplatin 복합화학요법의 효과와 안정성에 대한 연구
김경중 ( Gyung Jung Kim ),이세동 ( Sehe Dong Lee ),박종원 ( Jong Won Park ),신철호 ( Cheol Ho Sin ),황승재 ( Seung Jae Hwang ),남승현 ( Seung Hyun Nam ),김봉석 ( Bong Seog Kim ) 대한내과학회 2007 대한내과학회지 Vol.72 No.6
본 연구에서는 수술 후 재발한 진행성 또는 절제 불가능한 전이성 위암을 가진 42명의 환자를 대상으로 1차 항암요법으로 docetaxel과 cisplatin을 투여하여 높은 반응률과 감내할만한 부작용을 확인할 수 있었다. 향후 많은 환자를 대상으로 한 전향적 연구와 표적치료제를 포함한 병용치료에 대한 연구가 필요할 것으로 판단된다. Background: To evaluate the activity and safety of docetaxel and cisplatin for advanced gastric cancer as a first-line chemotherapy treatment. Methods: Between December 2001 and February 2006, forty-two patients with recurrent or metastatic gastric cancer were enrolled. Docetaxel (75 mg/m2) was administered as a 1-hour intravenous infusion on day 1 and cisplatin (60 mg/m2) was also administered as a 30-minute intravenous infusion on day 1 every three weeks until disease progression or severe toxicity was detected. The response was assessed every 2 cycles. The toxicities were evaluated for every course of chemotherapy according to NCI toxicity criteria. Results: The median age of the patients was 66 (range, 33~77) years. Among the forty-two patients, 38 were male. Twenty-seven patients had an Eastern Cooperative Oncology Group performance score of 0 or 1 and fifteen patients had a score of 2. All patients had adenocarcinoma. Thirty-three of the forty-two patients were assessable for response. Partial responses were observed in 14 patients. The overall response rate was 42.4% (95% C.I., 25.259.6%) and the median response duration was 5.7 (range, 1.4~17.2) months. The median overall survival of all patients was 8.1 (range, 1.2~47.0) months. During a total of 170 cycles, granulocytopenia worse than National Cancer Institute toxicity grade 3 occurred in 7.6% of the patients, thrombocytopenia in 0.6% and anemia in 3.5%, respectively. No deaths resulting from toxicity were observed. Non-hematologic toxicities were minor and were easily controlled. Conclusion: Combination chemotherapy with docetaxel and cisplatin has a tolerable efficacy with acceptable toxicities in patients with advanced gastric cancer as a first-line treatment. (Korean J Med 72:593-599, 2007)
증례 : 다검출 나선형 CT로 확인된 대동맥과 폐동맥으로 연결된 관상 동정맥루 1예
최익성 ( Ik Sung Choi ),조은희 ( Eun Hee Cho ),조근혁 ( Keun Hyuk Cho ),최재원 ( Jae Won Choi ),이세동 ( Sehe Dong Lee ),이근 ( Keun Lee ),곽서현 ( Seo Hyun Kwak ) 대한내과학회 2006 대한내과학회지 Vol.71 No.2
흉통을 주소로 내원한 환자에서 관상동맥 조영술 및 다검출 나선형 CT (MDCT)상 좌전하행지와 대동맥에서 망상형태의 common channel을 통해 폐동맥으로 연결된 관상 동맥루 1예를 진단하고 수술적 치료를 하였기에 이를 문헌고찰과 함께 보고하는 바이다. A congenital coronary artery fistula is a rare condition, which is an abnormal communication of the coronary artery with the ventricles or atriums or the pulmonary artery. A case of 69 year-old man, complaining of recent aggravating chest pain for 5 months is reported. The coronary angiography shows coronary artery-pulmonary artery fistula. Multidetector row CT shows coronary artery-pulmonary artery fistula combined with aortopulmonary fistula via common channel and the fistulas were surgically ligated.(Korean J Med 71:208-213, 2006)